NO307831B1 - 3-indolylpiperidiner, farmasøytiske preparater som inneholder disse, og anvendelse av forbindelsene til fremstilling av legemidler - Google Patents
3-indolylpiperidiner, farmasøytiske preparater som inneholder disse, og anvendelse av forbindelsene til fremstilling av legemidlerInfo
- Publication number
- NO307831B1 NO307831B1 NO951529A NO951529A NO307831B1 NO 307831 B1 NO307831 B1 NO 307831B1 NO 951529 A NO951529 A NO 951529A NO 951529 A NO951529 A NO 951529A NO 307831 B1 NO307831 B1 NO 307831B1
- Authority
- NO
- Norway
- Prior art keywords
- indolylpiperidines
- compounds
- manufacture
- pharmaceutical preparations
- preparations containing
- Prior art date
Links
- XKJJOWGAKBYIQV-UHFFFAOYSA-N 2-piperidin-3-yl-1h-indole Chemical class C1CCNCC1C1=CC2=CC=CC=C2N1 XKJJOWGAKBYIQV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- -1 methylenedioxy Chemical group 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Hydrogenated Pyridines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Treatment Of Water By Ion Exchange (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4414113A DE4414113A1 (de) | 1994-04-22 | 1994-04-22 | 3-Indolylpiperidine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO951529D0 NO951529D0 (no) | 1995-04-21 |
| NO951529L NO951529L (no) | 1995-10-23 |
| NO307831B1 true NO307831B1 (no) | 2000-06-05 |
Family
ID=6516183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO951529A NO307831B1 (no) | 1994-04-22 | 1995-04-21 | 3-indolylpiperidiner, farmasøytiske preparater som inneholder disse, og anvendelse av forbindelsene til fremstilling av legemidler |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5693655A (cs) |
| EP (1) | EP0683166B1 (cs) |
| JP (1) | JPH07291969A (cs) |
| KR (1) | KR100361950B1 (cs) |
| CN (1) | CN1047385C (cs) |
| AT (1) | ATE172730T1 (cs) |
| AU (1) | AU697749B2 (cs) |
| CA (1) | CA2147451C (cs) |
| CZ (1) | CZ285369B6 (cs) |
| DE (2) | DE4414113A1 (cs) |
| DK (1) | DK0683166T3 (cs) |
| ES (1) | ES2125508T3 (cs) |
| HU (1) | HUT74096A (cs) |
| NO (1) | NO307831B1 (cs) |
| PL (1) | PL180781B1 (cs) |
| RU (1) | RU2151148C1 (cs) |
| SK (1) | SK280881B6 (cs) |
| TW (1) | TW401416B (cs) |
| UA (1) | UA41333C2 (cs) |
| ZA (1) | ZA953260B (cs) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| GB9523462D0 (en) * | 1995-11-16 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
| ZA9711376B (en) | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
| DE19707628A1 (de) * | 1997-02-26 | 1998-08-27 | Merck Patent Gmbh | Oxazolidinone |
| ES2206963T3 (es) | 1997-07-25 | 2004-05-16 | H. Lundbeck A/S | Derivados de indol y de 2,3-dihidroindol, su preparacion y uso. |
| AP9801321A0 (en) * | 1997-08-15 | 2000-02-14 | Pfizer Prod Inc | 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-h-indole derivatives. |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| KR20010034605A (ko) | 1998-03-18 | 2001-04-25 | 우에하라 아끼라 | 방향족 복소환 유도체 |
| CN1166665C (zh) * | 1998-03-19 | 2004-09-15 | 日本农药株式会社 | 芳基哌啶衍生物及其用途 |
| US6204274B1 (en) | 1998-04-29 | 2001-03-20 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| US6310066B1 (en) | 1998-04-29 | 2001-10-30 | American Home Products Corp. | Antipsychotic indolyl derivatives |
| EA004248B1 (ru) | 1998-06-19 | 2004-02-26 | Х.Лундбекк А/С | Производные 4-, 5-, 6- и 7-замещенного индола и индолина, их получение и применение |
| WO1999067237A1 (en) * | 1998-06-19 | 1999-12-29 | H. Lundbeck A/S | 4,5,6 and 7-indole and indoline derivatives, their preparation and use |
| US6066637A (en) * | 1998-06-19 | 2000-05-23 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| AR020773A1 (es) * | 1998-10-16 | 2002-05-29 | Duphar Int Res | Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto |
| JP2002544223A (ja) * | 1999-05-12 | 2002-12-24 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | 精神病性障害の治療方法 |
| PT1212320E (pt) | 1999-08-23 | 2005-11-30 | Solvay Pharm Bv | Fenilpiperazinas como inibidores de reabsorcao de serotonina |
| US6806275B2 (en) | 2000-09-13 | 2004-10-19 | Nihon Nohyaku Co., Ltd. | Arylpiperidine derivatives and use thereof |
| AR032712A1 (es) | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
| US6903110B2 (en) | 2001-07-25 | 2005-06-07 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene |
| DE10217006A1 (de) * | 2002-04-16 | 2003-11-06 | Merck Patent Gmbh | Substituierte Indole |
| US7235569B2 (en) * | 2003-05-02 | 2007-06-26 | Wyeth | Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use |
| CN101268067A (zh) * | 2005-07-21 | 2008-09-17 | 弗·哈夫曼-拉罗切有限公司 | 作为v1a受体拮抗剂的吲哚-3-基-羰基-哌啶-苯并咪唑衍生物 |
| WO2016192657A1 (en) | 2015-06-03 | 2016-12-08 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2675801A (en) * | 1954-04-20 | Intramedbllary nail | ||
| FR2349331A1 (fr) * | 1976-04-30 | 1977-11-25 | Roussel Uclaf | Nouveaux derives de 2,3 dihydro a/4-(3-indolyl) 1-piperidinyl/methyl 1,4-benzodioxin-2-methanol, un procede pour leur preparation et leur application comme medicaments |
| GB2044254B (en) | 1979-01-26 | 1983-01-26 | Wyeth John & Brother Ltd | Piperidine derivatives |
| US4359468A (en) * | 1981-02-25 | 1982-11-16 | Boehringer Ingelheim Ltd. | Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones |
| HU198036B (en) * | 1983-08-22 | 1989-07-28 | Hoechst Roussel Pharma | Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them |
| US5256673A (en) * | 1983-11-25 | 1993-10-26 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds |
| US4548939A (en) * | 1984-10-01 | 1985-10-22 | Janssen Pharmaceutica N. V. | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
| IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
| GB8531665D0 (en) * | 1985-12-23 | 1986-02-05 | Wyeth John & Brother Ltd | Indole derivatives |
| IL90879A0 (en) * | 1988-09-02 | 1990-02-09 | Janssen Pharmaceutica Nv | 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them |
| JP2860688B2 (ja) * | 1990-03-14 | 1999-02-24 | 第一製薬株式会社 | インドール誘導体 |
| FR2675801A1 (fr) | 1991-04-24 | 1992-10-30 | Rhone Poulenc Rorer Sa | Piperidines, leur preparation et les medicaments les contenant. |
| DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| KR102044254B1 (ko) * | 2018-01-18 | 2019-11-13 | (주)우신에이펙 | 배광제어가 가능한 led 탐조등 |
-
1994
- 1994-04-22 DE DE4414113A patent/DE4414113A1/de not_active Withdrawn
-
1995
- 1995-03-22 UA UA95038268A patent/UA41333C2/uk unknown
- 1995-04-07 AT AT95105227T patent/ATE172730T1/de not_active IP Right Cessation
- 1995-04-07 ES ES95105227T patent/ES2125508T3/es not_active Expired - Lifetime
- 1995-04-07 EP EP95105227A patent/EP0683166B1/de not_active Expired - Lifetime
- 1995-04-07 DE DE59504032T patent/DE59504032D1/de not_active Expired - Lifetime
- 1995-04-07 DK DK95105227T patent/DK0683166T3/da active
- 1995-04-13 AU AU16488/95A patent/AU697749B2/en not_active Ceased
- 1995-04-17 JP JP7091077A patent/JPH07291969A/ja active Pending
- 1995-04-19 SK SK508-95A patent/SK280881B6/sk unknown
- 1995-04-20 CA CA002147451A patent/CA2147451C/en not_active Expired - Fee Related
- 1995-04-20 CN CN95104705A patent/CN1047385C/zh not_active Expired - Fee Related
- 1995-04-20 TW TW084103916A patent/TW401416B/zh active
- 1995-04-21 HU HU9501139A patent/HUT74096A/hu unknown
- 1995-04-21 US US08/426,405 patent/US5693655A/en not_active Expired - Lifetime
- 1995-04-21 RU RU95106675/04A patent/RU2151148C1/ru not_active IP Right Cessation
- 1995-04-21 ZA ZA953260A patent/ZA953260B/xx unknown
- 1995-04-21 CZ CZ951035A patent/CZ285369B6/cs not_active IP Right Cessation
- 1995-04-21 NO NO951529A patent/NO307831B1/no not_active IP Right Cessation
- 1995-04-21 PL PL95308287A patent/PL180781B1/pl not_active IP Right Cessation
- 1995-04-22 KR KR1019950009554A patent/KR100361950B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| SK280881B6 (sk) | 2000-08-14 |
| ATE172730T1 (de) | 1998-11-15 |
| NO951529L (no) | 1995-10-23 |
| RU95106675A (ru) | 1997-03-20 |
| CZ285369B6 (cs) | 1999-07-14 |
| EP0683166B1 (de) | 1998-10-28 |
| CZ103595A3 (en) | 1995-12-13 |
| KR950032176A (ko) | 1995-12-20 |
| HUT74096A (en) | 1996-11-28 |
| NO951529D0 (no) | 1995-04-21 |
| RU2151148C1 (ru) | 2000-06-20 |
| TW401416B (en) | 2000-08-11 |
| AU697749B2 (en) | 1998-10-15 |
| CA2147451A1 (en) | 1995-10-23 |
| PL308287A1 (en) | 1995-10-30 |
| ES2125508T3 (es) | 1999-03-01 |
| KR100361950B1 (ko) | 2003-02-05 |
| ZA953260B (en) | 1996-01-09 |
| DE59504032D1 (de) | 1998-12-03 |
| CA2147451C (en) | 2006-03-28 |
| US5693655A (en) | 1997-12-02 |
| HU9501139D0 (en) | 1995-06-28 |
| CN1114651A (zh) | 1996-01-10 |
| SK50895A3 (en) | 1995-11-08 |
| AU1648895A (en) | 1995-11-02 |
| DK0683166T3 (da) | 1999-07-12 |
| EP0683166A1 (de) | 1995-11-22 |
| DE4414113A1 (de) | 1995-10-26 |
| CN1047385C (zh) | 1999-12-15 |
| UA41333C2 (uk) | 2001-09-17 |
| PL180781B1 (pl) | 2001-04-30 |
| JPH07291969A (ja) | 1995-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO307831B1 (no) | 3-indolylpiperidiner, farmasøytiske preparater som inneholder disse, og anvendelse av forbindelsene til fremstilling av legemidler | |
| NZ508923A (en) | N-phenyl-1-Methyl-2-oxo-quinoline-3-carboxamide derivatives, pharmaceuticals thereof and their use in therapy | |
| DK0562956T3 (da) | Hidtil ukendte naphthylalkylaminer, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem | |
| NO179867C (no) | Sulfonamido- og sulfonamidokarbonyl-pyridin-2-karboksylsyreamider og anvendelse av forbindelsene som legemidler | |
| ATE152448T1 (de) | Heterozyklische alkylamide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen | |
| ATE126215T1 (de) | Anti-entzündende 4-aminophenol-derivate. | |
| DK0580502T3 (da) | 3-(hydroxybenzylidenyl)-indolin-2-oner og farmaceutiske sammensætninger indeholdende disse | |
| NO930036D0 (no) | Nye 2-cyano-3-hydroksy-enamider og farmasoeytiske preparater inneholdende disse som aktiv bestanddel | |
| NO940144L (no) | 2-(4-hydroksypiperidino)1-alkanolderivater som antiiskemiske midler | |
| IT1264857B1 (it) | Composizione farmaceutica liquida per uso orale contenente acido 2-(4-isobutilfenil) propionico | |
| NO302368B1 (no) | Kinoksalinforbindelser, farmasöytiske preparater som inneholder slike, og anvendelse av forbindelsene for fremstilling av preparatene | |
| DK0641759T3 (da) | Anvendelse af aromatiske carboxylsyrederivater til fremstilling af farmaceutiske præparater | |
| DK0486386T3 (da) | Hidtil ukendte N-benzoylprolinderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem | |
| GR1001597B (el) | Νέα βιολογικώς δραστικά παράγωγα εμπουρναμενίνης, φαρμακευτικές συν?έσεις οι οποίες περιέχουν αυτά και μέ?οδος δια την παρασκευή αυτών. | |
| NO301767B1 (no) | Salt av clavulansyre | |
| KR960703863A (ko) | 암 치료용 신규 비스-나프탈이미드(New Bis-naphthalimides for the Treatment of Cancer) | |
| DE69414194D1 (de) | Aminosäurederivate und ihre Verwendung als Enkephalinase-Inhibitoren | |
| DK0632026T3 (da) | Alfa-aminosyrederivater, en fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger, der indeholder dem | |
| DE69415682D1 (de) | Neue urethan enthaltende aminosteroid verbindungen | |
| DK0627916T3 (da) | Farmaceutisk præparat, anvendeligt som analgetikum og indeholdende (R)-2-(3-benzoylphenyl)propionsyre | |
| NO903291L (no) | Renin-hemmende aminooligohydroksyderivater. | |
| WO1995022544A3 (de) | Substituierte 1,3,8-triaza-spiro(4,5)-decan-4-on-derivate als vorstufen zur herstellung von pharmazeutika | |
| DE69215511D1 (de) | Gem-diphosphonsäure-nitrosocarbamoylderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zubereitungen | |
| NO304025B1 (no) | Heteroarenylpiperaziner, farmas°ytiske preparater inneholdende slike forbindelser og anvendelse derav som legemidler | |
| ES2076517T3 (es) | Ergolinas disustituidas en posiciones 2,13, su preparacion y utilizacion en medicamentos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |