NO314595B1 - Fremgangsmåte for fremstilling av et kim¶rt terapeutisk aktivt humanisert antistoff eller et terapeutisk aktivt fragment derav, DNA-sekvenssom koder for antistoffet, samt plasmid og stabil vertscellelinje som omfatterDNA-sekvensen - Google Patents
Fremgangsmåte for fremstilling av et kim¶rt terapeutisk aktivt humanisert antistoff eller et terapeutisk aktivt fragment derav, DNA-sekvenssom koder for antistoffet, samt plasmid og stabil vertscellelinje som omfatterDNA-sekvensen Download PDFInfo
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- NO314595B1 NO314595B1 NO19930825A NO930825A NO314595B1 NO 314595 B1 NO314595 B1 NO 314595B1 NO 19930825 A NO19930825 A NO 19930825A NO 930825 A NO930825 A NO 930825A NO 314595 B1 NO314595 B1 NO 314595B1
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- APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 description 1
- 229940055742 indium-111 Drugs 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 1
- 235000021243 milk fat Nutrition 0.000 description 1
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 1
- 229960000951 mycophenolic acid Drugs 0.000 description 1
- 210000004897 n-terminal region Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 238000013492 plasmid preparation Methods 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 229910000938 samarium–cobalt magnet Inorganic materials 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pretreatment Of Seeds And Plants (AREA)
- Nonmetallic Welding Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909019553A GB9019553D0 (en) | 1990-09-07 | 1990-09-07 | Specific binding agents |
| PCT/GB1991/001511 WO1992004380A1 (en) | 1990-09-07 | 1991-09-05 | Specific binding agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO930825D0 NO930825D0 (no) | 1993-03-05 |
| NO930825L NO930825L (no) | 1993-05-05 |
| NO314595B1 true NO314595B1 (no) | 2003-04-14 |
Family
ID=10681827
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19930825A NO314595B1 (no) | 1990-09-07 | 1993-03-05 | Fremgangsmåte for fremstilling av et kim¶rt terapeutisk aktivt humanisert antistoff eller et terapeutisk aktivt fragment derav, DNA-sekvenssom koder for antistoffet, samt plasmid og stabil vertscellelinje som omfatterDNA-sekvensen |
| NO20014822A NO315239B1 (no) | 1990-09-07 | 2001-10-04 | Kim¶rt humanisert antistoff eller fragment derav, samt anvendelse av samme |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20014822A NO315239B1 (no) | 1990-09-07 | 2001-10-04 | Kim¶rt humanisert antistoff eller fragment derav, samt anvendelse av samme |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6204366B1 (ja) |
| EP (1) | EP0483961B1 (ja) |
| JP (2) | JP3514456B2 (ja) |
| KR (1) | KR930702526A (ja) |
| AT (1) | ATE233279T1 (ja) |
| AU (1) | AU653167B2 (ja) |
| BG (1) | BG60716B1 (ja) |
| CA (1) | CA2090961C (ja) |
| DE (1) | DE69133200T2 (ja) |
| DK (1) | DK0483961T3 (ja) |
| ES (1) | ES2193129T3 (ja) |
| FI (2) | FI113873B (ja) |
| GB (1) | GB9019553D0 (ja) |
| HU (2) | HUT67796A (ja) |
| NO (2) | NO314595B1 (ja) |
| RO (1) | RO113432B1 (ja) |
| UA (1) | UA46691C2 (ja) |
| WO (1) | WO1992004380A1 (ja) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
| WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US6407213B1 (en) | 1991-06-14 | 2002-06-18 | Genentech, Inc. | Method for making humanized antibodies |
| US5869619A (en) * | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
| JP4157160B2 (ja) * | 1991-12-13 | 2008-09-24 | ゾーマ テクノロジー リミテッド | 改変抗体可変領域の調製のための方法 |
| AU5615594A (en) * | 1992-11-13 | 1994-06-08 | Cancer Research Fund Of Contra Costa | Polypeptides with specificity for neoplasias, kit, and diagnostic, vaccination, and therapeutic methods |
| US5804187A (en) | 1992-11-16 | 1998-09-08 | Cancer Research Fund Of Contra Costa | Modified antibodies with human milk fat globule specificity |
| CA2149529C (en) * | 1992-11-16 | 2006-05-02 | Fernado J. R. Do Couto | Peptides and anti-sense peptides with broad neoplastic specificity |
| US5792852A (en) * | 1992-11-16 | 1998-08-11 | Cancer Research Fund Of Contra Costa | Polynucleotides encoding modified antibodies with human milk fat globule specificity |
| US6281335B1 (en) * | 1993-10-08 | 2001-08-28 | Coulter Corporation | Hybridoma and anti-KC-4 humanized monoclonal antibody |
| JPH07203974A (ja) * | 1994-01-13 | 1995-08-08 | Tosoh Corp | 癌特異的ムチンを認識する抗体の遺伝子断片等 |
| EP0781847A1 (en) * | 1995-11-06 | 1997-07-02 | MERCK PATENT GmbH | Humanized monoclonal antibody |
| JP2002507544A (ja) * | 1997-11-14 | 2002-03-12 | ユーロ−セルティーク，エス．エイ． | 抗イディオタイプ応答を引き出す能力が増強された改変型の抗体 |
| GB2360771A (en) * | 2000-03-28 | 2001-10-03 | Antisoma Res Ltd | Compounds for targeting |
| AU4430701A (en) * | 2000-04-03 | 2001-10-15 | Antisoma Research Limited | Compounds for targeting |
| AU2002307064A1 (en) * | 2001-04-02 | 2002-10-15 | Purdue Pharma L.P. | Immunoglobulin construct containing anti-mucin variable domain sequences for eliciting an anti-idiotype anti-tumor response |
| GB0200657D0 (en) * | 2002-01-12 | 2002-02-27 | Antisoma Plc | Cancer treatment |
| CA2488441C (en) * | 2002-06-03 | 2015-01-27 | Genentech, Inc. | Synthetic antibody phage libraries |
| US20040059093A1 (en) * | 2002-07-16 | 2004-03-25 | Stuart Bussell | Methods to construct multimeric DNA and polymeric protein sequences as direct fusions or with linkers |
| CA2534055A1 (en) * | 2003-08-01 | 2005-02-10 | Genentech, Inc. | Antibody cdr polypeptide sequences with restricted diversity |
| GB0519398D0 (en) * | 2005-09-23 | 2005-11-02 | Antisoma Plc | Biological materials and uses thereof |
| US8679490B2 (en) | 2005-11-07 | 2014-03-25 | Genentech, Inc. | Binding polypeptides with diversified and consensus VH/VL hypervariable sequences |
| WO2007064919A2 (en) * | 2005-12-02 | 2007-06-07 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| US20120093833A1 (en) | 2010-10-13 | 2012-04-19 | Juan Carlos Almagro | Human Oncostatin M Antibodies and Methods of Use |
| US20140079722A1 (en) * | 2011-03-09 | 2014-03-20 | Centrose, Llc | Extracellular targeted drug conjugates |
| RU2493165C1 (ru) * | 2012-02-28 | 2013-09-20 | Общество с ограниченной ответственностью "Технофарма" | Наноантитело, специфически связывающее белок muc1, способ детекции белка muc1 с помощью наноантител |
| KR102103366B1 (ko) | 2012-04-30 | 2020-04-22 | 바이오테라, 인크. | β-글루칸 면역치료 방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607679D0 (en) * | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| AU1103988A (en) * | 1987-01-07 | 1988-07-27 | Imperial Cancer Research Technology Limited | Probe |
| JPH02500329A (ja) * | 1987-05-21 | 1990-02-08 | クリエイテイブ・バイオマリキユールズ・インコーポレーテツド | ターゲット化多機能蛋白質 |
| WO1989007268A1 (en) * | 1988-02-08 | 1989-08-10 | John Muir Cancer & Aging Institute | Monoclonal antibody specific to a novel mucin-like glycoprotein surface antigen on human carcinoma cells |
| EP0442926A1 (en) * | 1988-11-10 | 1991-08-28 | Imperial Cancer Research Technology Limited | Polypeptides |
| CA2003211A1 (en) * | 1988-11-17 | 1990-05-17 | Pei-Xiang Xing | Monoclonal antibodies |
| US5075219A (en) * | 1989-04-05 | 1991-12-24 | John Muir Cancer & Aging Institute | Monoclonal antibody which recognizes a specific glycoprotein of a human milk-fat globule membrane mucin antigen and said mucin antigen |
| HUT64600A (en) * | 1989-11-17 | 1994-01-28 | Unilever Nv | Method for producing specific binding materials |
-
1990
- 1990-09-07 GB GB909019553A patent/GB9019553D0/en active Pending
-
1991
- 1991-09-05 UA UA93080844A patent/UA46691C2/uk unknown
- 1991-09-05 HU HU9300609A patent/HUT67796A/hu unknown
- 1991-09-05 DK DK91308147T patent/DK0483961T3/da active
- 1991-09-05 CA CA002090961A patent/CA2090961C/en not_active Expired - Lifetime
- 1991-09-05 KR KR1019930700678A patent/KR930702526A/ko not_active Application Discontinuation
- 1991-09-05 US US07/987,264 patent/US6204366B1/en not_active Expired - Lifetime
- 1991-09-05 DE DE69133200T patent/DE69133200T2/de not_active Expired - Lifetime
- 1991-09-05 HU HU9300609A patent/HU9300609D0/hu unknown
- 1991-09-05 ES ES91308147T patent/ES2193129T3/es not_active Expired - Lifetime
- 1991-09-05 EP EP91308147A patent/EP0483961B1/en not_active Expired - Lifetime
- 1991-09-05 WO PCT/GB1991/001511 patent/WO1992004380A1/en active IP Right Grant
- 1991-09-05 RO RO93-00310A patent/RO113432B1/ro unknown
- 1991-09-05 AU AU84953/91A patent/AU653167B2/en not_active Expired
- 1991-09-05 JP JP51496191A patent/JP3514456B2/ja not_active Expired - Lifetime
- 1991-09-05 AT AT91308147T patent/ATE233279T1/de not_active IP Right Cessation
-
1993
- 1993-03-05 NO NO19930825A patent/NO314595B1/no not_active IP Right Cessation
- 1993-03-05 FI FI930984A patent/FI113873B/fi not_active IP Right Cessation
- 1993-04-05 BG BG97607A patent/BG60716B1/bg unknown
-
2000
- 2000-12-28 US US09/749,831 patent/US20020086978A1/en not_active Abandoned
-
2001
- 2001-08-31 FI FI20011739A patent/FI114611B/fi not_active IP Right Cessation
- 2001-10-04 NO NO20014822A patent/NO315239B1/no not_active IP Right Cessation
-
2002
- 2002-05-30 JP JP2002157535A patent/JP2003061689A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| NO20014822L (no) | 1993-05-05 |
| JPH06500468A (ja) | 1994-01-20 |
| HU9300609D0 (en) | 1993-05-28 |
| FI113873B (fi) | 2004-06-30 |
| BG60716B1 (en) | 1996-01-31 |
| US20020086978A1 (en) | 2002-07-04 |
| NO930825D0 (no) | 1993-03-05 |
| FI930984A0 (fi) | 1993-03-05 |
| ATE233279T1 (de) | 2003-03-15 |
| RO113432B1 (ro) | 1998-07-30 |
| FI930984A (fi) | 1993-03-05 |
| NO315239B1 (no) | 2003-08-04 |
| CA2090961A1 (en) | 1992-03-08 |
| DE69133200D1 (de) | 2003-04-03 |
| NO20014822D0 (no) | 2001-10-04 |
| DE69133200T2 (de) | 2003-11-20 |
| CA2090961C (en) | 2004-01-20 |
| EP0483961B1 (en) | 2003-02-26 |
| WO1992004380A1 (en) | 1992-03-19 |
| US6204366B1 (en) | 2001-03-20 |
| HUT67796A (en) | 1995-04-28 |
| AU8495391A (en) | 1992-03-30 |
| GB9019553D0 (en) | 1990-10-24 |
| BG97607A (bg) | 1994-03-31 |
| AU653167B2 (en) | 1994-09-22 |
| UA46691C2 (uk) | 2002-06-17 |
| KR930702526A (ko) | 1993-09-09 |
| JP3514456B2 (ja) | 2004-03-31 |
| JP2003061689A (ja) | 2003-03-04 |
| NO930825L (no) | 1993-05-05 |
| ES2193129T3 (es) | 2003-11-01 |
| EP0483961A1 (en) | 1992-05-06 |
| DK0483961T3 (da) | 2003-06-23 |
| FI114611B (fi) | 2004-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |