NO312761B1 - Fremgangsmåte for fremstilling av tetrahydroisokinoliner og beslektede heterosykliske forbindelser - Google Patents

Fremgangsmåte for fremstilling av tetrahydroisokinoliner og beslektede heterosykliske forbindelser Download PDF

Info

Publication number
NO312761B1
NO312761B1 NO19991495A NO991495A NO312761B1 NO 312761 B1 NO312761 B1 NO 312761B1 NO 19991495 A NO19991495 A NO 19991495A NO 991495 A NO991495 A NO 991495A NO 312761 B1 NO312761 B1 NO 312761B1
Authority
NO
Norway
Prior art keywords
formaldehyde
alkyl
compound
lewis acid
preparation
Prior art date
Application number
NO19991495A
Other languages
English (en)
Norwegian (no)
Other versions
NO991495D0 (no
NO991495L (no
Inventor
Timothy James-Norman Watson
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of NO991495D0 publication Critical patent/NO991495D0/no
Publication of NO991495L publication Critical patent/NO991495L/no
Publication of NO312761B1 publication Critical patent/NO312761B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18Aralkyl radicals
    • C07D217/20Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO19991495A 1996-09-27 1999-03-26 Fremgangsmåte for fremstilling av tetrahydroisokinoliner og beslektede heterosykliske forbindelser NO312761B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72258896A 1996-09-27 1996-09-27
PCT/US1997/013672 WO1998013351A1 (fr) 1996-09-27 1997-08-04 Reaction de pictet-spengler pour la synthese des tetrahydro-isoquinolines et composes heterocycliques associes

Publications (3)

Publication Number Publication Date
NO991495D0 NO991495D0 (no) 1999-03-26
NO991495L NO991495L (no) 1999-03-26
NO312761B1 true NO312761B1 (no) 2002-07-01

Family

ID=24902494

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19991495A NO312761B1 (no) 1996-09-27 1999-03-26 Fremgangsmåte for fremstilling av tetrahydroisokinoliner og beslektede heterosykliske forbindelser

Country Status (22)

Country Link
EP (1) EP0929527B1 (fr)
JP (1) JP2001510449A (fr)
KR (1) KR100445953B1 (fr)
CN (1) CN1101811C (fr)
AR (1) AR009364A1 (fr)
AT (1) ATE280761T1 (fr)
AU (1) AU711358B2 (fr)
BR (1) BR9712143B1 (fr)
CA (1) CA2266357C (fr)
DE (1) DE69731392T2 (fr)
DK (1) DK0929527T3 (fr)
ES (1) ES2230618T3 (fr)
HK (1) HK1022311A1 (fr)
HU (1) HUP9904161A3 (fr)
IL (1) IL129188A (fr)
NO (1) NO312761B1 (fr)
NZ (1) NZ334491A (fr)
PT (1) PT929527E (fr)
SI (1) SI0929527T1 (fr)
TW (1) TW434224B (fr)
WO (1) WO1998013351A1 (fr)
ZA (1) ZA978560B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100503571C (zh) * 2006-07-12 2009-06-24 中国药科大学 四氢异喹啉类衍生物、其制备方法及其医药用途
EP2420237A1 (fr) 2010-08-11 2012-02-22 Ville Takio Dérivés fluorés d'isoquinoléines endogènes pour leur utilisation dans le traitement de maladies liées aux passages d'isoquinoline endogène
CN103694170B (zh) * 2013-04-01 2016-04-06 常州夏青化工有限公司 6,7-二氟-1-甲基-1,2,3,4-四氢异喹啉盐酸盐的合成方法
CN110590795B (zh) * 2019-10-10 2021-01-22 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一类多并杂环螺羟吲哚类化合物的合成方法
FI130627B (en) 2021-03-31 2023-12-18 Equinorm Ltd NEW HETEROCYCLIC COMPOUNDS AND THEIR USE
CN113214252B (zh) * 2021-05-28 2022-02-11 常州大学 6-苯基-7-(吡啶-2-基)-7H-吲哚并[2,3-c]喹啉化合物的合成方法

Also Published As

Publication number Publication date
PT929527E (pt) 2005-01-31
NO991495D0 (no) 1999-03-26
CN1101811C (zh) 2003-02-19
TW434224B (en) 2001-05-16
DK0929527T3 (da) 2005-02-14
HK1022311A1 (en) 2000-08-04
DE69731392D1 (de) 2004-12-02
AU3906397A (en) 1998-04-17
BR9712143A (pt) 1999-08-31
BR9712143B1 (pt) 2009-05-05
IL129188A0 (en) 2000-02-17
DE69731392T2 (de) 2006-02-09
NZ334491A (en) 2000-04-28
EP0929527A1 (fr) 1999-07-21
NO991495L (no) 1999-03-26
ES2230618T3 (es) 2005-05-01
KR20000048638A (ko) 2000-07-25
IL129188A (en) 2004-03-28
HUP9904161A3 (en) 2001-01-29
KR100445953B1 (ko) 2004-08-25
EP0929527B1 (fr) 2004-10-27
JP2001510449A (ja) 2001-07-31
AR009364A1 (es) 2000-04-12
ZA978560B (en) 1998-03-27
CN1231660A (zh) 1999-10-13
SI0929527T1 (en) 2005-02-28
WO1998013351A1 (fr) 1998-04-02
HUP9904161A2 (hu) 2000-05-28
AU711358B2 (en) 1999-10-14
CA2266357A1 (fr) 1998-04-02
ATE280761T1 (de) 2004-11-15
CA2266357C (fr) 2003-07-29

Similar Documents

Publication Publication Date Title
AU615768B2 (en) 2-(3-oxocyclohexen-1-yl)aminobenzonitrile and related compounds
Kessar et al. Benzyne cyclization route to benzo [c] phenanthridine alkaloids. Synthesis of chelerythrine, decarine, and nitidine
Thompson et al. Synthesis and pharmacological evaluation of a series of dibenzo [a, d] cycloalkenimines as N-methyl-D-aspartate antagonists
EP3436425B1 (fr) Procédé de préparation amélioré de tartrate de butorphanol
SU651704A3 (ru) Способ получени производных дибензоциклогептена, рацемических или оптически активных, или их солей
Shono Synthesis of alkaloidal compounds using an electrochemical reaction as a key step
NO312761B1 (no) Fremgangsmåte for fremstilling av tetrahydroisokinoliner og beslektede heterosykliske forbindelser
Shinohara et al. An improved synthesis of 1, 2, 3, 4-tetrahydroisoquinolines via intramolecular cyclization of N-acyl-N-(aryl) methyl-2-(phenylsulfinyl) ethylamine by Pummerer reaction
FI68222B (fi) Foerfarande foer o-metylering av hydroxiaporfiner
Malhotra et al. Efficient asymmetric synthesis of N-protected-β-aryloxyamino acids via regioselective ring opening of serine sulfamidate carboxylic acid
US5808071A (en) Pictet-Spengler reaction for the synthesis of tetrahydroisoquinolines and related heterocyclic compounds
Shinohara et al. A synthesis of mono-and dimethoxy-1, 2, 3, 4-tetrahydroisoquinolines via Pummerer reaction: Effects of methoxyl groups on intramolecular cyclization
Schlosser et al. Three complementary methods offering access to 5-substituted 1, 2, 3, 4-tetrahydroisoquinolines
Barton et al. Phenol oxidation and biosynthesis. Part XXV. New syntheses of bis-(2-arylethyl) amines of biosynthetic importance
KR900000967B1 (ko) 벤질아민 유도체 및 그 제법
RU2372351C2 (ru) Полусинтетический способ получения десерпидина
US4507499A (en) N-(4-Hydroxybenzyl)-3,4,5-trimethoxybenzamide and method for producing trimethobenzamide chlorohydrate
GB2025932A (en) Indoloisoquinolines, and Processes for Producing them
Ahmad et al. Aryne Formation from 2-Bromolaudanosine. Fate of the 5, 6, 12, 12a-Tetrahydrodibenzo [b, g] indolizinium Ion and an Alternative Synthesis of Glaucine
EP0219505B1 (fr) Procede stereoselectif et intermediaires chiraux pour des aryloxydropanolamines
SK284841B6 (sk) 12,13-Dihydroxyderiváty tylozínu a spôsob výroby
FUJII et al. [4, 5-Dimethoxy-α-(3, 4-dim6thoxyphenyl)-o-tolyl] acetonitdle A By-Product from the Reaction of 3, 4-Dimethoxybenzyl Chloride with Sodium Cyanide
TRIMETHOXYLATED et al. REACTION OF N-TRIMETHOXYBENZYL-N-[2-(PHENYL-SULF1NYL) ETHYLlFORMAMIDES
Coşkun et al. Reactivity of Benzylic Acylammonium Chlorides. A Novel Method for the Synthesis of N-Phenacylamides
SU620210A3 (ru) Способ получени 2,4,5-триметилтиено (3,2- ) морфана или его солей

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees