NO313333B1 - Steroider substituert i posisjon 11, fremgangsmåte for fremstilling av disse, deres anvendelse samt farmasöytiskepreparater inneholdende disse - Google Patents

Steroider substituert i posisjon 11, fremgangsmåte for fremstilling av disse, deres anvendelse samt farmasöytiskepreparater inneholdende disse Download PDF

Info

Publication number
NO313333B1
NO313333B1 NO19993125A NO993125A NO313333B1 NO 313333 B1 NO313333 B1 NO 313333B1 NO 19993125 A NO19993125 A NO 19993125A NO 993125 A NO993125 A NO 993125A NO 313333 B1 NO313333 B1 NO 313333B1
Authority
NO
Norway
Prior art keywords
compounds
general formula
phenyl
ethoxy
lip
Prior art date
Application number
NO19993125A
Other languages
English (en)
Norwegian (no)
Other versions
NO993125D0 (no
NO993125L (no
Inventor
Yasmina Bouali
Francois Nique
Jean-Georges Teutsch
Patrick Van De Velde
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO993125D0 publication Critical patent/NO993125D0/no
Publication of NO993125L publication Critical patent/NO993125L/no
Publication of NO313333B1 publication Critical patent/NO313333B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO19993125A 1996-12-23 1999-06-23 Steroider substituert i posisjon 11, fremgangsmåte for fremstilling av disse, deres anvendelse samt farmasöytiskepreparater inneholdende disse NO313333B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9615829A FR2757519B1 (fr) 1996-12-23 1996-12-23 Steroides substitues en position 11, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant
PCT/FR1997/002379 WO1998028324A1 (fr) 1996-12-23 1997-12-22 Steroides substitues en position 11, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (3)

Publication Number Publication Date
NO993125D0 NO993125D0 (no) 1999-06-23
NO993125L NO993125L (no) 1999-08-20
NO313333B1 true NO313333B1 (no) 2002-09-16

Family

ID=9498983

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19993125A NO313333B1 (no) 1996-12-23 1999-06-23 Steroider substituert i posisjon 11, fremgangsmåte for fremstilling av disse, deres anvendelse samt farmasöytiskepreparater inneholdende disse

Country Status (33)

Country Link
US (3) US6207657B1 (ja)
EP (1) EP0946585B1 (ja)
JP (1) JP4376319B2 (ja)
KR (1) KR20000062288A (ja)
CN (1) CN1247541A (ja)
AP (1) AP9901567A0 (ja)
AR (1) AR010857A1 (ja)
AT (1) ATE216396T1 (ja)
AU (1) AU726350B2 (ja)
BR (1) BR9714433A (ja)
CA (1) CA2275955A1 (ja)
CZ (1) CZ227899A3 (ja)
DE (1) DE69712095T2 (ja)
DK (1) DK0946585T3 (ja)
EA (1) EA001868B1 (ja)
ES (1) ES2174329T3 (ja)
FR (1) FR2757519B1 (ja)
HR (1) HRP970711B1 (ja)
HU (1) HUP0001447A3 (ja)
ID (1) ID22627A (ja)
IL (1) IL130509A0 (ja)
NO (1) NO313333B1 (ja)
NZ (1) NZ336224A (ja)
PL (1) PL334124A1 (ja)
PT (1) PT946585E (ja)
SI (1) SI0946585T1 (ja)
SK (1) SK83099A3 (ja)
TR (1) TR199901453T2 (ja)
TW (1) TW492974B (ja)
UA (1) UA54483C2 (ja)
WO (1) WO1998028324A1 (ja)
YU (1) YU29299A (ja)
ZA (1) ZA9711324B (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2757519B1 (fr) * 1996-12-23 1999-06-11 Hoechst Marion Roussel Inc Steroides substitues en position 11, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant
FR2780060B1 (fr) 1998-06-23 2000-08-04 Hoechst Marion Roussel Inc Nouveaux 19-nor steroides 17-halogenes, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant
DE19929715A1 (de) * 1999-06-24 2000-12-28 Schering Ag 11ß-langkettig-substituierte Estratriene, Verfahren zur Herstellung , pharmazeutische Präparate, die diese 11ß-langkettig-substituierten Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
FR2826004B1 (fr) * 2001-06-13 2008-03-28 Aventis Pharma Sa Procede de preparation de derives estrogenes
FR2854402B1 (fr) * 2003-04-29 2008-07-04 Aventis Pharma Sa Nouveau procede et intermediaires de preparation de composes 19-nor-steroides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2640977A2 (en) * 1982-06-11 1990-06-29 Roussel Uclaf New position-11 substituted 19-norsteroids and their application as medicinal products.
US4859585A (en) * 1986-04-17 1989-08-22 Trustees Of Tufts College In-vitro methods for identifying compositions which are agonists and antagonists of estrogens
FR2643638B1 (fr) * 1989-02-24 1991-06-14 Roussel Uclaf Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
WO1994021667A1 (en) * 1993-03-25 1994-09-29 Iskra Industry Co., Ltd. Compound for inhibiting bone resorption and accelerating osteogenesis
DE4329867C1 (de) * 1993-09-03 1994-09-15 Siemens Ag Stromspiegel
FR2757519B1 (fr) * 1996-12-23 1999-06-11 Hoechst Marion Roussel Inc Steroides substitues en position 11, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant
FR2757399B1 (fr) * 1996-12-23 1999-12-17 Hoechst Marion Roussel Inc Application de composes steroides substitues en 11 pour la fabrication de medicaments ayant une activite estrogene dissociee
FR2761992B1 (fr) * 1997-04-09 1999-06-11 Hoechst Marion Roussel Inc Nouveaux steroides 4-halogenes, leur procede et intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2771096B1 (fr) * 1997-11-17 2000-08-11 Hoechst Marion Roussel Inc Nouveaux 19-nor steroides, substitues en position 11beta, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
HUP0001447A3 (en) 2001-03-28
AU726350B2 (en) 2000-11-02
EP0946585A1 (fr) 1999-10-06
DK0946585T3 (da) 2002-08-05
AU5667898A (en) 1998-07-17
NO993125D0 (no) 1999-06-23
WO1998028324A1 (fr) 1998-07-02
SI0946585T1 (en) 2002-10-31
JP4376319B2 (ja) 2009-12-02
DE69712095D1 (de) 2002-05-23
EA199900588A1 (ru) 2000-02-28
IL130509A0 (en) 2000-06-01
NZ336224A (en) 2001-02-23
US6541464B2 (en) 2003-04-01
CN1247541A (zh) 2000-03-15
HRP970711B1 (en) 2002-04-30
PL334124A1 (en) 2000-02-14
SK83099A3 (en) 2000-01-18
DE69712095T2 (de) 2002-11-14
PT946585E (pt) 2002-09-30
TW492974B (en) 2002-07-01
HRP970711A2 (en) 1998-10-31
HUP0001447A1 (hu) 2000-11-28
ID22627A (id) 1999-12-02
NO993125L (no) 1999-08-20
CA2275955A1 (fr) 1998-07-02
BR9714433A (pt) 2000-05-02
US6207657B1 (en) 2001-03-27
ATE216396T1 (de) 2002-05-15
EA001868B1 (ru) 2001-10-22
FR2757519A1 (fr) 1998-06-26
TR199901453T2 (xx) 1999-08-23
KR20000062288A (ko) 2000-10-25
JP2001507010A (ja) 2001-05-29
US20020198374A1 (en) 2002-12-26
US6482813B1 (en) 2002-11-19
ES2174329T3 (es) 2002-11-01
FR2757519B1 (fr) 1999-06-11
CZ227899A3 (cs) 1999-09-15
UA54483C2 (uk) 2003-03-17
AP9901567A0 (en) 1999-06-30
ZA9711324B (en) 1999-01-19
EP0946585B1 (fr) 2002-04-17
YU29299A (sh) 2001-05-28
AR010857A1 (es) 2000-07-12

Similar Documents

Publication Publication Date Title
US6455517B1 (en) Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
JPH07149790A (ja) 新規な11−ベンズアルドキシム−17β−メトキシ−17α−メトキシメチル−エストラジエン誘導体、その製法およびその物質を含有する医薬製剤
NO313333B1 (no) Steroider substituert i posisjon 11, fremgangsmåte for fremstilling av disse, deres anvendelse samt farmasöytiskepreparater inneholdende disse
US6479476B1 (en) 19-nor steroids substituted in position 11β, preparation method and intermediates, application as medicines and pharmaceutical compositions containing them
US6239121B1 (en) 4- Halogenated steroids, preparation method and intermediates, application as medicines and pharmaceutical compositions containing same
JP4263264B2 (ja) 解離したエストロゲン活性を有する薬剤を製造するための11位置換ステロイド化合物の用途
WO1998028324A9 (fr) Steroides substitues en position 11, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
NO318381B1 (no) 17-halogenerte 19-nor-steroidforbindelser og mellomprodukter for disse, fremgangsmate for fremstilling av steroidforbindelsene, medikamenter inneholdende steroidforbindelsene og anvendelse av steroidforbindelsene.
MXPA99005841A (en) Steroids substituted in position 11, method of preparation, application as medicines and pharmaceutical compositions containing them
MXPA00012483A (en) Novel 17-halogenated 19-nor steroids, method and intermediates for preparing same, use as medicines and pharmaceutical compositions containing same