ES2196028T3 - Liposomas fusogenicos y metodos de fabricacion y utilizacion. - Google Patents
Liposomas fusogenicos y metodos de fabricacion y utilizacion.Info
- Publication number
- ES2196028T3 ES2196028T3 ES94919976T ES94919976T ES2196028T3 ES 2196028 T3 ES2196028 T3 ES 2196028T3 ES 94919976 T ES94919976 T ES 94919976T ES 94919976 T ES94919976 T ES 94919976T ES 2196028 T3 ES2196028 T3 ES 2196028T3
- Authority
- ES
- Spain
- Prior art keywords
- lipid
- outermost
- lipid bilayer
- liposome
- bilayer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE FACILITA UN COMPUESTO DE LIPOSOMAS QUE CONTIENE UN LIPOSOMA QUE INCLUYE :(I) UNA BICAPA LIPIDICA EN SU PARTE MAS EXTERIOR QUE CONTIENE, ADEMAS DE UN LIPIDO PREFERIBLEMENTE BICAPADO NEUTRAL, UNA CANTIDAD EFECTIVA QUE FACILITE LA FUSION DE UN LIPIDO IONIZABLE QUE TENGA UNA CABECERA CATIONICA, GENERADORA DE PROTONES Y UNA CADENA DE ACIL INSATURADO; Y (II) UN COMPARTIMENTO ADYACENTE A LA BICAPA LIPIDICA EXTERIOR QUE CONTIENE UNA SOLUCION ACUOSA CON UN PRIMER PH. FUERA DEL LIPOSOMA EN LA COMPOSICION HAY UNA SOLUCION ACUOSA CON UN SEGUNDO PH. EL PRIMER PH ES INFERIOR AL PK{SUB,A} DEL LIPIDO IONIZABLE DE LA BICAPA LIPIDICA EXTERIOR Y EL SEGUNDO PH ES MAYOR QUE EL PK{SUB,A} DE UN LIPIDO IONIZABLE DE LA BICAPA LIPIDICA EXTERIOR, COMO PUEDE SER EL QUE EXISTE EN UN GRADIENTE DE PH A TRAVES DE LA BICAPA LIPIDICA EXTERIOR, ACUMULANDOSE EL LIPIDO IONIZABLE EN LA MONOCAPA INTERIOR DE LA BICAPA LIPIDICA EXTERIOR QUE RESPONDE AL GRADIENTE. EL LIPOSOMA PUEDE FUNDIRSE DE FORMA CONTROLADA CON OTRA BICAPA LIPIDICA, COMO POR EJEMPLO, LA MEMBRANA PLASMATICA DE LA CELULA DE UN MAMIFERO, MEDIANTE EL DEGRADADO DEL GRADIENTE DE PH CUANDO SE PRODUCE LA FUSION, DE FORMA QUE EL LIPIDO IONIZABLE ES NEUTRAL, INCLUSO CUANDO SE DISTRIBUYE EN LA BICAPA LIPIDICA EXTERIOR Y, FUSOGENICO. LA FUSION CONTROLADA PUEDE USARSE PARA CONTROLAR EL ENVIO DE UN AGENTE ACTIVO BIOLOGICAMENTE DENTRO DEL LIPOSOMA AL INTERIOR DE UNA CELULA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1994/003996 WO1995027478A1 (en) | 1994-04-12 | 1994-04-12 | Fusogenic liposomes and methods of making and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2196028T3 true ES2196028T3 (es) | 2003-12-16 |
Family
ID=22242444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94919976T Expired - Lifetime ES2196028T3 (es) | 1994-04-12 | 1994-04-12 | Liposomas fusogenicos y metodos de fabricacion y utilizacion. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0758883B1 (es) |
| JP (1) | JP3804025B2 (es) |
| KR (1) | KR100315132B1 (es) |
| AT (1) | ATE234605T1 (es) |
| AU (1) | AU689479B2 (es) |
| CA (1) | CA2187748C (es) |
| DE (1) | DE69432320T2 (es) |
| DK (1) | DK0758883T3 (es) |
| ES (1) | ES2196028T3 (es) |
| FI (1) | FI964083A (es) |
| NO (1) | NO318814B1 (es) |
| NZ (1) | NZ268146A (es) |
| WO (1) | WO1995027478A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6339069B1 (en) | 1996-10-15 | 2002-01-15 | Elan Pharmaceuticalstechnologies, Inc. | Peptide-lipid conjugates, liposomes and lipsomal drug delivery |
| ATE244572T1 (de) * | 1996-10-15 | 2003-07-15 | Liposome Co Inc | Peptid-lipid konjugate, liposomen und liposomale arzneimittelverabreichung |
| US6835395B1 (en) | 1997-05-14 | 2004-12-28 | The University Of British Columbia | Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles |
| JP4656675B2 (ja) | 1997-05-14 | 2011-03-23 | ユニバーシティー オブ ブリティッシュ コロンビア | 脂質小胞への荷電した治療剤の高率封入 |
| US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
| KR100737980B1 (ko) * | 1999-08-27 | 2007-07-12 | 아이넥스 파머슈티컬스 코포레이션 | 사이토카인 분비 자극용 및 면역반응 유도용 조성물 |
| EP1613285A2 (en) * | 2003-03-31 | 2006-01-11 | Alza Corporation | Lipid particles having asymmetric lipid coating and method of preparing same |
| EP1852177B1 (en) * | 2005-01-28 | 2014-02-26 | Japan Science and Technology Agency | Molecular aggregate capable of undergoing phase transition by dehydrating condensation and method of phase transition thereof |
| US20100215582A1 (en) | 2007-05-14 | 2010-08-26 | Konica Minolta Holdings, Inc. | Liposome and method for producing liposome |
| WO2011017297A2 (en) | 2009-08-03 | 2011-02-10 | The University Of North Carolina At Chapel Hill | Biodegradable delivery system complexes for the delivery of bioactive compounds |
| PT3338765T (pt) | 2009-12-01 | 2019-03-18 | Translate Bio Inc | Derivado de esteróide adequado para a administração de arnm em doenças genéticas humanas |
| BR112013031553A2 (pt) | 2011-06-08 | 2020-11-10 | Shire Human Genetic Therapies, Inc. | composições, mrna que codifica para uma hgla e seu uso, uso de pelo menos uma molécula de mrna e um veículo de transferência e uso de um mrna que codifica para proteína exógena |
| EP2859102A4 (en) | 2012-06-08 | 2016-05-11 | Shire Human Genetic Therapies | NUCLEASE RESISTANT POLYNUCLEOTIDES AND USES THEREOF |
| IL305374A (en) | 2013-03-14 | 2023-10-01 | Ethris Gmbh | CFTR mRNA Assemblies and Related Methods and Uses |
| US9957499B2 (en) | 2013-03-14 | 2018-05-01 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| CA2928188A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Mrna therapy for argininosuccinate synthetase deficiency |
| EP3574923A1 (en) | 2013-10-22 | 2019-12-04 | Translate Bio, Inc. | Mrna therapy for phenylketonuria |
| ES2750661T3 (es) | 2014-04-25 | 2020-03-26 | Translate Bio Inc | Métodos para la purificación de ARN mensajero |
| EP3585417B1 (en) | 2017-02-27 | 2023-02-22 | Translate Bio, Inc. | Method of making a codon-optimized cftr mrna |
| IL270631B2 (en) | 2017-05-16 | 2024-03-01 | Translate Bio Inc | Treatment of cystic fibrosis through the administration of mRNA with an optimal codon encoding ctfr |
| US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946787A (en) * | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| JP2760355B2 (ja) * | 1986-06-16 | 1998-05-28 | ザ リポソーム カンパニー，インコーポレイテッド | 不均整誘導リポソーム |
| JPH0395118A (ja) * | 1989-09-07 | 1991-04-19 | Green Cross Corp:The | プロスタグランジン含有脂肪小体製剤 |
| DE4013632A1 (de) * | 1990-04-27 | 1991-10-31 | Max Planck Gesellschaft | Liposomen mit positiver ueberschussladung |
| US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
-
1994
- 1994-04-12 EP EP94919976A patent/EP0758883B1/en not_active Expired - Lifetime
- 1994-04-12 ES ES94919976T patent/ES2196028T3/es not_active Expired - Lifetime
- 1994-04-12 JP JP52630695A patent/JP3804025B2/ja not_active Expired - Fee Related
- 1994-04-12 AT AT94919976T patent/ATE234605T1/de not_active IP Right Cessation
- 1994-04-12 KR KR1019960705605A patent/KR100315132B1/ko not_active IP Right Cessation
- 1994-04-12 NZ NZ268146A patent/NZ268146A/en not_active IP Right Cessation
- 1994-04-12 DK DK94919976T patent/DK0758883T3/da active
- 1994-04-12 DE DE69432320T patent/DE69432320T2/de not_active Expired - Fee Related
- 1994-04-12 CA CA002187748A patent/CA2187748C/en not_active Expired - Fee Related
- 1994-04-12 WO PCT/US1994/003996 patent/WO1995027478A1/en active IP Right Grant
- 1994-04-12 AU AU70915/94A patent/AU689479B2/en not_active Ceased
-
1996
- 1996-10-09 NO NO19964284A patent/NO318814B1/no unknown
- 1996-10-11 FI FI964083A patent/FI964083A/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0758883T3 (da) | 2003-06-02 |
| KR100315132B1 (ko) | 2002-06-26 |
| FI964083A0 (fi) | 1996-10-11 |
| WO1995027478A1 (en) | 1995-10-19 |
| DE69432320D1 (de) | 2003-04-24 |
| NO964284D0 (no) | 1996-10-09 |
| FI964083A (fi) | 1996-10-11 |
| ATE234605T1 (de) | 2003-04-15 |
| CA2187748A1 (en) | 1995-10-19 |
| EP0758883B1 (en) | 2003-03-19 |
| AU7091594A (en) | 1995-10-30 |
| NO318814B1 (no) | 2005-05-09 |
| EP0758883A1 (en) | 1997-02-26 |
| JP3804025B2 (ja) | 2006-08-02 |
| CA2187748C (en) | 2007-04-10 |
| NZ268146A (en) | 1997-10-24 |
| DE69432320T2 (de) | 2003-12-04 |
| NO964284L (no) | 1996-10-09 |
| JPH09511521A (ja) | 1997-11-18 |
| AU689479B2 (en) | 1998-04-02 |
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