NO309574B1 - Legemiddel-beholder oppnådd fra termoplastisk stivelsessmelte og fremgangsmåte for fremstilling derav - Google Patents
Legemiddel-beholder oppnådd fra termoplastisk stivelsessmelte og fremgangsmåte for fremstilling derav Download PDFInfo
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- NO309574B1 NO309574B1 NO921687A NO921687A NO309574B1 NO 309574 B1 NO309574 B1 NO 309574B1 NO 921687 A NO921687 A NO 921687A NO 921687 A NO921687 A NO 921687A NO 309574 B1 NO309574 B1 NO 309574B1
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- Norway
- Prior art keywords
- starch
- component
- weight
- cellulose
- container according
- Prior art date
Links
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- 229940079593 drug Drugs 0.000 title claims description 15
- 238000000034 method Methods 0.000 title claims description 14
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- 239000004628 starch-based polymer Substances 0.000 title description 2
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- 235000019698 starch Nutrition 0.000 claims abstract description 85
- 239000008107 starch Substances 0.000 claims abstract description 69
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- 239000000155 melt Substances 0.000 claims abstract description 21
- 238000004090 dissolution Methods 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 34
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- JVIPLYCGEZUBIO-UHFFFAOYSA-N 2-(4-fluorophenyl)-1,3-dioxoisoindole-5-carboxylic acid Chemical compound O=C1C2=CC(C(=O)O)=CC=C2C(=O)N1C1=CC=C(F)C=C1 JVIPLYCGEZUBIO-UHFFFAOYSA-N 0.000 claims description 2
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- 229940123457 Free radical scavenger Drugs 0.000 description 1
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- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 241001062472 Stokellia anisodon Species 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
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- UXELAVSYWBWGQM-UHFFFAOYSA-L disodium;2,2-diethyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCC(CC)(C([O-])=O)C(C([O-])=O)S(O)(=O)=O UXELAVSYWBWGQM-UHFFFAOYSA-L 0.000 description 1
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- 229910052742 iron Inorganic materials 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
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- 235000009973 maize Nutrition 0.000 description 1
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- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
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- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
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- 239000001253 polyvinylpolypyrrolidone Substances 0.000 description 1
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- 235000012015 potatoes Nutrition 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 150000003336 secondary aromatic amines Chemical class 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
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- 125000001424 substituent group Chemical group 0.000 description 1
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- 239000012815 thermoplastic material Substances 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
- C08L3/02—Starch; Degradation products thereof, e.g. dextrin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Materials For Medical Uses (AREA)
- Biological Depolymerization Polymers (AREA)
- Extrusion Moulding Of Plastics Or The Like (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)
- Casting Or Compression Moulding Of Plastics Or The Like (AREA)
- Adhesives Or Adhesive Processes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57546490A | 1990-08-30 | 1990-08-30 | |
| PCT/US1991/005873 WO1992004408A1 (en) | 1990-08-30 | 1991-08-19 | Shaped articles as obtained from a thermoplastic starch melt |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO921687D0 NO921687D0 (no) | 1992-04-29 |
| NO921687L NO921687L (no) | 1992-04-29 |
| NO309574B1 true NO309574B1 (no) | 2001-02-19 |
Family
ID=24300434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO921687A NO309574B1 (no) | 1990-08-30 | 1992-04-29 | Legemiddel-beholder oppnådd fra termoplastisk stivelsessmelte og fremgangsmåte for fremstilling derav |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0500885B1 (xx) |
| JP (1) | JP3201609B2 (xx) |
| KR (1) | KR920702388A (xx) |
| CN (1) | CN1059346A (xx) |
| AT (1) | ATE149545T1 (xx) |
| AU (1) | AU648109B2 (xx) |
| CA (1) | CA2072116C (xx) |
| DE (1) | DE69124983T2 (xx) |
| DK (1) | DK0500885T3 (xx) |
| ES (1) | ES2103003T3 (xx) |
| GR (1) | GR3023469T3 (xx) |
| IE (1) | IE912954A1 (xx) |
| NO (1) | NO309574B1 (xx) |
| NZ (1) | NZ239477A (xx) |
| PT (1) | PT98770B (xx) |
| WO (1) | WO1992004408A1 (xx) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG47625A1 (en) * | 1991-11-14 | 1998-04-17 | Bio Tech Biolog Naturverparkun | Biodegradable mould material |
| US6277899B1 (en) | 1992-08-03 | 2001-08-21 | Novamont S.P.A. | Biodegradable polymeric composition |
| IT1256914B (it) * | 1992-08-03 | 1995-12-27 | Novamont Spa | Composizione polimerica biodegradabile. |
| US5810961A (en) * | 1993-11-19 | 1998-09-22 | E. Khashoggi Industries, Llc | Methods for manufacturing molded sheets having a high starch content |
| US5352709A (en) * | 1993-01-29 | 1994-10-04 | International Technology Management Associates, Ltd. | Algal plastics |
| US5858350A (en) | 1993-12-01 | 1999-01-12 | Marine Polymer Technologies | Methods and compositions for poly-β-1→4-N-acetylglucosamine cell therapy system |
| DE19729305C2 (de) * | 1997-07-09 | 2000-07-06 | Aventis Res & Tech Gmbh & Co | Thermoplastische Mischung auf Basis von Stärke enthaltend mindestens eine kationische und mindestens eine anionische Stärke, Verfahren zu ihrer Herstellung sowie Verwendung |
| JP3672008B2 (ja) * | 1999-01-20 | 2005-07-13 | シオノギクオリカプス株式会社 | 硬質カプセル及びその製造方法 |
| EP1103254B1 (de) * | 1999-11-19 | 2005-03-23 | Swiss Caps Rechte und Lizenzen AG | Verfahren zum Herstellen eines Stärke enthaltenden Formkörpers, homogenisierte Stärke enthaltende Masse und Vorrichtung zum Herstellen einer Weichkapsel |
| DE10214327A1 (de) | 2001-10-23 | 2003-05-22 | Innogel Ag Zug | Netzwerk auf Polysaccharidbasis und Verfahren zu dessen Herstellung |
| WO2003035045A2 (de) * | 2001-10-23 | 2003-05-01 | Innogel Ag | Hartkapseln auf polysaccharidbasis und verfahren zu deren herstellung |
| US8435354B2 (en) * | 2005-10-11 | 2013-05-07 | The Procter & Gamble Company | Water stable compositions and articles comprising starch and methods of making the same |
| EP3000487B8 (en) | 2007-02-19 | 2022-06-15 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
| NZ602909A (en) | 2010-04-15 | 2015-01-30 | Marinepolymer Tech Inc | Anti-bacterial applications of poly -n-acetylglucosamine nanofibers |
| JP6144254B2 (ja) | 2011-04-15 | 2017-06-07 | マリン ポリマー テクノロジーズ，インコーポレーテッド | ポリ−ｎ−アセチルグルコサミンナノファイバを用いた疾患の治療 |
| DE102015121383B4 (de) * | 2015-12-08 | 2017-10-12 | Technische Universität Berlin | Modifizierte Cellulosefasern, Verfahren zu deren Herstellung, deren Verwendung, Filterhilfsmittel oder Filterplatten und Verfahren zur künstlichen Klärung von trüben Flüssigkeiten |
| CN110650994B (zh) | 2018-02-07 | 2020-11-24 | 株式会社大赛璐 | 乙酸纤维素粒子、化妆品组合物、以及乙酸纤维素粒子的制造方法 |
| JP6694559B1 (ja) | 2019-03-18 | 2020-05-13 | 株式会社ダイセル | セルロースアセテートを含む粒子、化粧品組成物、及びセルロースアセテートを含む粒子の製造方法 |
| JP7149885B2 (ja) | 2019-03-22 | 2022-10-07 | 株式会社ダイセル | セルロース誘導体粒子、化粧品組成物及びセルロース誘導体粒子の製造方法 |
| WO2022014084A1 (ja) | 2020-07-13 | 2022-01-20 | 株式会社ダイセル | セルロースアセテート粒子、化粧品組成物及びセルロースアセテート粒子の製造方法 |
| WO2022176825A1 (ja) | 2021-02-19 | 2022-08-25 | 株式会社ダイセル | セルロースアシレート組成物及びその製造方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2208651B (en) * | 1987-08-18 | 1991-05-08 | Warner Lambert Co | Shaped articles made from pre-processed starch |
| GB2214516B (en) * | 1988-01-25 | 1992-10-07 | Warner Lambert Co | Method of producing destructurised starch |
| IL94647A0 (en) * | 1989-07-06 | 1991-04-15 | Warner Lambert Co | Polymer base blend compositions containing destructurized starch |
| YU128990A (sh) * | 1989-07-11 | 1993-05-28 | Warner-Lambert Co. | Preparati polimernih smeša koji sadrže destrukturisani skrob |
-
1991
- 1991-08-19 AT AT91916235T patent/ATE149545T1/de not_active IP Right Cessation
- 1991-08-19 DE DE69124983T patent/DE69124983T2/de not_active Expired - Lifetime
- 1991-08-19 DK DK91916235.4T patent/DK0500885T3/da active
- 1991-08-19 CA CA002072116A patent/CA2072116C/en not_active Expired - Lifetime
- 1991-08-19 AU AU85261/91A patent/AU648109B2/en not_active Expired
- 1991-08-19 JP JP51564691A patent/JP3201609B2/ja not_active Expired - Lifetime
- 1991-08-19 WO PCT/US1991/005873 patent/WO1992004408A1/en active IP Right Grant
- 1991-08-19 KR KR1019920701004A patent/KR920702388A/ko not_active Application Discontinuation
- 1991-08-19 ES ES91916235T patent/ES2103003T3/es not_active Expired - Lifetime
- 1991-08-19 EP EP91916235A patent/EP0500885B1/en not_active Expired - Lifetime
- 1991-08-20 IE IE295491A patent/IE912954A1/en not_active IP Right Cessation
- 1991-08-20 NZ NZ239477A patent/NZ239477A/xx not_active IP Right Cessation
- 1991-08-20 CN CN91105908A patent/CN1059346A/zh active Pending
- 1991-08-23 PT PT98770A patent/PT98770B/pt not_active IP Right Cessation
-
1992
- 1992-04-29 NO NO921687A patent/NO309574B1/no not_active IP Right Cessation
-
1997
- 1997-05-16 GR GR970401118T patent/GR3023469T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992004408A1 (en) | 1992-03-19 |
| DE69124983T2 (de) | 1997-10-16 |
| IE912954A1 (en) | 1992-03-11 |
| PT98770A (pt) | 1992-08-31 |
| CA2072116A1 (en) | 1992-03-01 |
| EP0500885B1 (en) | 1997-03-05 |
| NO921687D0 (no) | 1992-04-29 |
| NZ239477A (en) | 1993-04-28 |
| DK0500885T3 (da) | 1997-08-25 |
| JP3201609B2 (ja) | 2001-08-27 |
| EP0500885A1 (en) | 1992-09-02 |
| NO921687L (no) | 1992-04-29 |
| CN1059346A (zh) | 1992-03-11 |
| AU648109B2 (en) | 1994-04-14 |
| AU8526191A (en) | 1992-03-30 |
| ATE149545T1 (de) | 1997-03-15 |
| GR3023469T3 (en) | 1997-08-29 |
| JPH05502267A (ja) | 1993-04-22 |
| KR920702388A (ko) | 1992-09-03 |
| ES2103003T3 (es) | 1997-08-16 |
| CA2072116C (en) | 2003-09-23 |
| DE69124983D1 (de) | 1997-04-10 |
| PT98770B (pt) | 1999-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |