PT1121375E - Composto de elevada pureza de (7alfa, 17alfa)-17-hidroxi-7-metil-19-nor-17-pregn-5(10)-en-20-in-3-ona - Google Patents

Composto de elevada pureza de (7alfa, 17alfa)-17-hidroxi-7-metil-19-nor-17-pregn-5(10)-en-20-in-3-ona

Info

Publication number
PT1121375E
PT1121375E PT99948994T PT99948994T PT1121375E PT 1121375 E PT1121375 E PT 1121375E PT 99948994 T PT99948994 T PT 99948994T PT 99948994 T PT99948994 T PT 99948994T PT 1121375 E PT1121375 E PT 1121375E
Authority
PT
Portugal
Prior art keywords
7alpha
17alpha
pregn
ona
hydroxy
Prior art date
Application number
PT99948994T
Other languages
English (en)
Inventor
Gerard Arnoud Josef Maria Sas
Peter Huub Gerard Kirchholtes
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8234220&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1121375(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of PT1121375E publication Critical patent/PT1121375E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT99948994T 1998-10-16 1999-10-11 Composto de elevada pureza de (7alfa, 17alfa)-17-hidroxi-7-metil-19-nor-17-pregn-5(10)-en-20-in-3-ona PT1121375E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98203460 1998-10-16

Publications (1)

Publication Number Publication Date
PT1121375E true PT1121375E (pt) 2003-07-31

Family

ID=8234220

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99948994T PT1121375E (pt) 1998-10-16 1999-10-11 Composto de elevada pureza de (7alfa, 17alfa)-17-hidroxi-7-metil-19-nor-17-pregn-5(10)-en-20-in-3-ona

Country Status (30)

Country Link
US (3) US6969708B1 (pt)
EP (2) EP1275379A3 (pt)
JP (1) JP2002527525A (pt)
KR (3) KR20060071897A (pt)
CN (2) CN100432093C (pt)
AR (1) AR020832A1 (pt)
AT (1) ATE239032T1 (pt)
AU (1) AU763232B2 (pt)
BR (1) BR9914441A (pt)
CA (1) CA2344686C (pt)
CO (1) CO5160271A1 (pt)
CZ (1) CZ298703B6 (pt)
DE (1) DE69907495T2 (pt)
DK (1) DK1121375T3 (pt)
ES (1) ES2197677T3 (pt)
HK (1) HK1039620B (pt)
HU (1) HUP0104206A3 (pt)
ID (1) ID28463A (pt)
IL (1) IL141850A (pt)
NO (1) NO317427B1 (pt)
NZ (1) NZ510501A (pt)
PE (1) PE20001377A1 (pt)
PL (1) PL197870B1 (pt)
PT (1) PT1121375E (pt)
RU (1) RU2220975C2 (pt)
SK (1) SK284569B6 (pt)
TR (2) TR200504091T2 (pt)
TW (2) TW200403251A (pt)
WO (1) WO2000023460A1 (pt)
ZA (1) ZA200101952B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL356465A1 (en) * 2002-10-04 2004-04-05 ANPHARM Przedsiębiorstwo Farmaceutyczne S.A. METHOD OF MANUFACTURE OF 17beta-HYDROXY-7alpha-METHYL-19-NOR-17alpha-PREGN-5(10)-ENE-20-YNE-3-ONE
TW200418525A (en) * 2002-11-20 2004-10-01 Akzo Nobel Nv Coated pharmaceutical tablets containing Tibolone
GB0304927D0 (en) 2003-03-04 2003-04-09 Resolution Chemicals Ltd Process for the production of tibolone
WO2005117899A1 (en) * 2004-06-02 2005-12-15 Cipla Limited Pharmaceutical composition comprising tibolone and process for procuding the same
TR201902609T4 (tr) 2005-02-01 2019-03-21 Atnahs Pharma Uk Ltd İbandronat polimorf A nın tıbbi kullanımı.
SI1848727T1 (sl) 2005-02-01 2015-09-30 F. Hoffmann-La Roche Ag Polimorf b ibandronata
EP1883648A1 (en) * 2005-05-23 2008-02-06 Newchem S.p.A. Process for the preparation of pure crystalline tibolone
CZ300465B6 (cs) * 2007-07-25 2009-05-27 Zentiva, A. S. Zpusob výroby komprimované farmaceutické formulace s obsahem tibolonu
ITMI20130120A1 (it) * 2013-01-25 2014-07-26 Ind Chimica Srl Processo per la preparazione in forma cristallina di tibolone, (7alfa,17alfa)-17-idrossi-7-metil-19-norpregn-5(10)-en-20-in-3-one
CN113423282A (zh) * 2018-12-17 2021-09-21 爱沐疗法公司 用于卵口服免疫疗法的制剂、制备方法和用于卵变态反应的治疗
CN114409717B (zh) * 2021-12-17 2023-03-17 湖南科益新生物医药有限公司 替勃龙中间体醚化物和替勃龙的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE665514A (pt) 1964-06-16
CH488682A (de) 1965-07-30 1970-04-15 Ciba Geigy Verfahren zur Herstellung von 4,9,11-Trienen der 19-Nor-androstanreihe
NL146838B (nl) 1966-06-24 1975-08-15 Organon Nv Werkwijze voor het bereiden van (delta)5(10)-3- keto-19-norsteroiden.
US3515719A (en) 1967-03-15 1970-06-02 Upjohn Co 7-methyl-6,19-epoxy steroids of the androstane series
US4701450A (en) * 1984-03-21 1987-10-20 Akzo N.V. Steroids for use as immunomodulators
JPH03503414A (ja) * 1988-03-25 1991-08-01 アクゾ・エヌ・ヴエー フッ化物塩を含有する医薬製剤
IE63051B1 (en) * 1989-03-18 1995-03-22 Akzo Nv Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
DE69418744T2 (de) * 1993-03-05 1999-11-11 Akzo Nobel N.V., Arnheim/Arnhem Verwendung von Pregnanderivaten zur Behandlung von Tumoren
CA2159419C (en) 1994-10-17 2006-07-04 Pieter De Haan Solid pharmaceutical composition comprising an excipient capable of binding water
IL123422A (en) * 1997-03-05 2003-05-29 Akzo Nobel Nv USE OF 7alpha-METHYL-17alpha-ETHYNYL-ESTRANE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE PROPHYLAXIS OR THE TREATMENT OF ATHEROSCLEROSIS
IL123984A (en) * 1997-04-22 2004-09-27 Akzo Nobel Nv Pharmacological dosage units containing tibolone and carrier pharmacy are acceptable

Also Published As

Publication number Publication date
TW577893B (en) 2004-03-01
US6969708B1 (en) 2005-11-29
DE69907495D1 (de) 2003-06-05
CN100378116C (zh) 2008-04-02
NZ510501A (en) 2003-10-31
CA2344686C (en) 2009-04-28
AU763232B2 (en) 2003-07-17
CA2344686A1 (en) 2000-04-27
ES2197677T3 (es) 2004-01-01
AU6202999A (en) 2000-05-08
PE20001377A1 (es) 2000-12-09
TR200101083T2 (tr) 2001-08-21
RU2220975C2 (ru) 2004-01-10
KR20010080133A (ko) 2001-08-22
CO5160271A1 (es) 2002-05-30
HUP0104206A3 (en) 2002-06-28
JP2002527525A (ja) 2002-08-27
PL197870B1 (pl) 2008-05-30
EP1275379A3 (en) 2003-03-26
KR100635018B1 (ko) 2006-10-17
NO20011664D0 (no) 2001-04-03
HK1039620B (zh) 2003-08-22
ATE239032T1 (de) 2003-05-15
CZ298703B6 (cs) 2007-12-27
TR200504091T2 (tr) 2006-05-22
KR20050003358A (ko) 2005-01-10
NO317427B1 (no) 2004-10-25
CN1769293A (zh) 2006-05-10
CN100432093C (zh) 2008-11-12
US20050245496A1 (en) 2005-11-03
CN1322210A (zh) 2001-11-14
EP1275379A2 (en) 2003-01-15
DE69907495T2 (de) 2004-05-06
SK284569B6 (sk) 2005-06-02
EP1121375B1 (en) 2003-05-02
IL141850A0 (en) 2002-03-10
WO2000023460A1 (en) 2000-04-27
DK1121375T3 (da) 2003-08-04
PL347264A1 (en) 2002-03-25
EP1121375A1 (en) 2001-08-08
TW200403251A (en) 2004-03-01
HUP0104206A2 (hu) 2002-04-29
IL141850A (en) 2005-11-20
US20040248870A1 (en) 2004-12-09
BR9914441A (pt) 2001-06-26
ZA200101952B (en) 2002-06-10
ID28463A (id) 2001-05-24
SK4932001A3 (en) 2001-12-03
CZ2001976A3 (cs) 2001-08-15
HK1039620A1 (en) 2002-05-03
NO20011664L (no) 2001-04-03
KR20060071897A (ko) 2006-06-27
AR020832A1 (es) 2002-05-29

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