NO314339B1 - 1,3-Dihydro-1-(fenylalkyl)-2H-imidazol-2-onderivater med PDE IV- og cytokinaktivitet - Google Patents

Info

Publication number

NO314339B1

NO314339B1 NO19974602A NO974602A NO314339B1 NO 314339 B1 NO314339 B1 NO 314339B1 NO 19974602 A NO19974602 A NO 19974602A NO 974602 A NO974602 A NO 974602A NO 314339 B1 NO314339 B1 NO 314339B1

Authority

NO

Norway

Prior art keywords

formula

alkyl

imidazol

dihydro

compound

Prior art date

1995-04-06

Links

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• 230000000694 effects Effects 0.000 title description 15
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• 108090000695 Cytokines Proteins 0.000 title description 14
• 125000003884 phenylalkyl group Chemical group 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 136
• 239000000203 mixture Substances 0.000 claims description 109
• 239000001257 hydrogen Substances 0.000 claims description 56
• 229910052739 hydrogen Inorganic materials 0.000 claims description 56
• 125000000217 alkyl group Chemical group 0.000 claims description 47
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• -1 bicyclo [2,2,1]heptanyl Chemical group 0.000 claims description 34
• 125000003118 aryl group Chemical group 0.000 claims description 27
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 21
• 239000002253 acid Substances 0.000 claims description 19
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• 229910052736 halogen Inorganic materials 0.000 claims description 14
• 150000002367 halogens Chemical class 0.000 claims description 14
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• 201000010099 disease Diseases 0.000 claims description 12
• 125000001424 substituent group Chemical group 0.000 claims description 12
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• 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 8
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
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• BWXQWXIYTNDSLQ-UHFFFAOYSA-N 3-[2-(3,4-diethoxyphenyl)ethyl]-1h-imidazol-2-one Chemical compound C1=C(OCC)C(OCC)=CC=C1CCN1C(=O)NC=C1 BWXQWXIYTNDSLQ-UHFFFAOYSA-N 0.000 claims description 3
• TWJFOISWLZFDAW-UHFFFAOYSA-N 3-[2-(3,4-dimethoxyphenyl)ethyl]-1h-imidazol-2-one Chemical compound C1=C(OC)C(OC)=CC=C1CCN1C(=O)NC=C1 TWJFOISWLZFDAW-UHFFFAOYSA-N 0.000 claims description 3
• LIGFHIQINFKZOA-UHFFFAOYSA-N 3-[2-(3,4-dimethoxyphenyl)propyl]-1h-imidazol-2-one Chemical compound C1=C(OC)C(OC)=CC=C1C(C)CN1C(=O)NC=C1 LIGFHIQINFKZOA-UHFFFAOYSA-N 0.000 claims description 3
• UBYNPNBASJLDED-UHFFFAOYSA-N 3-[2-(3,4-dimethoxyphenyl)propyl]-4-methyl-1h-imidazol-2-one Chemical compound C1=C(OC)C(OC)=CC=C1C(C)CN1C(=O)NC=C1C UBYNPNBASJLDED-UHFFFAOYSA-N 0.000 claims description 3
• VCGJMGSCXRICGA-UHFFFAOYSA-N 3-[2-(3-cyclopentyloxy-4-methoxyphenyl)propyl]-1h-imidazol-2-one Chemical compound COC1=CC=C(C(C)CN2C(NC=C2)=O)C=C1OC1CCCC1 VCGJMGSCXRICGA-UHFFFAOYSA-N 0.000 claims description 3
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