BR9712143B1 - reação de pictet-spengler para a sìntese de tetraidroisoquinolinas. - Google Patents
reação de pictet-spengler para a sìntese de tetraidroisoquinolinas.Info
- Publication number
- BR9712143B1 BR9712143B1 BRPI9712143-6A BR9712143A BR9712143B1 BR 9712143 B1 BR9712143 B1 BR 9712143B1 BR 9712143 A BR9712143 A BR 9712143A BR 9712143 B1 BR9712143 B1 BR 9712143B1
- Authority
- BR
- Brazil
- Prior art keywords
- tetrahydroisoquinolines
- pictet
- synthesis
- spengler reaction
- spengler
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72258896A | 1996-09-27 | 1996-09-27 | |
| PCT/US1997/013672 WO1998013351A1 (en) | 1996-09-27 | 1997-08-04 | Pictet-spengler reaction for the synthesis of tetrahydroisoquinolines and related heterocyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9712143A BR9712143A (pt) | 1999-08-31 |
| BR9712143B1 true BR9712143B1 (pt) | 2009-05-05 |
Family
ID=24902494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9712143-6A BR9712143B1 (pt) | 1996-09-27 | 1997-08-04 | reação de pictet-spengler para a sìntese de tetraidroisoquinolinas. |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0929527B1 (pt) |
| JP (1) | JP2001510449A (pt) |
| KR (1) | KR100445953B1 (pt) |
| CN (1) | CN1101811C (pt) |
| AR (1) | AR009364A1 (pt) |
| AT (1) | ATE280761T1 (pt) |
| AU (1) | AU711358B2 (pt) |
| BR (1) | BR9712143B1 (pt) |
| CA (1) | CA2266357C (pt) |
| DE (1) | DE69731392T2 (pt) |
| DK (1) | DK0929527T3 (pt) |
| ES (1) | ES2230618T3 (pt) |
| HK (1) | HK1022311A1 (pt) |
| HU (1) | HUP9904161A3 (pt) |
| IL (1) | IL129188A (pt) |
| NO (1) | NO312761B1 (pt) |
| NZ (1) | NZ334491A (pt) |
| PT (1) | PT929527E (pt) |
| SI (1) | SI0929527T1 (pt) |
| TW (1) | TW434224B (pt) |
| WO (1) | WO1998013351A1 (pt) |
| ZA (1) | ZA978560B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100503571C (zh) * | 2006-07-12 | 2009-06-24 | 中国药科大学 | 四氢异喹啉类衍生物、其制备方法及其医药用途 |
| EP2420237A1 (en) | 2010-08-11 | 2012-02-22 | Ville Takio | Fluorinated derivatives of endogenous isoquinolines for use in the treatment of diseases mediated through endogenous isoquinoline pathways |
| CN103694170B (zh) * | 2013-04-01 | 2016-04-06 | 常州夏青化工有限公司 | 6,7-二氟-1-甲基-1,2,3,4-四氢异喹啉盐酸盐的合成方法 |
| CN110590795B (zh) * | 2019-10-10 | 2021-01-22 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 一类多并杂环螺羟吲哚类化合物的合成方法 |
| FI130627B (en) | 2021-03-31 | 2023-12-18 | Equinorm Ltd | NEW HETEROCYCLIC COMPOUNDS AND THEIR USE |
| CN113214252B (zh) * | 2021-05-28 | 2022-02-11 | 常州大学 | 6-苯基-7-(吡啶-2-基)-7H-吲哚并[2,3-c]喹啉化合物的合成方法 |
-
1997
- 1997-08-04 NZ NZ334491A patent/NZ334491A/xx unknown
- 1997-08-04 BR BRPI9712143-6A patent/BR9712143B1/pt not_active IP Right Cessation
- 1997-08-04 WO PCT/US1997/013672 patent/WO1998013351A1/en active IP Right Grant
- 1997-08-04 HU HU9904161A patent/HUP9904161A3/hu unknown
- 1997-08-04 ES ES97936381T patent/ES2230618T3/es not_active Expired - Lifetime
- 1997-08-04 DK DK97936381T patent/DK0929527T3/da active
- 1997-08-04 KR KR10-1999-7002580A patent/KR100445953B1/ko not_active IP Right Cessation
- 1997-08-04 PT PT97936381T patent/PT929527E/pt unknown
- 1997-08-04 DE DE69731392T patent/DE69731392T2/de not_active Expired - Fee Related
- 1997-08-04 CA CA002266357A patent/CA2266357C/en not_active Expired - Fee Related
- 1997-08-04 AU AU39063/97A patent/AU711358B2/en not_active Ceased
- 1997-08-04 CN CN97198263A patent/CN1101811C/zh not_active Expired - Fee Related
- 1997-08-04 JP JP51562398A patent/JP2001510449A/ja not_active Ceased
- 1997-08-04 IL IL12918897A patent/IL129188A/en not_active IP Right Cessation
- 1997-08-04 SI SI9730683T patent/SI0929527T1/xx unknown
- 1997-08-04 EP EP97936381A patent/EP0929527B1/en not_active Expired - Lifetime
- 1997-08-04 AT AT97936381T patent/ATE280761T1/de not_active IP Right Cessation
- 1997-09-17 AR ARP970104243A patent/AR009364A1/es active IP Right Grant
- 1997-09-23 TW TW086113858A patent/TW434224B/zh not_active IP Right Cessation
- 1997-09-23 ZA ZA9708560A patent/ZA978560B/xx unknown
-
1999
- 1999-03-26 NO NO19991495A patent/NO312761B1/no not_active IP Right Cessation
-
2000
- 2000-02-28 HK HK00101202A patent/HK1022311A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100445953B1 (ko) | 2004-08-25 |
| PT929527E (pt) | 2005-01-31 |
| CA2266357C (en) | 2003-07-29 |
| DE69731392D1 (de) | 2004-12-02 |
| CN1101811C (zh) | 2003-02-19 |
| DE69731392T2 (de) | 2006-02-09 |
| AU711358B2 (en) | 1999-10-14 |
| ATE280761T1 (de) | 2004-11-15 |
| ES2230618T3 (es) | 2005-05-01 |
| EP0929527A1 (en) | 1999-07-21 |
| NO312761B1 (no) | 2002-07-01 |
| ZA978560B (en) | 1998-03-27 |
| EP0929527B1 (en) | 2004-10-27 |
| TW434224B (en) | 2001-05-16 |
| HUP9904161A3 (en) | 2001-01-29 |
| BR9712143A (pt) | 1999-08-31 |
| AR009364A1 (es) | 2000-04-12 |
| NO991495D0 (no) | 1999-03-26 |
| NZ334491A (en) | 2000-04-28 |
| IL129188A0 (en) | 2000-02-17 |
| KR20000048638A (ko) | 2000-07-25 |
| SI0929527T1 (en) | 2005-02-28 |
| JP2001510449A (ja) | 2001-07-31 |
| WO1998013351A1 (en) | 1998-04-02 |
| CA2266357A1 (en) | 1998-04-02 |
| NO991495L (no) | 1999-03-26 |
| DK0929527T3 (da) | 2005-02-14 |
| HK1022311A1 (en) | 2000-08-04 |
| CN1231660A (zh) | 1999-10-13 |
| IL129188A (en) | 2004-03-28 |
| HUP9904161A2 (hu) | 2000-05-28 |
| AU3906397A (en) | 1998-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08G | Application fees: restoration [chapter 8.7 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/06/2009, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B25D | Requested change of name of applicant approved |
Owner name: AVENTIS PHARMACEUTICALS INC. (US) Free format text: ALTERADO DE: HOECHST MARION ROUSSEL, INC. |
|
| B24C | Patent annual fee: request for for restoration |
Free format text: REFERENTE A 13A E 14A ANUIDADE(S). |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time | ||
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |