NO317426B1 - Nye forbindelser og sammensetninger,og anvendelse av disse nye forbindelser for fremstillling av et legemiddel for forebyggelse eller behandling av diabetes mellitus svekket glukosetoleranse hyperlipedemi, forsterkning av insulinsensitivitet og forbedring av insulinresistens - Google Patents
Nye forbindelser og sammensetninger,og anvendelse av disse nye forbindelser for fremstillling av et legemiddel for forebyggelse eller behandling av diabetes mellitus svekket glukosetoleranse hyperlipedemi, forsterkning av insulinsensitivitet og forbedring av insulinresistens Download PDFInfo
- Publication number
- NO317426B1 NO317426B1 NO20005531A NO20005531A NO317426B1 NO 317426 B1 NO317426 B1 NO 317426B1 NO 20005531 A NO20005531 A NO 20005531A NO 20005531 A NO20005531 A NO 20005531A NO 317426 B1 NO317426 B1 NO 317426B1
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- Norway
- Prior art keywords
- group
- carbon atoms
- ethyl acetate
- added
- methyl
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 167
- 206010022489 Insulin Resistance Diseases 0.000 title claims abstract description 24
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 13
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title claims abstract description 13
- 208000002705 Glucose Intolerance Diseases 0.000 title claims abstract description 10
- 201000009104 prediabetes syndrome Diseases 0.000 title claims abstract description 10
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- 208000031226 Hyperlipidaemia Diseases 0.000 title description 4
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 61
- 125000001424 substituent group Chemical group 0.000 claims abstract description 56
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- 125000002252 acyl group Chemical group 0.000 claims abstract description 38
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 35
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 31
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 29
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims abstract description 26
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 23
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- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims abstract description 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims abstract 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 234
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- 125000005843 halogen group Chemical group 0.000 claims description 12
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 125000000335 thiazolyl group Chemical group 0.000 claims description 6
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
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- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims description 5
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- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 4
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- 125000002757 morpholinyl group Chemical group 0.000 claims description 3
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- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 3
- 125000003386 piperidinyl group Chemical group 0.000 claims description 3
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 3
- 125000002053 thietanyl group Chemical group 0.000 claims description 3
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- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims description 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 2
- 125000000018 nitroso group Chemical group N(=O)* 0.000 claims description 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract description 27
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract description 12
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- 238000000034 method Methods 0.000 description 67
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Classifications
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP12792298 | 1998-05-11 | ||
JP12792198 | 1998-05-11 | ||
PCT/JP1999/002407 WO1999058510A1 (en) | 1998-05-11 | 1999-05-10 | Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity |
Publications (3)
Publication Number | Publication Date |
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NO20005531D0 NO20005531D0 (no) | 2000-11-02 |
NO20005531L NO20005531L (no) | 2001-01-05 |
NO317426B1 true NO317426B1 (no) | 2004-10-25 |
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NO20005531A NO317426B1 (no) | 1998-05-11 | 2000-11-02 | Nye forbindelser og sammensetninger,og anvendelse av disse nye forbindelser for fremstillling av et legemiddel for forebyggelse eller behandling av diabetes mellitus svekket glukosetoleranse hyperlipedemi, forsterkning av insulinsensitivitet og forbedring av insulinresistens |
Country Status (27)
Country | Link |
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US (3) | US6251926B1 (ko) |
EP (2) | EP1077957B1 (ko) |
JP (1) | JP2000198772A (ko) |
KR (1) | KR100388120B1 (ko) |
CN (1) | CN1148361C (ko) |
AR (1) | AR029876A1 (ko) |
AT (1) | ATE272625T1 (ko) |
AU (1) | AU766831B2 (ko) |
BR (1) | BR9910371A (ko) |
CA (1) | CA2331879A1 (ko) |
CO (1) | CO5040066A1 (ko) |
DE (1) | DE69919156T2 (ko) |
ES (1) | ES2226377T3 (ko) |
HK (1) | HK1034972A1 (ko) |
HU (1) | HUP0103714A3 (ko) |
ID (1) | ID28699A (ko) |
IL (1) | IL139470A0 (ko) |
LV (1) | LV12606B (ko) |
MY (1) | MY123337A (ko) |
NO (1) | NO317426B1 (ko) |
NZ (1) | NZ508066A (ko) |
PE (1) | PE20000625A1 (ko) |
PL (1) | PL344002A1 (ko) |
PT (1) | PT1077957E (ko) |
RU (1) | RU2213738C2 (ko) |
SK (1) | SK16412000A3 (ko) |
WO (1) | WO1999058510A1 (ko) |
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-
1999
- 1999-05-10 KR KR10-2000-7000081A patent/KR100388120B1/ko not_active IP Right Cessation
- 1999-05-10 ES ES99918355T patent/ES2226377T3/es not_active Expired - Lifetime
- 1999-05-10 CN CNB998060070A patent/CN1148361C/zh not_active Expired - Fee Related
- 1999-05-10 SK SK1641-2000A patent/SK16412000A3/sk unknown
- 1999-05-10 PT PT99918355T patent/PT1077957E/pt unknown
- 1999-05-10 HU HU0103714A patent/HUP0103714A3/hu unknown
- 1999-05-10 BR BR9910371-0A patent/BR9910371A/pt not_active IP Right Cessation
- 1999-05-10 ID IDW20002324A patent/ID28699A/id unknown
- 1999-05-10 AU AU36297/99A patent/AU766831B2/en not_active Ceased
- 1999-05-10 DE DE69919156T patent/DE69919156T2/de not_active Expired - Lifetime
- 1999-05-10 CA CA002331879A patent/CA2331879A1/en not_active Abandoned
- 1999-05-10 PL PL99344002A patent/PL344002A1/xx not_active Application Discontinuation
- 1999-05-10 MY MYPI99001832A patent/MY123337A/en unknown
- 1999-05-10 IL IL13947099A patent/IL139470A0/xx unknown
- 1999-05-10 EP EP99918355A patent/EP1077957B1/en not_active Expired - Lifetime
- 1999-05-10 AR ARP990102190A patent/AR029876A1/es unknown
- 1999-05-10 EP EP04075569A patent/EP1428531A1/en not_active Withdrawn
- 1999-05-10 WO PCT/JP1999/002407 patent/WO1999058510A1/en not_active Application Discontinuation
- 1999-05-10 US US09/423,854 patent/US6251926B1/en not_active Expired - Fee Related
- 1999-05-10 RU RU2000131183/04A patent/RU2213738C2/ru not_active IP Right Cessation
- 1999-05-10 AT AT99918355T patent/ATE272625T1/de not_active IP Right Cessation
- 1999-05-10 NZ NZ508066A patent/NZ508066A/xx unknown
- 1999-05-11 PE PE1999000393A patent/PE20000625A1/es not_active Application Discontinuation
- 1999-05-11 CO CO99029123A patent/CO5040066A1/es unknown
- 1999-12-28 JP JP11373202A patent/JP2000198772A/ja active Pending
-
2000
- 2000-11-01 LV LVP-00-148A patent/LV12606B/en unknown
- 2000-11-02 NO NO20005531A patent/NO317426B1/no unknown
- 2000-11-16 US US09/714,699 patent/US6495581B1/en not_active Expired - Fee Related
-
2001
- 2001-08-15 HK HK01105750A patent/HK1034972A1/xx not_active IP Right Cessation
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2002
- 2002-12-27 US US10/331,056 patent/US6924300B2/en not_active Expired - Fee Related
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