NO311070B1 - Fremgangsmåte for fremstilling av et farmasöytisk preparat inneholdende trandolapril og verapamil - Google Patents
Fremgangsmåte for fremstilling av et farmasöytisk preparat inneholdende trandolapril og verapamil Download PDFInfo
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- NO311070B1 NO311070B1 NO19914637A NO914637A NO311070B1 NO 311070 B1 NO311070 B1 NO 311070B1 NO 19914637 A NO19914637 A NO 19914637A NO 914637 A NO914637 A NO 914637A NO 311070 B1 NO311070 B1 NO 311070B1
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- Norway
- Prior art keywords
- atoms
- alkyl
- trandolapril
- compounds
- aryl
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- 229940013977 trandolapril and verapamil Drugs 0.000 title claims abstract description 5
- 238000000034 method Methods 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title description 10
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 17
- 239000008187 granular material Substances 0.000 claims description 15
- 235000019359 magnesium stearate Nutrition 0.000 claims description 9
- 108010010803 Gelatin Proteins 0.000 claims description 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- 229920000159 gelatin Polymers 0.000 claims description 8
- 239000008273 gelatin Substances 0.000 claims description 8
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- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
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- RZTAMFZIAATZDJ-HNNXBMFYSA-N 5-o-ethyl 3-o-methyl (4s)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-HNNXBMFYSA-N 0.000 abstract description 24
- 229960003580 felodipine Drugs 0.000 abstract description 24
- HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 abstract description 19
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- VXFJYXUZANRPDJ-WTNASJBWSA-N Trandopril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@H]2CCCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 VXFJYXUZANRPDJ-WTNASJBWSA-N 0.000 abstract description 11
- JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 abstract description 11
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- 239000001257 hydrogen Substances 0.000 description 12
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- 238000006243 chemical reaction Methods 0.000 description 7
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 6
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- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
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- QIJLJZOGPPQCOG-NFAWXSAZSA-N (2s)-1-[(2s)-3-[(2r)-2-(cyclohexanecarbonylamino)propanoyl]sulfanyl-2-methylpropanoyl]pyrrolidine-2-carboxylic acid Chemical compound N([C@H](C)C(=O)SC[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)C(=O)C1CCCCC1 QIJLJZOGPPQCOG-NFAWXSAZSA-N 0.000 description 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 2
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4037691 | 1990-11-27 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO914637D0 NO914637D0 (no) | 1991-11-26 |
| NO914637L NO914637L (no) | 1992-05-29 |
| NO311070B1 true NO311070B1 (no) | 2001-10-08 |
Family
ID=6419005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19914637A NO311070B1 (no) | 1990-11-27 | 1991-11-26 | Fremgangsmåte for fremstilling av et farmasöytisk preparat inneholdende trandolapril og verapamil |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US5236933A (ko) |
| EP (2) | EP0488059B1 (ko) |
| JP (1) | JP2608355B2 (ko) |
| KR (1) | KR100225997B1 (ko) |
| CN (1) | CN1060679C (ko) |
| AT (2) | ATE176592T1 (ko) |
| AU (1) | AU655784B2 (ko) |
| CA (1) | CA2055948C (ko) |
| CY (2) | CY2109B1 (ko) |
| CZ (2) | CZ286168B6 (ko) |
| DE (2) | DE59106422D1 (ko) |
| DK (2) | DK0649654T3 (ko) |
| ES (2) | ES2079545T3 (ko) |
| GR (2) | GR3017588T3 (ko) |
| HK (2) | HK1006148A1 (ko) |
| HU (1) | HU219447B (ko) |
| IE (1) | IE68600B1 (ko) |
| NO (1) | NO311070B1 (ko) |
| SK (1) | SK279626B6 (ko) |
| TW (1) | TW197945B (ko) |
| YU (1) | YU48978B (ko) |
| ZA (1) | ZA919318B (ko) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW197945B (ko) * | 1990-11-27 | 1993-01-11 | Hoechst Ag | |
| TW483763B (en) * | 1994-09-02 | 2002-04-21 | Astra Ab | Pharmaceutical composition comprising of ramipril and dihydropyridine compound |
| FR2733911B1 (fr) * | 1995-05-09 | 1998-05-29 | Takeda Chemical Industries Ltd | Composition pharmaceutique pour maladies renales ou cardio-vasculaires |
| WO1999020260A2 (en) * | 1997-10-17 | 1999-04-29 | Eurogene Limited | The use of inhibitors of the renin-angiotensin system for the treatment of hypoxia or impaired metabolic function |
| AU2002355419A1 (en) * | 2001-08-06 | 2003-02-24 | Genomed, Llc | Methods and compositions for treating diseases associated with excesses in ace |
| US20050032784A1 (en) * | 2003-04-01 | 2005-02-10 | University Of Florida Research Foundation, Inc. | Combination drug therapy for treating hypertension |
| GB0318094D0 (en) * | 2003-08-01 | 2003-09-03 | Pfizer Ltd | Novel combination |
| US20050112123A1 (en) * | 2003-10-06 | 2005-05-26 | Vaughan Michael R. | Methods of treating proteinuria |
| CA2586547A1 (en) * | 2004-11-05 | 2006-05-11 | King Pharmaceuticals Research & Development, Inc. | Stabilized individually coated ramipril particles, compositions and methods |
| WO2021078359A1 (en) | 2019-10-21 | 2021-04-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of inhibitors of cubilin for the treatment of chronic kidney diseases |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4113715A (en) * | 1977-01-17 | 1978-09-12 | E. R. Squibb & Sons, Inc. | Amino acid derivatives |
| IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| US4294832A (en) * | 1979-04-28 | 1981-10-13 | Tanabe Seiyaku Co., Ltd. | Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof |
| DE3044236A1 (de) * | 1980-11-25 | 1982-06-16 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
| DE2937779A1 (de) * | 1979-09-19 | 1981-04-09 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
| FR2487829A2 (fr) * | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| US4350704A (en) * | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
| US4350633A (en) * | 1980-07-01 | 1982-09-21 | American Home Products Corporation | N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives |
| DE3177311D1 (de) * | 1980-08-30 | 1994-06-09 | Hoechst Ag | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung. |
| US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| FR2492381A1 (fr) * | 1980-10-21 | 1982-04-23 | Science Union & Cie | Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| US4470972A (en) * | 1981-04-28 | 1984-09-11 | Schering Corporation | 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids |
| US4374847A (en) * | 1980-10-27 | 1983-02-22 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
| GB2086390B (en) * | 1980-11-03 | 1984-06-06 | Ciba Geigy Ag | 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application |
| US4462943A (en) * | 1980-11-24 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Carboxyalkyl amino acid derivatives of various substituted prolines |
| EP0065301A1 (en) * | 1981-05-18 | 1982-11-24 | Merck & Co. Inc. | Isoquinoline carboxylic acid derivates, process for preparing and pharmaceutical composition containing the same |
| US4454292A (en) * | 1981-07-20 | 1984-06-12 | American Home Products Corporation | N-[2-Substituted-1-oxoalkyl]-2,3-dihydro-1H-indole-2-carboxylic acid derivatives |
| DE3269625D1 (en) * | 1981-08-11 | 1986-04-10 | Ciba Geigy Ag | Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use |
| DE3226768A1 (de) * | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
| EP0079522B1 (en) * | 1981-11-09 | 1986-05-07 | Merck & Co. Inc. | N-carboxymethyl(amidino)lysyl-proline antihypertensive agents |
| GR78413B (ko) * | 1981-12-29 | 1984-09-27 | Hoechst Ag | |
| DE3437917A1 (de) * | 1984-10-17 | 1986-04-17 | Bayer Ag, 5090 Leverkusen | Kombination von dihydropyridinen mit ace-hemmern sowie ihre verwendung in arzneimitteln |
| DE3633496A1 (de) * | 1986-10-02 | 1988-04-14 | Hoechst Ag | Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln |
| US5093129A (en) * | 1989-01-30 | 1992-03-03 | E. R. Squibb & Sons, Inc. | Method for treating addiction to a drug of abuse employing an ace inhibitor |
| TW197945B (ko) * | 1990-11-27 | 1993-01-11 | Hoechst Ag | |
| DE4109134A1 (de) * | 1991-03-20 | 1992-09-24 | Knoll Ag | Erzeugnisse, enthaltend verapamil und trandolapril |
-
1991
- 1991-08-17 TW TW080106524A patent/TW197945B/zh active
- 1991-11-18 YU YU180491A patent/YU48978B/sh unknown
- 1991-11-21 DE DE59106422T patent/DE59106422D1/de not_active Expired - Lifetime
- 1991-11-21 ES ES91119892T patent/ES2079545T3/es not_active Expired - Lifetime
- 1991-11-21 DE DE59109099T patent/DE59109099D1/de not_active Expired - Lifetime
- 1991-11-21 DK DK94117179T patent/DK0649654T3/da active
- 1991-11-21 EP EP91119892A patent/EP0488059B1/de not_active Expired - Lifetime
- 1991-11-21 AT AT94117179T patent/ATE176592T1/de not_active IP Right Cessation
- 1991-11-21 AT AT91119892T patent/ATE127346T1/de not_active IP Right Cessation
- 1991-11-21 EP EP94117179A patent/EP0649654B1/de not_active Expired - Lifetime
- 1991-11-21 ES ES94117179T patent/ES2129563T3/es not_active Expired - Lifetime
- 1991-11-21 DK DK91119892.7T patent/DK0488059T3/da active
- 1991-11-26 IE IE411191A patent/IE68600B1/en not_active IP Right Cessation
- 1991-11-26 SK SK3587-91A patent/SK279626B6/sk not_active IP Right Cessation
- 1991-11-26 ZA ZA919318A patent/ZA919318B/xx unknown
- 1991-11-26 AU AU88117/91A patent/AU655784B2/en not_active Expired
- 1991-11-26 CN CN91111099A patent/CN1060679C/zh not_active Expired - Lifetime
- 1991-11-26 JP JP3310608A patent/JP2608355B2/ja not_active Expired - Lifetime
- 1991-11-26 NO NO19914637A patent/NO311070B1/no not_active IP Right Cessation
- 1991-11-26 HU HU674/91A patent/HU219447B/hu unknown
- 1991-11-26 CA CA002055948A patent/CA2055948C/en not_active Expired - Lifetime
- 1991-11-26 US US07/798,501 patent/US5236933A/en not_active Expired - Lifetime
- 1991-11-26 CZ CS19913587A patent/CZ286168B6/cs not_active IP Right Cessation
- 1991-11-27 KR KR1019910021370A patent/KR100225997B1/ko not_active IP Right Cessation
-
1993
- 1993-05-06 US US08/057,516 patent/US5366994A/en not_active Expired - Lifetime
-
1995
- 1995-09-29 GR GR950402701T patent/GR3017588T3/el unknown
-
1997
- 1997-09-08 CZ CZ19972830A patent/CZ286187B6/cs not_active IP Right Cessation
-
1998
- 1998-06-12 HK HK98105249A patent/HK1006148A1/xx not_active IP Right Cessation
- 1998-09-04 CY CY9800023A patent/CY2109B1/xx unknown
- 1998-12-09 HK HK98113023A patent/HK1011927A1/xx not_active IP Right Cessation
-
1999
- 1999-04-21 GR GR990401103T patent/GR3030022T3/el unknown
-
2000
- 2000-06-16 CY CY0000027A patent/CY2191B1/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |