MX9304378A - Metodo de preparacion de derivados de carbamato defisostigmina a partir de eseretoles. - Google Patents
Metodo de preparacion de derivados de carbamato defisostigmina a partir de eseretoles.Info
- Publication number
- MX9304378A MX9304378A MX9304378A MX9304378A MX9304378A MX 9304378 A MX9304378 A MX 9304378A MX 9304378 A MX9304378 A MX 9304378A MX 9304378 A MX9304378 A MX 9304378A MX 9304378 A MX9304378 A MX 9304378A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- compound
- eseretols
- defisostigmine
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Esta solicitud se refiere a un nuevo procedimiento para preparar un producto de fórmula; el cual procedimiento comprende (a) poner en contacto un compuesto de fórmula II para proporcionar un compuesto de fórmula III (b) poner en contacto la mezcla de reacción que contiene el compuesto de fórmula III bien (1) con un isocianato de fórmula R1NCO y aislar un producto de fórmula I en donde R2 es hidrógeno; o bien (2) con un compuesto de fórmula IV para proporcionar un compuesto de fórmula V poner en contacto la mezcla de reacción que contiene el compuesto de fórmula V obteniendo en la etapa (b) con un compuesto de fórmula R1R2NH en donde R1 y R2 son como se definieron antes; y aislar el producto de fórmula I.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/918,337 US5302721A (en) | 1992-07-21 | 1992-07-21 | Method of preparation of physostigmine carbamate derivatives from eseretholes |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9304378A true MX9304378A (es) | 1994-03-31 |
Family
ID=25440209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9304378A MX9304378A (es) | 1992-07-21 | 1993-07-20 | Metodo de preparacion de derivados de carbamato defisostigmina a partir de eseretoles. |
Country Status (17)
Country | Link |
---|---|
US (2) | US5302721A (es) |
EP (1) | EP0581107A1 (es) |
JP (2) | JP2656207B2 (es) |
KR (1) | KR940005628A (es) |
CN (1) | CN1039717C (es) |
AU (1) | AU657422B2 (es) |
CA (1) | CA2100909A1 (es) |
CZ (1) | CZ284561B6 (es) |
FI (1) | FI933263A (es) |
HU (1) | HUT68895A (es) |
IL (1) | IL106390A0 (es) |
MX (1) | MX9304378A (es) |
NO (1) | NO300635B1 (es) |
NZ (1) | NZ248179A (es) |
PH (1) | PH30149A (es) |
RU (1) | RU2108334C1 (es) |
TW (1) | TW297816B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
US6133444A (en) * | 1993-12-22 | 2000-10-17 | Perseptive Biosystems, Inc. | Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions |
DE69632324T2 (de) * | 1995-06-07 | 2005-06-16 | PerSeptive Biosystems, Inc., Framingham | Pna-dna-chimäre und pna-synthone zu deren herstellung |
US5665880A (en) * | 1996-10-31 | 1997-09-09 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseretholes |
US5677457A (en) * | 1996-12-19 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseroline ethers |
US6495700B1 (en) | 2002-01-09 | 2002-12-17 | Axonyx, Inc. | Process for producing phenserine and its analog |
CA2543322A1 (en) | 2003-10-21 | 2005-05-12 | Sention, Inc. | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents |
JP4419518B2 (ja) * | 2003-10-30 | 2010-02-24 | アイシン精機株式会社 | シートスライド装置 |
EP1779867A4 (en) * | 2004-07-01 | 2009-12-02 | Eisai R&D Man Co Ltd | MEANS FOR PROMOTING NERVE REVENERATION |
JP2010518010A (ja) * | 2007-02-02 | 2010-05-27 | コルシド・ファーマシューティカルズ・インコーポレイテッド | コリンエステラーゼを阻害する化合物 |
WO2009011901A2 (en) * | 2007-07-18 | 2009-01-22 | Colucid Pharmaceuticals, Inc. | Methods for promoting wakefulness |
US8593728B2 (en) * | 2009-02-19 | 2013-11-26 | Toyota Motor Engineering & Manufacturing North America, Inc. | Multilayer photonic structures |
AU2009270830A1 (en) * | 2008-07-16 | 2010-01-21 | Colucid Pharmaceuticals, Inc. | Stigmine conjugates for substance use disorders |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE349887B (es) * | 1971-02-10 | 1972-10-09 | Asea Atom Ab | |
IT1199076B (it) * | 1984-03-01 | 1988-12-30 | Consiglio Nazionale Ricerche | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
-
1992
- 1992-07-21 US US07/918,337 patent/US5302721A/en not_active Expired - Fee Related
-
1993
- 1993-07-13 EP EP93111210A patent/EP0581107A1/en not_active Withdrawn
- 1993-07-19 NZ NZ248179A patent/NZ248179A/xx unknown
- 1993-07-19 IL IL106390A patent/IL106390A0/xx unknown
- 1993-07-19 PH PH46538A patent/PH30149A/en unknown
- 1993-07-19 KR KR1019930013531A patent/KR940005628A/ko not_active Application Discontinuation
- 1993-07-19 FI FI933263A patent/FI933263A/fi unknown
- 1993-07-20 RU RU93046065A patent/RU2108334C1/ru active
- 1993-07-20 CA CA002100909A patent/CA2100909A1/en not_active Abandoned
- 1993-07-20 NO NO932615A patent/NO300635B1/no not_active IP Right Cessation
- 1993-07-20 JP JP5178785A patent/JP2656207B2/ja not_active Expired - Lifetime
- 1993-07-20 MX MX9304378A patent/MX9304378A/es not_active IP Right Cessation
- 1993-07-20 AU AU42050/93A patent/AU657422B2/en not_active Ceased
- 1993-07-20 CZ CZ931453A patent/CZ284561B6/cs not_active IP Right Cessation
- 1993-07-20 CN CN93108976A patent/CN1039717C/zh not_active Expired - Fee Related
- 1993-07-21 HU HU9302108A patent/HUT68895A/hu unknown
- 1993-08-04 TW TW082106218A patent/TW297816B/zh active
-
1994
- 1994-02-17 US US08/198,013 patent/US5455354A/en not_active Expired - Fee Related
-
1996
- 1996-12-03 JP JP8322639A patent/JP2843798B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU657422B2 (en) | 1995-03-09 |
FI933263A (fi) | 1994-01-22 |
RU2108334C1 (ru) | 1998-04-10 |
KR940005628A (ko) | 1994-03-22 |
IL106390A0 (en) | 1993-11-15 |
TW297816B (es) | 1997-02-11 |
NZ248179A (en) | 1995-01-27 |
CZ145393A3 (en) | 1994-03-16 |
HU9302108D0 (en) | 1993-10-28 |
NO932615D0 (no) | 1993-07-20 |
JPH06179677A (ja) | 1994-06-28 |
AU4205093A (en) | 1994-01-27 |
JP2656207B2 (ja) | 1997-09-24 |
CA2100909A1 (en) | 1994-01-22 |
FI933263A0 (fi) | 1993-07-19 |
CZ284561B6 (cs) | 1999-01-13 |
NO300635B1 (no) | 1997-06-30 |
JP2843798B2 (ja) | 1999-01-06 |
EP0581107A1 (en) | 1994-02-02 |
US5302721A (en) | 1994-04-12 |
CN1083816A (zh) | 1994-03-16 |
JPH09165389A (ja) | 1997-06-24 |
HUT68895A (en) | 1995-08-28 |
PH30149A (en) | 1997-01-21 |
CN1039717C (zh) | 1998-09-09 |
NO932615L (no) | 1994-01-24 |
US5455354A (en) | 1995-10-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |