NO318814B1 - Liposomsammensetninger, dehydrerte unilamellaere liposomer og fremgangsmater derav. - Google Patents
Liposomsammensetninger, dehydrerte unilamellaere liposomer og fremgangsmater derav. Download PDFInfo
- Publication number
- NO318814B1 NO318814B1 NO19964284A NO964284A NO318814B1 NO 318814 B1 NO318814 B1 NO 318814B1 NO 19964284 A NO19964284 A NO 19964284A NO 964284 A NO964284 A NO 964284A NO 318814 B1 NO318814 B1 NO 318814B1
- Authority
- NO
- Norway
- Prior art keywords
- lipid
- liposome
- aqueous solution
- ionizable lipid
- ionizable
- Prior art date
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- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- IPIVAXLHTVNRBS-UHFFFAOYSA-N decanoyl chloride Chemical compound CCCCCCCCCC(Cl)=O IPIVAXLHTVNRBS-UHFFFAOYSA-N 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
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- 235000019441 ethanol Nutrition 0.000 description 1
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- 238000011049 filling Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
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- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
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- 230000010189 intracellular transport Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
- 230000002911 mydriatic effect Effects 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid Chemical compound CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
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- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000000264 spin echo pulse sequence Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
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- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1994/003996 WO1995027478A1 (fr) | 1994-04-12 | 1994-04-12 | Liposomes de fusion, leurs procedes de preparation et d'utilisation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO964284L NO964284L (no) | 1996-10-09 |
| NO964284D0 NO964284D0 (no) | 1996-10-09 |
| NO318814B1 true NO318814B1 (no) | 2005-05-09 |
Family
ID=22242444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19964284A NO318814B1 (no) | 1994-04-12 | 1996-10-09 | Liposomsammensetninger, dehydrerte unilamellaere liposomer og fremgangsmater derav. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0758883B1 (fr) |
| JP (1) | JP3804025B2 (fr) |
| KR (1) | KR100315132B1 (fr) |
| AT (1) | ATE234605T1 (fr) |
| AU (1) | AU689479B2 (fr) |
| CA (1) | CA2187748C (fr) |
| DE (1) | DE69432320T2 (fr) |
| DK (1) | DK0758883T3 (fr) |
| ES (1) | ES2196028T3 (fr) |
| FI (1) | FI964083A0 (fr) |
| NO (1) | NO318814B1 (fr) |
| NZ (1) | NZ268146A (fr) |
| WO (1) | WO1995027478A1 (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6339069B1 (en) | 1996-10-15 | 2002-01-15 | Elan Pharmaceuticalstechnologies, Inc. | Peptide-lipid conjugates, liposomes and lipsomal drug delivery |
| WO1998016240A1 (fr) * | 1996-10-15 | 1998-04-23 | The Liposome Company, Inc. | Conjugues de peptide-lipide, liposomes et apport de medicaments par des liposomes |
| JP4656675B2 (ja) | 1997-05-14 | 2011-03-23 | ユニバーシティー オブ ブリティッシュ コロンビア | 脂質小胞への荷電した治療剤の高率封入 |
| US6835395B1 (en) | 1997-05-14 | 2004-12-28 | The University Of British Columbia | Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles |
| US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
| EP1212085B1 (fr) * | 1999-08-27 | 2007-10-31 | INEX Pharmaceuticals Corp. | Compositions stimulant la secretion de cytokine et provoquant une reaction immunitaire |
| KR20060034215A (ko) * | 2003-03-31 | 2006-04-21 | 알자 코포레이션 | 비대칭 지질 코팅을 가지는 지질 입자 및 그 제조 방법 |
| EP2669002A1 (fr) * | 2005-01-28 | 2013-12-04 | Japan Science and Technology Agency | Agrégat moléculaire capable de subir une transition de phase par condensation déshydratante et procédé de transition de phase de celui-ci |
| JP5532921B2 (ja) | 2007-05-14 | 2014-06-25 | コニカミノルタ株式会社 | リポソーム |
| US9937128B2 (en) | 2009-08-03 | 2018-04-10 | The University Of North Carolina At Chapel Hill | Liposomes comprising a calcium phosphate-containing precipitate |
| PT3338765T (pt) | 2009-12-01 | 2019-03-18 | Translate Bio Inc | Derivado de esteróide adequado para a administração de arnm em doenças genéticas humanas |
| AU2012267531B2 (en) | 2011-06-08 | 2017-06-22 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mRNA delivery |
| EP3536787A1 (fr) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Polynucléotides résistant aux nucléases et leurs utilisations |
| HUE042640T2 (hu) | 2013-03-14 | 2019-07-29 | Translate Bio Inc | CFTR-mRNS-készítmények, valamint kapcsolódó eljárások és alkalmazások |
| JP6586075B2 (ja) | 2013-03-14 | 2019-10-02 | トランスレイト バイオ， インコーポレイテッド | メッセンジャーｒｎａの精製方法 |
| EP3060258A1 (fr) | 2013-10-22 | 2016-08-31 | Shire Human Genetic Therapies, Inc. | Thérapie à l'arnm pour la phénylcétonurie |
| ES2707966T3 (es) | 2013-10-22 | 2019-04-08 | Translate Bio Inc | Terapia de ARNm para la deficiencia en síntesis de argininosuccinato |
| KR20220158867A (ko) | 2014-04-25 | 2022-12-01 | 샤이어 휴먼 지네틱 테라피즈 인크. | 메신저 rna 의 정제 방법 |
| EP3585417B1 (fr) | 2017-02-27 | 2023-02-22 | Translate Bio, Inc. | Méthode de préparation d'arnm cftr à codons optimisés |
| WO2018213476A1 (fr) | 2017-05-16 | 2018-11-22 | Translate Bio, Inc. | Traitement de la fibrose kystique par administration d'arnm à codons optimisés codant pour la cftr |
| CA3108544A1 (fr) | 2018-08-24 | 2020-02-27 | Translate Bio, Inc. | Procedes de purification d'arn messager |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946787A (en) * | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| EP0269720B1 (fr) * | 1986-06-16 | 1992-02-19 | The Liposome Company, Inc. | Induction d'asymetrie dans des vesicules |
| JPH0395118A (ja) * | 1989-09-07 | 1991-04-19 | Green Cross Corp:The | プロスタグランジン含有脂肪小体製剤 |
| DE4013632A1 (de) * | 1990-04-27 | 1991-10-31 | Max Planck Gesellschaft | Liposomen mit positiver ueberschussladung |
| US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
-
1994
- 1994-04-12 EP EP94919976A patent/EP0758883B1/fr not_active Expired - Lifetime
- 1994-04-12 AU AU70915/94A patent/AU689479B2/en not_active Ceased
- 1994-04-12 NZ NZ268146A patent/NZ268146A/en not_active IP Right Cessation
- 1994-04-12 DE DE69432320T patent/DE69432320T2/de not_active Expired - Fee Related
- 1994-04-12 KR KR1019960705605A patent/KR100315132B1/ko not_active IP Right Cessation
- 1994-04-12 WO PCT/US1994/003996 patent/WO1995027478A1/fr active IP Right Grant
- 1994-04-12 DK DK94919976T patent/DK0758883T3/da active
- 1994-04-12 AT AT94919976T patent/ATE234605T1/de not_active IP Right Cessation
- 1994-04-12 CA CA002187748A patent/CA2187748C/fr not_active Expired - Fee Related
- 1994-04-12 JP JP52630695A patent/JP3804025B2/ja not_active Expired - Fee Related
- 1994-04-12 ES ES94919976T patent/ES2196028T3/es not_active Expired - Lifetime
-
1996
- 1996-10-09 NO NO19964284A patent/NO318814B1/no unknown
- 1996-10-11 FI FI964083A patent/FI964083A0/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI964083A (fi) | 1996-10-11 |
| NZ268146A (en) | 1997-10-24 |
| EP0758883B1 (fr) | 2003-03-19 |
| AU689479B2 (en) | 1998-04-02 |
| NO964284L (no) | 1996-10-09 |
| CA2187748A1 (fr) | 1995-10-19 |
| DE69432320T2 (de) | 2003-12-04 |
| EP0758883A1 (fr) | 1997-02-26 |
| JP3804025B2 (ja) | 2006-08-02 |
| DE69432320D1 (de) | 2003-04-24 |
| KR100315132B1 (ko) | 2002-06-26 |
| JPH09511521A (ja) | 1997-11-18 |
| ES2196028T3 (es) | 2003-12-16 |
| AU7091594A (en) | 1995-10-30 |
| FI964083A0 (fi) | 1996-10-11 |
| WO1995027478A1 (fr) | 1995-10-19 |
| ATE234605T1 (de) | 2003-04-15 |
| CA2187748C (fr) | 2007-04-10 |
| DK0758883T3 (da) | 2003-06-02 |
| NO964284D0 (no) | 1996-10-09 |
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