EA199900588A1 - Стероиды, замещенные в положении 11, способ их получения, их применение в качестве лекарственного средства и содержащие их фармацевтические композиции - Google Patents

Стероиды, замещенные в положении 11, способ их получения, их применение в качестве лекарственного средства и содержащие их фармацевтические композиции

Info

Publication number
EA199900588A1
EA199900588A1 EA199900588A EA199900588A EA199900588A1 EA 199900588 A1 EA199900588 A1 EA 199900588A1 EA 199900588 A EA199900588 A EA 199900588A EA 199900588 A EA199900588 A EA 199900588A EA 199900588 A1 EA199900588 A1 EA 199900588A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
steroids
medicine
reception
substituted
Prior art date
Application number
EA199900588A
Other languages
English (en)
Other versions
EA001868B1 (ru
Inventor
Иамина Буали
Франсуа Ник
Жан-Жорж Тетш
Патрик Ван Де Вельд
Original Assignee
Хехст Марион Руссель
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хехст Марион Руссель filed Critical Хехст Марион Руссель
Publication of EA199900588A1 publication Critical patent/EA199900588A1/ru
Publication of EA001868B1 publication Critical patent/EA001868B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Abstract

Объектом изобретения являются стероидные соединения общей формулы (I), в которой n = 2,3, либо Rи R= H, (C-C)алкил, либо Rи Rобразуют вместе с азотом гетероцикл, X = OH, при необходимости этерифицированный, Y = алкил(C-C), а также их аддитивные соли, способ их получения, их использование в качестве лекарственных средств и содержащие их фармацевтические композиции.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900588A 1996-12-23 1997-12-22 Стероиды, замещенные в положении 11, способ их получения, их применение в качестве лекарственного средства и содержащие их фармацевтические композиции EA001868B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9615829A FR2757519B1 (fr) 1996-12-23 1996-12-23 Steroides substitues en position 11, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant
PCT/FR1997/002379 WO1998028324A1 (fr) 1996-12-23 1997-12-22 Steroides substitues en position 11, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
EA199900588A1 true EA199900588A1 (ru) 2000-02-28
EA001868B1 EA001868B1 (ru) 2001-10-22

Family

ID=9498983

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900588A EA001868B1 (ru) 1996-12-23 1997-12-22 Стероиды, замещенные в положении 11, способ их получения, их применение в качестве лекарственного средства и содержащие их фармацевтические композиции

Country Status (33)

Country Link
US (3) US6207657B1 (ru)
EP (1) EP0946585B1 (ru)
JP (1) JP4376319B2 (ru)
KR (1) KR20000062288A (ru)
CN (1) CN1247541A (ru)
AP (1) AP9901567A0 (ru)
AR (1) AR010857A1 (ru)
AT (1) ATE216396T1 (ru)
AU (1) AU726350B2 (ru)
BR (1) BR9714433A (ru)
CA (1) CA2275955A1 (ru)
CZ (1) CZ227899A3 (ru)
DE (1) DE69712095T2 (ru)
DK (1) DK0946585T3 (ru)
EA (1) EA001868B1 (ru)
ES (1) ES2174329T3 (ru)
FR (1) FR2757519B1 (ru)
HR (1) HRP970711B1 (ru)
HU (1) HUP0001447A3 (ru)
ID (1) ID22627A (ru)
IL (1) IL130509A0 (ru)
NO (1) NO313333B1 (ru)
NZ (1) NZ336224A (ru)
PL (1) PL334124A1 (ru)
PT (1) PT946585E (ru)
SI (1) SI0946585T1 (ru)
SK (1) SK83099A3 (ru)
TR (1) TR199901453T2 (ru)
TW (1) TW492974B (ru)
UA (1) UA54483C2 (ru)
WO (1) WO1998028324A1 (ru)
YU (1) YU29299A (ru)
ZA (1) ZA9711324B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2757519B1 (fr) * 1996-12-23 1999-06-11 Hoechst Marion Roussel Inc Steroides substitues en position 11, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant
FR2780060B1 (fr) 1998-06-23 2000-08-04 Hoechst Marion Roussel Inc Nouveaux 19-nor steroides 17-halogenes, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant
DE19929715A1 (de) 1999-06-24 2000-12-28 Schering Ag 11ß-langkettig-substituierte Estratriene, Verfahren zur Herstellung , pharmazeutische Präparate, die diese 11ß-langkettig-substituierten Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
FR2826004B1 (fr) * 2001-06-13 2008-03-28 Aventis Pharma Sa Procede de preparation de derives estrogenes
FR2854402B1 (fr) * 2003-04-29 2008-07-04 Aventis Pharma Sa Nouveau procede et intermediaires de preparation de composes 19-nor-steroides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2640977A2 (en) * 1982-06-11 1990-06-29 Roussel Uclaf New position-11 substituted 19-norsteroids and their application as medicinal products.
US4859585A (en) * 1986-04-17 1989-08-22 Trustees Of Tufts College In-vitro methods for identifying compositions which are agonists and antagonists of estrogens
FR2643638B1 (fr) * 1989-02-24 1991-06-14 Roussel Uclaf Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
WO1994021667A1 (en) * 1993-03-25 1994-09-29 Iskra Industry Co., Ltd. Compound for inhibiting bone resorption and accelerating osteogenesis
DE4329867C1 (de) * 1993-09-03 1994-09-15 Siemens Ag Stromspiegel
FR2757399B1 (fr) * 1996-12-23 1999-12-17 Hoechst Marion Roussel Inc Application de composes steroides substitues en 11 pour la fabrication de medicaments ayant une activite estrogene dissociee
FR2757519B1 (fr) * 1996-12-23 1999-06-11 Hoechst Marion Roussel Inc Steroides substitues en position 11, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant
FR2761992B1 (fr) * 1997-04-09 1999-06-11 Hoechst Marion Roussel Inc Nouveaux steroides 4-halogenes, leur procede et intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2771096B1 (fr) * 1997-11-17 2000-08-11 Hoechst Marion Roussel Inc Nouveaux 19-nor steroides, substitues en position 11beta, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
TW492974B (en) 2002-07-01
ZA9711324B (en) 1999-01-19
SK83099A3 (en) 2000-01-18
US20020198374A1 (en) 2002-12-26
EP0946585B1 (fr) 2002-04-17
HRP970711A2 (en) 1998-10-31
PL334124A1 (en) 2000-02-14
US6541464B2 (en) 2003-04-01
KR20000062288A (ko) 2000-10-25
CN1247541A (zh) 2000-03-15
DE69712095D1 (de) 2002-05-23
FR2757519B1 (fr) 1999-06-11
NO993125L (no) 1999-08-20
UA54483C2 (ru) 2003-03-17
SI0946585T1 (en) 2002-10-31
DE69712095T2 (de) 2002-11-14
CA2275955A1 (fr) 1998-07-02
WO1998028324A1 (fr) 1998-07-02
US6207657B1 (en) 2001-03-27
PT946585E (pt) 2002-09-30
NZ336224A (en) 2001-02-23
HUP0001447A3 (en) 2001-03-28
NO313333B1 (no) 2002-09-16
AP9901567A0 (en) 1999-06-30
ID22627A (id) 1999-12-02
NO993125D0 (no) 1999-06-23
JP2001507010A (ja) 2001-05-29
AR010857A1 (es) 2000-07-12
TR199901453T2 (xx) 1999-08-23
ATE216396T1 (de) 2002-05-15
HRP970711B1 (en) 2002-04-30
BR9714433A (pt) 2000-05-02
CZ227899A3 (cs) 1999-09-15
JP4376319B2 (ja) 2009-12-02
YU29299A (sh) 2001-05-28
ES2174329T3 (es) 2002-11-01
EP0946585A1 (fr) 1999-10-06
FR2757519A1 (fr) 1998-06-26
AU726350B2 (en) 2000-11-02
HUP0001447A1 (hu) 2000-11-28
IL130509A0 (en) 2000-06-01
EA001868B1 (ru) 2001-10-22
DK0946585T3 (da) 2002-08-05
AU5667898A (en) 1998-07-17
US6482813B1 (en) 2002-11-19

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU