NO309228B1 - K-252a derivater som öker neurotrofin-indusert aktivitet og anvendelse av slike derivater - Google Patents
K-252a derivater som öker neurotrofin-indusert aktivitet og anvendelse av slike derivater Download PDFInfo
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- NO309228B1 NO309228B1 NO961087A NO961087A NO309228B1 NO 309228 B1 NO309228 B1 NO 309228B1 NO 961087 A NO961087 A NO 961087A NO 961087 A NO961087 A NO 961087A NO 309228 B1 NO309228 B1 NO 309228B1
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- Prior art keywords
- carbon atoms
- alkyl
- neurotrophin
- derivatives
- compound
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- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical class C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 231100000747 viability assay Toxicity 0.000 description 1
- 238000003026 viability measurement method Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 229910000166 zirconium phosphate Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/122,893 US5468872A (en) | 1993-09-16 | 1993-09-16 | K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders |
| PCT/US1994/010495 WO1995007911A1 (en) | 1993-09-16 | 1994-09-16 | K-252a DERIVATIVES WHICH ENHANCE NEUROTROPHIN-INDUCED ACTIVITY |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO961087D0 NO961087D0 (no) | 1996-03-15 |
| NO961087L NO961087L (no) | 1996-05-13 |
| NO309228B1 true NO309228B1 (no) | 2001-01-02 |
Family
ID=22405467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO961087A NO309228B1 (no) | 1993-09-16 | 1996-03-15 | K-252a derivater som öker neurotrofin-indusert aktivitet og anvendelse av slike derivater |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5468872A (xx) |
| EP (1) | EP0719268B1 (xx) |
| JP (2) | JP3943126B2 (xx) |
| KR (1) | KR100186912B1 (xx) |
| AT (1) | ATE203751T1 (xx) |
| AU (1) | AU693480B2 (xx) |
| CA (1) | CA2171561C (xx) |
| DE (1) | DE69427862T2 (xx) |
| ES (1) | ES2160637T3 (xx) |
| FI (1) | FI961236A (xx) |
| HU (1) | HU222570B1 (xx) |
| NO (1) | NO309228B1 (xx) |
| NZ (2) | NZ274355A (xx) |
| WO (1) | WO1995007911A1 (xx) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2123096A1 (en) * | 1991-11-08 | 1993-05-13 | Beat J. Knusel | Compositions containing k-252 compounds for potentiation of neurotrophin activity |
| DE4243321A1 (de) * | 1992-12-21 | 1994-06-23 | Goedecke Ag | Aminosäurederivate von Heterocyclen als PKC-Inhibitoren |
| EP0675125A1 (en) * | 1994-03-18 | 1995-10-04 | Kyowa Hakko Kogyo Co., Ltd. | A therapeutic agent for thrombocytopenia and indolocarbazole derivatives |
| US5770577A (en) * | 1994-11-14 | 1998-06-23 | Amgen Inc. | BDNF and NT-3 polypeptides selectively linked to polyethylene glycol |
| AU6657596A (en) * | 1995-07-31 | 1997-02-26 | Ciba-Geigy Ag | Trindene compounds |
| AU6733996A (en) * | 1995-07-31 | 1997-02-26 | Ciba-Geigy Ag | Staurosporine analogues |
| US5808060A (en) * | 1995-12-11 | 1998-09-15 | Cephalon, Inc. | Fused isoindolones |
| US6875865B1 (en) | 1996-06-03 | 2005-04-05 | Cephalon, Inc. | Selected derivatives of K-252a |
| UA67725C2 (en) | 1996-06-03 | 2004-07-15 | Cephalon Inc | K-252a derivatives and a method for improvement of functioning and cell survival enhancement |
| US6093713A (en) | 1997-12-31 | 2000-07-25 | Kyowa, Hakko, Kogyo Co., Ltd. | 3'-epimeric K-252A derivatives |
| US6811992B1 (en) | 1998-05-14 | 2004-11-02 | Ya Fang Liu | Method for identifying MLK inhibitors for the treatment of neurological conditions |
| US6127401A (en) * | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
| US6013646A (en) * | 1998-07-02 | 2000-01-11 | Bayer Corporation | Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer |
| US6200968B1 (en) | 1998-08-06 | 2001-03-13 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| US7795246B2 (en) * | 1998-08-06 | 2010-09-14 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| JP2002525329A (ja) | 1998-09-25 | 2002-08-13 | セフアロン・インコーポレーテツド | 感覚毛細胞及び蝸牛ニューロンへの損傷を予防する／処置するための方法 |
| AU5870800A (en) * | 1999-06-09 | 2000-12-28 | Ljl Biosystems, Inc. | Cell-signaling assays |
| WO2001010440A1 (en) * | 1999-08-09 | 2001-02-15 | Trustees Of Dartmouth College | COMPOSITIONS AND METHODS TO ENHANCE CANCER CHEMOTHERAPY IN p53 DEFECTIVE TUMORS |
| FR2798931B1 (fr) | 1999-09-22 | 2001-11-16 | Oreal | Nouveaux composes indoliques, leur utilisation pour la teinture et le maquillage des matieres keratiniques, compositions les contenant et procedes de teinture |
| US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| US6653290B2 (en) * | 2000-10-06 | 2003-11-25 | Bristol-Myers Squibb Company | Tumor proliferation inhibitors |
| US6677450B2 (en) | 2000-10-06 | 2004-01-13 | Bristol-Myers Squibb Company | Topoisomerase inhibitors |
| US6610727B2 (en) | 2000-10-06 | 2003-08-26 | Bristol-Myers Squibb Company | Anhydro sugar derivatives of indolocarbazoles |
| US6555677B2 (en) * | 2000-10-31 | 2003-04-29 | Merck & Co., Inc. | Phase transfer catalyzed glycosidation of an indolocarbazole |
| MXPA03008589A (es) | 2001-03-22 | 2003-12-08 | Bristol Myers Squibb Co | Derivados de azucar citotoxicos selectivos de topoisomerasa i de indolopirrolocarbazoles. |
| US7018999B2 (en) * | 2001-05-16 | 2006-03-28 | Cephalon, Inc. | Methods for the treatment and prevention of pain |
| US20040186044A1 (en) * | 2002-11-06 | 2004-09-23 | Cosgaya Jose Miguel | Modulation of myelination by interaction with P75 and TRK receptors |
| ATE545429T1 (de) | 2002-12-20 | 2012-03-15 | Lundbeck & Co As H | Modulation der neurotrophinaktivität;screeningsverfahren |
| WO2004085648A2 (en) | 2003-03-19 | 2004-10-07 | Biogen Idec Ma Inc. | Nogo receptor binding protein |
| AU2005258335B2 (en) | 2004-06-24 | 2011-03-17 | Biogen Ma Inc. | Treatment of conditions involving demyelination |
| MX2007001155A (es) * | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
| SG163591A1 (en) | 2005-07-08 | 2010-08-30 | Biogen Idec Inc | Sp35 antibodies and uses thereof |
| US20080021013A1 (en) * | 2006-07-21 | 2008-01-24 | Cephalon, Inc. | JAK inhibitors for treatment of myeloproliferative disorders |
| WO2008013782A2 (en) | 2006-07-24 | 2008-01-31 | Biogen Idec Ma Inc. | Methods for promoting myelination, neuronal survival and oligodendrocyte differentiation via administration of sp35 or trka antagonists |
| SI3225251T1 (sl) * | 2006-12-21 | 2020-03-31 | H. Lundbeck A/S | Modulacija aktivnosti pronevrotrofinov |
| US20090155352A1 (en) * | 2007-11-20 | 2009-06-18 | Cephalon, Inc. | Microemulsion containing indolocarbazole compound and dosage forms containing the same |
| ES2326459B1 (es) | 2008-04-08 | 2010-05-28 | Universidad De Oviedo | Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos. |
| DK2982695T3 (da) | 2008-07-09 | 2019-05-13 | Biogen Ma Inc | Sammensætninger, der omfatter antistoffer mod lingo eller fragmenter deraf |
| CN102264398B (zh) * | 2008-12-22 | 2013-12-18 | 克雷毕里斯股份有限公司 | 合成吲哚并咔唑化合物的聚合物缀合物 |
| CN103242404A (zh) * | 2012-02-03 | 2013-08-14 | 复旦大学 | N-鼠李糖基苯并咔唑化合物及其合成方法和在制药中的用途 |
| WO2013173364A2 (en) | 2012-05-14 | 2013-11-21 | Biogen Idec Ma Inc. | Lingo-2 antagonists for treatment of conditions involving motor neurons |
| CN103012417B (zh) * | 2013-01-08 | 2015-01-07 | 中国科学院昆明植物研究所 | 黄皮属植物中的咔唑生物碱,以其为抗肿瘤活性成分的药物组合物,其制备方法和应用 |
| WO2016112270A1 (en) | 2015-01-08 | 2016-07-14 | Biogen Ma Inc. | Lingo-1 antagonists and uses for treatment of demyelinating disorders |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60257652A (ja) * | 1984-06-02 | 1985-12-19 | Canon Inc | 画像処理装置 |
| US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
| JPH0826036B2 (ja) * | 1987-01-22 | 1996-03-13 | 協和醗酵工業株式会社 | 生理活性物質ｋ−２５２の誘導体 |
| US4735939A (en) * | 1987-02-27 | 1988-04-05 | The Dow Chemical Company | Insecticidal activity of staurosporine |
| US4923986A (en) * | 1987-03-09 | 1990-05-08 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of physiologically active substance K-252 |
| US5093330A (en) * | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| JPH07113027B2 (ja) * | 1987-12-24 | 1995-12-06 | 協和醗酵工業株式会社 | Ｋ−２５２誘導体 |
| DE3835842A1 (de) * | 1988-10-21 | 1990-04-26 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| DE3803620A1 (de) * | 1988-02-06 | 1989-08-17 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| US5231001A (en) * | 1991-03-14 | 1993-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Trk tyrosine kinase receptor is the physiological receptor for nerve growth factor |
| JPH06509333A (ja) * | 1991-07-03 | 1994-10-20 | リジェネロン ファーマシューティカルズ，インコーポレーテッド | ニューロトロフィン活性に対する方法およびアッセイ系 |
| CA2123096A1 (en) * | 1991-11-08 | 1993-05-13 | Beat J. Knusel | Compositions containing k-252 compounds for potentiation of neurotrophin activity |
| JPH05247056A (ja) * | 1992-03-03 | 1993-09-24 | Kyowa Hakko Kogyo Co Ltd | インドロカルバゾール誘導体 |
| DE4217964A1 (de) * | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
| DE4217963A1 (de) * | 1992-05-30 | 1993-12-02 | Goedecke Ag | Verwendung von Indolocarbazolen zur Behandlung von AIDS |
| US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
-
1993
- 1993-09-16 US US08/122,893 patent/US5468872A/en not_active Expired - Lifetime
-
1994
- 1994-09-16 AU AU78363/94A patent/AU693480B2/en not_active Ceased
- 1994-09-16 WO PCT/US1994/010495 patent/WO1995007911A1/en active IP Right Grant
- 1994-09-16 JP JP50937995A patent/JP3943126B2/ja not_active Expired - Fee Related
- 1994-09-16 DE DE69427862T patent/DE69427862T2/de not_active Expired - Fee Related
- 1994-09-16 KR KR1019960701361A patent/KR100186912B1/ko not_active IP Right Cessation
- 1994-09-16 HU HU9600657A patent/HU222570B1/hu not_active IP Right Cessation
- 1994-09-16 AT AT94929228T patent/ATE203751T1/de not_active IP Right Cessation
- 1994-09-16 NZ NZ274355A patent/NZ274355A/en not_active IP Right Cessation
- 1994-09-16 EP EP94929228A patent/EP0719268B1/en not_active Expired - Lifetime
- 1994-09-16 CA CA002171561A patent/CA2171561C/en not_active Expired - Fee Related
- 1994-09-16 ES ES94929228T patent/ES2160637T3/es not_active Expired - Lifetime
- 1994-09-16 US US08/307,530 patent/US5516772A/en not_active Expired - Lifetime
-
1996
- 1996-03-15 NO NO961087A patent/NO309228B1/no not_active IP Right Cessation
- 1996-03-15 FI FI961236A patent/FI961236A/fi unknown
-
1997
- 1997-01-08 NZ NZ314037A patent/NZ314037A/xx not_active IP Right Cessation
-
2005
- 2005-04-26 JP JP2005127746A patent/JP2005220141A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI961236A0 (fi) | 1996-03-15 |
| EP0719268A1 (en) | 1996-07-03 |
| ES2160637T3 (es) | 2001-11-16 |
| NO961087D0 (no) | 1996-03-15 |
| US5516772A (en) | 1996-05-14 |
| KR100186912B1 (ko) | 1999-05-01 |
| NZ314037A (en) | 2000-09-29 |
| HU222570B1 (hu) | 2003-08-28 |
| JP3943126B2 (ja) | 2007-07-11 |
| DE69427862D1 (de) | 2001-09-06 |
| NO961087L (no) | 1996-05-13 |
| AU7836394A (en) | 1995-04-03 |
| HUT74679A (en) | 1997-01-28 |
| AU693480B2 (en) | 1998-07-02 |
| NZ274355A (en) | 1997-03-24 |
| US5468872A (en) | 1995-11-21 |
| JP2005220141A (ja) | 2005-08-18 |
| EP0719268B1 (en) | 2001-08-01 |
| ATE203751T1 (de) | 2001-08-15 |
| HU9600657D0 (en) | 1996-05-28 |
| WO1995007911A1 (en) | 1995-03-23 |
| CA2171561C (en) | 1999-08-03 |
| JPH09502730A (ja) | 1997-03-18 |
| DE69427862T2 (de) | 2002-04-11 |
| KR960704894A (ko) | 1996-10-09 |
| CA2171561A1 (en) | 1995-03-23 |
| FI961236A (fi) | 1996-03-15 |
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Legal Events
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| MM1K | Lapsed by not paying the annual fees |