ATE298325T1 - Verfahren zur herstellung von n-(4-hydroxyphenyl)-n'-(4'-aminophenyl)-piperaz ne - Google Patents

Verfahren zur herstellung von n-(4-hydroxyphenyl)-n'-(4'-aminophenyl)-piperaz ne

Info

Publication number
ATE298325T1
ATE298325T1 AT00976949T AT00976949T ATE298325T1 AT E298325 T1 ATE298325 T1 AT E298325T1 AT 00976949 T AT00976949 T AT 00976949T AT 00976949 T AT00976949 T AT 00976949T AT E298325 T1 ATE298325 T1 AT E298325T1
Authority
AT
Austria
Prior art keywords
compound
formula
producing
piperaz
aminophenyl
Prior art date
Application number
AT00976949T
Other languages
English (en)
Inventor
Brigitte Giesinger
Ingrid Mergelsberg
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE298325T1 publication Critical patent/ATE298325T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
AT00976949T 1999-11-08 2000-11-06 Verfahren zur herstellung von n-(4-hydroxyphenyl)-n'-(4'-aminophenyl)-piperaz ne ATE298325T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43504999A 1999-11-08 1999-11-08
PCT/US2000/030457 WO2001034587A2 (en) 1999-11-08 2000-11-06 Process for preparing n-(4-hydroxy-phenyl)-n'-(4'-aminophenyl)-piperazine

Publications (1)

Publication Number Publication Date
ATE298325T1 true ATE298325T1 (de) 2005-07-15

Family

ID=23726755

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00976949T ATE298325T1 (de) 1999-11-08 2000-11-06 Verfahren zur herstellung von n-(4-hydroxyphenyl)-n'-(4'-aminophenyl)-piperaz ne

Country Status (10)

Country Link
EP (1) EP1230231B1 (de)
JP (1) JP4903963B2 (de)
CN (1) CN1177840C (de)
AT (1) ATE298325T1 (de)
AU (1) AU1465301A (de)
CA (1) CA2390296C (de)
DE (1) DE60020988T2 (de)
ES (1) ES2240202T3 (de)
MX (1) MXPA02004545A (de)
WO (1) WO2001034587A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5200939B2 (ja) 2005-12-23 2013-06-05 アリアド・ファーマシューティカルズ・インコーポレイテッド 二環式ヘテロアリール化合物
CN102906087B (zh) 2010-05-19 2016-03-23 桑多斯股份公司 制备手性三唑酮的方法
US9206146B2 (en) 2010-05-19 2015-12-08 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
US9073904B2 (en) 2010-05-19 2015-07-07 Sandoz Ag Preparation of posaconazole intermediates
BR112012029225B1 (pt) 2010-05-19 2020-10-27 Sandoz Ag processo para a preparação de um composto quiral, composto quiral e uso de um composto quiral
CN101824009A (zh) * 2010-05-27 2010-09-08 北京德众万全药物技术开发有限公司 一种泊沙康唑及其哌嗪中间体的简单制备方法
WO2012172015A1 (en) 2011-06-16 2012-12-20 Sandoz Ag Process for the preparation of a chiral compound
CA2815506C (en) 2012-12-12 2018-12-11 Ariad Pharmaceuticals, Inc. Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
EP2789610A1 (de) 2013-04-10 2014-10-15 Sandoz Ag Reinigung von Posaconazol-Zwischenprodukten
CN108003118A (zh) * 2017-12-27 2018-05-08 张家口市格瑞高新技术有限公司 一种泊沙康唑中间体1-（4-羟基苯基）-4-（4-氨基苯基）-哌嗪的制备工艺
CN114516849B (zh) * 2020-11-18 2025-04-29 江苏恒盛药业有限公司 一种1-(4-氨基苯基)-4-(4-羟基苯基)哌嗪的合成方法
CN114276315A (zh) * 2021-12-16 2022-04-05 苏州汉德创宏生化科技有限公司 一种4-[4-[4-(4-羟基苯基)哌嗪-1-基]苯基]氨基甲酸苯酯的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0753715B2 (ja) * 1986-02-25 1995-06-07 大塚製薬株式会社 ベンゾヘテロ環化合物
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
JPH04247074A (ja) * 1991-02-01 1992-09-03 Yoshitomi Pharmaceut Ind Ltd ４−モルホリノ安息香酸誘導体の製造法
DE4234295A1 (de) * 1992-10-12 1994-04-14 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JPH0971564A (ja) * 1995-07-06 1997-03-18 Japan Tobacco Inc ベンズアミドオキシム誘導体及びその医薬用途

Also Published As

Publication number Publication date
EP1230231A2 (de) 2002-08-14
CA2390296A1 (en) 2001-05-17
HK1046142A1 (en) 2002-12-27
CA2390296C (en) 2009-12-29
JP2003513966A (ja) 2003-04-15
ES2240202T3 (es) 2005-10-16
DE60020988D1 (de) 2005-07-28
EP1230231B1 (de) 2005-06-22
DE60020988T2 (de) 2006-04-27
CN1387520A (zh) 2002-12-25
AU1465301A (en) 2001-06-06
MXPA02004545A (es) 2002-09-02
CN1177840C (zh) 2004-12-01
WO2001034587A3 (en) 2002-03-21
JP4903963B2 (ja) 2012-03-28
WO2001034587A2 (en) 2001-05-17

Similar Documents

Publication Publication Date Title
ATE298325T1 (de) Verfahren zur herstellung von n-(4-hydroxyphenyl)-n'-(4'-aminophenyl)-piperaz ne
DE69803982D1 (de) Verfahren zur herstellung von 2-alkoxyestradiolen
ATE261946T1 (de) Verfahren zur herstellung von thiazolidin
DE69931753D1 (de) Azoverbindungen sowie verfahren zur herstellung derselben
ATE330933T1 (de) Verfahren zur herstellung von optisch aktiven amino-alkoholen
ATE227270T1 (de) Verfahren zur herstellung von isoharnstoffen
ECSP055803A (es) Ésteres de ácido carbámico con actividad anticolinérgica
DE60010682D1 (de) Verfahren zur herstellung von zwischenprodukten für pestizide
ATE549295T1 (de) Verfahren zur entfernung von n2o bei der salpetersäureherstellung
ATE385232T1 (de) Verfahren zur herstellung von 3, 3', 6, 6'- tetraalkylen-2, 2'-biphenolen und 3, 3', 6, 6'- tetraalkylen-5, 5'-dihalo-2, 2' biphenolen
ATE240286T1 (de) Verfahren zur herstellung von 1-aryl-3- cyclopropyl-1,3-propandionen
DE60107292D1 (de) Verfahren zur herstellung von (+)-trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidin
ATE282589T1 (de) Verfahren zur herstellung eines chiralen-beta- aminosäureesters
DE59803194D1 (de) Verfahren zur herstellung von 1,3-disubstituierten 2-nitroguanidinen
ATE260923T1 (de) Verfahren zur herstellung von 7-amino-3- methoxymethyl-3-cephem-4-carbonsäure
DE60133395D1 (de) Verfahren zur herstellung von alpha'-chlorketonen
ATE28858T1 (de) Derivate von n-(methoxyphenacyl)aminen, ihre therapeutische verwendung und verfahren zu ihrer herstellung.
ATE444951T1 (de) Verbessertes verfahren zur herstellung von isocyanaten
ATE165824T1 (de) Verfahren zur herstellung von 2-perfluoroalkyl-3- oxazolin-5-one
ATE231485T1 (de) Verfahren zur herstellung von arylmalonaten
DE69904652D1 (de) Verfahren zur Herstellung von optisch aktiven Aminoalkoholen
ATE56423T1 (de) Verfahren zur herstellung optisch aktiver alpha- haloalkylarylketone.
ATE297478T1 (de) Verfahren zur herstellung von orthocarbonsäuretrialkylestern
ATE251118T1 (de) Verfahren zur herstellung von alkylendiamin-n,n'- dibernsteinsäure-eisen-base komplex mit ph- kontrolle
DE50009160D1 (de) Verfahren zur herstellung von optisch aktiven 3,3,3- trifluormethyl- 2- alkylpropionsäurederivaten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties