NO318194B1 - <O>19</O>Fluor merket antracyklinon og antracyklinderivater anvendelse av samme samt farmasoytisk sammensetning inneholdende samme - Google Patents
<O>19</O>Fluor merket antracyklinon og antracyklinderivater anvendelse av samme samt farmasoytisk sammensetning inneholdende samme Download PDFInfo
- Publication number
- NO318194B1 NO318194B1 NO19985928A NO985928A NO318194B1 NO 318194 B1 NO318194 B1 NO 318194B1 NO 19985928 A NO19985928 A NO 19985928A NO 985928 A NO985928 A NO 985928A NO 318194 B1 NO318194 B1 NO 318194B1
- Authority
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- Norway
- Prior art keywords
- hydrogen
- substituted
- formula
- amino
- trifluoroacetyl
- Prior art date
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- 229940045799 anthracyclines and related substance Drugs 0.000 title claims description 13
- 229910052731 fluorine Inorganic materials 0.000 title claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 4
- 239000011737 fluorine Substances 0.000 title description 4
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title 1
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- 239000001257 hydrogen Substances 0.000 claims description 58
- 150000001875 compounds Chemical class 0.000 claims description 50
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 27
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- 125000003118 aryl group Chemical group 0.000 claims description 17
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- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000000434 field desorption mass spectrometry Methods 0.000 description 1
- 238000003818 flash chromatography Methods 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000006038 hexenyl group Chemical group 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- VESAIDYCLWTAAV-UHFFFAOYSA-N n-benzyl-2,2,2-trifluoroethanamine Chemical compound FC(F)(F)CNCC1=CC=CC=C1 VESAIDYCLWTAAV-UHFFFAOYSA-N 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004365 octenyl group Chemical group C(=CCCCCCC)* 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000006919 peptide aggregation Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 208000012263 renal involvement Diseases 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical group 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- WJKHJLXJJJATHN-UHFFFAOYSA-N triflic anhydride Chemical compound FC(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F WJKHJLXJJJATHN-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Radiology & Medical Imaging (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9613433.3A GB9613433D0 (en) | 1996-06-26 | 1996-06-26 | Fluoro labelled anthracyclinone and anthracycline derivatives |
| PCT/EP1997/003234 WO1997049433A1 (en) | 1996-06-26 | 1997-06-18 | Fluoro labelled anthracyclinone and anthracycline derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO985928D0 NO985928D0 (no) | 1998-12-17 |
| NO985928L NO985928L (no) | 1998-12-17 |
| NO318194B1 true NO318194B1 (no) | 2005-02-14 |
Family
ID=10795944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19985928A NO318194B1 (no) | 1996-06-26 | 1998-12-17 | <O>19</O>Fluor merket antracyklinon og antracyklinderivater anvendelse av samme samt farmasoytisk sammensetning inneholdende samme |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6103700A (es) |
| EP (1) | EP0910415B1 (es) |
| JP (1) | JP2000514784A (es) |
| KR (1) | KR100451685B1 (es) |
| CN (1) | CN1263514C (es) |
| AR (1) | AR008616A1 (es) |
| AT (1) | ATE266427T1 (es) |
| AU (1) | AU726935B2 (es) |
| BR (1) | BR9710857A (es) |
| CA (1) | CA2258630A1 (es) |
| DE (1) | DE69729092D1 (es) |
| EA (1) | EA002203B1 (es) |
| GB (1) | GB9613433D0 (es) |
| HU (1) | HUP9903651A3 (es) |
| IL (1) | IL127465A (es) |
| NO (1) | NO318194B1 (es) |
| NZ (1) | NZ333660A (es) |
| PL (1) | PL190149B1 (es) |
| TW (1) | TW494099B (es) |
| UA (1) | UA66344C2 (es) |
| WO (1) | WO1997049433A1 (es) |
| ZA (1) | ZA975629B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9805082D0 (en) * | 1998-03-10 | 1998-05-06 | Pharmacia & Upjohn Spa | Heterocyclyl anthracyclinone derivatives |
| GB9805080D0 (en) * | 1998-03-10 | 1998-05-06 | Pharmacia & Upjohn Spa | Amino anthracyclinone derivatives |
| US6589504B1 (en) | 2000-09-22 | 2003-07-08 | Pharmacia & Upjohn Company | Compounds and methods for diagnosing and treating amyloid-related conditions |
| US6828347B2 (en) | 2002-11-06 | 2004-12-07 | Illinois Institute Of Technology | Anti-viral multi-quinone compounds and regiospecific synthesis thereof |
| EP2584369A1 (en) * | 2011-10-17 | 2013-04-24 | Koninklijke Philips Electronics N.V. | Magnetic field probe for MRI with a fluoroelastomer or a solution of a fluorine-containing compound |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1573037A (en) * | 1977-05-05 | 1980-08-13 | Farmaceutici Italia | Anthracyclines |
| GB1573036A (en) * | 1977-05-05 | 1980-08-13 | Farmaceutici Italia | Anthracyclines |
| US4345070A (en) * | 1980-09-29 | 1982-08-17 | Farmitalia Carlo Erba S.P.A. | Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin |
| GB9114549D0 (en) * | 1991-07-05 | 1991-08-21 | Erba Carlo Spa | Mono and bis alkylamino-anthracyclines |
| GB9416007D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Anthracyclinone derivatives |
| GB9418260D0 (en) * | 1994-09-09 | 1994-10-26 | Erba Carlo Spa | Anthracycline derivatives |
| WO1997016191A1 (en) * | 1995-11-02 | 1997-05-09 | Warner-Lambert Company | Inhibition of amyloidosis by 9-acridinones |
-
1996
- 1996-06-26 GB GBGB9613433.3A patent/GB9613433D0/en active Pending
-
1997
- 1997-06-18 EP EP97928258A patent/EP0910415B1/en not_active Expired - Lifetime
- 1997-06-18 IL IL12746597A patent/IL127465A/xx not_active IP Right Cessation
- 1997-06-18 CN CNB971958947A patent/CN1263514C/zh not_active Expired - Fee Related
- 1997-06-18 DE DE69729092T patent/DE69729092D1/de not_active Expired - Lifetime
- 1997-06-18 CA CA002258630A patent/CA2258630A1/en not_active Abandoned
- 1997-06-18 US US09/202,954 patent/US6103700A/en not_active Expired - Fee Related
- 1997-06-18 EA EA199900054A patent/EA002203B1/ru not_active IP Right Cessation
- 1997-06-18 HU HU9903651A patent/HUP9903651A3/hu unknown
- 1997-06-18 JP JP10502309A patent/JP2000514784A/ja not_active Withdrawn
- 1997-06-18 AT AT97928258T patent/ATE266427T1/de not_active IP Right Cessation
- 1997-06-18 NZ NZ333660A patent/NZ333660A/xx unknown
- 1997-06-18 BR BR9710857A patent/BR9710857A/pt not_active Application Discontinuation
- 1997-06-18 KR KR10-1998-0710656A patent/KR100451685B1/ko not_active IP Right Cessation
- 1997-06-18 UA UA99010341A patent/UA66344C2/uk unknown
- 1997-06-18 AU AU32622/97A patent/AU726935B2/en not_active Ceased
- 1997-06-18 PL PL97330907A patent/PL190149B1/pl not_active IP Right Cessation
- 1997-06-18 WO PCT/EP1997/003234 patent/WO1997049433A1/en active IP Right Grant
- 1997-06-23 TW TW086108749A patent/TW494099B/zh not_active IP Right Cessation
- 1997-06-25 AR ARP970102787A patent/AR008616A1/es unknown
- 1997-06-25 ZA ZA9705629A patent/ZA975629B/xx unknown
-
1998
- 1998-12-17 NO NO19985928A patent/NO318194B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL330907A1 (en) | 1999-06-07 |
| US6103700A (en) | 2000-08-15 |
| KR100451685B1 (ko) | 2004-12-30 |
| HUP9903651A2 (hu) | 2000-03-28 |
| EP0910415A1 (en) | 1999-04-28 |
| ZA975629B (en) | 1998-01-30 |
| PL190149B1 (pl) | 2005-11-30 |
| CN1223592A (zh) | 1999-07-21 |
| AR008616A1 (es) | 2000-02-09 |
| IL127465A0 (en) | 1999-10-28 |
| UA66344C2 (en) | 2004-05-17 |
| KR20000022236A (ko) | 2000-04-25 |
| NZ333660A (en) | 2000-07-28 |
| EP0910415B1 (en) | 2004-05-12 |
| NO985928D0 (no) | 1998-12-17 |
| IL127465A (en) | 2005-11-20 |
| AU3262297A (en) | 1998-01-14 |
| EA002203B1 (ru) | 2002-02-28 |
| WO1997049433A1 (en) | 1997-12-31 |
| HUP9903651A3 (en) | 2000-05-29 |
| BR9710857A (pt) | 1999-08-17 |
| AU726935B2 (en) | 2000-11-23 |
| DE69729092D1 (de) | 2004-06-17 |
| CN1263514C (zh) | 2006-07-12 |
| NO985928L (no) | 1998-12-17 |
| GB9613433D0 (en) | 1996-08-28 |
| ATE266427T1 (de) | 2004-05-15 |
| EA199900054A1 (ru) | 1999-06-24 |
| JP2000514784A (ja) | 2000-11-07 |
| TW494099B (en) | 2002-07-11 |
| CA2258630A1 (en) | 1997-12-31 |
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