NO308312B1 - FremgangsmÕte til fremstilling av et kimerisk protein, DNA- molekyl som koder proteinet, rekombinant DNA-molekyl og celle som omfatter DNA-molekylet - Google Patents
FremgangsmÕte til fremstilling av et kimerisk protein, DNA- molekyl som koder proteinet, rekombinant DNA-molekyl og celle som omfatter DNA-molekyletInfo
- Publication number
- NO308312B1 NO308312B1 NO972259A NO972259A NO308312B1 NO 308312 B1 NO308312 B1 NO 308312B1 NO 972259 A NO972259 A NO 972259A NO 972259 A NO972259 A NO 972259A NO 308312 B1 NO308312 B1 NO 308312B1
- Authority
- NO
- Norway
- Prior art keywords
- dna molecule
- protein
- cells
- cell
- producing
- Prior art date
Links
- 108020004414 DNA Proteins 0.000 title abstract 4
- 102000053602 DNA Human genes 0.000 title 3
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 102000003972 Fibroblast growth factor 7 Human genes 0.000 abstract 2
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 abstract 2
- 101001060261 Homo sapiens Fibroblast growth factor 7 Proteins 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 210000003722 extracellular fluid Anatomy 0.000 abstract 1
- 102000057239 human FGF7 Human genes 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30428189A | 1989-01-31 | 1989-01-31 | |
PCT/US1990/000418 WO1990008771A1 (en) | 1989-01-31 | 1990-01-30 | Dna encoding a growth factor specific for epithelial cells |
Publications (3)
Publication Number | Publication Date |
---|---|
NO972259L NO972259L (no) | 1997-05-16 |
NO972259D0 NO972259D0 (no) | 1997-05-16 |
NO308312B1 true NO308312B1 (no) | 2000-08-28 |
Family
ID=23175833
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO972259A NO308312B1 (no) | 1989-01-31 | 1997-05-16 | FremgangsmÕte til fremstilling av et kimerisk protein, DNA- molekyl som koder proteinet, rekombinant DNA-molekyl og celle som omfatter DNA-molekylet |
NO972617A NO308310B1 (no) | 1989-01-31 | 1997-06-06 | Hovedsakelig rent KGF protein og dets anvendelse |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO972617A NO308310B1 (no) | 1989-01-31 | 1997-06-06 | Hovedsakelig rent KGF protein og dets anvendelse |
Country Status (22)
Country | Link |
---|---|
US (8) | US6420531B1 (no) |
EP (2) | EP1016716A3 (no) |
JP (6) | JP3298874B2 (no) |
KR (1) | KR950012805B1 (no) |
AT (1) | ATE197800T1 (no) |
AU (2) | AU647732B2 (no) |
CA (2) | CA2038398C (no) |
DE (2) | DE69033668T2 (no) |
DK (1) | DK0555205T3 (no) |
ES (1) | ES2153816T3 (no) |
FI (1) | FI114711B (no) |
GE (1) | GEP20022681B (no) |
HU (1) | HU218090B (no) |
IE (1) | IE20020188A1 (no) |
LT (1) | LT3472B (no) |
LU (1) | LU91237I2 (no) |
LV (1) | LV10284B (no) |
NL (1) | NL300230I2 (no) |
NO (2) | NO308312B1 (no) |
RU (1) | RU2250213C2 (no) |
SG (1) | SG46699A1 (no) |
WO (1) | WO1990008771A1 (no) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE197800T1 (de) | 1989-01-31 | 2000-12-15 | Jeffrey S Rubin | Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor |
GB9203533D0 (en) * | 1992-02-19 | 1992-04-08 | Erba Carlo Spa | Use of the conjugate between a fibroblast growth factor and a saporin in treating ocular pathologies |
US5814605A (en) * | 1993-03-26 | 1998-09-29 | Amgen Inc. | Therapeutic uses of keratinocyte growth factor |
CZ285996B6 (cs) * | 1993-03-26 | 1999-12-15 | Amgen Inc. | Způsob in vitro stimulace produkce nekeratinocytových epithelových buněk a růstový faktor keratinocytů pro léčbu chorob |
CZ343795A3 (en) * | 1993-06-29 | 1996-07-17 | Chiron Corp | Shortened keratinocyte growth factor /kgf/ exhibiting increased biological activity |
US7084119B2 (en) | 1993-06-29 | 2006-08-01 | Chiron Corporation | Truncated keratinocyte growth factor (KGF) having increased biological activity |
US6268212B1 (en) | 1993-10-18 | 2001-07-31 | Amgen Inc. | Tissue specific transgene expression |
US6008328A (en) * | 1994-10-13 | 1999-12-28 | Amgen Inc. | Method for purifying keratinocyte growth factors |
ES2197926T3 (es) * | 1994-10-13 | 2004-01-16 | Amgen Inc. | Metodo para purificar factores de crecimiento de queratinocitos. |
HUT78069A (hu) * | 1994-10-13 | 1999-08-30 | Amgen Inc. | Keratinocita növekedési faktor analógok |
CN1168678A (zh) * | 1994-10-13 | 1997-12-24 | 安姆根有限公司 | 用kgf治疗糖尿病的方法 |
US6818439B1 (en) | 1994-12-30 | 2004-11-16 | Chiron Corporation | Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders |
US6030613A (en) | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
US7232667B2 (en) | 1995-02-14 | 2007-06-19 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 polynucleotides |
US6077692A (en) * | 1995-02-14 | 2000-06-20 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 |
US6693077B1 (en) | 1995-02-14 | 2004-02-17 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 |
DE69637332T2 (de) | 1995-10-11 | 2008-10-09 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Kombinierung von PDGF, KGF, IGF und IGFBP für Wundheilung |
US6692961B1 (en) | 1996-10-11 | 2004-02-17 | Invitrogen Corporation | Defined systems for epithelial cell culture and use thereof |
US20030144202A1 (en) * | 1996-10-15 | 2003-07-31 | Amgen Inc. | Uses of keratinocyte growth factor-2 |
US6743422B1 (en) | 1996-10-15 | 2004-06-01 | Amgen, Inc. | Keratinocyte growth factor-2 products |
DE19716098A1 (de) * | 1997-04-17 | 1998-10-22 | Univ Ludwigs Albert | Fibroblasten mit einem Fremdgen enthaltende Zusammensetzung zur Behandlung von Wunden |
US6228839B1 (en) | 1997-12-19 | 2001-05-08 | Emory University | Use of keratinocyte growth factor to improve oxidative status |
US6869927B1 (en) | 1997-12-22 | 2005-03-22 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 formulations |
KR20010033484A (ko) * | 1997-12-22 | 2001-04-25 | 휴먼 게놈 사이언시즈, 인크. | 각질세포 성장 인자-2 제제 |
AU762519B2 (en) * | 1998-02-13 | 2003-06-26 | Human Genome Sciences, Inc. | Therapeutic uses of keratinocyte growth factor-2 |
US6335317B1 (en) | 1998-04-10 | 2002-01-01 | Emory University | Use of gut-trophic growth factors to improve oxidative status |
US7022683B1 (en) | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
US6313103B1 (en) | 1998-05-13 | 2001-11-06 | Carrington Laboratories, Inc. | Pectic substance as a growth factor stabilizer |
US5929051A (en) * | 1998-05-13 | 1999-07-27 | Carrington Laboratories, Inc. | Aloe pectins |
US6372494B1 (en) * | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
US6783546B2 (en) | 1999-09-13 | 2004-08-31 | Keraplast Technologies, Ltd. | Implantable prosthetic or tissue expanding device |
US6371984B1 (en) | 1999-09-13 | 2002-04-16 | Keraplast Technologies, Ltd. | Implantable prosthetic or tissue expanding device |
US6395414B1 (en) | 2000-02-11 | 2002-05-28 | General Motors Corporation | Staged venting of fuel cell system during rapid shutdown |
US6376112B1 (en) | 2000-02-11 | 2002-04-23 | General Motors Corporation | Controlled shutdown of a fuel cell |
US6413662B1 (en) | 2000-02-22 | 2002-07-02 | General Motors Corporation | Fuel cell system shutdown with anode pressure control |
JP2001302691A (ja) * | 2000-04-17 | 2001-10-31 | Nichirei Corp | ヒトkgfに対する抗体 |
AU2002309473A1 (en) * | 2001-01-08 | 2002-10-08 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 |
WO2002069232A2 (en) | 2001-02-19 | 2002-09-06 | Merck Patent Gmbh | Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity |
US7494669B2 (en) | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
MXPA04001526A (es) * | 2001-08-21 | 2004-05-31 | Chiron Corp | Composiciones de polipetidos kgf. |
US7202066B2 (en) * | 2002-01-29 | 2007-04-10 | Carrington Laboratories, Inc. | Combination of a growth factor and a protease enzyme |
GB0206309D0 (en) * | 2002-03-16 | 2002-05-01 | Axordia Ltd | Isolated cells |
WO2004019001A2 (en) * | 2002-08-20 | 2004-03-04 | Curagen Corporation | Methods for diagnosing and treatment of conditions that alter phosphate transport in mammals |
US8304387B2 (en) | 2004-12-15 | 2012-11-06 | Swedish Orphan Biovitrum Ab (Publ) | Therapeutic formulations of keratinocyte growth factor |
US20080119433A1 (en) * | 2006-07-06 | 2008-05-22 | Aaron Thomas Tabor | Compositions and Methods for Genetic Modification of Cells Having Cosmetic Function to Enhance Cosmetic Appearance |
CN101679495B (zh) * | 2007-01-05 | 2013-07-17 | 赫里克斯生物医疗公司 | 用于细胞学和免疫学调节的短的生物活性肽 |
BR112012000865A2 (pt) * | 2009-07-17 | 2019-09-24 | T Tabor Aaron | "composição e método para a modificação genética cosmética de células substancialmente intactas" |
WO2013149258A2 (en) | 2012-03-30 | 2013-10-03 | Charles Drew University of Medicine and Science | Compositions and methods for treating or preventing metabolic syndrome disorders |
KR102277147B1 (ko) * | 2017-12-13 | 2021-07-13 | 건국대학교 산학협력단 | 섬유아 성장인자 유래 펩타이드의 골 또는 연골 분화 촉진 용도 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5096825A (en) * | 1983-01-12 | 1992-03-17 | Chiron Corporation | Gene for human epidermal growth factor and synthesis and expression thereof |
US4444760A (en) * | 1983-06-17 | 1984-04-24 | Merck & Co., Inc. | Purification and characterization of a protein fibroblast growth factor |
US4473679A (en) | 1983-12-12 | 1984-09-25 | Borg-Warner Chemicals, Inc. | Thermoplastic acrylic elastomers |
US4743679A (en) * | 1986-02-24 | 1988-05-10 | Creative Biomolecules, Inc. | Process for producing human epidermal growth factor and analogs thereof |
US4868113A (en) | 1986-03-03 | 1989-09-19 | Rorer Biotechnology, Inc. | Recombinant DNA vector encoding human endothelial cell growth factor |
US4983679A (en) | 1986-05-29 | 1991-01-08 | E. I. Dupont De Nemours And Company | β-(keto or sulfonyl)esters from reaction of silylketene acetal and acyl or sulfonyl compound |
AU617795B2 (en) | 1988-03-17 | 1991-12-05 | Leukotech A/S | Heparin-binding proteins, dna coding for them, processes for producing them as well as therapeutic preparations containing them |
ATE197800T1 (de) | 1989-01-31 | 2000-12-15 | Jeffrey S Rubin | Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor |
CZ343795A3 (en) | 1993-06-29 | 1996-07-17 | Chiron Corp | Shortened keratinocyte growth factor /kgf/ exhibiting increased biological activity |
CN1168678A (zh) | 1994-10-13 | 1997-12-24 | 安姆根有限公司 | 用kgf治疗糖尿病的方法 |
-
1990
- 1990-01-30 AT AT90903253T patent/ATE197800T1/de active
- 1990-01-30 HU HU998/90A patent/HU218090B/hu unknown
- 1990-01-30 WO PCT/US1990/000418 patent/WO1990008771A1/en active IP Right Grant
- 1990-01-30 SG SG1996008633A patent/SG46699A1/en unknown
- 1990-01-30 RU SU5001740/13A patent/RU2250213C2/ru active
- 1990-01-30 EP EP00103140A patent/EP1016716A3/en not_active Withdrawn
- 1990-01-30 DK DK90903253T patent/DK0555205T3/da active
- 1990-01-30 ES ES90903253T patent/ES2153816T3/es not_active Expired - Lifetime
- 1990-01-30 GE GEAP1990983A patent/GEP20022681B/en unknown
- 1990-01-30 EP EP90903253A patent/EP0555205B1/en not_active Expired - Lifetime
- 1990-01-30 JP JP50341390A patent/JP3298874B2/ja not_active Expired - Lifetime
- 1990-01-30 DE DE69033668T patent/DE69033668T2/de not_active Expired - Lifetime
- 1990-01-30 AU AU50496/90A patent/AU647732B2/en not_active Expired
- 1990-01-31 IE IE20020188A patent/IE20020188A1/en not_active Application Discontinuation
- 1990-09-29 KR KR90702202A patent/KR950012805B1/ko not_active IP Right Cessation
-
1991
- 1991-03-15 CA CA002038398A patent/CA2038398C/en not_active Expired - Lifetime
- 1991-03-15 CA CA2349875A patent/CA2349875C/en not_active Expired - Lifetime
- 1991-07-30 FI FI913637A patent/FI114711B/fi active
-
1992
- 1992-12-23 LV LVP-92-410A patent/LV10284B/xx unknown
-
1993
- 1993-06-21 LT LTIP667A patent/LT3472B/lt not_active IP Right Cessation
-
1994
- 1994-06-28 AU AU65986/94A patent/AU684278B2/en not_active Expired
-
1995
- 1995-05-31 US US08/455,620 patent/US6420531B1/en not_active Expired - Lifetime
- 1995-05-31 US US08/455,655 patent/US5654405A/en not_active Expired - Lifetime
- 1995-05-31 US US08/455,641 patent/US5707805A/en not_active Expired - Lifetime
- 1995-05-31 US US08/455,975 patent/US6833132B1/en not_active Expired - Lifetime
- 1995-05-31 US US08/455,628 patent/US5665870A/en not_active Expired - Lifetime
- 1995-05-31 US US08/455,672 patent/US5741642A/en not_active Expired - Lifetime
- 1995-06-07 US US08/480,948 patent/US5731170A/en not_active Expired - Lifetime
- 1995-06-07 US US08/477,982 patent/US6709842B1/en not_active Expired - Lifetime
- 1995-12-27 JP JP7341890A patent/JP2716416B2/ja not_active Expired - Lifetime
-
1997
- 1997-05-16 NO NO972259A patent/NO308312B1/no not_active IP Right Cessation
- 1997-06-06 NO NO972617A patent/NO308310B1/no not_active IP Right Cessation
- 1997-10-22 JP JP09290175A patent/JP3088983B2/ja not_active Expired - Lifetime
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1999
- 1999-10-06 JP JP28551799A patent/JP3802292B2/ja not_active Expired - Lifetime
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2000
- 2000-10-11 JP JP2000311208A patent/JP3802329B2/ja not_active Expired - Lifetime
-
2006
- 2006-03-06 JP JP2006060217A patent/JP2006149407A/ja not_active Withdrawn
- 2006-04-11 DE DE200612000021 patent/DE122006000021I1/de active Pending
- 2006-04-19 NL NL300230C patent/NL300230I2/nl unknown
- 2006-04-24 LU LU91237C patent/LU91237I2/fr unknown
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