NO314595B1 - Fremgangsmåte for fremstilling av et kim¶rt terapeutisk aktivt humanisert antistoff eller et terapeutisk aktivt fragment derav, DNA-sekvenssom koder for antistoffet, samt plasmid og stabil vertscellelinje som omfatterDNA-sekvensen - Google Patents
Fremgangsmåte for fremstilling av et kim¶rt terapeutisk aktivt humanisert antistoff eller et terapeutisk aktivt fragment derav, DNA-sekvenssom koder for antistoffet, samt plasmid og stabil vertscellelinje som omfatterDNA-sekvensen Download PDFInfo
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- NO314595B1 NO314595B1 NO19930825A NO930825A NO314595B1 NO 314595 B1 NO314595 B1 NO 314595B1 NO 19930825 A NO19930825 A NO 19930825A NO 930825 A NO930825 A NO 930825A NO 314595 B1 NO314595 B1 NO 314595B1
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- APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 description 1
- 229940055742 indium-111 Drugs 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 1
- 235000021243 milk fat Nutrition 0.000 description 1
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 1
- 229960000951 mycophenolic acid Drugs 0.000 description 1
- 210000004897 n-terminal region Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 238000013492 plasmid preparation Methods 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 229910000938 samarium–cobalt magnet Inorganic materials 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pretreatment Of Seeds And Plants (AREA)
- Nonmetallic Welding Materials (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909019553A GB9019553D0 (en) | 1990-09-07 | 1990-09-07 | Specific binding agents |
| PCT/GB1991/001511 WO1992004380A1 (en) | 1990-09-07 | 1991-09-05 | Specific binding agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO930825D0 NO930825D0 (no) | 1993-03-05 |
| NO930825L NO930825L (no) | 1993-05-05 |
| NO314595B1 true NO314595B1 (no) | 2003-04-14 |
Family
ID=10681827
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19930825A NO314595B1 (no) | 1990-09-07 | 1993-03-05 | Fremgangsmåte for fremstilling av et kim¶rt terapeutisk aktivt humanisert antistoff eller et terapeutisk aktivt fragment derav, DNA-sekvenssom koder for antistoffet, samt plasmid og stabil vertscellelinje som omfatterDNA-sekvensen |
| NO20014822A NO315239B1 (no) | 1990-09-07 | 2001-10-04 | Kim¶rt humanisert antistoff eller fragment derav, samt anvendelse av samme |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20014822A NO315239B1 (no) | 1990-09-07 | 2001-10-04 | Kim¶rt humanisert antistoff eller fragment derav, samt anvendelse av samme |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6204366B1 (bg) |
| EP (1) | EP0483961B1 (bg) |
| JP (2) | JP3514456B2 (bg) |
| KR (1) | KR930702526A (bg) |
| AT (1) | ATE233279T1 (bg) |
| AU (1) | AU653167B2 (bg) |
| BG (1) | BG60716B1 (bg) |
| CA (1) | CA2090961C (bg) |
| DE (1) | DE69133200T2 (bg) |
| DK (1) | DK0483961T3 (bg) |
| ES (1) | ES2193129T3 (bg) |
| FI (2) | FI113873B (bg) |
| GB (1) | GB9019553D0 (bg) |
| HU (2) | HUT67796A (bg) |
| NO (2) | NO314595B1 (bg) |
| RO (1) | RO113432B1 (bg) |
| UA (1) | UA46691C2 (bg) |
| WO (1) | WO1992004380A1 (bg) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
| WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| WO1992022653A1 (en) * | 1991-06-14 | 1992-12-23 | Genentech, Inc. | Method for making humanized antibodies |
| US5869619A (en) * | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
| CA2103887C (en) * | 1991-12-13 | 2005-08-30 | Gary M. Studnicka | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
| WO1994011508A2 (en) * | 1992-11-13 | 1994-05-26 | Cancer Research Fund Of Contra Costa | Polypeptides with specificity for neoplasias, kit, and diagnostic, vaccination, and therapeutic methods |
| US5792852A (en) * | 1992-11-16 | 1998-08-11 | Cancer Research Fund Of Contra Costa | Polynucleotides encoding modified antibodies with human milk fat globule specificity |
| DE69332930T2 (de) * | 1992-11-16 | 2004-02-26 | Cancer Research Fund Of Contra Costa, Walnut Creek | Peptide mit breiter neoplastischer spezifizität |
| US6281335B1 (en) * | 1993-10-08 | 2001-08-28 | Coulter Corporation | Hybridoma and anti-KC-4 humanized monoclonal antibody |
| US5804187A (en) * | 1992-11-16 | 1998-09-08 | Cancer Research Fund Of Contra Costa | Modified antibodies with human milk fat globule specificity |
| JPH07203974A (ja) * | 1994-01-13 | 1995-08-08 | Tosoh Corp | 癌特異的ムチンを認識する抗体の遺伝子断片等 |
| EP0781847A1 (en) * | 1995-11-06 | 1997-07-02 | MERCK PATENT GmbH | Humanized monoclonal antibody |
| EP1032420A4 (en) * | 1997-11-14 | 2004-09-15 | Euro Celtique Sa | IMMUNOGLOBULIN MOLECULES WITH SYNTHETIC VARIABLE REGION AND MODIFIED SPECIFICITY |
| GB2360771A (en) * | 2000-03-28 | 2001-10-03 | Antisoma Res Ltd | Compounds for targeting |
| AU4430701A (en) * | 2000-04-03 | 2001-10-15 | Antisoma Research Limited | Compounds for targeting |
| AU2002307064A1 (en) * | 2001-04-02 | 2002-10-15 | Purdue Pharma L.P. | Immunoglobulin construct containing anti-mucin variable domain sequences for eliciting an anti-idiotype anti-tumor response |
| GB0200657D0 (en) * | 2002-01-12 | 2002-02-27 | Antisoma Plc | Cancer treatment |
| CA2488441C (en) * | 2002-06-03 | 2015-01-27 | Genentech, Inc. | Synthetic antibody phage libraries |
| WO2004007687A2 (en) * | 2002-07-16 | 2004-01-22 | Stuart Bussell | Methods to construct multimeric dna and polymeric protein sequences as direct fusions or with linkers |
| CA2534055A1 (en) * | 2003-08-01 | 2005-02-10 | Genentech, Inc. | Antibody cdr polypeptide sequences with restricted diversity |
| GB0519398D0 (en) * | 2005-09-23 | 2005-11-02 | Antisoma Plc | Biological materials and uses thereof |
| EP1957531B1 (en) | 2005-11-07 | 2016-04-13 | Genentech, Inc. | Binding polypeptides with diversified and consensus vh/vl hypervariable sequences |
| US20070237764A1 (en) * | 2005-12-02 | 2007-10-11 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| CN103261223B (zh) | 2010-10-13 | 2017-03-29 | 詹森生物科技公司 | 人制瘤素m抗体及使用方法 |
| US20140079722A1 (en) * | 2011-03-09 | 2014-03-20 | Centrose, Llc | Extracellular targeted drug conjugates |
| RU2493165C1 (ru) * | 2012-02-28 | 2013-09-20 | Общество с ограниченной ответственностью "Технофарма" | Наноантитело, специфически связывающее белок muc1, способ детекции белка muc1 с помощью наноантител |
| EP2844262B1 (en) | 2012-04-30 | 2018-01-10 | Biothera, Inc. | Beta-glucan immunotherapeutic preparation |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607679D0 (en) * | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| CA1339204C (en) * | 1987-01-07 | 1997-08-05 | Joyce Taylor-Papadimitriou | Mucin core polypeptide, antibodies and probes |
| DE3856559T2 (de) * | 1987-05-21 | 2004-04-29 | Micromet Ag | Multifunktionelle Proteine mit vorbestimmter Zielsetzung |
| JPH03503120A (ja) * | 1988-02-08 | 1991-07-18 | ジョン ミュア キャンサー アンド エージング インスティチュート ディビジョン オブ ジョン ミュア メモリアル ホスピタル | ヒトのガン細胞における新規なムチン様糖蛋白質表面抗原に特異的なモノクローナル抗体 |
| EP0442926A1 (en) * | 1988-11-10 | 1991-08-28 | Imperial Cancer Research Technology Limited | Polypeptides |
| JPH02273195A (ja) | 1988-11-17 | 1990-11-07 | Univ Melbourne | ヒト多型性上皮ムチンと反応するモノクローナル抗体 |
| US5075219A (en) * | 1989-04-05 | 1991-12-24 | John Muir Cancer & Aging Institute | Monoclonal antibody which recognizes a specific glycoprotein of a human milk-fat globule membrane mucin antigen and said mucin antigen |
| HUT64600A (en) * | 1989-11-17 | 1994-01-28 | Unilever Nv | Method for producing specific binding materials |
-
1990
- 1990-09-07 GB GB909019553A patent/GB9019553D0/en active Pending
-
1991
- 1991-09-05 UA UA93080844A patent/UA46691C2/uk unknown
- 1991-09-05 US US07/987,264 patent/US6204366B1/en not_active Expired - Lifetime
- 1991-09-05 AT AT91308147T patent/ATE233279T1/de not_active IP Right Cessation
- 1991-09-05 DE DE69133200T patent/DE69133200T2/de not_active Expired - Lifetime
- 1991-09-05 WO PCT/GB1991/001511 patent/WO1992004380A1/en active IP Right Grant
- 1991-09-05 AU AU84953/91A patent/AU653167B2/en not_active Expired
- 1991-09-05 CA CA002090961A patent/CA2090961C/en not_active Expired - Lifetime
- 1991-09-05 ES ES91308147T patent/ES2193129T3/es not_active Expired - Lifetime
- 1991-09-05 HU HU9300609A patent/HUT67796A/hu unknown
- 1991-09-05 DK DK91308147T patent/DK0483961T3/da active
- 1991-09-05 RO RO93-00310A patent/RO113432B1/ro unknown
- 1991-09-05 KR KR1019930700678A patent/KR930702526A/ko not_active Application Discontinuation
- 1991-09-05 HU HU9300609A patent/HU9300609D0/hu unknown
- 1991-09-05 EP EP91308147A patent/EP0483961B1/en not_active Expired - Lifetime
- 1991-09-05 JP JP51496191A patent/JP3514456B2/ja not_active Expired - Lifetime
-
1993
- 1993-03-05 FI FI930984A patent/FI113873B/fi not_active IP Right Cessation
- 1993-03-05 NO NO19930825A patent/NO314595B1/no not_active IP Right Cessation
- 1993-04-05 BG BG97607A patent/BG60716B1/bg unknown
-
2000
- 2000-12-28 US US09/749,831 patent/US20020086978A1/en not_active Abandoned
-
2001
- 2001-08-31 FI FI20011739A patent/FI114611B/fi not_active IP Right Cessation
- 2001-10-04 NO NO20014822A patent/NO315239B1/no not_active IP Right Cessation
-
2002
- 2002-05-30 JP JP2002157535A patent/JP2003061689A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2090961A1 (en) | 1992-03-08 |
| FI113873B (fi) | 2004-06-30 |
| EP0483961B1 (en) | 2003-02-26 |
| DE69133200D1 (de) | 2003-04-03 |
| NO20014822L (no) | 1993-05-05 |
| GB9019553D0 (en) | 1990-10-24 |
| NO20014822D0 (no) | 2001-10-04 |
| NO315239B1 (no) | 2003-08-04 |
| UA46691C2 (uk) | 2002-06-17 |
| ES2193129T3 (es) | 2003-11-01 |
| AU8495391A (en) | 1992-03-30 |
| FI930984A (fi) | 1993-03-05 |
| US6204366B1 (en) | 2001-03-20 |
| EP0483961A1 (en) | 1992-05-06 |
| NO930825D0 (no) | 1993-03-05 |
| ATE233279T1 (de) | 2003-03-15 |
| RO113432B1 (ro) | 1998-07-30 |
| BG60716B1 (en) | 1996-01-31 |
| JP2003061689A (ja) | 2003-03-04 |
| US20020086978A1 (en) | 2002-07-04 |
| CA2090961C (en) | 2004-01-20 |
| HU9300609D0 (en) | 1993-05-28 |
| FI930984A0 (fi) | 1993-03-05 |
| KR930702526A (ko) | 1993-09-09 |
| JPH06500468A (ja) | 1994-01-20 |
| FI114611B (fi) | 2004-11-30 |
| JP3514456B2 (ja) | 2004-03-31 |
| WO1992004380A1 (en) | 1992-03-19 |
| HUT67796A (en) | 1995-04-28 |
| DE69133200T2 (de) | 2003-11-20 |
| BG97607A (bg) | 1994-03-31 |
| AU653167B2 (en) | 1994-09-22 |
| NO930825L (no) | 1993-05-05 |
| DK0483961T3 (da) | 2003-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |