JP3804025B2 - 融合性リポソーム、その製造方法およびその使用方法 - Google Patents
融合性リポソーム、その製造方法およびその使用方法 Download PDFInfo
- Publication number
- JP3804025B2 JP3804025B2 JP52630695A JP52630695A JP3804025B2 JP 3804025 B2 JP3804025 B2 JP 3804025B2 JP 52630695 A JP52630695 A JP 52630695A JP 52630695 A JP52630695 A JP 52630695A JP 3804025 B2 JP3804025 B2 JP 3804025B2
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- bilayer
- liposome
- ionizable
- liposomes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1994/003996 WO1995027478A1 (en) | 1994-04-12 | 1994-04-12 | Fusogenic liposomes and methods of making and using same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09511521A JPH09511521A (ja) | 1997-11-18 |
JP3804025B2 true JP3804025B2 (ja) | 2006-08-02 |
Family
ID=22242444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52630695A Expired - Fee Related JP3804025B2 (ja) | 1994-04-12 | 1994-04-12 | 融合性リポソーム、その製造方法およびその使用方法 |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0758883B1 (es) |
JP (1) | JP3804025B2 (es) |
KR (1) | KR100315132B1 (es) |
AT (1) | ATE234605T1 (es) |
AU (1) | AU689479B2 (es) |
CA (1) | CA2187748C (es) |
DE (1) | DE69432320T2 (es) |
DK (1) | DK0758883T3 (es) |
ES (1) | ES2196028T3 (es) |
FI (1) | FI964083A0 (es) |
NO (1) | NO318814B1 (es) |
NZ (1) | NZ268146A (es) |
WO (1) | WO1995027478A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6339069B1 (en) | 1996-10-15 | 2002-01-15 | Elan Pharmaceuticalstechnologies, Inc. | Peptide-lipid conjugates, liposomes and lipsomal drug delivery |
DE69723473T2 (de) * | 1996-10-15 | 2004-05-27 | The Liposome Co., Inc. | Peptid-lipid konjugate, liposomen und liposomale arzneimittelverabreichung |
US6835395B1 (en) | 1997-05-14 | 2004-12-28 | The University Of British Columbia | Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles |
JP4656675B2 (ja) | 1997-05-14 | 2011-03-23 | ユニバーシティー オブ ブリティッシュ コロンビア | 脂質小胞への荷電した治療剤の高率封入 |
US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
WO2001015726A2 (en) * | 1999-08-27 | 2001-03-08 | Inex Pharmaceuticals Corp. | Compositions for stimulating cytokine secretion and inducing an immune response |
MXPA05010499A (es) * | 2003-03-31 | 2006-05-25 | Johnson & Johnson | Particulas lipidicas que tienen un revestimiento lipidico asimetrico y metodo de preparacion de las mismas. |
JP4787818B2 (ja) | 2005-01-28 | 2011-10-05 | 独立行政法人科学技術振興機構 | 脱水縮合反応により相転移を生じ得る分子集合体およびその相転移方法 |
US20100215582A1 (en) * | 2007-05-14 | 2010-08-26 | Konica Minolta Holdings, Inc. | Liposome and method for producing liposome |
US9937128B2 (en) | 2009-08-03 | 2018-04-10 | The University Of North Carolina At Chapel Hill | Liposomes comprising a calcium phosphate-containing precipitate |
DK3338765T3 (en) | 2009-12-01 | 2019-03-04 | Translate Bio Inc | STEROID DERIVATIVE FOR THE SUPPLY OF MRNA IN HUMANGENETIC DISEASES |
PL2717893T3 (pl) | 2011-06-08 | 2019-12-31 | Translate Bio, Inc. | Kompozycje nanocząstek lipidowych i sposoby do dostarczania mRNA |
WO2013185067A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
BR112015022660A2 (pt) | 2013-03-14 | 2017-10-31 | Shire Human Genetic Therapies | métodos para a purificação de rna mensageiro |
ES2689523T3 (es) | 2013-03-14 | 2018-11-14 | Translate Bio, Inc. | Composiciones a base de ARNM del gen CFTR y métodos y usos relacionados |
EA201992208A1 (ru) | 2013-10-22 | 2020-07-31 | Транслейт Био, Инк. | ЛЕЧЕНИЕ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК |
EP3501605B1 (en) | 2013-10-22 | 2023-06-28 | Translate Bio, Inc. | Mrna therapy for argininosuccinate synthetase deficiency |
CN110511927A (zh) | 2014-04-25 | 2019-11-29 | 川斯勒佰尔公司 | 信使rna的纯化方法 |
EA201991747A1 (ru) | 2017-02-27 | 2020-06-04 | Транслейт Био, Инк. | НОВАЯ КОДОН-ОПТИМИЗИРОВАННАЯ мРНК CFTR |
US11173190B2 (en) | 2017-05-16 | 2021-11-16 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR |
AU2019325702A1 (en) | 2018-08-24 | 2021-02-25 | Translate Bio, Inc. | Methods for purification of messenger RNA |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4946787A (en) * | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
WO1987007530A1 (en) * | 1986-06-16 | 1987-12-17 | The Liposome Company, Inc. | Induction of asymmetry in vesicles |
JPH0395118A (ja) * | 1989-09-07 | 1991-04-19 | Green Cross Corp:The | プロスタグランジン含有脂肪小体製剤 |
DE4013632A1 (de) * | 1990-04-27 | 1991-10-31 | Max Planck Gesellschaft | Liposomen mit positiver ueberschussladung |
US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
-
1994
- 1994-04-12 KR KR1019960705605A patent/KR100315132B1/ko not_active IP Right Cessation
- 1994-04-12 DK DK94919976T patent/DK0758883T3/da active
- 1994-04-12 ES ES94919976T patent/ES2196028T3/es not_active Expired - Lifetime
- 1994-04-12 JP JP52630695A patent/JP3804025B2/ja not_active Expired - Fee Related
- 1994-04-12 AT AT94919976T patent/ATE234605T1/de not_active IP Right Cessation
- 1994-04-12 NZ NZ268146A patent/NZ268146A/en not_active IP Right Cessation
- 1994-04-12 EP EP94919976A patent/EP0758883B1/en not_active Expired - Lifetime
- 1994-04-12 CA CA002187748A patent/CA2187748C/en not_active Expired - Fee Related
- 1994-04-12 WO PCT/US1994/003996 patent/WO1995027478A1/en active IP Right Grant
- 1994-04-12 DE DE69432320T patent/DE69432320T2/de not_active Expired - Fee Related
- 1994-04-12 AU AU70915/94A patent/AU689479B2/en not_active Ceased
-
1996
- 1996-10-09 NO NO19964284A patent/NO318814B1/no unknown
- 1996-10-11 FI FI964083A patent/FI964083A0/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI964083A (fi) | 1996-10-11 |
CA2187748C (en) | 2007-04-10 |
AU7091594A (en) | 1995-10-30 |
NZ268146A (en) | 1997-10-24 |
NO964284D0 (no) | 1996-10-09 |
NO318814B1 (no) | 2005-05-09 |
DE69432320D1 (de) | 2003-04-24 |
NO964284L (no) | 1996-10-09 |
EP0758883B1 (en) | 2003-03-19 |
KR100315132B1 (ko) | 2002-06-26 |
FI964083A0 (fi) | 1996-10-11 |
EP0758883A1 (en) | 1997-02-26 |
CA2187748A1 (en) | 1995-10-19 |
ATE234605T1 (de) | 2003-04-15 |
AU689479B2 (en) | 1998-04-02 |
JPH09511521A (ja) | 1997-11-18 |
WO1995027478A1 (en) | 1995-10-19 |
DK0758883T3 (da) | 2003-06-02 |
ES2196028T3 (es) | 2003-12-16 |
DE69432320T2 (de) | 2003-12-04 |
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