NO312192B1 - Nitrogenoksidsyntaseinhibitorer, anvendelse og fremgangsmåte for fremstilling derav, samt farmasöytisk formulering - Google Patents

Nitrogenoksidsyntaseinhibitorer, anvendelse og fremgangsmåte for fremstilling derav, samt farmasöytisk formulering Download PDF

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Publication number
NO312192B1
NO312192B1 NO19993429A NO993429A NO312192B1 NO 312192 B1 NO312192 B1 NO 312192B1 NO 19993429 A NO19993429 A NO 19993429A NO 993429 A NO993429 A NO 993429A NO 312192 B1 NO312192 B1 NO 312192B1
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NO
Norway
Prior art keywords
formula
compound
salt
diamino
solvate
Prior art date
Application number
NO19993429A
Other languages
English (en)
Norwegian (no)
Other versions
NO993429D0 (no
NO993429L (no
Inventor
Richard Mansfield Beams
Martin James Drysdale
Karl Witold Franzmann
Anthony Joseph Frend
Harold Francis Hodson
Richard Graham Knowles
Daryl David Rees
David Alan Sawyer
Original Assignee
Glaxo Group Ltd
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Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO993429D0 publication Critical patent/NO993429D0/no
Publication of NO993429L publication Critical patent/NO993429L/no
Publication of NO312192B1 publication Critical patent/NO312192B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
NO19993429A 1997-01-13 1999-07-12 Nitrogenoksidsyntaseinhibitorer, anvendelse og fremgangsmåte for fremstilling derav, samt farmasöytisk formulering NO312192B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78340297A 1997-01-13 1997-01-13
PCT/EP1998/000096 WO1998030537A1 (en) 1997-01-13 1998-01-09 Nitric oxide synthase inhibitors

Publications (3)

Publication Number Publication Date
NO993429D0 NO993429D0 (no) 1999-07-12
NO993429L NO993429L (no) 1999-07-12
NO312192B1 true NO312192B1 (no) 2002-04-08

Family

ID=25129141

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19993429A NO312192B1 (no) 1997-01-13 1999-07-12 Nitrogenoksidsyntaseinhibitorer, anvendelse og fremgangsmåte for fremstilling derav, samt farmasöytisk formulering

Country Status (35)

Country Link
EP (1) EP0958277B1 (es)
JP (1) JP3251301B2 (es)
KR (1) KR20000070070A (es)
CN (1) CN1149190C (es)
AP (1) AP1204A (es)
AR (1) AR011069A1 (es)
AT (1) ATE209183T1 (es)
AU (1) AU723095B2 (es)
BR (1) BR9806870B1 (es)
CA (1) CA2277877C (es)
CO (1) CO4950524A1 (es)
CY (1) CY2263B1 (es)
CZ (1) CZ293099B6 (es)
DE (1) DE69803272T2 (es)
DK (1) DK0958277T3 (es)
EA (1) EA002033B1 (es)
EE (1) EE04013B1 (es)
ES (1) ES2168737T3 (es)
HK (1) HK1021531A1 (es)
HU (1) HU226241B1 (es)
ID (1) ID21981A (es)
IL (1) IL130551A (es)
IS (1) IS1847B (es)
MY (1) MY117948A (es)
NO (1) NO312192B1 (es)
NZ (1) NZ336379A (es)
PE (1) PE44599A1 (es)
PL (1) PL189973B1 (es)
PT (1) PT958277E (es)
RS (1) RS49673B (es)
SK (1) SK283201B6 (es)
TR (1) TR199901680T2 (es)
TW (2) TW538021B (es)
WO (1) WO1998030537A1 (es)
ZA (1) ZA98179B (es)

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JP2000504041A (ja) 2000-04-04
BR9806870A (pt) 2000-04-18
CA2277877C (en) 2008-01-08
HUP0001539A3 (en) 2003-01-28
KR20000070070A (ko) 2000-11-25
AU6208398A (en) 1998-08-03
SK283201B6 (sk) 2003-03-04
CO4950524A1 (es) 2000-09-01
CN1249744A (zh) 2000-04-05
HU226241B1 (en) 2008-07-28
EA002033B1 (ru) 2001-12-24
EE9900281A (et) 2000-02-15
AU723095B2 (en) 2000-08-17
ID21981A (id) 1999-08-19
AP9901603A0 (en) 1999-09-30
EP0958277A1 (en) 1999-11-24
TR199901680T2 (xx) 1999-09-21
NZ336379A (en) 2001-01-26
EE04013B1 (et) 2003-04-15
DE69803272D1 (en) 2002-02-21
JP3251301B2 (ja) 2002-01-28
HUP0001539A2 (hu) 2000-11-28
IL130551A0 (en) 2000-06-01
ATE209183T1 (de) 2001-12-15
MY117948A (en) 2004-08-30
PL334368A1 (en) 2000-02-28
TW502010B (en) 2002-09-11
NO993429D0 (no) 1999-07-12
CZ293099B6 (cs) 2004-02-18
BR9806870B1 (pt) 2009-05-05
TW538021B (en) 2003-06-21
PE44599A1 (es) 1999-05-05
CY2263B1 (en) 2003-07-04
CA2277877A1 (en) 1998-07-16
PT958277E (pt) 2002-05-31
ES2168737T3 (es) 2002-06-16
DK0958277T3 (da) 2002-02-18
IS5094A (is) 1999-06-25
PL189973B1 (pl) 2005-10-31
IL130551A (en) 2004-01-04
EA199900532A1 (ru) 2000-08-28
WO1998030537A1 (en) 1998-07-16
YU31399A (sh) 2002-06-19
AP1204A (en) 2003-09-15
CZ248399A3 (cs) 1999-12-15
HK1021531A1 (en) 2000-06-16
NO993429L (no) 1999-07-12
CN1149190C (zh) 2004-05-12
ZA98179B (en) 1999-07-09
SK93399A3 (en) 2000-03-13
EP0958277B1 (en) 2001-11-21
IS1847B (is) 2003-02-07
DE69803272T2 (de) 2002-07-18
AR011069A1 (es) 2000-08-02
RS49673B (sr) 2007-11-15

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