NO311644B1 - Vitronektinreseptor-antagonister, farmasöytisk preparat inneholdende disse og anvendelse derav - Google Patents
Vitronektinreseptor-antagonister, farmasöytisk preparat inneholdende disse og anvendelse derav Download PDFInfo
- Publication number
- NO311644B1 NO311644B1 NO19975976A NO975976A NO311644B1 NO 311644 B1 NO311644 B1 NO 311644B1 NO 19975976 A NO19975976 A NO 19975976A NO 975976 A NO975976 A NO 975976A NO 311644 B1 NO311644 B1 NO 311644B1
- Authority
- NO
- Norway
- Prior art keywords
- arom
- mmol
- methylene chloride
- silica gel
- oxo
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19653647A DE19653647A1 (de) | 1996-12-20 | 1996-12-20 | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
Publications (3)
Publication Number | Publication Date |
---|---|
NO975976D0 NO975976D0 (no) | 1997-12-19 |
NO975976L NO975976L (no) | 1998-06-22 |
NO311644B1 true NO311644B1 (no) | 2001-12-27 |
Family
ID=7815762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19975976A NO311644B1 (no) | 1996-12-20 | 1997-12-19 | Vitronektinreseptor-antagonister, farmasöytisk preparat inneholdende disse og anvendelse derav |
Country Status (21)
Country | Link |
---|---|
US (4) | US6011045A (ja) |
EP (1) | EP0854140B1 (ja) |
JP (1) | JP4081167B2 (ja) |
KR (1) | KR19980064656A (ja) |
CN (2) | CN1103775C (ja) |
AR (1) | AR010370A1 (ja) |
AU (1) | AU730737B2 (ja) |
BR (1) | BR9706385A (ja) |
CA (1) | CA2225273A1 (ja) |
CZ (1) | CZ411397A3 (ja) |
DE (1) | DE19653647A1 (ja) |
HU (1) | HUP9702508A3 (ja) |
ID (1) | ID19253A (ja) |
IL (1) | IL122641A0 (ja) |
MX (1) | MX9710392A (ja) |
NO (1) | NO311644B1 (ja) |
NZ (1) | NZ329430A (ja) |
PL (1) | PL323970A1 (ja) |
RU (1) | RU2198892C2 (ja) |
TW (1) | TW523510B (ja) |
ZA (1) | ZA9711316B (ja) |
Families Citing this family (29)
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CZ20012320A3 (cs) | 1998-12-23 | 2002-10-16 | G. D. Searle & Co. | Léčivo s obsahem inhibitoru cyklooxygenázy-2 a jednoho nebo více antineoplastických činidel pro kombinační terapii při léčení neoplasie |
US6395897B1 (en) | 1999-03-02 | 2002-05-28 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5 |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
US6545032B1 (en) * | 1999-09-17 | 2003-04-08 | Torrey Pines Institute For Molecular Studies | Synthesis of [3,5,7]-H-imidazo[1,5-a] imidazol-2(3H)-one compounds |
CO5261573A1 (es) | 1999-11-19 | 2003-03-31 | Novartis Ag | Derivados de benzoxa y bezotiazol, compuesto y composicion farmaceutica que los contiene y proceso para la preparacion de la mencionada composicion |
US20040136949A1 (en) | 2001-04-24 | 2004-07-15 | Matthias Grell | Combination therapy using anti-angiogenic agents and tnf alpha |
EP2428226A1 (en) | 2001-10-22 | 2012-03-14 | The Scripps Research Institute | Antibody targeting compounds |
US8440217B1 (en) | 2005-06-15 | 2013-05-14 | Mawaheb M. EL-Naggar | Method and system with contact lens product for treating and preventing adverse eye conditions |
JP2009512443A (ja) * | 2005-10-20 | 2009-03-26 | ザ スクリップス リサーチ インスチチュート | 免疫染色及び免疫標的化のためのFc標識化 |
AR056155A1 (es) * | 2005-10-26 | 2007-09-19 | Bristol Myers Squibb Co | Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica |
US7615075B2 (en) * | 2005-11-04 | 2009-11-10 | Rush University Medical Center | Plastic implant impregnated with a degradation protector |
EP2338518A1 (en) | 2006-01-18 | 2011-06-29 | Merck Patent GmbH | Specific therapy using integrin ligands for treating cancer |
US7553836B2 (en) * | 2006-02-06 | 2009-06-30 | Bristol-Myers Squibb Company | Melanin concentrating hormone receptor-1 antagonists |
MX2009007597A (es) | 2007-01-18 | 2009-07-22 | Merck Patent Gmbh | Terapia especifica y medicamento que utilizan ligandos de integrina para tratar el cancer. |
DE102007012210B4 (de) * | 2007-03-08 | 2009-10-15 | Filt Lungen- Und Thoraxdiagnostik Gmbh | Transportabler Pneumotachograph zur Messung von Bestandteilen des Exspirationsvolumens sowie ein Verfahren hierzu |
DK2124562T3 (en) | 2007-03-09 | 2016-08-01 | Second Genome Inc | BICYCLOHETEROARYLFORBINDELSER AS P2X7 modulators and uses thereof |
PE20091928A1 (es) * | 2008-05-29 | 2009-12-31 | Bristol Myers Squibb Co | Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos |
WO2010093706A2 (en) | 2009-02-10 | 2010-08-19 | The Scripps Research Institute | Chemically programmed vaccination |
WO2010096722A1 (en) * | 2009-02-20 | 2010-08-26 | Takeda Pharmaceutical Company Limited | 3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors |
BRPI1011206A2 (pt) | 2009-05-25 | 2016-03-15 | Merck Patent Gmbh | administração contínua de ligantes de integrina para tratar câncer |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
KR20160147007A (ko) | 2014-05-30 | 2016-12-21 | 화이자 인코포레이티드 | 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체 |
JOP20150179B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
JOP20150177B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
ES2727379T3 (es) | 2014-12-03 | 2019-10-15 | Janssen Pharmaceutica Nv | Compuestos de 6,7-dihidropirazolo[1,5-a]pirazin-4(5H)-ona y su uso como moduladores alostéricos negativos de receptores de mGlu2 |
ES2727158T3 (es) | 2014-12-03 | 2019-10-14 | Janssen Pharmaceutica Nv | Ligandos para PET de mGluR2 radiomarcados |
AU2016374571B2 (en) | 2015-12-18 | 2021-05-06 | Janssen Pharmaceutica Nv | Radiolabelled mGluR2/3 PET ligands |
ES2820823T3 (es) | 2015-12-18 | 2021-04-22 | Janssen Pharmaceutica Nv | Ligandos PET mGluR2/3 radiomarcados |
WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
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DE2937779A1 (de) | 1979-09-19 | 1981-04-09 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
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ZA806976B (en) | 1979-11-13 | 1981-10-28 | Ventrex Lab Inc | Method and apparatus for carrying out solid phase in vitro diagnostic assays |
FR2503155A2 (fr) | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
FR2487829A2 (fr) | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
US4350704A (en) | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
DE3177311D1 (de) | 1980-08-30 | 1994-06-09 | Hoechst Ag | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung. |
US4344949A (en) | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
FR2492381A1 (fr) | 1980-10-21 | 1982-04-23 | Science Union & Cie | Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
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GR78413B (ja) | 1981-12-29 | 1984-09-27 | Hoechst Ag | |
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DE3227055A1 (de) | 1982-07-20 | 1984-01-26 | Hoechst Ag, 6230 Frankfurt | Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung |
DE3242151A1 (de) | 1982-11-13 | 1984-05-17 | Hoechst Ag, 6230 Frankfurt | Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung |
DE3246503A1 (de) | 1982-12-16 | 1984-06-20 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
DE3643012A1 (de) | 1986-12-17 | 1988-06-30 | Hoechst Ag | 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
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PT100631B (pt) * | 1991-06-28 | 1999-06-30 | Smithkline Beecham Corp | Antagonistas biciclicos de fibrinogenio, seu uso e composicoes farmaceuticas que os contem |
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CA2190870A1 (en) * | 1994-05-27 | 1995-12-07 | George D. Hartman | Compounds for inhibiting osteoclast-mediated bone resorption |
WO1996000730A1 (en) * | 1994-06-29 | 1996-01-11 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
EP0762882A4 (en) * | 1994-06-29 | 2002-09-11 | Smithkline Beecham Corp | Vibronectin Receptor Antagonists |
WO1996026190A1 (en) * | 1995-02-22 | 1996-08-29 | Smithkline Beecham Corporation | Integrin receptor antagonists |
DE19516483A1 (de) * | 1995-05-05 | 1996-11-07 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
PT910563E (pt) * | 1995-06-29 | 2003-09-30 | Smithkline Beecham Corp | Antagonistas de receptores de integrina |
KR19990076876A (ko) * | 1995-12-29 | 1999-10-25 | 스티븐 베네티아너 | 비트로넥틴 수용체 길항제 |
CN1209063A (zh) * | 1995-12-29 | 1999-02-24 | 史密丝克莱恩比彻姆公司 | 玻连蛋白受体拮抗剂 |
PL327694A1 (en) * | 1995-12-29 | 1998-12-21 | Smithkline Beecham Corp | Antagonists of vitronectin receptor |
PT796855E (pt) * | 1996-03-20 | 2002-07-31 | Hoechst Ag | Inibicao da reabsorcao nos ossos e antagonistas de vitronectina |
DE19629816A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
DE19629817A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
-
1996
- 1996-12-20 DE DE19653647A patent/DE19653647A1/de not_active Withdrawn
-
1997
- 1997-12-12 EP EP97121932.4A patent/EP0854140B1/de not_active Expired - Lifetime
- 1997-12-17 ZA ZA9711316A patent/ZA9711316B/xx unknown
- 1997-12-17 BR BR9706385A patent/BR9706385A/pt not_active IP Right Cessation
- 1997-12-18 AU AU48465/97A patent/AU730737B2/en not_active Ceased
- 1997-12-18 NZ NZ329430A patent/NZ329430A/xx unknown
- 1997-12-18 MX MX9710392A patent/MX9710392A/es unknown
- 1997-12-18 AR ARP970105995A patent/AR010370A1/es unknown
- 1997-12-18 IL IL12264197A patent/IL122641A0/xx unknown
- 1997-12-18 ID IDP973918A patent/ID19253A/id unknown
- 1997-12-18 CZ CZ974113A patent/CZ411397A3/cs unknown
- 1997-12-19 CN CN97129784A patent/CN1103775C/zh not_active Expired - Fee Related
- 1997-12-19 HU HU9702508A patent/HUP9702508A3/hu unknown
- 1997-12-19 NO NO19975976A patent/NO311644B1/no unknown
- 1997-12-19 RU RU97122265/04A patent/RU2198892C2/ru not_active IP Right Cessation
- 1997-12-19 CA CA002225273A patent/CA2225273A1/en not_active Abandoned
- 1997-12-20 PL PL97323970A patent/PL323970A1/xx unknown
- 1997-12-20 KR KR1019970073884A patent/KR19980064656A/ko not_active Application Discontinuation
- 1997-12-22 JP JP36552997A patent/JP4081167B2/ja not_active Expired - Lifetime
- 1997-12-22 US US08/995,521 patent/US6011045A/en not_active Expired - Lifetime
-
1998
- 1998-02-11 TW TW086119132A patent/TW523510B/zh active
-
1999
- 1999-10-05 US US09/412,331 patent/US6207663B1/en not_active Expired - Lifetime
-
2001
- 2001-02-06 US US09/777,011 patent/US6387895B1/en not_active Expired - Lifetime
-
2002
- 2002-05-13 US US10/142,975 patent/US6867208B2/en not_active Expired - Lifetime
-
2003
- 2003-01-22 CN CN03101487A patent/CN1440971A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
US6867208B2 (en) | 2005-03-15 |
EP0854140A3 (de) | 2000-03-08 |
US20030027807A1 (en) | 2003-02-06 |
NZ329430A (en) | 1999-05-28 |
HUP9702508A2 (hu) | 1999-06-28 |
HU9702508D0 (en) | 1998-03-02 |
EP0854140B1 (de) | 2013-11-06 |
ID19253A (id) | 1998-06-28 |
CN1200374A (zh) | 1998-12-02 |
PL323970A1 (en) | 1998-06-22 |
CN1440971A (zh) | 2003-09-10 |
US6387895B1 (en) | 2002-05-14 |
AR010370A1 (es) | 2000-06-07 |
JPH11147867A (ja) | 1999-06-02 |
TW523510B (en) | 2003-03-11 |
ZA9711316B (en) | 1998-06-22 |
JP4081167B2 (ja) | 2008-04-23 |
EP0854140A2 (de) | 1998-07-22 |
AU4846597A (en) | 1998-06-25 |
KR19980064656A (ko) | 1998-10-07 |
MX9710392A (es) | 1998-06-30 |
BR9706385A (pt) | 1999-07-20 |
CZ411397A3 (cs) | 1998-07-15 |
IL122641A0 (en) | 1998-08-16 |
CA2225273A1 (en) | 1998-06-20 |
AU730737B2 (en) | 2001-03-15 |
NO975976L (no) | 1998-06-22 |
RU2198892C2 (ru) | 2003-02-20 |
NO975976D0 (no) | 1997-12-19 |
US6011045A (en) | 2000-01-04 |
HUP9702508A3 (en) | 2001-04-28 |
US6207663B1 (en) | 2001-03-27 |
DE19653647A1 (de) | 1998-06-25 |
CN1103775C (zh) | 2003-03-26 |
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