ES2196028T3 - Liposomas fusogenicos y metodos de fabricacion y utilizacion. - Google Patents
Liposomas fusogenicos y metodos de fabricacion y utilizacion.Info
- Publication number
- ES2196028T3 ES2196028T3 ES94919976T ES94919976T ES2196028T3 ES 2196028 T3 ES2196028 T3 ES 2196028T3 ES 94919976 T ES94919976 T ES 94919976T ES 94919976 T ES94919976 T ES 94919976T ES 2196028 T3 ES2196028 T3 ES 2196028T3
- Authority
- ES
- Spain
- Prior art keywords
- liposoma
- lipidic
- external
- lipid
- fusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002502 liposome Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000002632 lipids Chemical class 0.000 abstract 5
- 230000004927 fusion Effects 0.000 abstract 4
- 239000007788 liquid Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000232 Lipid Bilayer Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE FACILITA UN COMPUESTO DE LIPOSOMAS QUE CONTIENE UN LIPOSOMA QUE INCLUYE :(I) UNA BICAPA LIPIDICA EN SU PARTE MAS EXTERIOR QUE CONTIENE, ADEMAS DE UN LIPIDO PREFERIBLEMENTE BICAPADO NEUTRAL, UNA CANTIDAD EFECTIVA QUE FACILITE LA FUSION DE UN LIPIDO IONIZABLE QUE TENGA UNA CABECERA CATIONICA, GENERADORA DE PROTONES Y UNA CADENA DE ACIL INSATURADO; Y (II) UN COMPARTIMENTO ADYACENTE A LA BICAPA LIPIDICA EXTERIOR QUE CONTIENE UNA SOLUCION ACUOSA CON UN PRIMER PH. FUERA DEL LIPOSOMA EN LA COMPOSICION HAY UNA SOLUCION ACUOSA CON UN SEGUNDO PH. EL PRIMER PH ES INFERIOR AL PK{SUB,A} DEL LIPIDO IONIZABLE DE LA BICAPA LIPIDICA EXTERIOR Y EL SEGUNDO PH ES MAYOR QUE EL PK{SUB,A} DE UN LIPIDO IONIZABLE DE LA BICAPA LIPIDICA EXTERIOR, COMO PUEDE SER EL QUE EXISTE EN UN GRADIENTE DE PH A TRAVES DE LA BICAPA LIPIDICA EXTERIOR, ACUMULANDOSE EL LIPIDO IONIZABLE EN LA MONOCAPA INTERIOR DE LA BICAPA LIPIDICA EXTERIOR QUE RESPONDE AL GRADIENTE. EL LIPOSOMA PUEDE FUNDIRSE DE FORMA CONTROLADA CON OTRA BICAPA LIPIDICA, COMO POR EJEMPLO, LA MEMBRANA PLASMATICA DE LA CELULA DE UN MAMIFERO, MEDIANTE EL DEGRADADO DEL GRADIENTE DE PH CUANDO SE PRODUCE LA FUSION, DE FORMA QUE EL LIPIDO IONIZABLE ES NEUTRAL, INCLUSO CUANDO SE DISTRIBUYE EN LA BICAPA LIPIDICA EXTERIOR Y, FUSOGENICO. LA FUSION CONTROLADA PUEDE USARSE PARA CONTROLAR EL ENVIO DE UN AGENTE ACTIVO BIOLOGICAMENTE DENTRO DEL LIPOSOMA AL INTERIOR DE UNA CELULA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1994/003996 WO1995027478A1 (en) | 1994-04-12 | 1994-04-12 | Fusogenic liposomes and methods of making and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2196028T3 true ES2196028T3 (es) | 2003-12-16 |
Family
ID=22242444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94919976T Expired - Lifetime ES2196028T3 (es) | 1994-04-12 | 1994-04-12 | Liposomas fusogenicos y metodos de fabricacion y utilizacion. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0758883B1 (es) |
| JP (1) | JP3804025B2 (es) |
| KR (1) | KR100315132B1 (es) |
| AT (1) | ATE234605T1 (es) |
| AU (1) | AU689479B2 (es) |
| CA (1) | CA2187748C (es) |
| DE (1) | DE69432320T2 (es) |
| DK (1) | DK0758883T3 (es) |
| ES (1) | ES2196028T3 (es) |
| FI (1) | FI964083A0 (es) |
| NO (1) | NO318814B1 (es) |
| NZ (1) | NZ268146A (es) |
| WO (1) | WO1995027478A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6339069B1 (en) | 1996-10-15 | 2002-01-15 | Elan Pharmaceuticalstechnologies, Inc. | Peptide-lipid conjugates, liposomes and lipsomal drug delivery |
| AU725376B2 (en) * | 1996-10-15 | 2000-10-12 | Transave, Inc. | Peptide-lipid conjugates, liposomes and liposomal drug delivery |
| US6835395B1 (en) | 1997-05-14 | 2004-12-28 | The University Of British Columbia | Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles |
| CA2289702C (en) * | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
| BR0013834A (pt) * | 1999-08-27 | 2002-04-23 | Inex Pharmaceuticals Corp | Composições e métodos para estimular a secreção de citoquinas e induzir uma resposta imunológica |
| JP2007524604A (ja) * | 2003-03-31 | 2007-08-30 | アルザ・コーポレーシヨン | 非対称の脂質被膜を有する脂質粒子およびその製造方法 |
| WO2006080157A1 (ja) * | 2005-01-28 | 2006-08-03 | Japan Science And Technology Agency | 脱水縮合反応により相転移を生じ得る分子集合体およびその相転移方法 |
| WO2008140081A1 (ja) | 2007-05-14 | 2008-11-20 | Konica Minolta Holdings, Inc. | リポソームおよびリポソームの製造方法 |
| US9937128B2 (en) * | 2009-08-03 | 2018-04-10 | The University Of North Carolina At Chapel Hill | Liposomes comprising a calcium phosphate-containing precipitate |
| SI3338765T1 (sl) | 2009-12-01 | 2019-05-31 | Translate Bio, Inc. | Derivat steroida za dostavo MRNA pri humanih genetskih boleznih |
| CN103906527B (zh) | 2011-06-08 | 2020-07-10 | 川斯勒佰尔公司 | Mrna递送的脂质纳米颗粒组合物和方法 |
| EP2859102A4 (en) | 2012-06-08 | 2016-05-11 | Shire Human Genetic Therapies | NUCLEASE RESISTANT POLYNUCLEOTIDES AND USES THEREOF |
| KR102248744B1 (ko) | 2013-03-14 | 2021-05-06 | 샤이어 휴먼 지네틱 테라피즈 인크. | Cftr mrna 조성물 및 관련 방법 및 사용 |
| US9957499B2 (en) | 2013-03-14 | 2018-05-01 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| EP3060303B1 (en) | 2013-10-22 | 2018-11-14 | Translate Bio, Inc. | Mrna therapy for argininosuccinate synthetase deficiency |
| CA2928186A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Mrna therapy for phenylketonuria |
| SG11201608725YA (en) | 2014-04-25 | 2016-11-29 | Shire Human Genetic Therapies | Methods for purification of messenger rna |
| MA47603A (fr) | 2017-02-27 | 2020-01-01 | Translate Bio Inc | Nouvel arnm cftr à codons optimisés |
| ES2993135T3 (en) | 2017-05-16 | 2024-12-23 | Translate Bio Inc | Codon-optimized mrna encoding cftr for use in treating cystic fibrosis |
| EP3841208A1 (en) | 2018-08-24 | 2021-06-30 | Translate Bio, Inc. | Methods for purification of messenger rna |
| WO2020106946A1 (en) | 2018-11-21 | 2020-05-28 | Translate Bio, Inc. | TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946787A (en) * | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| JP2760355B2 (ja) * | 1986-06-16 | 1998-05-28 | ザ リポソーム カンパニー，インコーポレイテッド | 不均整誘導リポソーム |
| JPH0395118A (ja) * | 1989-09-07 | 1991-04-19 | Green Cross Corp:The | プロスタグランジン含有脂肪小体製剤 |
| DE4013632A1 (de) * | 1990-04-27 | 1991-10-31 | Max Planck Gesellschaft | Liposomen mit positiver ueberschussladung |
| US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
-
1994
- 1994-04-12 DE DE69432320T patent/DE69432320T2/de not_active Expired - Fee Related
- 1994-04-12 DK DK94919976T patent/DK0758883T3/da active
- 1994-04-12 KR KR1019960705605A patent/KR100315132B1/ko not_active Expired - Fee Related
- 1994-04-12 WO PCT/US1994/003996 patent/WO1995027478A1/en active IP Right Grant
- 1994-04-12 ES ES94919976T patent/ES2196028T3/es not_active Expired - Lifetime
- 1994-04-12 NZ NZ268146A patent/NZ268146A/en not_active IP Right Cessation
- 1994-04-12 AU AU70915/94A patent/AU689479B2/en not_active Ceased
- 1994-04-12 CA CA002187748A patent/CA2187748C/en not_active Expired - Fee Related
- 1994-04-12 AT AT94919976T patent/ATE234605T1/de not_active IP Right Cessation
- 1994-04-12 JP JP52630695A patent/JP3804025B2/ja not_active Expired - Fee Related
- 1994-04-12 EP EP94919976A patent/EP0758883B1/en not_active Expired - Lifetime
-
1996
- 1996-10-09 NO NO19964284A patent/NO318814B1/no unknown
- 1996-10-11 FI FI964083A patent/FI964083A0/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO964284L (no) | 1996-10-09 |
| NZ268146A (en) | 1997-10-24 |
| ATE234605T1 (de) | 2003-04-15 |
| WO1995027478A1 (en) | 1995-10-19 |
| FI964083A7 (fi) | 1996-10-11 |
| DE69432320D1 (de) | 2003-04-24 |
| NO964284D0 (no) | 1996-10-09 |
| FI964083A0 (fi) | 1996-10-11 |
| DE69432320T2 (de) | 2003-12-04 |
| CA2187748C (en) | 2007-04-10 |
| EP0758883B1 (en) | 2003-03-19 |
| DK0758883T3 (da) | 2003-06-02 |
| JPH09511521A (ja) | 1997-11-18 |
| KR100315132B1 (ko) | 2002-06-26 |
| JP3804025B2 (ja) | 2006-08-02 |
| AU7091594A (en) | 1995-10-30 |
| AU689479B2 (en) | 1998-04-02 |
| NO318814B1 (no) | 2005-05-09 |
| CA2187748A1 (en) | 1995-10-19 |
| EP0758883A1 (en) | 1997-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2196028T3 (es) | Liposomas fusogenicos y metodos de fabricacion y utilizacion. | |
| ES2148568T3 (es) | Formulaciones de disoluciones acuosas estables de interferon alfa. | |
| ES2162638T3 (es) | Vehiculos de suministro de farmacos con gelificacion termica que contienen eteres de celulosa. | |
| Cereijido et al. | Fluxes and distribution of sodium in frog skin: a new model | |
| AR015560A1 (es) | Producto de papel tisu suave | |
| CO5050344A1 (es) | Composicion dentifrica que contiene ingredientes reactivos encapsulados | |
| ES2039898T3 (es) | Acondicionamiento para una composicion liquida lista para su uso realizada a partir de una composicion liquida concentrada y procedimiento de realizacion. | |
| ES2129980T3 (es) | Sistema de afeitado en humedo con un material compuesto que favorece el afeitado, con un complejo de inclusion de un agente suavizante de la piel y ciclodextrina. | |
| AR020633A1 (es) | Parche cosmetico, farmaceutico o dermatologico. | |
| PE106898A1 (es) | Composicion liquida de aseo personal que contiene un agente humectante de piel lipofilico compuesto de gotitas relativamente grandes | |
| BR9807646A (pt) | Composição concentrada desinfetante lìquida aquosa, e, composição desinfetante. | |
| ES2192256T3 (es) | Soluciones farmaceuticas inyectables que contienen paracetamol y combinaciones de paracetamol con otras sustancias activas. | |
| MXPA97007996A (es) | Preparado para el transporte de sustancias activas a traves de barreras. | |
| ES8900197A1 (es) | Procedimiento para la preparacion de liposomas a partir de una mezcla de un componente lipido y agua | |
| SE9704386L (sv) | Flerkammarbehållare för medicinsk lösning | |
| DE60104872D1 (de) | Stabilisierte ophthalmische wasserstoffperoxidlösung | |
| PE17897A1 (es) | Formulacion transdermica en parche del 3-(4-butiltio)-1,2,5-tiadiazol-3-il)-1-azabiciclo (2,2,2) octano | |
| AR246159A1 (es) | Agente antiparasitario con accion mejorada. | |
| US6740330B1 (en) | Method of treating acne vulgaris and composition | |
| WO1994017782A3 (de) | Verwendung von hohen elektrolytkonzentrationen in kosmetischen reinigungsmitteln | |
| ES2000033A6 (es) | Composicion de bitionol sulfoxido porcedimiento para su fabricacion y metodo de utilizacion de aquella | |
| BR9714499A (pt) | Processo para branquear os dentes. | |
| ES2084602T3 (es) | Una composicion para suavizar tejidos. | |
| KR20170099261A (ko) | 피부용 마스크 | |
| ES2097201T3 (es) | Detergentes liquidos. |