DK0555205T3 - DNA, der koder for en væstfaktor, som er specifik for epitelceller - Google Patents

DNA, der koder for en væstfaktor, som er specifik for epitelceller

Info

Publication number
DK0555205T3
DK0555205T3 DK90903253T DK90903253T DK0555205T3 DK 0555205 T3 DK0555205 T3 DK 0555205T3 DK 90903253 T DK90903253 T DK 90903253T DK 90903253 T DK90903253 T DK 90903253T DK 0555205 T3 DK0555205 T3 DK 0555205T3
Authority
DK
Denmark
Prior art keywords
cells
growth factor
protein
kgf
dna encoding
Prior art date
Application number
DK90903253T
Other languages
Danish (da)
English (en)
Inventor
Jeffrey S Rubin
Paul W Finch
Stuart A Aaronson
Original Assignee
Jeffrey S Rubin
Paul W Finch
Stuart A Aaronson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23175833&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0555205(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Jeffrey S Rubin, Paul W Finch, Stuart A Aaronson filed Critical Jeffrey S Rubin
Application granted granted Critical
Publication of DK0555205T3 publication Critical patent/DK0555205T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK90903253T 1989-01-31 1990-01-30 DNA, der koder for en væstfaktor, som er specifik for epitelceller DK0555205T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30428189A 1989-01-31 1989-01-31
PCT/US1990/000418 WO1990008771A1 (en) 1989-01-31 1990-01-30 Dna encoding a growth factor specific for epithelial cells

Publications (1)

Publication Number Publication Date
DK0555205T3 true DK0555205T3 (da) 2001-03-05

Family

ID=23175833

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90903253T DK0555205T3 (da) 1989-01-31 1990-01-30 DNA, der koder for en væstfaktor, som er specifik for epitelceller

Country Status (22)

Country Link
US (8) US6420531B1 (no)
EP (2) EP1016716A3 (no)
JP (6) JP3298874B2 (no)
KR (1) KR950012805B1 (no)
AT (1) ATE197800T1 (no)
AU (2) AU647732B2 (no)
CA (2) CA2038398C (no)
DE (2) DE69033668T2 (no)
DK (1) DK0555205T3 (no)
ES (1) ES2153816T3 (no)
FI (1) FI114711B (no)
GE (1) GEP20022681B (no)
HU (1) HU218090B (no)
IE (1) IE20020188A1 (no)
LT (1) LT3472B (no)
LU (1) LU91237I2 (no)
LV (1) LV10284B (no)
NL (1) NL300230I2 (no)
NO (2) NO308312B1 (no)
RU (1) RU2250213C2 (no)
SG (1) SG46699A1 (no)
WO (1) WO1990008771A1 (no)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE197800T1 (de) 1989-01-31 2000-12-15 Jeffrey S Rubin Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor
GB9203533D0 (en) * 1992-02-19 1992-04-08 Erba Carlo Spa Use of the conjugate between a fibroblast growth factor and a saporin in treating ocular pathologies
US5814605A (en) * 1993-03-26 1998-09-29 Amgen Inc. Therapeutic uses of keratinocyte growth factor
CZ285996B6 (cs) * 1993-03-26 1999-12-15 Amgen Inc. Způsob in vitro stimulace produkce nekeratinocytových epithelových buněk a růstový faktor keratinocytů pro léčbu chorob
CZ343795A3 (en) * 1993-06-29 1996-07-17 Chiron Corp Shortened keratinocyte growth factor /kgf/ exhibiting increased biological activity
US7084119B2 (en) 1993-06-29 2006-08-01 Chiron Corporation Truncated keratinocyte growth factor (KGF) having increased biological activity
US6268212B1 (en) 1993-10-18 2001-07-31 Amgen Inc. Tissue specific transgene expression
US6008328A (en) * 1994-10-13 1999-12-28 Amgen Inc. Method for purifying keratinocyte growth factors
ES2197926T3 (es) * 1994-10-13 2004-01-16 Amgen Inc. Metodo para purificar factores de crecimiento de queratinocitos.
HUT78069A (hu) * 1994-10-13 1999-08-30 Amgen Inc. Keratinocita növekedési faktor analógok
CN1168678A (zh) * 1994-10-13 1997-12-24 安姆根有限公司 用kgf治疗糖尿病的方法
US6818439B1 (en) 1994-12-30 2004-11-16 Chiron Corporation Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders
US6030613A (en) 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
US6077692A (en) * 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
DE69637332T2 (de) 1995-10-11 2008-10-09 Novartis Vaccines and Diagnostics, Inc., Emeryville Kombinierung von PDGF, KGF, IGF und IGFBP für Wundheilung
US6692961B1 (en) 1996-10-11 2004-02-17 Invitrogen Corporation Defined systems for epithelial cell culture and use thereof
US20030144202A1 (en) * 1996-10-15 2003-07-31 Amgen Inc. Uses of keratinocyte growth factor-2
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
DE19716098A1 (de) * 1997-04-17 1998-10-22 Univ Ludwigs Albert Fibroblasten mit einem Fremdgen enthaltende Zusammensetzung zur Behandlung von Wunden
US6228839B1 (en) 1997-12-19 2001-05-08 Emory University Use of keratinocyte growth factor to improve oxidative status
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
KR20010033484A (ko) * 1997-12-22 2001-04-25 휴먼 게놈 사이언시즈, 인크. 각질세포 성장 인자-2 제제
AU762519B2 (en) * 1998-02-13 2003-06-26 Human Genome Sciences, Inc. Therapeutic uses of keratinocyte growth factor-2
US6335317B1 (en) 1998-04-10 2002-01-01 Emory University Use of gut-trophic growth factors to improve oxidative status
US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US6313103B1 (en) 1998-05-13 2001-11-06 Carrington Laboratories, Inc. Pectic substance as a growth factor stabilizer
US5929051A (en) * 1998-05-13 1999-07-27 Carrington Laboratories, Inc. Aloe pectins
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6371984B1 (en) 1999-09-13 2002-04-16 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6395414B1 (en) 2000-02-11 2002-05-28 General Motors Corporation Staged venting of fuel cell system during rapid shutdown
US6376112B1 (en) 2000-02-11 2002-04-23 General Motors Corporation Controlled shutdown of a fuel cell
US6413662B1 (en) 2000-02-22 2002-07-02 General Motors Corporation Fuel cell system shutdown with anode pressure control
JP2001302691A (ja) * 2000-04-17 2001-10-31 Nichirei Corp ヒトｋｇｆに対する抗体
AU2002309473A1 (en) * 2001-01-08 2002-10-08 Human Genome Sciences, Inc. Keratinocyte growth factor-2
WO2002069232A2 (en) 2001-02-19 2002-09-06 Merck Patent Gmbh Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity
US7494669B2 (en) 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
MXPA04001526A (es) * 2001-08-21 2004-05-31 Chiron Corp Composiciones de polipetidos kgf.
US7202066B2 (en) * 2002-01-29 2007-04-10 Carrington Laboratories, Inc. Combination of a growth factor and a protease enzyme
GB0206309D0 (en) * 2002-03-16 2002-05-01 Axordia Ltd Isolated cells
WO2004019001A2 (en) * 2002-08-20 2004-03-04 Curagen Corporation Methods for diagnosing and treatment of conditions that alter phosphate transport in mammals
US8304387B2 (en) 2004-12-15 2012-11-06 Swedish Orphan Biovitrum Ab (Publ) Therapeutic formulations of keratinocyte growth factor
US20080119433A1 (en) * 2006-07-06 2008-05-22 Aaron Thomas Tabor Compositions and Methods for Genetic Modification of Cells Having Cosmetic Function to Enhance Cosmetic Appearance
CN101679495B (zh) * 2007-01-05 2013-07-17 赫里克斯生物医疗公司 用于细胞学和免疫学调节的短的生物活性肽
BR112012000865A2 (pt) * 2009-07-17 2019-09-24 T Tabor Aaron "composição e método para a modificação genética cosmética de células substancialmente intactas"
WO2013149258A2 (en) 2012-03-30 2013-10-03 Charles Drew University of Medicine and Science Compositions and methods for treating or preventing metabolic syndrome disorders
KR102277147B1 (ko) * 2017-12-13 2021-07-13 건국대학교 산학협력단 섬유아 성장인자 유래 펩타이드의 골 또는 연골 분화 촉진 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096825A (en) * 1983-01-12 1992-03-17 Chiron Corporation Gene for human epidermal growth factor and synthesis and expression thereof
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
US4473679A (en) 1983-12-12 1984-09-25 Borg-Warner Chemicals, Inc. Thermoplastic acrylic elastomers
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
US4868113A (en) 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor
US4983679A (en) 1986-05-29 1991-01-08 E. I. Dupont De Nemours And Company β-(keto or sulfonyl)esters from reaction of silylketene acetal and acyl or sulfonyl compound
AU617795B2 (en) 1988-03-17 1991-12-05 Leukotech A/S Heparin-binding proteins, dna coding for them, processes for producing them as well as therapeutic preparations containing them
ATE197800T1 (de) 1989-01-31 2000-12-15 Jeffrey S Rubin Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor
CZ343795A3 (en) 1993-06-29 1996-07-17 Chiron Corp Shortened keratinocyte growth factor /kgf/ exhibiting increased biological activity
CN1168678A (zh) 1994-10-13 1997-12-24 安姆根有限公司 用kgf治疗糖尿病的方法

Also Published As

Publication number Publication date
LTIP667A (en) 1995-01-31
NL300230I1 (nl) 2006-07-03
EP1016716A2 (en) 2000-07-05
LU91237I2 (fr) 2007-02-22
AU6598694A (en) 1994-09-08
CA2349875C (en) 2010-02-09
GEP20022681B (en) 2002-04-25
LV10284A (lv) 1994-10-20
JPH04504415A (ja) 1992-08-06
EP0555205A1 (en) 1993-08-18
JPH10243800A (ja) 1998-09-14
JP2001157594A (ja) 2001-06-12
NL300230I2 (nl) 2006-09-01
NO308312B1 (no) 2000-08-28
JP2000102396A (ja) 2000-04-11
ATE197800T1 (de) 2000-12-15
NO972617D0 (no) 1997-06-06
DE122006000021I1 (de) 2006-07-13
JP3802329B2 (ja) 2006-07-26
US5654405A (en) 1997-08-05
NO308310B1 (no) 2000-08-28
LT3472B (en) 1995-10-25
JP3088983B2 (ja) 2000-09-18
US5731170A (en) 1998-03-24
SG46699A1 (en) 1998-02-20
WO1990008771A1 (en) 1990-08-09
JP2716416B2 (ja) 1998-02-18
KR950012805B1 (en) 1995-10-21
IE20020188A1 (en) 2002-06-26
US5741642A (en) 1998-04-21
CA2038398C (en) 2002-01-22
EP0555205A4 (en) 1992-06-02
EP1016716A3 (en) 2000-07-12
FI913637A0 (fi) 1991-07-30
JP3802292B2 (ja) 2006-07-26
CA2349875A1 (en) 1992-09-16
JP3298874B2 (ja) 2002-07-08
RU2250213C2 (ru) 2005-04-20
NO972259L (no) 1997-05-16
JP2006149407A (ja) 2006-06-15
AU647732B2 (en) 1994-03-31
NO972617L (no) 1997-06-06
DE69033668D1 (de) 2001-01-04
US5665870A (en) 1997-09-09
EP0555205B1 (en) 2000-11-29
DE69033668T2 (de) 2001-04-12
ES2153816T3 (es) 2001-03-16
LV10284B (en) 1995-04-20
US6833132B1 (en) 2004-12-21
AU684278B2 (en) 1997-12-11
JPH08277227A (ja) 1996-10-22
KR910700257A (ko) 1991-03-14
CA2038398A1 (en) 1992-09-16
NO972259D0 (no) 1997-05-16
HUT58759A (en) 1992-03-30
US6709842B1 (en) 2004-03-23
HU218090B (hu) 2000-05-28
US5707805A (en) 1998-01-13
FI114711B (fi) 2004-12-15
US6420531B1 (en) 2002-07-16
AU5049690A (en) 1990-08-24

Similar Documents

Publication Publication Date Title
DK0555205T3 (da) DNA, der koder for en væstfaktor, som er specifik for epitelceller
NO963371L (no) Hematopoietisk protein samt materialer og fremgangsmåter for fremstilling av det
DE3881776D1 (de) Dns-konstruktionen, enthaltend eine kluyveromyces-alpha-factor-leadersequenz zur leitung der sekretion von heterologen polypeptiden.
ATE342357T1 (de) Verwendung von chimären proteinen im transport von ausgewählten substanten in die zelle
ATE135371T1 (de) Mit akuter pankreatitis assoziiertes protein, mittel zur diagnose von akuter pankreatitis
ATE199095T1 (de) Heparin bindendes mitogen mit homologie zum epidermis wachstumsfaktor (egf)
HUP0002472A2 (hu) Izolált dendritikus sejtmembrán-fehérje gének
Henry et al. Co‐operation between metastatic tumor cells and macrophages in the degradation of basement membrane (type IV) collagen
ZHANG et al. Increased proteolytic cleavage of α1-antitrypsin (α1-proteinase inhibitor) in knee-joint synovial fluid from patients with rheumatoid arthritis
BR0010479A (pt) Gene tipo prp
NO178504C (no) Fr.måte for fr.stilling av minaktivin,DNA-molekyl,gen,vert,prober,preparat som omfatter prober,reagens for lokalisering og defini. av grenser for tumor i histologiske pröver,samt anvendelse av DNA-molekyl,minaktivin og preparat
Addo-Boadu et al. Azelaic acid decreases the fibrinolytic potential of cultured human melanoma cells in vitro
DE3879055D1 (de) Die sm-b/b1-antigene, das klonen der sm-b/b1-antigene und der nachweis von systemischem lupus erythematosus unter verwendung der sm b/b1-antigene.
ATE335005T1 (de) Menschliches protein mit in vitro antiproliferativer aktivität.
BR9808718A (pt) Polinucleotìdeo isolado, sequência de polinucleotìdeo isolado, vetor de expressão, célula cultivada, construção de dna, proteìna de fusão, polipeptìdeo isolado, processos para produzir um polipeptìdeo de convertase pró-hormÈnio humano 4, para determinar substratos de pró-hormÈnio de polipeptìdeo, para detectar, em uma amostra de teste, a presença de um modulador de atividade de polipeptìdeo de convertase pró-hormÈnio humano, e, para produzir um anticorpo para polipeptìdeo de convertase pró-hormÈnio humano 4
DE59009360D1 (de) Für das Plazentaprotein 9 (PP9) kodierende cDNA, ihre Isolierung und Verwendung.