IL115102A - Crystalline form) R (- 7 - Acetyl - 5 -) 4 - Aminophenyl (8, 9 - Dihydro - 8 - Methyl - H7 - 1, 3 - Dioxolo] 4 T h - 5 [] 2, 3 [- Benzodiazepine - Google Patents

Crystalline form) R (- 7 - Acetyl - 5 -) 4 - Aminophenyl (8, 9 - Dihydro - 8 - Methyl - H7 - 1, 3 - Dioxolo] 4 T h - 5 [] 2, 3 [- Benzodiazepine

Info

Publication number
IL115102A
IL115102A IL11510295A IL11510295A IL115102A IL 115102 A IL115102 A IL 115102A IL 11510295 A IL11510295 A IL 11510295A IL 11510295 A IL11510295 A IL 11510295A IL 115102 A IL115102 A IL 115102A
Authority
IL
Israel
Prior art keywords
methyl
acetyl
dioxolo
compound
aminophenyl
Prior art date
Application number
IL11510295A
Other languages
English (en)
Hebrew (he)
Other versions
IL115102A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/412,242 external-priority patent/US6329364B1/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL115102A0 publication Critical patent/IL115102A0/xx
Publication of IL115102A publication Critical patent/IL115102A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL11510295A 1994-08-31 1995-08-30 Crystalline form) R (- 7 - Acetyl - 5 -) 4 - Aminophenyl (8, 9 - Dihydro - 8 - Methyl - H7 - 1, 3 - Dioxolo] 4 T h - 5 [] 2, 3 [- Benzodiazepine IL115102A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29864594A 1994-08-31 1994-08-31
US08/412,242 US6329364B1 (en) 1994-08-31 1995-03-28 Crystalline form of dihydro-2,3-benzodiazepine derivative

Publications (2)

Publication Number Publication Date
IL115102A0 IL115102A0 (en) 1995-12-08
IL115102A true IL115102A (en) 1998-12-27

Family

ID=26970796

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11510295A IL115102A (en) 1994-08-31 1995-08-30 Crystalline form) R (- 7 - Acetyl - 5 -) 4 - Aminophenyl (8, 9 - Dihydro - 8 - Methyl - H7 - 1, 3 - Dioxolo] 4 T h - 5 [] 2, 3 [- Benzodiazepine

Country Status (20)

Country Link
EP (1) EP0699678B1 (fr)
JP (1) JP3449835B2 (fr)
CN (1) CN1073996C (fr)
AT (1) ATE262531T1 (fr)
AU (1) AU695424B2 (fr)
BR (1) BR9503843A (fr)
CA (1) CA2157248C (fr)
CZ (1) CZ288679B6 (fr)
DE (1) DE69532739T2 (fr)
DK (1) DK0699678T3 (fr)
ES (1) ES2214491T3 (fr)
FI (1) FI112489B (fr)
HK (1) HK1013820A1 (fr)
HU (1) HU223843B1 (fr)
IL (1) IL115102A (fr)
NO (1) NO309192B1 (fr)
NZ (1) NZ272898A (fr)
PL (1) PL181086B1 (fr)
PT (1) PT699678E (fr)
TR (1) TR199501070A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017903A (en) 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
US5824662A (en) * 1996-09-27 1998-10-20 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
PL332413A1 (en) 1996-09-27 1999-09-13 Guilford Pharm Inc Compositions containing inhibitors of naaladase as well as methods of treating glutamatic anomaly and influencing neuronic functions among animals
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
NZ503301A (en) * 1997-08-12 2002-09-27 Egyt Gyogyszervegyeszeti Gyar 1,3-dioxolo[4,5-h][2,3]benzodiazepine derivatives useful as AMPA/Kainate receptor inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU219778B (hu) 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
HU219777B (hu) * 1993-07-02 2001-07-30 Gyógyszerkutató Intézet Kft. Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására

Also Published As

Publication number Publication date
BR9503843A (pt) 1996-09-10
FI112489B (fi) 2003-12-15
CZ222195A3 (en) 1996-03-13
JPH0881469A (ja) 1996-03-26
FI954066A (fi) 1996-03-01
JP3449835B2 (ja) 2003-09-22
PL181086B1 (pl) 2001-05-31
CA2157248C (fr) 2000-02-22
PT699678E (pt) 2004-07-30
EP0699678A1 (fr) 1996-03-06
NO953394L (no) 1996-03-01
AU3035795A (en) 1996-03-14
NO309192B1 (no) 2000-12-27
CZ288679B6 (cs) 2001-08-15
DE69532739T2 (de) 2005-03-17
AU695424B2 (en) 1998-08-13
ATE262531T1 (de) 2004-04-15
IL115102A0 (en) 1995-12-08
CN1128264A (zh) 1996-08-07
HUT72675A (en) 1996-05-28
DK0699678T3 (da) 2004-06-28
CN1073996C (zh) 2001-10-31
NO953394D0 (no) 1995-08-30
EP0699678B1 (fr) 2004-03-24
DE69532739D1 (de) 2004-04-29
PL310228A1 (en) 1996-03-04
HK1013820A1 (en) 1999-09-10
TR199501070A2 (tr) 1996-06-21
ES2214491T3 (es) 2004-09-16
FI954066A0 (fi) 1995-08-30
HU223843B1 (hu) 2005-02-28
HU9502549D0 (en) 1995-10-30
NZ272898A (en) 1996-12-20
CA2157248A1 (fr) 1996-03-01

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US6329364B1 (en) Crystalline form of dihydro-2,3-benzodiazepine derivative
EP0699678B1 (fr) Forme cristalline d'un dérivé de dihydro-2,3-benzodiazépine
CA2198751C (fr) Derives de dihydro-2,3-benzodiazepine
EP0699676B1 (fr) Forme physique d'un dérivé de dihydro-2,3-benzodaizépine
RU2146677C1 (ru) Физическая форма (r)-7-ацетил-5-(4-аминофенил)-8,9-дигидро-8-метил-7н-1,3- диоксоло[4,5-h]-[2,3]-бензодиазепина, способ ее получения и фармацевтическая композиция
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