AR009364A1 - PROCEDIMIENTO PARA LA SíNTESIS DE TETRAHIDROISOQUINOLINAS Y COMPUESTOS HETEROCíCLICOS RELACIONADOS. - Google Patents

PROCEDIMIENTO PARA LA SíNTESIS DE TETRAHIDROISOQUINOLINAS Y COMPUESTOS HETEROCíCLICOS RELACIONADOS.

Info

Publication number
AR009364A1
AR009364A1 ARP970104243A ARP970104243A AR009364A1 AR 009364 A1 AR009364 A1 AR 009364A1 AR P970104243 A ARP970104243 A AR P970104243A AR P970104243 A ARP970104243 A AR P970104243A AR 009364 A1 AR009364 A1 AR 009364A1
Authority
AR
Argentina
Prior art keywords
synthesis
procedure
tetrahydroisokinolins
heterocyclic compounds
related heterocyclic
Prior art date
Application number
ARP970104243A
Other languages
English (en)
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of AR009364A1 publication Critical patent/AR009364A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

El procedimiento comprende la síntesis de compuestos de formula (1): donde R1 y R2 son cada uno independientemente alquilo C1-3 o R1 y R2 juntos formanalquileno C2-7, n es un numero entero de 0 a 2; R3 es hidrogeno, alquilo C1-4 -CF3 y -OH, y Tse s paratoluensulfonilo, mediante reaccion en condicionesalcalinas de un compuesto de formula (2); con un ácido de Lewis adecuado en un solvente generador de formaldehido.
ARP970104243A 1996-09-27 1997-09-17 PROCEDIMIENTO PARA LA SíNTESIS DE TETRAHIDROISOQUINOLINAS Y COMPUESTOS HETEROCíCLICOS RELACIONADOS. AR009364A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72258896A 1996-09-27 1996-09-27

Publications (1)

Publication Number Publication Date
AR009364A1 true AR009364A1 (es) 2000-04-12

Family

ID=24902494

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104243A AR009364A1 (es) 1996-09-27 1997-09-17 PROCEDIMIENTO PARA LA SíNTESIS DE TETRAHIDROISOQUINOLINAS Y COMPUESTOS HETEROCíCLICOS RELACIONADOS.

Country Status (22)

Country Link
EP (1) EP0929527B1 (es)
JP (1) JP2001510449A (es)
KR (1) KR100445953B1 (es)
CN (1) CN1101811C (es)
AR (1) AR009364A1 (es)
AT (1) ATE280761T1 (es)
AU (1) AU711358B2 (es)
BR (1) BR9712143B1 (es)
CA (1) CA2266357C (es)
DE (1) DE69731392T2 (es)
DK (1) DK0929527T3 (es)
ES (1) ES2230618T3 (es)
HK (1) HK1022311A1 (es)
HU (1) HUP9904161A3 (es)
IL (1) IL129188A (es)
NO (1) NO312761B1 (es)
NZ (1) NZ334491A (es)
PT (1) PT929527E (es)
SI (1) SI0929527T1 (es)
TW (1) TW434224B (es)
WO (1) WO1998013351A1 (es)
ZA (1) ZA978560B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100503571C (zh) * 2006-07-12 2009-06-24 中国药科大学 四氢异喹啉类衍生物、其制备方法及其医药用途
EP2420237A1 (en) 2010-08-11 2012-02-22 Ville Takio Fluorinated derivatives of endogenous isoquinolines for use in the treatment of diseases mediated through endogenous isoquinoline pathways
CN103694170B (zh) * 2013-04-01 2016-04-06 常州夏青化工有限公司 6,7-二氟-1-甲基-1,2,3,4-四氢异喹啉盐酸盐的合成方法
CN110590795B (zh) * 2019-10-10 2021-01-22 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一类多并杂环螺羟吲哚类化合物的合成方法
FI130627B (en) 2021-03-31 2023-12-18 Equinorm Ltd NEW HETEROCYCLIC COMPOUNDS AND THEIR USE
CN113214252B (zh) * 2021-05-28 2022-02-11 常州大学 6-苯基-7-(吡啶-2-基)-7H-吲哚并[2,3-c]喹啉化合物的合成方法

Also Published As

Publication number Publication date
NO991495D0 (no) 1999-03-26
CA2266357C (en) 2003-07-29
BR9712143A (pt) 1999-08-31
BR9712143B1 (pt) 2009-05-05
EP0929527B1 (en) 2004-10-27
EP0929527A1 (en) 1999-07-21
CN1231660A (zh) 1999-10-13
HUP9904161A2 (hu) 2000-05-28
NZ334491A (en) 2000-04-28
JP2001510449A (ja) 2001-07-31
DE69731392D1 (de) 2004-12-02
CA2266357A1 (en) 1998-04-02
AU3906397A (en) 1998-04-17
ES2230618T3 (es) 2005-05-01
IL129188A (en) 2004-03-28
DK0929527T3 (da) 2005-02-14
HK1022311A1 (en) 2000-08-04
NO991495L (no) 1999-03-26
WO1998013351A1 (en) 1998-04-02
KR100445953B1 (ko) 2004-08-25
CN1101811C (zh) 2003-02-19
ATE280761T1 (de) 2004-11-15
DE69731392T2 (de) 2006-02-09
IL129188A0 (en) 2000-02-17
KR20000048638A (ko) 2000-07-25
TW434224B (en) 2001-05-16
NO312761B1 (no) 2002-07-01
SI0929527T1 (en) 2005-02-28
AU711358B2 (en) 1999-10-14
ZA978560B (en) 1998-03-27
PT929527E (pt) 2005-01-31
HUP9904161A3 (en) 2001-01-29

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