DE69033668T2 - Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor - Google Patents

Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor

Info

Publication number
DE69033668T2
DE69033668T2 DE69033668T DE69033668T DE69033668T2 DE 69033668 T2 DE69033668 T2 DE 69033668T2 DE 69033668 T DE69033668 T DE 69033668T DE 69033668 T DE69033668 T DE 69033668T DE 69033668 T2 DE69033668 T2 DE 69033668T2
Authority
DE
Germany
Prior art keywords
cells
growth factor
protein
epithelic
kgf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69033668T
Other languages
English (en)
Other versions
DE69033668D1 (de
Inventor
Jeffrey S Rubin
Paul W Finch
Stuart A Aaronson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23175833&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69033668(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69033668D1 publication Critical patent/DE69033668D1/de
Publication of DE69033668T2 publication Critical patent/DE69033668T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69033668T 1989-01-31 1990-01-30 Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor Expired - Lifetime DE69033668T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30428189A 1989-01-31 1989-01-31
PCT/US1990/000418 WO1990008771A1 (en) 1989-01-31 1990-01-30 Dna encoding a growth factor specific for epithelial cells

Publications (2)

Publication Number Publication Date
DE69033668D1 DE69033668D1 (de) 2001-01-04
DE69033668T2 true DE69033668T2 (de) 2001-04-12

Family

ID=23175833

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69033668T Expired - Lifetime DE69033668T2 (de) 1989-01-31 1990-01-30 Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor
DE200612000021 Pending DE122006000021I1 (de) 1989-01-31 2006-04-11 Dns kodierend für einen für epithelzellen spezifischen Wachstumsfaktor

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE200612000021 Pending DE122006000021I1 (de) 1989-01-31 2006-04-11 Dns kodierend für einen für epithelzellen spezifischen Wachstumsfaktor

Country Status (22)

Country Link
US (8) US5654405A (de)
EP (2) EP0555205B1 (de)
JP (6) JP3298874B2 (de)
KR (1) KR950012805B1 (de)
AT (1) ATE197800T1 (de)
AU (2) AU647732B2 (de)
CA (2) CA2349875C (de)
DE (2) DE69033668T2 (de)
DK (1) DK0555205T3 (de)
ES (1) ES2153816T3 (de)
FI (1) FI114711B (de)
GE (1) GEP20022681B (de)
HU (1) HU218090B (de)
IE (1) IE20020188A1 (de)
LT (1) LT3472B (de)
LU (1) LU91237I2 (de)
LV (1) LV10284B (de)
NL (1) NL300230I2 (de)
NO (2) NO308312B1 (de)
RU (1) RU2250213C2 (de)
SG (1) SG46699A1 (de)
WO (1) WO1990008771A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20022681B (en) 1989-01-31 2002-04-25 Aaronson Us Stuart A Protein KFG, Antibodies, Pharmaceutical Composition, Their Use, recombinant DNA, Cell, Method for Discoveries and Production of Proteins, Method for Stimulation of Epithelial Cells Growth
GB9203533D0 (en) * 1992-02-19 1992-04-08 Erba Carlo Spa Use of the conjugate between a fibroblast growth factor and a saporin in treating ocular pathologies
KR100390340B1 (ko) * 1993-03-26 2003-09-26 암겐 인코포레이티드 케라티노사이트성장인자산물을함유하는제약학적조성물
US5965530A (en) * 1993-03-26 1999-10-12 Amgen Inc. Therapeutic uses of keratinocyte growth factor
US7084119B2 (en) 1993-06-29 2006-08-01 Chiron Corporation Truncated keratinocyte growth factor (KGF) having increased biological activity
ES2227527T3 (es) 1993-06-29 2005-04-01 Chiron Corp Un factor de crecimiento de queratinocitos (kgf) truncado que tiene actividad biologica aumentada.
US6268212B1 (en) 1993-10-18 2001-07-31 Amgen Inc. Tissue specific transgene expression
DK0785949T3 (da) * 1994-10-13 2003-08-18 Amgen Inc Fremgangsmåde til oprensning af keratinocytvækstfaktorer
ES2273338T3 (es) * 1994-10-13 2007-05-01 Amgen Inc. Metodo para el tratamiento de la diabetes mellitus usando kfg.
PT785950E (pt) * 1994-10-13 2003-09-30 Amgen Inc Analogos do factor de crescimento de queratinocitos
US6008328A (en) * 1994-10-13 1999-12-28 Amgen Inc. Method for purifying keratinocyte growth factors
US6818439B1 (en) 1994-12-30 2004-11-16 Chiron Corporation Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders
US6030613A (en) 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6077692A (en) 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
ES2293137T3 (es) 1995-10-11 2008-03-16 Novartis Vaccines And Diagnostics, Inc. Combinacion de pdgf, kgf,igf e igfbp para curacion de heridas.
US6692961B1 (en) 1996-10-11 2004-02-17 Invitrogen Corporation Defined systems for epithelial cell culture and use thereof
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
US20030144202A1 (en) * 1996-10-15 2003-07-31 Amgen Inc. Uses of keratinocyte growth factor-2
DE19716098A1 (de) * 1997-04-17 1998-10-22 Univ Ludwigs Albert Fibroblasten mit einem Fremdgen enthaltende Zusammensetzung zur Behandlung von Wunden
US6228839B1 (en) 1997-12-19 2001-05-08 Emory University Use of keratinocyte growth factor to improve oxidative status
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
EP1041996A4 (de) 1997-12-22 2003-05-14 Human Genome Sciences Inc Keratinozyten wachstumsfaktor-2 formulierungen
JP2002507546A (ja) * 1998-02-13 2002-03-12 ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド 角質細胞増殖因子−２の治療的使用
US6335317B1 (en) 1998-04-10 2002-01-01 Emory University Use of gut-trophic growth factors to improve oxidative status
US6313103B1 (en) 1998-05-13 2001-11-06 Carrington Laboratories, Inc. Pectic substance as a growth factor stabilizer
US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US5929051A (en) * 1998-05-13 1999-07-27 Carrington Laboratories, Inc. Aloe pectins
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
US6371984B1 (en) * 1999-09-13 2002-04-16 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6376112B1 (en) 2000-02-11 2002-04-23 General Motors Corporation Controlled shutdown of a fuel cell
US6395414B1 (en) 2000-02-11 2002-05-28 General Motors Corporation Staged venting of fuel cell system during rapid shutdown
US6413662B1 (en) 2000-02-22 2002-07-02 General Motors Corporation Fuel cell system shutdown with anode pressure control
JP2001302691A (ja) * 2000-04-17 2001-10-31 Nichirei Corp ヒトｋｇｆに対する抗体
WO2002077155A2 (en) * 2001-01-08 2002-10-03 Human Genome Sciences, Inc. Keratinocyte growth factor-2
PL362414A1 (en) 2001-02-19 2004-11-02 Merck Patent Gmbh Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity
US7494669B2 (en) 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
CA2457781A1 (en) 2001-08-21 2003-02-27 Chiron Corporation Kgf polypeptide compositions
US7202066B2 (en) * 2002-01-29 2007-04-10 Carrington Laboratories, Inc. Combination of a growth factor and a protease enzyme
GB0206309D0 (en) * 2002-03-16 2002-05-01 Axordia Ltd Isolated cells
WO2004019001A2 (en) * 2002-08-20 2004-03-04 Curagen Corporation Methods for diagnosing and treatment of conditions that alter phosphate transport in mammals
WO2006065861A2 (en) 2004-12-15 2006-06-22 Amgen Inc Therapeutic formulations of keratinocyte growth factor
WO2008005533A2 (en) * 2006-07-06 2008-01-10 Aaron Thomas Tabor Compositions and methods for genetic modification of cells having cosmetic function to enhance cosmetic appearance
JP5342455B2 (ja) * 2007-01-05 2013-11-13 へリックス バイオメディックス インコーポレイテッド 細胞調整及び免疫調整のための短い生物活性ペプチド
BR112012000865A2 (pt) 2009-07-17 2019-09-24 T Tabor Aaron "composição e método para a modificação genética cosmética de células substancialmente intactas"
WO2013149258A2 (en) 2012-03-30 2013-10-03 Charles Drew University of Medicine and Science Compositions and methods for treating or preventing metabolic syndrome disorders
KR102277147B1 (ko) * 2017-12-13 2021-07-13 건국대학교 산학협력단 섬유아 성장인자 유래 펩타이드의 골 또는 연골 분화 촉진 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096825A (en) * 1983-01-12 1992-03-17 Chiron Corporation Gene for human epidermal growth factor and synthesis and expression thereof
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
US4473679A (en) 1983-12-12 1984-09-25 Borg-Warner Chemicals, Inc. Thermoplastic acrylic elastomers
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
US4868113A (en) 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor
US4983679A (en) 1986-05-29 1991-01-08 E. I. Dupont De Nemours And Company β-(keto or sulfonyl)esters from reaction of silylketene acetal and acyl or sulfonyl compound
NZ228370A (en) 1988-03-17 1994-01-26 Novo Nordisk As Heparin-binding protein and preparation thereof.
GEP20022681B (en) 1989-01-31 2002-04-25 Aaronson Us Stuart A Protein KFG, Antibodies, Pharmaceutical Composition, Their Use, recombinant DNA, Cell, Method for Discoveries and Production of Proteins, Method for Stimulation of Epithelial Cells Growth
ES2227527T3 (es) 1993-06-29 2005-04-01 Chiron Corp Un factor de crecimiento de queratinocitos (kgf) truncado que tiene actividad biologica aumentada.
ES2273338T3 (es) 1994-10-13 2007-05-01 Amgen Inc. Metodo para el tratamiento de la diabetes mellitus usando kfg.

Also Published As

Publication number Publication date
JP2001157594A (ja) 2001-06-12
IE20020188A1 (en) 2002-06-26
JPH10243800A (ja) 1998-09-14
ATE197800T1 (de) 2000-12-15
JP3802292B2 (ja) 2006-07-26
NO972259D0 (no) 1997-05-16
EP0555205A1 (de) 1993-08-18
NL300230I1 (nl) 2006-07-03
US6420531B1 (en) 2002-07-16
JP2716416B2 (ja) 1998-02-18
NO308310B1 (no) 2000-08-28
JP2006149407A (ja) 2006-06-15
AU5049690A (en) 1990-08-24
CA2349875A1 (en) 1992-09-16
AU647732B2 (en) 1994-03-31
AU684278B2 (en) 1997-12-11
US5654405A (en) 1997-08-05
HUT58759A (en) 1992-03-30
AU6598694A (en) 1994-09-08
RU2250213C2 (ru) 2005-04-20
US6709842B1 (en) 2004-03-23
LT3472B (en) 1995-10-25
NO972617D0 (no) 1997-06-06
FI913637A0 (fi) 1991-07-30
EP0555205A4 (de) 1992-06-02
ES2153816T3 (es) 2001-03-16
CA2349875C (en) 2010-02-09
JP3802329B2 (ja) 2006-07-26
JP2000102396A (ja) 2000-04-11
GEP20022681B (en) 2002-04-25
EP1016716A3 (de) 2000-07-12
WO1990008771A1 (en) 1990-08-09
US5741642A (en) 1998-04-21
CA2038398C (en) 2002-01-22
LTIP667A (en) 1995-01-31
JP3088983B2 (ja) 2000-09-18
NO972259L (no) 1997-05-16
NO972617L (no) 1997-06-06
DE69033668D1 (de) 2001-01-04
JPH04504415A (ja) 1992-08-06
US5665870A (en) 1997-09-09
SG46699A1 (en) 1998-02-20
JPH08277227A (ja) 1996-10-22
JP3298874B2 (ja) 2002-07-08
DE122006000021I1 (de) 2006-07-13
HU218090B (hu) 2000-05-28
LU91237I2 (fr) 2007-02-22
LV10284B (en) 1995-04-20
LV10284A (lv) 1994-10-20
DK0555205T3 (da) 2001-03-05
EP0555205B1 (de) 2000-11-29
US5707805A (en) 1998-01-13
NO308312B1 (no) 2000-08-28
US5731170A (en) 1998-03-24
NL300230I2 (nl) 2006-09-01
KR910700257A (ko) 1991-03-14
KR950012805B1 (en) 1995-10-21
US6833132B1 (en) 2004-12-21
EP1016716A2 (de) 2000-07-05
CA2038398A1 (en) 1992-09-16
FI114711B (fi) 2004-12-15

Similar Documents

Publication Publication Date Title
DE69033668D1 (de) Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor
NO963371L (no) Hematopoietisk protein samt materialer og fremgangsmåter for fremstilling av det
FI820075L (fi) Rekombination-dna-medel och foerfarande
DE68929043T2 (de) Für androgen-rezeptor-protein kodierende dna
EP0252685A3 (en) Diagnostic methods for detecting lymphomas in humans
DE3881776D1 (de) Dns-konstruktionen, enthaltend eine kluyveromyces-alpha-factor-leadersequenz zur leitung der sekretion von heterologen polypeptiden.
PT101297A (pt) Factores mitogenicos gliais, sua preparacao e utilizacao
CA2413857A1 (en) Pd-l2 molecules: pd-1 ligands and uses therefor
ATE135371T1 (de) Mit akuter pankreatitis assoziiertes protein, mittel zur diagnose von akuter pankreatitis
HUP0002472A2 (hu) Izolált dendritikus sejtmembrán-fehérje gének
DE60144021D1 (de) Für zellzyklusproteine kodierende nukleinsäure und deren verwendung
DE3853955D1 (de) Ein gen, das für glukuronidpermeas kodiert.
ATE335005T1 (de) Menschliches protein mit in vitro antiproliferativer aktivität.

Legal Events

Date Code Title Description
8363 Opposition against the patent