NO313961B1 - IL-8-reseptor-antagonister, anvendelse derav samt farmasöytiske preparater - Google Patents
IL-8-reseptor-antagonister, anvendelse derav samt farmasöytiske preparater Download PDFInfo
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- NO313961B1 NO313961B1 NO19993586A NO993586A NO313961B1 NO 313961 B1 NO313961 B1 NO 313961B1 NO 19993586 A NO19993586 A NO 19993586A NO 993586 A NO993586 A NO 993586A NO 313961 B1 NO313961 B1 NO 313961B1
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- Prior art keywords
- urea
- cyano
- bromophenyl
- benzimidazolin
- mmol
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3599197P | 1997-01-23 | 1997-01-23 | |
| US4282997P | 1997-04-08 | 1997-04-08 | |
| PCT/US1998/001291 WO1998032439A1 (en) | 1997-01-23 | 1998-01-23 | Il-8 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO993586D0 NO993586D0 (no) | 1999-07-22 |
| NO993586L NO993586L (no) | 1999-09-21 |
| NO313961B1 true NO313961B1 (no) | 2003-01-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19993586A NO313961B1 (no) | 1997-01-23 | 1999-07-22 | IL-8-reseptor-antagonister, anvendelse derav samt farmasöytiske preparater |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6300325B1 (ko) |
| EP (1) | EP0991406A4 (ko) |
| JP (1) | JP2001511130A (ko) |
| KR (1) | KR20000070368A (ko) |
| CN (1) | CN1217660C (ko) |
| AU (1) | AU726858B2 (ko) |
| BR (1) | BR9807083A (ko) |
| CA (1) | CA2278504A1 (ko) |
| HU (1) | HUP0001943A3 (ko) |
| IL (1) | IL131004A0 (ko) |
| NO (1) | NO313961B1 (ko) |
| NZ (1) | NZ336861A (ko) |
| PL (1) | PL334756A1 (ko) |
| TR (1) | TR199901710T2 (ko) |
| WO (1) | WO1998032439A1 (ko) |
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| JP2000513360A (ja) | 1996-06-27 | 2000-10-10 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ―８レセプターアンタゴニスト |
| WO1999065310A1 (en) * | 1998-06-17 | 1999-12-23 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| DE19842363A1 (de) * | 1998-09-16 | 2000-03-30 | Forssmann Wolf Georg | Verwendung von Chemokinen zur Stammzellmobilisation und von Chemokin-Antagonisten zur Vermeidung von Tumormetastasierung |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| IL144144A0 (en) | 1999-01-13 | 2002-05-23 | Bayer Ag | Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
| AR029637A1 (es) * | 1999-05-28 | 2003-07-10 | Smithkline Beecham Corp | Compuestos de guanidina, antagonistas de los receptores de la il-8, una composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de un medicamento |
| CO5190696A1 (es) * | 1999-06-16 | 2002-08-29 | Smithkline Beecham Corp | Antagonistas de los receptores il-8 |
| DE10038709A1 (de) * | 2000-08-09 | 2002-02-28 | Aventis Pharma Gmbh | Substituierte und unsubstituierte Benzooxathiazole sowie daraus abgeleitete Verbindungen |
| US20030204085A1 (en) * | 2001-02-02 | 2003-10-30 | Taveras Arthur G. | 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists |
| US7132445B2 (en) * | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| PT1598340E (pt) | 2001-04-18 | 2009-04-13 | Euro Celtique Sa | Derivados de 1-(4-piperidinil)-1,3-di-hidro-2h-benzoxazole- 2-ona e compostos relacionados como análogos de nociceptina e ligandos orl1 para o tratamento da dor |
| CA2462862A1 (en) * | 2001-10-12 | 2003-04-17 | Schering Corporation | 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists |
| US6878709B2 (en) * | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
| WO2003068229A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
| EP2324825A1 (en) | 2002-02-11 | 2011-05-25 | Bayer Healthcare LLC | Aryl ureas with angiogenesis inhibiting activity |
| CA2479126C (en) * | 2002-03-18 | 2011-11-15 | Schering Corporation | Combination treatments for chemokine-mediated diseases |
| US7115644B2 (en) * | 2002-09-13 | 2006-10-03 | Boehringer Ingelheim Pharmaceuticals Inc. | Heterocyclic compounds |
| ES2321186T3 (es) * | 2002-10-09 | 2009-06-03 | Schering Corporation | Dioxidos de tiadiazol y monoxidos de tiadiazol como ligandos de los receptores de quimioquinas cxc y cc. |
| MY143477A (en) * | 2002-10-29 | 2011-05-31 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| ATE384264T1 (de) | 2003-05-20 | 2008-02-15 | Bayer Pharmaceuticals Corp | Diaryl-harnstoffe mit kinasehemmender wirkung |
| NZ580384A (en) | 2003-07-23 | 2011-03-31 | Bayer Pharmaceuticals Corp | 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions |
| DE602004016211D1 (en) * | 2003-12-19 | 2008-10-09 | Schering Corp | Thiadiazole als cxc- und cc-chemokinrezeptorliganden |
| CN1918156B (zh) * | 2003-12-22 | 2010-10-27 | 先灵公司 | 作为cxc-和cc-趋化因子受体配体的异噻唑二氧化物 |
| GB0403038D0 (en) | 2004-02-11 | 2004-03-17 | Novartis Ag | Organic compounds |
| CN1984899B (zh) | 2004-05-12 | 2011-07-27 | 先灵公司 | Cxcr1和cxcr2趋化因子拮抗剂 |
| EP1812008A4 (en) * | 2004-10-20 | 2008-10-29 | Smithkline Beecham Corp | ANTAGONISTS OF THE IL-8 RECEPTOR |
| CA2580690A1 (en) * | 2004-10-21 | 2006-05-04 | Transtech Pharma, Inc. | Bissulfonamide compounds as agonists of galr1, compositions, and methods of use |
| DE602006017849D1 (de) * | 2005-06-29 | 2010-12-09 | Schering Corp | 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc-chemokinrezeptors |
| CA2613607A1 (en) * | 2005-06-29 | 2007-01-04 | Schering Corporation | Di-substituted oxadiazoles as cxc-chemokine receptor ligands |
| RU2008145871A (ru) * | 2006-04-21 | 2010-05-27 | Смитклайн Бичам Корпорейшн (US) | Антагонисты рецептора il-8 |
| PT2009992E (pt) * | 2006-04-21 | 2012-09-06 | Glaxosmithkline Llc | Antagonistas de receptores da il-8 |
| AR061571A1 (es) * | 2006-06-23 | 2008-09-03 | Smithkline Beecham Corp | Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un |
| KR20090028811A (ko) * | 2006-07-07 | 2009-03-19 | 쉐링 코포레이션 | Ｃｘｃ-케모카인 수용체 리간드로서의 3,4-이치환된 사이클로부텐-1,2-디온 |
| CN102066372B (zh) | 2009-08-24 | 2014-09-17 | 苏州爱斯鹏药物研发有限责任公司 | 含脲基的5，6元杂芳双环化合物作为激酶抑制剂 |
| CN111362878B (zh) * | 2020-03-18 | 2023-09-19 | 湖南复瑞生物医药技术有限责任公司 | 一种4-氨基-1,3-二氢-苯并咪唑-2-酮的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK160941C (da) | 1988-06-28 | 1991-10-21 | Novo Nordisk As | Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar |
| EP0809492A4 (en) | 1995-02-17 | 2007-01-24 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
| WO1997049399A1 (en) | 1996-06-27 | 1997-12-31 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| JP2000515495A (ja) * | 1996-06-27 | 2000-11-21 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ―８レセプターアンタゴニスト |
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1998
- 1998-01-23 JP JP53213898A patent/JP2001511130A/ja not_active Ceased
- 1998-01-23 KR KR1019997006601A patent/KR20000070368A/ko not_active Application Discontinuation
- 1998-01-23 PL PL98334756A patent/PL334756A1/xx unknown
- 1998-01-23 IL IL13100498A patent/IL131004A0/xx unknown
- 1998-01-23 WO PCT/US1998/001291 patent/WO1998032439A1/en not_active Application Discontinuation
- 1998-01-23 BR BR9807083-5A patent/BR9807083A/pt not_active Application Discontinuation
- 1998-01-23 NZ NZ336861A patent/NZ336861A/xx unknown
- 1998-01-23 HU HU0001943A patent/HUP0001943A3/hu unknown
- 1998-01-23 CA CA002278504A patent/CA2278504A1/en not_active Abandoned
- 1998-01-23 TR TR1999/01710T patent/TR199901710T2/xx unknown
- 1998-01-23 CN CN988035650A patent/CN1217660C/zh not_active Expired - Fee Related
- 1998-01-23 US US09/341,378 patent/US6300325B1/en not_active Expired - Fee Related
- 1998-01-23 EP EP98905988A patent/EP0991406A4/en not_active Withdrawn
- 1998-01-23 AU AU61339/98A patent/AU726858B2/en not_active Ceased
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1999
- 1999-07-22 NO NO19993586A patent/NO313961B1/no not_active IP Right Cessation
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| Publication number | Publication date |
|---|---|
| BR9807083A (pt) | 2000-04-18 |
| CN1217660C (zh) | 2005-09-07 |
| AU6133998A (en) | 1998-08-18 |
| NO993586D0 (no) | 1999-07-22 |
| WO1998032439A1 (en) | 1998-07-30 |
| IL131004A0 (en) | 2001-01-28 |
| HUP0001943A3 (en) | 2002-12-28 |
| US6300325B1 (en) | 2001-10-09 |
| KR20000070368A (ko) | 2000-11-25 |
| PL334756A1 (en) | 2000-03-13 |
| AU726858B2 (en) | 2000-11-23 |
| EP0991406A4 (en) | 2000-12-13 |
| NO993586L (no) | 1999-09-21 |
| TR199901710T2 (xx) | 1999-09-21 |
| EP0991406A1 (en) | 2000-04-12 |
| CA2278504A1 (en) | 1998-07-30 |
| HUP0001943A2 (hu) | 2001-01-29 |
| NZ336861A (en) | 2001-01-26 |
| JP2001511130A (ja) | 2001-08-07 |
| CN1251038A (zh) | 2000-04-19 |
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