HUP9801075A2 - Kombinált állandó dózisú angiotenzint átalakító enzim inhibítor kalciumcsatorna-antagonista, eljárás ennek előállítására, valamint alkalmazása szív- és érrendszeri betegségek kezelésében - Google Patents
Kombinált állandó dózisú angiotenzint átalakító enzim inhibítor kalciumcsatorna-antagonista, eljárás ennek előállítására, valamint alkalmazása szív- és érrendszeri betegségek kezelésébenInfo
- Publication number
- HUP9801075A2 HUP9801075A2 HU9801075A HUP9801075A HUP9801075A2 HU P9801075 A2 HUP9801075 A2 HU P9801075A2 HU 9801075 A HU9801075 A HU 9801075A HU P9801075 A HUP9801075 A HU P9801075A HU P9801075 A2 HUP9801075 A2 HU P9801075A2
- Authority
- HU
- Hungary
- Prior art keywords
- dose
- calcium channel
- enzyme inhibitor
- preparation
- treatment
- Prior art date
Links
- 239000005541 ACE inhibitor Substances 0.000 title abstract 2
- 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 title abstract 2
- 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 title abstract 2
- 229940127291 Calcium channel antagonist Drugs 0.000 title abstract 2
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title abstract 2
- 239000000480 calcium channel blocker Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000002526 effect on cardiovascular system Effects 0.000 title 1
- 239000004575 stone Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- PVHUJELLJLJGLN-INIZCTEOSA-N (S)-nitrendipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC([N+]([O-])=O)=C1 PVHUJELLJLJGLN-INIZCTEOSA-N 0.000 abstract 1
- 108010061435 Enalapril Proteins 0.000 abstract 1
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 abstract 1
- 229960000873 enalapril Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960005425 nitrendipine Drugs 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
A találmány egy angiőtenzin kőnvertáló enzim inhibitőr és egykalciűmcsatőrna-antagőnista meghatárőzőtt dózisú kőmbinációja, azzaljelemezve, hőgy a) enalapril vagy gyógyászatilag alkalmazható sójánakegy dózisát és b) nitrendipin vagy gyógyászatilag alkalmazható sójánakegy másik dózisát tartalmazza, és a kőmbináció egyszeri dózisúgalenűsi készítmény főrmájában alkalmazandó. A találmány tárgyát képezi a fenti kőmbinációt tartalmazó gyógyászatikészítmények, tővábbá annak előállítására szőlgáló eljárás. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009701017A ES2125198B1 (es) | 1997-05-13 | 1997-05-13 | Asociacion a dosis fija de un inhibidor de la enzima convertidora de angiotensina y de un antagonista de los canales de calcio, procedimiento para su preparacion y su utilizacion para el tratamiento de enfermees cardiovasculares. |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9801075D0 HU9801075D0 (en) | 1998-07-28 |
HUP9801075A2 true HUP9801075A2 (hu) | 1999-01-28 |
HUP9801075A3 HUP9801075A3 (en) | 2000-12-28 |
Family
ID=8299270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9801075A HUP9801075A3 (en) | 1997-05-13 | 1998-05-12 | Fixed-dose association of an angiotensinconverting enzyme inhibitor and of a calcium channel antagonist, method for preparation and use thereof in the treatment of cardiovascular illnesses |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP0884054B9 (hu) |
JP (1) | JP3576806B2 (hu) |
CN (1) | CN1146418C (hu) |
AR (1) | AR011730A1 (hu) |
AT (1) | ATE236653T1 (hu) |
AU (1) | AU735404B2 (hu) |
BR (1) | BR9805597A (hu) |
CA (1) | CA2234899C (hu) |
CZ (1) | CZ292616B6 (hu) |
DE (1) | DE69813083T2 (hu) |
DK (1) | DK0884054T3 (hu) |
ES (2) | ES2125198B1 (hu) |
HU (1) | HUP9801075A3 (hu) |
IL (1) | IL124253A (hu) |
NO (1) | NO315545B1 (hu) |
NZ (1) | NZ330447A (hu) |
PL (1) | PL192117B1 (hu) |
PT (1) | PT884054E (hu) |
RU (1) | RU2182002C2 (hu) |
SK (1) | SK284337B6 (hu) |
TR (1) | TR199800847A3 (hu) |
TW (1) | TW562679B (hu) |
ZA (1) | ZA983806B (hu) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU226950B1 (en) * | 1999-11-03 | 2010-03-29 | Richter Gedeon Nyrt | The magnesium salt of enalapril and antihypertensive pharmaceutical composition containing it |
AU2001246883B2 (en) * | 2000-04-11 | 2004-08-12 | Sankyo Company, Limited | Stabilized pharmaceutical compositions containing calcium channel blockers |
KR100596257B1 (ko) * | 2001-01-26 | 2006-07-03 | 쉐링 코포레이션 | 스테롤 흡수 억제제를 포함하는 조성물, 및 페록시솜 증식인자-활성화 수용체 활성화제와 스테롤 흡수 억제제를 포함하는 조성물 및 조합물 |
UA84694C2 (ru) * | 2002-12-16 | 2008-11-25 | Киссеи Фармасьютикал Ко., Лтд. | Капсула для лечения дизурии, содержащая гранулиновое индолиновое соединение - блокатор -адренорецепторов |
RU2618471C2 (ru) * | 2012-12-03 | 2017-05-03 | Закрытое Акционерное Общество "Вертекс" | Пероральная фармацевтическая композиция диуретика и ингибитора АПФ в микронизированной форме, лекарственное средство и его применение |
CN109350733A (zh) * | 2018-06-08 | 2019-02-19 | 山东理工职业学院 | 一种马来酸依那普利片剂的制备方法 |
CN109985013B (zh) * | 2019-05-10 | 2021-08-10 | 河北君圣药业有限公司 | 一种尼群地平分散片及其制备方法 |
CN115501224A (zh) * | 2022-10-09 | 2022-12-23 | 南昌大学第一附属医院 | 马来酸依那普利叶酸片联合通心络在制备治疗高血压合并颈动脉硬化药物的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3437917A1 (de) * | 1984-10-17 | 1986-04-17 | Bayer Ag, 5090 Leverkusen | Kombination von dihydropyridinen mit ace-hemmern sowie ihre verwendung in arzneimitteln |
USH734H (en) * | 1988-03-07 | 1990-02-06 | E. R. Squibb & Sons, Inc. | Method for inhibiting onset of or treating migraine headaches employing an ACE inhibitor |
JPH01275529A (ja) * | 1988-03-21 | 1989-11-06 | E R Squibb & Sons Inc | 晩発性運動障害の抑制治療剤 |
CA2007525A1 (en) * | 1989-01-30 | 1990-07-30 | Zola P. Horovitz | Method for facilating dieting employing an ace inhibitor |
US5160744A (en) * | 1991-06-27 | 1992-11-03 | Alza Corporation | Verapmil therapy |
US5246944A (en) * | 1991-08-13 | 1993-09-21 | Merck & Co., Inc. | Quinoline angiotensin ii antagonists incorporating a substituted benzyl element |
SI9111842A (sl) * | 1991-11-25 | 1998-04-30 | Krka | Stabilna formulacija soli enalaprila, postopek za njeno pripravo in njena uporaba |
SI9300504A (en) * | 1993-09-28 | 1995-04-30 | Krka | Process for preparation solid dispersions and deposits of calcium antagonist dihidropyrimidine derivates and pharmaceutical compositions comprising the same |
US5573780A (en) * | 1995-08-04 | 1996-11-12 | Apotex Usa Inc. | Stable solid formulation of enalapril salt and process for preparation thereof |
-
1997
- 1997-05-13 ES ES009701017A patent/ES2125198B1/es not_active Expired - Fee Related
-
1998
- 1998-04-28 IL IL12425398A patent/IL124253A/xx not_active IP Right Cessation
- 1998-05-05 CZ CZ19981381A patent/CZ292616B6/cs not_active IP Right Cessation
- 1998-05-06 ZA ZA983806A patent/ZA983806B/xx unknown
- 1998-05-08 NO NO19982112A patent/NO315545B1/no not_active IP Right Cessation
- 1998-05-11 SK SK616-98A patent/SK284337B6/sk not_active IP Right Cessation
- 1998-05-11 AR ARP980102163A patent/AR011730A1/es active IP Right Grant
- 1998-05-11 TW TW087107210A patent/TW562679B/zh not_active IP Right Cessation
- 1998-05-12 CN CNB981098371A patent/CN1146418C/zh not_active Expired - Lifetime
- 1998-05-12 DK DK98500119T patent/DK0884054T3/da active
- 1998-05-12 CA CA002234899A patent/CA2234899C/en not_active Expired - Lifetime
- 1998-05-12 DE DE69813083T patent/DE69813083T2/de not_active Expired - Lifetime
- 1998-05-12 PT PT98500119T patent/PT884054E/pt unknown
- 1998-05-12 ES ES98500119T patent/ES2197443T3/es not_active Expired - Lifetime
- 1998-05-12 EP EP98500119A patent/EP0884054B9/en not_active Revoked
- 1998-05-12 PL PL326246A patent/PL192117B1/pl unknown
- 1998-05-12 RU RU98109345/14A patent/RU2182002C2/ru active
- 1998-05-12 AT AT98500119T patent/ATE236653T1/de active
- 1998-05-12 HU HU9801075A patent/HUP9801075A3/hu unknown
- 1998-05-13 TR TR1998/00847A patent/TR199800847A3/tr unknown
- 1998-05-13 BR BR9805597-6A patent/BR9805597A/pt active Search and Examination
- 1998-05-13 AU AU65973/98A patent/AU735404B2/en not_active Expired
- 1998-05-13 JP JP13059098A patent/JP3576806B2/ja not_active Expired - Lifetime
- 1998-05-13 NZ NZ330447A patent/NZ330447A/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB9A | Succession in title |
Owner name: FERRER INTERNACIONAL, S.A., ES Free format text: FORMER OWNER(S): LABORATORIOS VITA, S.A., ES; PROCTER & GAMBLE PHARMACEUTICALS S.A.R.L., CH; PROCTER & GAMBLE PHARMACEUTICALS S.A.R.L., CH; VITA-INVEST, S.A., ES |
|
GB9A | Succession in title |
Owner name: FERRER INTERNACIONAL, S.A., ES Free format text: FORMER OWNER(S): FERRER INTERNACIONAL, S.A., ES; LABORATORIOS VITA, S.A., ES; PROCTER & GAMBLE PHARMACEUTICALS S.A.R.L., CH; PROCTER & GAMBLE PHARMACEUTICALS S.A.R.L., CH; PROCTER & GAMBLE PHARMACEUTICALS S.A.R.L., CH; VITA-INVEST, S.A., ES |
|
FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |