NO317427B1 - Sammensetning med hoy renhet omfattende (7<alfa>, 17<alfa>)-17-hydroksy-7-metyl-19-nor-17-pregn-5(10)-en-20-yn-3-on - Google Patents
Sammensetning med hoy renhet omfattende (7<alfa>, 17<alfa>)-17-hydroksy-7-metyl-19-nor-17-pregn-5(10)-en-20-yn-3-on Download PDFInfo
- Publication number
- NO317427B1 NO317427B1 NO20011664A NO20011664A NO317427B1 NO 317427 B1 NO317427 B1 NO 317427B1 NO 20011664 A NO20011664 A NO 20011664A NO 20011664 A NO20011664 A NO 20011664A NO 317427 B1 NO317427 B1 NO 317427B1
- Authority
- NO
- Norway
- Prior art keywords
- hydroxy
- methyl
- pregn
- less
- amount
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 150000001875 compounds Chemical class 0.000 claims description 22
- 239000013078 crystal Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 14
- 239000007787 solid Substances 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 7
- 238000009472 formulation Methods 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 230000032683 aging Effects 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 3
- 238000003786 synthesis reaction Methods 0.000 claims description 3
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- WZDGZWOAQTVYBX-XOINTXKNSA-N tibolone Chemical compound C([C@@H]12)C[C@]3(C)[C@@](C#C)(O)CC[C@H]3[C@@H]1[C@H](C)CC1=C2CCC(=O)C1 WZDGZWOAQTVYBX-XOINTXKNSA-N 0.000 description 37
- 229960001023 tibolone Drugs 0.000 description 36
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 26
- 101000764229 Rattus norvegicus Mitochondrial import receptor subunit TOM40 homolog Proteins 0.000 description 21
- 239000003826 tablet Substances 0.000 description 16
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 15
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 13
- 238000003860 storage Methods 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- 239000008187 granular material Substances 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 238000001035 drying Methods 0.000 description 6
- 239000002775 capsule Substances 0.000 description 5
- 239000012535 impurity Substances 0.000 description 5
- 235000006408 oxalic acid Nutrition 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 4
- 238000005550 wet granulation Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 229920001592 potato starch Polymers 0.000 description 3
- 230000035882 stress Effects 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000006317 isomerization reaction Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- 229920000715 Mucilage Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000001548 androgenic effect Effects 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 229960005215 dichloroacetic acid Drugs 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- -1 for example Substances 0.000 description 1
- 230000002431 foraging effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000000757 progestagenic effect Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98203460 | 1998-10-16 | ||
| PCT/EP1999/007768 WO2000023460A1 (en) | 1998-10-16 | 1999-10-11 | HIGH PURITY COMPOSITION COMPRISING (7α,17α)- 17-HYDROXY- 7-METHYL- 19-NOR-17-PREGN- 5(10)-EN-20-YN-3-ONE |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20011664L NO20011664L (no) | 2001-04-03 |
| NO20011664D0 NO20011664D0 (no) | 2001-04-03 |
| NO317427B1 true NO317427B1 (no) | 2004-10-25 |
Family
ID=8234220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20011664A NO317427B1 (no) | 1998-10-16 | 2001-04-03 | Sammensetning med hoy renhet omfattende (7<alfa>, 17<alfa>)-17-hydroksy-7-metyl-19-nor-17-pregn-5(10)-en-20-yn-3-on |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US6969708B1 (xx) |
| EP (2) | EP1121375B1 (xx) |
| JP (1) | JP2002527525A (xx) |
| KR (3) | KR20050003358A (xx) |
| CN (2) | CN100378116C (xx) |
| AR (1) | AR020832A1 (xx) |
| AT (1) | ATE239032T1 (xx) |
| AU (1) | AU763232B2 (xx) |
| BR (1) | BR9914441A (xx) |
| CA (1) | CA2344686C (xx) |
| CO (1) | CO5160271A1 (xx) |
| CZ (1) | CZ298703B6 (xx) |
| DE (1) | DE69907495T2 (xx) |
| DK (1) | DK1121375T3 (xx) |
| ES (1) | ES2197677T3 (xx) |
| HK (1) | HK1039620B (xx) |
| HU (1) | HUP0104206A3 (xx) |
| ID (1) | ID28463A (xx) |
| IL (1) | IL141850A (xx) |
| NO (1) | NO317427B1 (xx) |
| NZ (1) | NZ510501A (xx) |
| PE (1) | PE20001377A1 (xx) |
| PL (1) | PL197870B1 (xx) |
| PT (1) | PT1121375E (xx) |
| RU (1) | RU2220975C2 (xx) |
| SK (1) | SK284569B6 (xx) |
| TR (2) | TR200504091T2 (xx) |
| TW (2) | TW577893B (xx) |
| WO (1) | WO2000023460A1 (xx) |
| ZA (1) | ZA200101952B (xx) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL356465A1 (en) * | 2002-10-04 | 2004-04-05 | ANPHARM Przedsiębiorstwo Farmaceutyczne S.A. | METHOD OF MANUFACTURE OF 17beta-HYDROXY-7alpha-METHYL-19-NOR-17alpha-PREGN-5(10)-ENE-20-YNE-3-ONE |
| TW200418525A (en) * | 2002-11-20 | 2004-10-01 | Akzo Nobel Nv | Coated pharmaceutical tablets containing Tibolone |
| GB0304927D0 (en) | 2003-03-04 | 2003-04-09 | Resolution Chemicals Ltd | Process for the production of tibolone |
| WO2005117899A1 (en) * | 2004-06-02 | 2005-12-15 | Cipla Limited | Pharmaceutical composition comprising tibolone and process for procuding the same |
| RU2387661C2 (ru) | 2005-02-01 | 2010-04-27 | Ф.Хоффманн-Ля Рош Аг | Полиморфная модификация в ибандроната |
| CN101111504B (zh) * | 2005-02-01 | 2011-12-21 | 霍夫曼-拉罗奇有限公司 | 伊班膦酸盐多晶型物a |
| EP1883648A1 (en) * | 2005-05-23 | 2008-02-06 | Newchem S.p.A. | Process for the preparation of pure crystalline tibolone |
| CZ300465B6 (cs) * | 2007-07-25 | 2009-05-27 | Zentiva, A. S. | Zpusob výroby komprimované farmaceutické formulace s obsahem tibolonu |
| ITMI20130120A1 (it) * | 2013-01-25 | 2014-07-26 | Ind Chimica Srl | Processo per la preparazione in forma cristallina di tibolone, (7alfa,17alfa)-17-idrossi-7-metil-19-norpregn-5(10)-en-20-in-3-one |
| EP3897181A4 (en) * | 2018-12-17 | 2022-08-24 | Société des Produits Nestlé S.A. | ORAL EGG IMMUNOTHERAPY FORMULATIONS, MANUFACTURING METHODS AND TREATMENTS FOR EGG ALLERGIES |
| CN114409717B (zh) * | 2021-12-17 | 2023-03-17 | 湖南科益新生物医药有限公司 | 替勃龙中间体醚化物和替勃龙的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE665514A (xx) * | 1964-06-16 | |||
| CH488682A (de) | 1965-07-30 | 1970-04-15 | Ciba Geigy | Verfahren zur Herstellung von 4,9,11-Trienen der 19-Nor-androstanreihe |
| NL146838B (nl) | 1966-06-24 | 1975-08-15 | Organon Nv | Werkwijze voor het bereiden van (delta)5(10)-3- keto-19-norsteroiden. |
| US3515719A (en) | 1967-03-15 | 1970-06-02 | Upjohn Co | 7-methyl-6,19-epoxy steroids of the androstane series |
| US4701450A (en) * | 1984-03-21 | 1987-10-20 | Akzo N.V. | Steroids for use as immunomodulators |
| AU3435989A (en) * | 1988-03-25 | 1989-10-16 | Akzo N.V. | Pharmaceutical preparation containing a fluoride salt |
| IE63051B1 (en) * | 1989-03-18 | 1995-03-22 | Akzo Nv | Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one |
| DE69418744T2 (de) * | 1993-03-05 | 1999-11-11 | Akzo Nobel Nv | Verwendung von Pregnanderivaten zur Behandlung von Tumoren |
| CA2159419C (en) * | 1994-10-17 | 2006-07-04 | Pieter De Haan | Solid pharmaceutical composition comprising an excipient capable of binding water |
| IL123422A (en) * | 1997-03-05 | 2003-05-29 | Akzo Nobel Nv | USE OF 7alpha-METHYL-17alpha-ETHYNYL-ESTRANE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE PROPHYLAXIS OR THE TREATMENT OF ATHEROSCLEROSIS |
| IL123984A (en) * | 1997-04-22 | 2004-09-27 | Akzo Nobel Nv | Pharmacological dosage units containing tibolone and carrier pharmacy are acceptable |
-
1999
- 1999-10-11 PT PT99948994T patent/PT1121375E/pt unknown
- 1999-10-11 KR KR10-2004-7016210A patent/KR20050003358A/ko not_active Application Discontinuation
- 1999-10-11 CA CA002344686A patent/CA2344686C/en not_active Expired - Fee Related
- 1999-10-11 ID IDW20010850A patent/ID28463A/id unknown
- 1999-10-11 US US09/787,215 patent/US6969708B1/en not_active Expired - Fee Related
- 1999-10-11 NZ NZ510501A patent/NZ510501A/en not_active IP Right Cessation
- 1999-10-11 EP EP99948994A patent/EP1121375B1/en not_active Revoked
- 1999-10-11 RU RU2001113281/04A patent/RU2220975C2/ru not_active IP Right Cessation
- 1999-10-11 ES ES99948994T patent/ES2197677T3/es not_active Expired - Lifetime
- 1999-10-11 DE DE69907495T patent/DE69907495T2/de not_active Revoked
- 1999-10-11 KR KR1020067011204A patent/KR20060071897A/ko not_active Application Discontinuation
- 1999-10-11 TW TW088117530A patent/TW577893B/zh not_active IP Right Cessation
- 1999-10-11 CN CNB99811734XA patent/CN100378116C/zh not_active Expired - Fee Related
- 1999-10-11 AT AT99948994T patent/ATE239032T1/de not_active IP Right Cessation
- 1999-10-11 BR BR9914441-7A patent/BR9914441A/pt not_active Application Discontinuation
- 1999-10-11 SK SK493-2001A patent/SK284569B6/sk not_active IP Right Cessation
- 1999-10-11 TR TR2005/04091T patent/TR200504091T2/xx unknown
- 1999-10-11 IL IL14185099A patent/IL141850A/xx not_active IP Right Cessation
- 1999-10-11 HU HU0104206A patent/HUP0104206A3/hu unknown
- 1999-10-11 EP EP02022689A patent/EP1275379A3/en not_active Withdrawn
- 1999-10-11 CZ CZ20010976A patent/CZ298703B6/cs not_active IP Right Cessation
- 1999-10-11 DK DK99948994T patent/DK1121375T3/da active
- 1999-10-11 AU AU62029/99A patent/AU763232B2/en not_active Expired
- 1999-10-11 WO PCT/EP1999/007768 patent/WO2000023460A1/en active IP Right Grant
- 1999-10-11 TR TR2001/01083T patent/TR200101083T2/xx unknown
- 1999-10-11 CN CNB2005101186668A patent/CN100432093C/zh not_active Expired - Fee Related
- 1999-10-11 KR KR1020017004639A patent/KR100635018B1/ko not_active IP Right Cessation
- 1999-10-11 PL PL347264A patent/PL197870B1/pl not_active IP Right Cessation
- 1999-10-11 TW TW092128164A patent/TW200403251A/zh unknown
- 1999-10-11 JP JP2000577186A patent/JP2002527525A/ja not_active Withdrawn
- 1999-10-15 CO CO99065751A patent/CO5160271A1/es unknown
- 1999-10-15 PE PE1999001042A patent/PE20001377A1/es not_active Application Discontinuation
- 1999-10-15 AR ARP990105229A patent/AR020832A1/es unknown
-
2001
- 2001-03-08 ZA ZA200101952A patent/ZA200101952B/en unknown
- 2001-04-03 NO NO20011664A patent/NO317427B1/no not_active IP Right Cessation
-
2002
- 2002-01-18 HK HK02100410.0A patent/HK1039620B/zh not_active IP Right Cessation
-
2004
- 2004-07-08 US US10/887,397 patent/US20040248870A1/en not_active Abandoned
-
2005
- 2005-07-07 US US11/176,842 patent/US20050245496A1/en not_active Abandoned
Also Published As
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