NO309192B1 - Krystallinsk form av dihydro-2,3-benzodiazepinderivat - Google Patents
Krystallinsk form av dihydro-2,3-benzodiazepinderivat Download PDFInfo
- Publication number
- NO309192B1 NO309192B1 NO953394A NO953394A NO309192B1 NO 309192 B1 NO309192 B1 NO 309192B1 NO 953394 A NO953394 A NO 953394A NO 953394 A NO953394 A NO 953394A NO 309192 B1 NO309192 B1 NO 309192B1
- Authority
- NO
- Norway
- Prior art keywords
- methyl
- compound
- acetyl
- dihydro
- ethanol
- Prior art date
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 13
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- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims abstract 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29864594A | 1994-08-31 | 1994-08-31 | |
| US08/412,242 US6329364B1 (en) | 1994-08-31 | 1995-03-28 | Crystalline form of dihydro-2,3-benzodiazepine derivative |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO953394D0 NO953394D0 (no) | 1995-08-30 |
| NO953394L NO953394L (no) | 1996-03-01 |
| NO309192B1 true NO309192B1 (no) | 2000-12-27 |
Family
ID=26970796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO953394A NO309192B1 (no) | 1994-08-31 | 1995-08-30 | Krystallinsk form av dihydro-2,3-benzodiazepinderivat |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0699678B1 (fr) |
| JP (1) | JP3449835B2 (fr) |
| CN (1) | CN1073996C (fr) |
| AT (1) | ATE262531T1 (fr) |
| AU (1) | AU695424B2 (fr) |
| BR (1) | BR9503843A (fr) |
| CA (1) | CA2157248C (fr) |
| CZ (1) | CZ288679B6 (fr) |
| DE (1) | DE69532739T2 (fr) |
| DK (1) | DK0699678T3 (fr) |
| ES (1) | ES2214491T3 (fr) |
| FI (1) | FI112489B (fr) |
| HK (1) | HK1013820A1 (fr) |
| HU (1) | HU223843B1 (fr) |
| IL (1) | IL115102A (fr) |
| NO (1) | NO309192B1 (fr) |
| NZ (1) | NZ272898A (fr) |
| PL (1) | PL181086B1 (fr) |
| PT (1) | PT699678E (fr) |
| TR (1) | TR199501070A2 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017903A (en) | 1996-09-27 | 2000-01-25 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors |
| US5824662A (en) * | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
| PL332413A1 (en) | 1996-09-27 | 1999-09-13 | Guilford Pharm Inc | Compositions containing inhibitors of naaladase as well as methods of treating glutamatic anomaly and influencing neuronic functions among animals |
| UA67749C2 (uk) * | 1997-08-12 | 2004-07-15 | Егіш Дьйодьсердьяр Рт. | Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування |
| NZ503301A (en) * | 1997-08-12 | 2002-09-27 | Egyt Gyogyszervegyeszeti Gyar | 1,3-dioxolo[4,5-h][2,3]benzodiazepine derivatives useful as AMPA/Kainate receptor inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU219778B (hu) | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
| HU219777B (hu) * | 1993-07-02 | 2001-07-30 | Gyógyszerkutató Intézet Kft. | Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására |
-
1995
- 1995-08-29 TR TR95/01070A patent/TR199501070A2/xx unknown
- 1995-08-30 NZ NZ272898A patent/NZ272898A/en not_active IP Right Cessation
- 1995-08-30 CZ CZ19952221A patent/CZ288679B6/cs not_active IP Right Cessation
- 1995-08-30 EP EP95306052A patent/EP0699678B1/fr not_active Expired - Lifetime
- 1995-08-30 IL IL11510295A patent/IL115102A/en not_active IP Right Cessation
- 1995-08-30 AT AT95306052T patent/ATE262531T1/de not_active IP Right Cessation
- 1995-08-30 JP JP22157595A patent/JP3449835B2/ja not_active Expired - Fee Related
- 1995-08-30 DK DK95306052T patent/DK0699678T3/da active
- 1995-08-30 PT PT95306052T patent/PT699678E/pt unknown
- 1995-08-30 ES ES95306052T patent/ES2214491T3/es not_active Expired - Lifetime
- 1995-08-30 BR BR9503843A patent/BR9503843A/pt not_active IP Right Cessation
- 1995-08-30 DE DE69532739T patent/DE69532739T2/de not_active Expired - Lifetime
- 1995-08-30 CA CA002157248A patent/CA2157248C/fr not_active Expired - Fee Related
- 1995-08-30 PL PL95310228A patent/PL181086B1/pl not_active IP Right Cessation
- 1995-08-30 HU HU9502549A patent/HU223843B1/hu not_active IP Right Cessation
- 1995-08-30 FI FI954066A patent/FI112489B/fi active
- 1995-08-30 NO NO953394A patent/NO309192B1/no not_active IP Right Cessation
- 1995-08-30 AU AU30357/95A patent/AU695424B2/en not_active Ceased
- 1995-08-30 CN CN95109527A patent/CN1073996C/zh not_active Expired - Fee Related
-
1998
- 1998-12-23 HK HK98115183A patent/HK1013820A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9503843A (pt) | 1996-09-10 |
| FI112489B (fi) | 2003-12-15 |
| CZ222195A3 (en) | 1996-03-13 |
| JPH0881469A (ja) | 1996-03-26 |
| FI954066A (fi) | 1996-03-01 |
| JP3449835B2 (ja) | 2003-09-22 |
| PL181086B1 (pl) | 2001-05-31 |
| CA2157248C (fr) | 2000-02-22 |
| PT699678E (pt) | 2004-07-30 |
| EP0699678A1 (fr) | 1996-03-06 |
| NO953394L (no) | 1996-03-01 |
| AU3035795A (en) | 1996-03-14 |
| CZ288679B6 (cs) | 2001-08-15 |
| DE69532739T2 (de) | 2005-03-17 |
| AU695424B2 (en) | 1998-08-13 |
| ATE262531T1 (de) | 2004-04-15 |
| IL115102A0 (en) | 1995-12-08 |
| CN1128264A (zh) | 1996-08-07 |
| HUT72675A (en) | 1996-05-28 |
| DK0699678T3 (da) | 2004-06-28 |
| CN1073996C (zh) | 2001-10-31 |
| NO953394D0 (no) | 1995-08-30 |
| EP0699678B1 (fr) | 2004-03-24 |
| DE69532739D1 (de) | 2004-04-29 |
| PL310228A1 (en) | 1996-03-04 |
| HK1013820A1 (en) | 1999-09-10 |
| TR199501070A2 (tr) | 1996-06-21 |
| ES2214491T3 (es) | 2004-09-16 |
| FI954066A0 (fi) | 1995-08-30 |
| HU223843B1 (hu) | 2005-02-28 |
| HU9502549D0 (en) | 1995-10-30 |
| IL115102A (en) | 1998-12-27 |
| NZ272898A (en) | 1996-12-20 |
| CA2157248A1 (fr) | 1996-03-01 |
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| MM1K | Lapsed by not paying the annual fees |