DE69432320D1 - Fusogene liposomen und verfahren zu deren herstellung und verwendung - Google Patents

Fusogene liposomen und verfahren zu deren herstellung und verwendung

Info

Publication number
DE69432320D1
DE69432320D1 DE69432320T DE69432320T DE69432320D1 DE 69432320 D1 DE69432320 D1 DE 69432320D1 DE 69432320 T DE69432320 T DE 69432320T DE 69432320 T DE69432320 T DE 69432320T DE 69432320 D1 DE69432320 D1 DE 69432320D1
Authority
DE
Germany
Prior art keywords
lipid
outermost
lipid bilayer
liposome
bilayer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69432320T
Other languages
English (en)
Other versions
DE69432320T2 (de
Inventor
Austin Bailey
R Cullis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transave LLC
Original Assignee
Elan Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharmaceuticals LLC filed Critical Elan Pharmaceuticals LLC
Publication of DE69432320D1 publication Critical patent/DE69432320D1/de
Application granted granted Critical
Publication of DE69432320T2 publication Critical patent/DE69432320T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69432320T 1994-04-12 1994-04-12 Fusogene liposomen und verfahren zu deren herstellung und verwendung Expired - Fee Related DE69432320T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/003996 WO1995027478A1 (en) 1994-04-12 1994-04-12 Fusogenic liposomes and methods of making and using same

Publications (2)

Publication Number Publication Date
DE69432320D1 true DE69432320D1 (de) 2003-04-24
DE69432320T2 DE69432320T2 (de) 2003-12-04

Family

ID=22242444

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69432320T Expired - Fee Related DE69432320T2 (de) 1994-04-12 1994-04-12 Fusogene liposomen und verfahren zu deren herstellung und verwendung

Country Status (13)

Country Link
EP (1) EP0758883B1 (de)
JP (1) JP3804025B2 (de)
KR (1) KR100315132B1 (de)
AT (1) ATE234605T1 (de)
AU (1) AU689479B2 (de)
CA (1) CA2187748C (de)
DE (1) DE69432320T2 (de)
DK (1) DK0758883T3 (de)
ES (1) ES2196028T3 (de)
FI (1) FI964083A (de)
NO (1) NO318814B1 (de)
NZ (1) NZ268146A (de)
WO (1) WO1995027478A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339069B1 (en) 1996-10-15 2002-01-15 Elan Pharmaceuticalstechnologies, Inc. Peptide-lipid conjugates, liposomes and lipsomal drug delivery
ATE244572T1 (de) * 1996-10-15 2003-07-15 Liposome Co Inc Peptid-lipid konjugate, liposomen und liposomale arzneimittelverabreichung
US6835395B1 (en) 1997-05-14 2004-12-28 The University Of British Columbia Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
JP4656675B2 (ja) 1997-05-14 2011-03-23 ユニバーシティー オブ ブリティッシュ コロンビア 脂質小胞への荷電した治療剤の高率封入
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
KR100737980B1 (ko) * 1999-08-27 2007-07-12 아이넥스 파머슈티컬스 코포레이션 사이토카인 분비 자극용 및 면역반응 유도용 조성물
EP1613285A2 (de) * 2003-03-31 2006-01-11 Alza Corporation Fettpartikel mit asymmetrischer lipid-beschichtung und herstellungsverfahren dafür
EP1852177B1 (de) * 2005-01-28 2014-02-26 Japan Science and Technology Agency Molekulares aggregat, das dazu befähigt ist, eine phasenumwandlung durch dehydratisierende kondensation zu durchlaufen, und verfahren zur phasenumwandlung davon
US20100215582A1 (en) 2007-05-14 2010-08-26 Konica Minolta Holdings, Inc. Liposome and method for producing liposome
WO2011017297A2 (en) 2009-08-03 2011-02-10 The University Of North Carolina At Chapel Hill Biodegradable delivery system complexes for the delivery of bioactive compounds
PT3338765T (pt) 2009-12-01 2019-03-18 Translate Bio Inc Derivado de esteróide adequado para a administração de arnm em doenças genéticas humanas
BR112013031553A2 (pt) 2011-06-08 2020-11-10 Shire Human Genetic Therapies, Inc. composições, mrna que codifica para uma hgla e seu uso, uso de pelo menos uma molécula de mrna e um veículo de transferência e uso de um mrna que codifica para proteína exógena
EP2859102A4 (de) 2012-06-08 2016-05-11 Shire Human Genetic Therapies Nukleaseresistente polynukleotide und verwendungen davon
IL305374A (en) 2013-03-14 2023-10-01 Ethris Gmbh CFTR mRNA Assemblies and Related Methods and Uses
US9957499B2 (en) 2013-03-14 2018-05-01 Translate Bio, Inc. Methods for purification of messenger RNA
CA2928188A1 (en) 2013-10-22 2015-04-30 Shire Human Genetic Therapies, Inc. Mrna therapy for argininosuccinate synthetase deficiency
EP3574923A1 (de) 2013-10-22 2019-12-04 Translate Bio, Inc. Mrna-therapie für phenylketonurie
ES2750661T3 (es) 2014-04-25 2020-03-26 Translate Bio Inc Métodos para la purificación de ARN mensajero
EP3585417B1 (de) 2017-02-27 2023-02-22 Translate Bio, Inc. Methode der herstellung von codon-optimierter cftr-mrna
IL270631B2 (en) 2017-05-16 2024-03-01 Translate Bio Inc Treatment of cystic fibrosis through the administration of mRNA with an optimal codon encoding ctfr
US11174500B2 (en) 2018-08-24 2021-11-16 Translate Bio, Inc. Methods for purification of messenger RNA

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946787A (en) * 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
JP2760355B2 (ja) * 1986-06-16 1998-05-28 ザ リポソーム カンパニー，インコーポレイテッド 不均整誘導リポソーム
JPH0395118A (ja) * 1989-09-07 1991-04-19 Green Cross Corp:The プロスタグランジン含有脂肪小体製剤
DE4013632A1 (de) * 1990-04-27 1991-10-31 Max Planck Gesellschaft Liposomen mit positiver ueberschussladung
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells

Also Published As

Publication number Publication date
DK0758883T3 (da) 2003-06-02
KR100315132B1 (ko) 2002-06-26
FI964083A0 (fi) 1996-10-11
WO1995027478A1 (en) 1995-10-19
NO964284D0 (no) 1996-10-09
FI964083A (fi) 1996-10-11
ATE234605T1 (de) 2003-04-15
CA2187748A1 (en) 1995-10-19
EP0758883B1 (de) 2003-03-19
AU7091594A (en) 1995-10-30
NO318814B1 (no) 2005-05-09
EP0758883A1 (de) 1997-02-26
ES2196028T3 (es) 2003-12-16
JP3804025B2 (ja) 2006-08-02
CA2187748C (en) 2007-04-10
NZ268146A (en) 1997-10-24
DE69432320T2 (de) 2003-12-04
NO964284L (no) 1996-10-09
JPH09511521A (ja) 1997-11-18
AU689479B2 (en) 1998-04-02

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: TRANSAVE, INC., MONMOUTH JUNCTION, N.J., US

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee