NO317888B1 - Arylalkanoylpyridaziner, fremgangsmate for fremstilling av forbindelsene, forbindelsene foranvendelse som legemidler, farmasoytiske preparater som inneholder dem, fremgangsmatefor fremstilling av preparatene, samt anvendelse av forbindelsene til fremstilling av legemidler - Google Patents
Arylalkanoylpyridaziner, fremgangsmate for fremstilling av forbindelsene, forbindelsene foranvendelse som legemidler, farmasoytiske preparater som inneholder dem, fremgangsmatefor fremstilling av preparatene, samt anvendelse av forbindelsene til fremstilling av legemidler Download PDFInfo
- Publication number
- NO317888B1 NO317888B1 NO20006412A NO20006412A NO317888B1 NO 317888 B1 NO317888 B1 NO 317888B1 NO 20006412 A NO20006412 A NO 20006412A NO 20006412 A NO20006412 A NO 20006412A NO 317888 B1 NO317888 B1 NO 317888B1
- Authority
- NO
- Norway
- Prior art keywords
- phenyl
- formula
- carboxamide
- ylcarbonyl
- methoxyphenyl
- Prior art date
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- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical compound COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 description 1
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- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
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- 239000007921 spray Substances 0.000 description 1
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- 239000008107 starch Substances 0.000 description 1
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- 150000003462 sulfoxides Chemical class 0.000 description 1
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- UBOXGVDOUJQMTN-UHFFFAOYSA-N trichloroethylene Natural products ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/33—Heterocyclic compounds
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
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- Biomedical Technology (AREA)
- Neurosurgery (AREA)
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- Hematology (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19826841A DE19826841A1 (de) | 1998-06-16 | 1998-06-16 | Arylalkanoylpyridazine |
| PCT/EP1999/003151 WO1999065880A1 (de) | 1998-06-16 | 1999-05-07 | Arylalkanoylpyridazine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20006412L NO20006412L (no) | 2000-12-15 |
| NO20006412D0 NO20006412D0 (no) | 2000-12-15 |
| NO317888B1 true NO317888B1 (no) | 2004-12-27 |
Family
ID=7871071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20006412A NO317888B1 (no) | 1998-06-16 | 2000-12-15 | Arylalkanoylpyridaziner, fremgangsmate for fremstilling av forbindelsene, forbindelsene foranvendelse som legemidler, farmasoytiske preparater som inneholder dem, fremgangsmatefor fremstilling av preparatene, samt anvendelse av forbindelsene til fremstilling av legemidler |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6417188B1 (zh) |
| EP (1) | EP1087946B1 (zh) |
| JP (1) | JP4137378B2 (zh) |
| KR (1) | KR100673638B1 (zh) |
| CN (1) | CN1168720C (zh) |
| AR (1) | AR019676A1 (zh) |
| AU (1) | AU750019B2 (zh) |
| BR (1) | BR9911177A (zh) |
| CA (1) | CA2335104C (zh) |
| CZ (1) | CZ298805B6 (zh) |
| DE (2) | DE19826841A1 (zh) |
| ES (1) | ES2277444T3 (zh) |
| HU (1) | HUP0102215A3 (zh) |
| ID (1) | ID27735A (zh) |
| NO (1) | NO317888B1 (zh) |
| PL (1) | PL344796A1 (zh) |
| SK (1) | SK287362B6 (zh) |
| TW (1) | TW515795B (zh) |
| WO (1) | WO1999065880A1 (zh) |
| ZA (1) | ZA200100418B (zh) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19915364A1 (de) * | 1999-04-06 | 2000-10-12 | Merck Patent Gmbh | Verwendung von Arylalkanoylpyridazinen |
| DE19932315A1 (de) * | 1999-07-10 | 2001-01-11 | Merck Patent Gmbh | Benzoylpyridazine |
| FR2803593B1 (fr) | 2000-01-06 | 2002-02-15 | Sanofi Synthelabo | Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| DE10064997A1 (de) * | 2000-12-23 | 2002-06-27 | Merck Patent Gmbh | Benzoylpyridazine |
| KR20040012720A (ko) * | 2001-02-12 | 2004-02-11 | 메르크 파텐트 게엠베하 | 심근 질환에서 제 4형 포스포디에스테라제 저해제의 용도 |
| SK1862004A3 (en) * | 2001-10-31 | 2004-08-03 | Type 4 phosphodiesterase inhibitors and uses thereof | |
| ATE335486T1 (de) | 2001-11-05 | 2006-09-15 | Merck Patent Gmbh | Hydrazono-malonitrile |
| DE10224888A1 (de) * | 2002-06-05 | 2003-12-24 | Merck Patent Gmbh | Pyridazinderivate |
| DE10225574A1 (de) * | 2002-06-10 | 2003-12-18 | Merck Patent Gmbh | Aryloxime |
| CN101684079B (zh) | 2003-08-29 | 2013-04-03 | 三井化学株式会社 | 农园艺用杀虫剂的制备中间体及制备方法 |
| KR100857312B1 (ko) * | 2004-01-28 | 2008-09-05 | 미쓰이 가가쿠 가부시키가이샤 | 아미드 유도체 및 그 제조 방법 및 그의 살충제로서의 사용 방법 |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| FR2953836B1 (fr) * | 2009-12-14 | 2012-03-16 | Sanofi Aventis | Nouveaux derives (heterocycle-tetrahydro-pyridine)-(piperazinyl)-1-alcanone et (heterocycle-dihydro-pyrrolidine)-(piperazinyl)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
| EP2606894A1 (en) | 2011-12-20 | 2013-06-26 | Sanofi | Novel therapeutic use of p75 receptor antagonists |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19632549A1 (de) * | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
-
1998
- 1998-06-16 DE DE19826841A patent/DE19826841A1/de not_active Withdrawn
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1999
- 1999-05-07 KR KR1020007013328A patent/KR100673638B1/ko not_active IP Right Cessation
- 1999-05-07 HU HU0102215A patent/HUP0102215A3/hu unknown
- 1999-05-07 BR BR9911177-2A patent/BR9911177A/pt not_active IP Right Cessation
- 1999-05-07 CA CA002335104A patent/CA2335104C/en not_active Expired - Fee Related
- 1999-05-07 ES ES99939760T patent/ES2277444T3/es not_active Expired - Lifetime
- 1999-05-07 ID IDW20010080A patent/ID27735A/id unknown
- 1999-05-07 CZ CZ20004632A patent/CZ298805B6/cs not_active IP Right Cessation
- 1999-05-07 CN CNB998074187A patent/CN1168720C/zh not_active Expired - Fee Related
- 1999-05-07 EP EP99939760A patent/EP1087946B1/de not_active Expired - Lifetime
- 1999-05-07 JP JP2000554707A patent/JP4137378B2/ja not_active Expired - Fee Related
- 1999-05-07 DE DE59914151T patent/DE59914151D1/de not_active Expired - Lifetime
- 1999-05-07 WO PCT/EP1999/003151 patent/WO1999065880A1/de active IP Right Grant
- 1999-05-07 PL PL99344796A patent/PL344796A1/xx unknown
- 1999-05-07 AU AU42590/99A patent/AU750019B2/en not_active Ceased
- 1999-05-07 US US09/719,467 patent/US6417188B1/en not_active Expired - Fee Related
- 1999-05-07 SK SK1893-2000A patent/SK287362B6/sk not_active IP Right Cessation
- 1999-06-14 TW TW088109913A patent/TW515795B/zh not_active IP Right Cessation
- 1999-06-16 AR ARP990102875A patent/AR019676A1/es not_active Application Discontinuation
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2000
- 2000-12-15 NO NO20006412A patent/NO317888B1/no not_active IP Right Cessation
-
2001
- 2001-01-15 ZA ZA200100418A patent/ZA200100418B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1087946B1 (de) | 2007-01-10 |
| US6417188B1 (en) | 2002-07-09 |
| ID27735A (id) | 2001-04-26 |
| DE19826841A1 (de) | 1999-12-23 |
| NO20006412L (no) | 2000-12-15 |
| TW515795B (en) | 2003-01-01 |
| DE59914151D1 (en) | 2007-02-22 |
| NO20006412D0 (no) | 2000-12-15 |
| CA2335104A1 (en) | 1999-12-23 |
| WO1999065880A1 (de) | 1999-12-23 |
| SK18932000A3 (sk) | 2001-06-11 |
| AU750019B2 (en) | 2002-07-11 |
| EP1087946A1 (de) | 2001-04-04 |
| ES2277444T3 (es) | 2007-07-01 |
| PL344796A1 (en) | 2001-11-19 |
| CN1305465A (zh) | 2001-07-25 |
| ZA200100418B (en) | 2002-05-07 |
| AR019676A1 (es) | 2002-03-13 |
| AU4259099A (en) | 2000-01-05 |
| CZ20004632A3 (cs) | 2001-04-11 |
| CA2335104C (en) | 2008-03-11 |
| KR20010043858A (ko) | 2001-05-25 |
| CZ298805B6 (cs) | 2008-02-06 |
| JP2002518377A (ja) | 2002-06-25 |
| HUP0102215A2 (hu) | 2002-03-28 |
| CN1168720C (zh) | 2004-09-29 |
| JP4137378B2 (ja) | 2008-08-20 |
| HUP0102215A3 (en) | 2002-05-28 |
| KR100673638B1 (ko) | 2007-01-23 |
| BR9911177A (pt) | 2001-03-13 |
| SK287362B6 (sk) | 2010-08-09 |
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