YU180491A - Postupak za dobijanje farmaceutskih preparata sa sinergističkim dejstvom koji sadrže aceinhibitore u kombinaciji sa kalcijum-antagonistima - Google Patents

Postupak za dobijanje farmaceutskih preparata sa sinergističkim dejstvom koji sadrže aceinhibitore u kombinaciji sa kalcijum-antagonistima

Info

Publication number
YU180491A
YU180491A YU180491A YU180491A YU180491A YU 180491 A YU180491 A YU 180491A YU 180491 A YU180491 A YU 180491A YU 180491 A YU180491 A YU 180491A YU 180491 A YU180491 A YU 180491A
Authority
YU
Yugoslavia
Prior art keywords
combination
aceinhibitors
procedure
pharmaceutical preparations
calcium antagonists
Prior art date
Application number
YU180491A
Other languages
English (en)
Other versions
YU48978B (sh
Inventor
R. Becker
R.Y. Henning
V. Teetz
H. Urbach
Original Assignee
Hoechst Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6419005&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU180491(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst Ag. filed Critical Hoechst Ag.
Publication of YU180491A publication Critical patent/YU180491A/sh
Publication of YU48978B publication Critical patent/YU48978B/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE FARMACEUTSKIH PREPARATA SA SINERGISTIČKIM DEJSTVOM KOJI SADRŽE ACEINHIBITORE U KOMBINACIJI SA KALCIJUM-ANTAGONISTIMA, pronalazak se odnosi na postupak za dobijanje farmaceutskih preparata sa sinergističkim dejstvom, koji sadrže ACE-inhibitore u kombinaciji sa kalcijum-antagonistima. Predloženi postupak se karakteriše mešanjem trandaloprila i verapamila sa vodenim rastvorom želatina, sušenjem dobivene smeše i mlevenjem u granulat. Dobijeni granulat se zajedno sa drugim fiziološki prihvatljivim pomoćnim materijama formira u pogodan oblik za davanje. Odnos kalcijumantagonista i ACE-inhibitora mora da bude 1-15 : 30-1. Farmaceutski preparati sprečavaju i leče proteinureju.
YU180491A 1990-11-27 1991-11-18 Postupak za dobijanje preparata koji sadrži trandolapril i verapamil YU48978B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4037691 1990-11-27

Publications (2)

Publication Number Publication Date
YU180491A true YU180491A (sh) 1995-12-04
YU48978B YU48978B (sh) 2003-02-28

Family

ID=6419005

Family Applications (1)

Application Number Title Priority Date Filing Date
YU180491A YU48978B (sh) 1990-11-27 1991-11-18 Postupak za dobijanje preparata koji sadrži trandolapril i verapamil

Country Status (22)

Country Link
US (2) US5236933A (sh)
EP (2) EP0649654B1 (sh)
JP (1) JP2608355B2 (sh)
KR (1) KR100225997B1 (sh)
CN (1) CN1060679C (sh)
AT (2) ATE127346T1 (sh)
AU (1) AU655784B2 (sh)
CA (1) CA2055948C (sh)
CY (2) CY2109B1 (sh)
CZ (2) CZ286168B6 (sh)
DE (2) DE59109099D1 (sh)
DK (2) DK0649654T3 (sh)
ES (2) ES2129563T3 (sh)
GR (2) GR3017588T3 (sh)
HK (2) HK1006148A1 (sh)
HU (1) HU219447B (sh)
IE (1) IE68600B1 (sh)
NO (1) NO311070B1 (sh)
SK (1) SK279626B6 (sh)
TW (1) TW197945B (sh)
YU (1) YU48978B (sh)
ZA (1) ZA919318B (sh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW197945B (sh) * 1990-11-27 1993-01-11 Hoechst Ag
TW483763B (en) * 1994-09-02 2002-04-21 Astra Ab Pharmaceutical composition comprising of ramipril and dihydropyridine compound
FR2733911B1 (fr) * 1995-05-09 1998-05-29 Takeda Chemical Industries Ltd Composition pharmaceutique pour maladies renales ou cardio-vasculaires
PL197164B1 (pl) * 1997-10-17 2008-03-31 Ark Therapeutics Ltd Zastosowanie inhibitorów układu renina-angiotensyna
US20030040509A1 (en) * 2001-08-06 2003-02-27 Genomed, Llc Methods and compositions for treating diseases associated with excesses in ACE
US20050032784A1 (en) * 2003-04-01 2005-02-10 University Of Florida Research Foundation, Inc. Combination drug therapy for treating hypertension
GB0318094D0 (en) * 2003-08-01 2003-09-03 Pfizer Ltd Novel combination
US20050112123A1 (en) * 2003-10-06 2005-05-26 Vaughan Michael R. Methods of treating proteinuria
JP2008519063A (ja) * 2004-11-05 2008-06-05 キング・ファーマシューティカルズ・リサーチ・アンド・デベロプメント・インコーポレイティッド 安定化ラミプリル組成物及びその製造方法
WO2021078359A1 (en) 2019-10-21 2021-04-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of inhibitors of cubilin for the treatment of chronic kidney diseases

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4294832A (en) * 1979-04-28 1981-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
DE3044236A1 (de) * 1980-11-25 1982-06-16 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate und verfahren zu ihrer herstellung
DE2937779A1 (de) * 1979-09-19 1981-04-09 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate und verfahren zu ihrer herstellung
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4350633A (en) * 1980-07-01 1982-09-21 American Home Products Corporation N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
DE3177311D1 (de) * 1980-08-30 1994-06-09 Hoechst Ag Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung.
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
FR2492381A1 (fr) * 1980-10-21 1982-04-23 Science Union & Cie Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4470972A (en) * 1981-04-28 1984-09-11 Schering Corporation 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
EP0065301A1 (en) * 1981-05-18 1982-11-24 Merck & Co. Inc. Isoquinoline carboxylic acid derivates, process for preparing and pharmaceutical composition containing the same
US4454292A (en) * 1981-07-20 1984-06-12 American Home Products Corporation N-[2-Substituted-1-oxoalkyl]-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
GB2103614B (en) * 1981-08-11 1984-11-21 Ciba Geigy Ag Benzazepin-2-ones
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
EP0079522B1 (en) * 1981-11-09 1986-05-07 Merck & Co. Inc. N-carboxymethyl(amidino)lysyl-proline antihypertensive agents
NZ202903A (en) * 1981-12-29 1988-01-08 Hoechst Ag 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions
DE3437917A1 (de) * 1984-10-17 1986-04-17 Bayer Ag, 5090 Leverkusen Kombination von dihydropyridinen mit ace-hemmern sowie ihre verwendung in arzneimitteln
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
US5093129A (en) * 1989-01-30 1992-03-03 E. R. Squibb & Sons, Inc. Method for treating addiction to a drug of abuse employing an ace inhibitor
TW197945B (sh) * 1990-11-27 1993-01-11 Hoechst Ag
DE4109134A1 (de) * 1991-03-20 1992-09-24 Knoll Ag Erzeugnisse, enthaltend verapamil und trandolapril

Also Published As

Publication number Publication date
EP0488059A3 (en) 1992-11-25
US5236933A (en) 1993-08-17
EP0649654A1 (de) 1995-04-26
CS358791A3 (en) 1992-06-17
EP0488059B1 (de) 1995-09-06
HU219447B (hu) 2001-04-28
HK1006148A1 (en) 1999-02-12
GR3030022T3 (en) 1999-07-30
SK279626B6 (sk) 1999-01-11
CN1072601A (zh) 1993-06-02
DK0649654T3 (da) 1999-09-20
JP2608355B2 (ja) 1997-05-07
HU913674D0 (en) 1992-02-28
YU48978B (sh) 2003-02-28
CA2055948A1 (en) 1992-05-28
ES2129563T3 (es) 1999-06-16
ATE127346T1 (de) 1995-09-15
HK1011927A1 (en) 1999-07-23
ATE176592T1 (de) 1999-02-15
CZ286168B6 (cs) 2000-02-16
AU8811791A (en) 1992-05-28
GR3017588T3 (en) 1995-12-31
TW197945B (sh) 1993-01-11
DE59109099D1 (de) 1999-03-25
IE914111A1 (en) 1992-06-03
AU655784B2 (en) 1995-01-12
KR920009392A (ko) 1992-06-25
NO914637L (no) 1992-05-29
IE68600B1 (en) 1996-06-26
CN1060679C (zh) 2001-01-17
JPH04308533A (ja) 1992-10-30
US5366994A (en) 1994-11-22
NO914637D0 (no) 1991-11-26
CA2055948C (en) 2002-11-12
EP0488059A2 (de) 1992-06-03
DE59106422D1 (de) 1995-10-12
CZ286187B6 (cs) 2000-02-16
EP0649654B1 (de) 1999-02-10
NO311070B1 (no) 2001-10-08
CY2191B1 (en) 2002-11-08
HUT62468A (en) 1993-05-28
DK0488059T3 (da) 1996-01-02
KR100225997B1 (ko) 1999-10-15
ES2079545T3 (es) 1996-01-16
CY2109B1 (en) 2002-04-26
ZA919318B (en) 1992-08-26

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