ATE244572T1 - Peptid-lipid konjugate, liposomen und liposomale arzneimittelverabreichung - Google Patents
Peptid-lipid konjugate, liposomen und liposomale arzneimittelverabreichungInfo
- Publication number
- ATE244572T1 ATE244572T1 AT97910950T AT97910950T ATE244572T1 AT E244572 T1 ATE244572 T1 AT E244572T1 AT 97910950 T AT97910950 T AT 97910950T AT 97910950 T AT97910950 T AT 97910950T AT E244572 T1 ATE244572 T1 AT E244572T1
- Authority
- AT
- Austria
- Prior art keywords
- liposomes
- peptide
- lipid conjugates
- drug administration
- liposomal drug
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2754496P | 1996-10-15 | 1996-10-15 | |
PCT/US1997/018538 WO1998016240A1 (en) | 1996-10-15 | 1997-10-15 | Peptide-lipid conjugates, liposomes and liposomal drug delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE244572T1 true ATE244572T1 (de) | 2003-07-15 |
Family
ID=21838338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97910950T ATE244572T1 (de) | 1996-10-15 | 1997-10-15 | Peptid-lipid konjugate, liposomen und liposomale arzneimittelverabreichung |
Country Status (13)
Country | Link |
---|---|
US (2) | US6087325A (de) |
EP (1) | EP0964690B1 (de) |
AT (1) | ATE244572T1 (de) |
AU (1) | AU725376B2 (de) |
CA (1) | CA2276267C (de) |
DE (1) | DE69723473T2 (de) |
DK (1) | DK0964690T3 (de) |
HU (1) | HUP0000150A3 (de) |
IL (1) | IL130823A (de) |
NO (1) | NO993258L (de) |
NZ (1) | NZ336539A (de) |
SK (1) | SK283518B6 (de) |
WO (1) | WO1998016240A1 (de) |
Families Citing this family (115)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5545553A (en) * | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
US5981501A (en) * | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
US7422902B1 (en) * | 1995-06-07 | 2008-09-09 | The University Of British Columbia | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
US6339069B1 (en) * | 1996-10-15 | 2002-01-15 | Elan Pharmaceuticalstechnologies, Inc. | Peptide-lipid conjugates, liposomes and lipsomal drug delivery |
US20030104044A1 (en) * | 1997-05-14 | 2003-06-05 | Semple Sean C. | Compositions for stimulating cytokine secretion and inducing an immune response |
JP4656675B2 (ja) | 1997-05-14 | 2011-03-23 | ユニバーシティー オブ ブリティッシュ コロンビア | 脂質小胞への荷電した治療剤の高率封入 |
GB9721901D0 (en) | 1997-10-16 | 1997-12-17 | Univ Manchester | Particles |
US6410328B1 (en) * | 1998-02-03 | 2002-06-25 | Protiva Biotherapeutics Inc. | Sensitizing cells to compounds using lipid-mediated gene and compound delivery |
AU4089899A (en) | 1998-05-20 | 1999-12-06 | University Of Tennessee Research Corporation, The | Stable envelope proteins for retroviral, viral and liposome vectors and use in gene and drug therapy |
AU3412500A (en) * | 1999-03-25 | 2000-10-16 | Agene Research Institute Co., Ltd. | Lipid-based artificial particles inducing cell-mediated immunity |
GB9919338D0 (en) | 1999-08-16 | 1999-10-20 | Celltech Therapeutics Ltd | Biological products |
US20050249794A1 (en) * | 1999-08-27 | 2005-11-10 | Semple Sean C | Compositions for stimulating cytokine secretion and inducing an immune response |
US6682545B1 (en) * | 1999-10-06 | 2004-01-27 | The Penn State Research Foundation | System and device for preventing restenosis in body vessels |
EP1228030B1 (de) | 1999-11-09 | 2005-06-01 | Alcon Inc. | Benzenoidderivate von 15-hydroxyeicosatetraensäure und verfahren zur verwendung zur behandlung des trockenen auges |
KR20020050237A (ko) | 1999-11-09 | 2002-06-26 | 구이도 콜러, 스테판 바슬러 | 오메가 체인이 변형된 15-하이드록시에이코사테트라엔산유도체 및 안구 건조증의 치료를 위한 그들의 사용방법 |
CA2386636A1 (en) | 1999-11-09 | 2001-05-17 | Alcon, Inc. | 15-hydroxyeicosatetraenoic acid-related compounds and methods of use |
AU1226001A (en) | 1999-11-09 | 2001-06-06 | Alcon Universal Limited | Phospholipids of hydroxyeicosatetraenoic acid-like derivatives |
US6552084B2 (en) | 1999-11-09 | 2003-04-22 | Alcon Universal Ltd. | Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders |
PT1227809E (pt) | 1999-11-09 | 2005-06-30 | Alcon Inc | Analogos do acido 15-hidroxieicosatetraenoico interrompidos por um heteroatomo e metodos de utilizacao |
US6458854B2 (en) | 1999-11-09 | 2002-10-01 | Alcon Universal Ltd. | Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use |
KR20020050240A (ko) | 1999-11-09 | 2002-06-26 | 구이도 콜러, 스테판 바슬러 | 하이드록시에이코사테트라에노에이트 염, 조성물 및 안구건조증 치료에서의 사용 방법 |
AU776146B2 (en) | 1999-11-09 | 2004-08-26 | Alcon Inc. | 3-heteroatom substituted and two carbon homologs of 15-HETE and methods of use |
US6320062B1 (en) | 1999-11-09 | 2001-11-20 | Alcon Universal Ltd. | 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders |
US6803385B2 (en) | 1999-11-09 | 2004-10-12 | Alcon, Inc. | Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders |
WO2001034553A2 (en) | 1999-11-09 | 2001-05-17 | Alcon Universal Ltd. | 2,2-difluoro 15-hydroxyeicosatetraenoic acid analogs and methods of use |
PL360826A1 (en) | 2000-03-15 | 2004-09-20 | Bristol-Myers Squibb Pharma Company | Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use |
US20020073441A1 (en) | 2000-12-13 | 2002-06-13 | Ross Brian D. | Compositions and methods for detecting proteolytic activity |
FI113840B (fi) * | 2001-03-26 | 2004-06-30 | Ctt Cancer Targeting Tech Oy | Matriisi-metalloproteinaasi-inhibiittorien käyttö liposomien kohdentamisessa |
ATE536185T1 (de) * | 2001-03-26 | 2011-12-15 | Dana Farber Cancer Inst Inc | Verfahren zur abschwächung von reaktionen auf hautreizende mittel |
CA2443644A1 (en) * | 2001-04-04 | 2003-01-16 | Elan Corporation, Plc | Genetic analysis of peyers's patches and m cells and methods and compositions targeting peyer's patches and m cell receptors |
US6743905B2 (en) * | 2001-04-16 | 2004-06-01 | Applera Corporation | Mobility-modified nucleobase polymers and methods of using same |
EP1418876A4 (de) | 2001-08-17 | 2007-07-11 | Univ Pittsburgh | Verabreichung von östradiol-metaboliten zur behandlung oder prävention von adipositas, des metabolischen syndroms, von diabetes und von gefäss- und nierenerkrankungen |
US6943267B1 (en) | 2001-08-24 | 2005-09-13 | Utah State University | Thiophosphonate inhibitors of phosphatase enzymes and metallophosphatases |
US20080279936A1 (en) * | 2001-10-10 | 2008-11-13 | The University Of Pittsburgh | Estradiol metabolites for reduction of endothelin production |
US7696163B2 (en) | 2001-10-10 | 2010-04-13 | Novo Nordisk A/S | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
US7795210B2 (en) | 2001-10-10 | 2010-09-14 | Novo Nordisk A/S | Protein remodeling methods and proteins/peptides produced by the methods |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7179617B2 (en) * | 2001-10-10 | 2007-02-20 | Neose Technologies, Inc. | Factor IX: remolding and glycoconjugation of Factor IX |
US7214660B2 (en) * | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US8008252B2 (en) * | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
US7399613B2 (en) * | 2001-10-10 | 2008-07-15 | Neose Technologies, Inc. | Sialic acid nucleotide sugars |
EP1441763A2 (de) * | 2001-11-07 | 2004-08-04 | Inex Pharmaceuticals Corp. | Mukosale adjuvantien, die ein oligonukleotid und ein kationisch lipid enthält |
US7887833B2 (en) * | 2001-12-04 | 2011-02-15 | Ben-Gurion University Of The Negev Research And Development Authority | Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting |
JP2005528887A (ja) * | 2002-01-31 | 2005-09-29 | エクスプレッシブ コンストラクツ,インコーポレイテッド | 微生物の検出方法 |
US20040009944A1 (en) * | 2002-05-10 | 2004-01-15 | Inex Pharmaceuticals Corporation | Methylated immunostimulatory oligonucleotides and methods of using the same |
DE60336555D1 (de) | 2002-06-21 | 2011-05-12 | Novo Nordisk Healthcare Ag | Pegylierte glykoformen von faktor vii |
ATE415413T1 (de) * | 2002-07-15 | 2008-12-15 | Univ Princeton | Iap-bindende verbindungen |
US20040146959A1 (en) * | 2002-09-09 | 2004-07-29 | Graham Ronald J. | Fluorescent enzyme assay methods and compositions |
KR101111477B1 (ko) * | 2002-12-03 | 2012-02-23 | 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 | 치료제와 연결된 콜레스테롤을 포함하는 접합체 |
US7169892B2 (en) | 2003-01-10 | 2007-01-30 | Astellas Pharma Inc. | Lipid-peptide-polymer conjugates for long blood circulation and tumor specific drug delivery systems |
JPWO2004063216A1 (ja) * | 2003-01-10 | 2006-06-15 | アステラス製薬株式会社 | 血中滞留および癌組織特異的薬物送達のためのコンジュゲート |
US7192941B2 (en) * | 2003-02-20 | 2007-03-20 | University Of Pittsburgh | Estradiol metabolites for the treatment of pulmonary hypertension |
US20060194775A1 (en) * | 2003-02-20 | 2006-08-31 | University Of Pittsburgh | Estradiol metabolites for the treatment of pulmonary hypertension |
KR20060003862A (ko) | 2003-03-14 | 2006-01-11 | 네오스 테크놀로지스, 인크. | 수용성분기폴리머 및 그 접합체 |
WO2007022512A2 (en) * | 2005-08-19 | 2007-02-22 | Neose Technologies, Inc. | Glycopegylated factor vii and factor viia |
SG155777A1 (en) * | 2003-04-09 | 2009-10-29 | Neose Technologies Inc | Glycopegylation methods and proteins/peptides produced by the methods |
US7691603B2 (en) * | 2003-04-09 | 2010-04-06 | Novo Nordisk A/S | Intracellular formation of peptide conjugates |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
MXPA05011832A (es) | 2003-05-09 | 2006-02-17 | Neose Technologies Inc | Composiciones y metodos para la preparacion de mutantes de glicosilacion de la hormona de crecimiento humano. |
US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
US20050054752A1 (en) * | 2003-09-08 | 2005-03-10 | O'brien John P. | Peptide-based diblock and triblock dispersants and diblock polymers |
CA2542099A1 (en) * | 2003-10-11 | 2005-04-21 | Inex Pharmaceuticals Corporation | Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity |
US7842661B2 (en) | 2003-11-24 | 2010-11-30 | Novo Nordisk A/S | Glycopegylated erythropoietin formulations |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
WO2005054856A1 (en) * | 2003-11-26 | 2005-06-16 | Applera Corporation | Fluorogenic homogeneous binding assay methods and compostions |
EP1687635A2 (de) * | 2003-11-26 | 2006-08-09 | Applera Corporation | Ligandenhaltige micellen und verwendungen davon |
US20080318850A1 (en) * | 2003-12-03 | 2008-12-25 | Neose Technologies, Inc. | Glycopegylated Factor Ix |
US7956032B2 (en) * | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
US8361961B2 (en) | 2004-01-08 | 2013-01-29 | Biogenerix Ag | O-linked glycosylation of peptides |
WO2005071095A2 (en) * | 2004-01-16 | 2005-08-04 | Applera Corporation | Fluorogenic kinase assays and substrates for kinases and phosphatases |
US7608579B2 (en) * | 2004-06-16 | 2009-10-27 | Pneumrx, Inc. | Lung volume reduction using glue compositions |
US7678767B2 (en) | 2004-06-16 | 2010-03-16 | Pneumrx, Inc. | Glue compositions for lung volume reduction |
US20050281740A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue |
US20050281798A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting sites of damaged lung tissue using composition |
US20050281739A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue using compositions |
US20050281799A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting damaged lung tissue using compositions |
US7553810B2 (en) * | 2004-06-16 | 2009-06-30 | Pneumrx, Inc. | Lung volume reduction using glue composition |
US20060035302A1 (en) * | 2004-06-21 | 2006-02-16 | Applera Corporation | Kinase substrates with multiple phosphorylation sites |
WO2006014567A2 (en) | 2004-07-08 | 2006-02-09 | Pneumrx, Inc. | Pleural effusion treatment device, method and material |
US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
WO2006031811A2 (en) | 2004-09-10 | 2006-03-23 | Neose Technologies, Inc. | Glycopegylated interferon alpha |
US20060121553A1 (en) * | 2004-10-29 | 2006-06-08 | Applera Corporation | Fluorogenic enzyme assay methods, kits and compositions using charge-balancers |
ES2572779T3 (es) | 2004-10-29 | 2016-06-02 | Ratiopharm Gmbh | Remodelación y glucopegilación del Factor de Crecimiento de Fibroblastos (FGF) |
WO2006066258A2 (en) * | 2004-12-17 | 2006-06-22 | Neose Technologies, Inc. | Lipoconjugation of peptides |
WO2006074074A2 (en) * | 2004-12-30 | 2006-07-13 | Applera Corporation | Compositions, methods and kits for real-time enzyme assays using charged molecules |
WO2006074467A2 (en) | 2005-01-10 | 2006-07-13 | Neose Technologies, Inc. | Glycopegylated granulocyte colony stimulating factor |
WO2006088245A1 (ja) * | 2005-02-18 | 2006-08-24 | The University Of Tokushima | ポリオキシアルキレン鎖含有脂質誘導体及び該誘導体を含有する脂質膜構造体 |
JP2006248978A (ja) * | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
JP2008538181A (ja) * | 2005-03-30 | 2008-10-16 | ネオス テクノロジーズ インコーポレイテッド | 昆虫細胞系において増殖させたペプチドを生産するための製造方法 |
EP1871795A4 (de) * | 2005-04-08 | 2010-03-31 | Biogenerix Ag | Zusammensetzungen und verfahren zur herstellung von glycosylierungsmutanten eines proteaseresistenten menschlichen wachstumshormons |
JP5216580B2 (ja) | 2005-05-25 | 2013-06-19 | ノヴォ ノルディスク アー/エス | グリコペグ化第ix因子 |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
US20080206142A1 (en) * | 2006-06-16 | 2008-08-28 | Lipid Sciences, Inc. | Novel Peptides That Promote Lipid Efflux |
US20080199398A1 (en) * | 2006-06-16 | 2008-08-21 | Brewer H Bryan | Novel Peptides That Promote Lipid Efflux |
US20080227686A1 (en) * | 2006-06-16 | 2008-09-18 | Lipid Sciences, Inc. | Novel Peptides that Promote Lipid Efflux |
US20080280818A1 (en) * | 2006-07-21 | 2008-11-13 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
US20100297218A1 (en) * | 2006-09-20 | 2010-11-25 | Pneumrx, Inc. | Tissue adhesive compositions and methods thereof |
US20080138284A1 (en) * | 2006-09-26 | 2008-06-12 | Lipid Sciences, Inc. | Novel Peptides That Promote Lipid Efflux |
US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
US20080207487A1 (en) * | 2006-11-02 | 2008-08-28 | Neose Technologies, Inc. | Manufacturing process for the production of polypeptides expressed in insect cell-lines |
ES2406267T3 (es) | 2007-04-03 | 2013-06-06 | Biogenerix Ag | Métodos de tratamiento usando G-CSF glicopegilado |
US20090053167A1 (en) * | 2007-05-14 | 2009-02-26 | Neose Technologies, Inc. | C-, S- and N-glycosylation of peptides |
JP5876649B2 (ja) | 2007-06-12 | 2016-03-02 | ラツィオファルム ゲーエムベーハーratiopharm GmbH | ヌクレオチド糖の改良製造法 |
US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
EP2227567A4 (de) * | 2007-10-28 | 2011-03-30 | Eci Biotech Inc | Sensoren zur messung von verunreinigungen |
US20130189239A1 (en) | 2008-02-27 | 2013-07-25 | Novo Nordisk A/S | Conjugated Factor VIII Molecules |
AU2012255194B2 (en) * | 2011-05-16 | 2017-01-05 | Danmarks Tekniske Universitet | Charge triggering of self-organized nanoparticles |
EP2537532A1 (de) | 2011-06-22 | 2012-12-26 | J. Stefan Institute | Cathepsinbindende Verbindungen, die an ein Nanogerät gebunden sind, und deren diagnostische und therapeutische Verwendung |
WO2013036827A2 (en) * | 2011-09-08 | 2013-03-14 | The Regents Of The University Of California | Fungal-specific metalloproteases and uses thereof |
WO2019022671A1 (en) * | 2017-07-28 | 2019-01-31 | National University Of Singapore | BIOMOLECULAR COMPOSITES COMPRISING MODIFIED CELLULAR PHANTOMS |
CN112402379B (zh) * | 2020-12-04 | 2022-04-22 | 中南大学湘雅二医院 | 一种仿生外泌体及其制备和应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4920016A (en) * | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5554728A (en) * | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
EP0758883B1 (de) * | 1994-04-12 | 2003-03-19 | The Liposome Company, Inc. | Fusogene liposomen und verfahren zu deren herstellung und verwendung |
-
1997
- 1997-10-15 CA CA002276267A patent/CA2276267C/en not_active Expired - Fee Related
- 1997-10-15 AT AT97910950T patent/ATE244572T1/de not_active IP Right Cessation
- 1997-10-15 HU HU0000150A patent/HUP0000150A3/hu active IP Right Revival
- 1997-10-15 IL IL13082397A patent/IL130823A/xx not_active IP Right Cessation
- 1997-10-15 DK DK97910950T patent/DK0964690T3/da active
- 1997-10-15 EP EP97910950A patent/EP0964690B1/de not_active Expired - Lifetime
- 1997-10-15 WO PCT/US1997/018538 patent/WO1998016240A1/en active IP Right Grant
- 1997-10-15 SK SK992-99A patent/SK283518B6/sk unknown
- 1997-10-15 NZ NZ336539A patent/NZ336539A/xx unknown
- 1997-10-15 US US08/950,618 patent/US6087325A/en not_active Expired - Fee Related
- 1997-10-15 AU AU48207/97A patent/AU725376B2/en not_active Ceased
- 1997-10-15 DE DE69723473T patent/DE69723473T2/de not_active Expired - Fee Related
-
1998
- 1998-10-07 US US09/168,010 patent/US6143716A/en not_active Expired - Fee Related
-
1999
- 1999-06-30 NO NO993258A patent/NO993258L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0964690A4 (de) | 2000-03-29 |
CA2276267A1 (en) | 1998-04-23 |
DK0964690T3 (da) | 2003-10-20 |
NZ336539A (en) | 2000-09-29 |
WO1998016240A1 (en) | 1998-04-23 |
US6143716A (en) | 2000-11-07 |
HUP0000150A2 (en) | 2000-07-28 |
US6087325A (en) | 2000-07-11 |
SK99299A3 (en) | 2000-05-16 |
EP0964690B1 (de) | 2003-07-09 |
DE69723473T2 (de) | 2004-05-27 |
SK283518B6 (sk) | 2003-08-05 |
IL130823A0 (en) | 2001-01-28 |
NO993258D0 (no) | 1999-06-30 |
NO993258L (no) | 1999-07-30 |
DE69723473D1 (de) | 2003-08-14 |
IL130823A (en) | 2005-12-18 |
EP0964690A1 (de) | 1999-12-22 |
HUP0000150A3 (en) | 2002-07-29 |
AU4820797A (en) | 1998-05-11 |
CA2276267C (en) | 2009-12-22 |
AU725376B2 (en) | 2000-10-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE244572T1 (de) | Peptid-lipid konjugate, liposomen und liposomale arzneimittelverabreichung | |
ES2194114T3 (es) | Formulaciones liposomicas de mitoxantrona. | |
TR200101307T2 (tr) | Antranilik asit amidler ve ilaç olarak kullanılmaları. | |
TR199801541A2 (xx) | N,N-Dietil-m-Toluamid'in (DEET) Anti-Parazit i�levi | |
BR9912694A (pt) | Composto para preparar medicamento de administração pulmonar | |
DK1296647T3 (da) | Polymermicellepræparater | |
DK0909183T3 (da) | DHA-konjugerede farmaceutisk midler | |
TW262461B (de) | ||
DK0942724T3 (da) | Gelformuleringer til topisk medikamentlevering | |
MY119403A (en) | Novel compounds with analgesic effect. | |
DE60038183D1 (de) | Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe | |
GEP20053688B (en) | Substituted-Triazolopyrimidines as Anticancer Agents | |
PT806941E (pt) | Composicoes anti-bacterianas liposomicas de rigidez baixa | |
PT902789E (pt) | Derivados de androsteno | |
BR0206347A (pt) | Conjugados de compostos de macrolìdeo especìficos a células imunes com compostos antiinflamatórios para objetivação celular aperfeiçoada de terapia antiinflamatória | |
NO20013517L (no) | Makrolider med anti-inflammatorisk aktivitet | |
ES2187646T3 (es) | Procedimientos para el tratamiento de inflamaciones y composiciones correspondientes. | |
TR200103457T2 (tr) | 4-Fenil-Pirimidin Türevleri. | |
NO20031410D0 (no) | Antitumorterapi innbefattende distamycinderivater | |
NO982863L (no) | Nye forbindelser med analgetisk effekt | |
NZ325874A (en) | Combination injection preparation | |
CA2130988A1 (en) | Pharmaceutical Composition for Treatment of Sudden Deafness | |
GEP20002177B (en) | Ointment “Levaskani” for Treatment of Wounds and Burns | |
UA23985A (uk) | Спосіб лікуваhhя запальhих захворюваhь вhутрішhіх геhіталій у дівчат та підлітків | |
MX9707574A (es) | Metodo para inhibir el crecimiento de celulas de mamiferos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |