NO305705B1 - Fremgangsmate for fremstilling av et gjaerglukan - Google Patents
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- Publication number
- NO305705B1 NO305705B1 NO19912645A NO912645A NO305705B1 NO 305705 B1 NO305705 B1 NO 305705B1 NO 19912645 A NO19912645 A NO 19912645A NO 912645 A NO912645 A NO 912645A NO 305705 B1 NO305705 B1 NO 305705B1
- Authority
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- Norway
- Prior art keywords
- glucan
- insoluble
- yeast residue
- residue
- insoluble yeast
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Polymers & Plastics (AREA)
- Genetics & Genomics (AREA)
- Medical Informatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Farming Of Fish And Shellfish (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54957590A | 1990-07-06 | 1990-07-06 |
Publications (3)
Publication Number | Publication Date |
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NO912645D0 NO912645D0 (no) | 1991-07-05 |
NO912645L NO912645L (no) | 1992-01-07 |
NO305705B1 true NO305705B1 (no) | 1999-07-12 |
Family
ID=24193557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19912645A NO305705B1 (no) | 1990-07-06 | 1991-07-05 | Fremgangsmate for fremstilling av et gjaerglukan |
Country Status (12)
Country | Link |
---|---|
US (1) | US5401727A (fr) |
EP (1) | EP0466037B1 (fr) |
JP (1) | JP2828799B2 (fr) |
AT (1) | ATE160787T1 (fr) |
AU (1) | AU628752B2 (fr) |
CA (1) | CA2040374C (fr) |
DE (1) | DE69128308T2 (fr) |
DK (1) | DK0466037T3 (fr) |
ES (1) | ES2109929T3 (fr) |
FI (1) | FI104537B (fr) |
GR (1) | GR3026130T3 (fr) |
NO (1) | NO305705B1 (fr) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0665649B2 (ja) * | 1991-02-01 | 1994-08-24 | 台糖株式会社 | 甲殻類の生体防御能増強剤、感染症予防ワクチン及び飼料 |
JP3522772B2 (ja) * | 1991-05-21 | 2004-04-26 | 台糖株式会社 | ワクチンの免疫効果増強剤 |
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US20040127458A1 (en) * | 2000-11-06 | 2004-07-01 | Hunter Kenneth W. | Beta-glucan containing compositions, methods for manufacturing beta-glucans, and for manufacturing and using beta-glucans and conjugates thereof as vaccine adjuvants |
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US8222232B2 (en) * | 2001-02-16 | 2012-07-17 | Cargill, Incorporated | Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass |
US7816514B2 (en) | 2001-02-16 | 2010-10-19 | Cargill, Incorporated | Glucosamine and method of making glucosamine from microbial biomass |
US7323140B2 (en) * | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
US6939864B1 (en) | 2001-07-09 | 2005-09-06 | Purdue Research Foundation | Animal feed compositions and methods of using the same |
KR20050043751A (ko) * | 2001-11-06 | 2005-05-11 | 오리엔트 캔서 세라피 컴퍼니 리미티드 | 항암 조성물 |
DE10222358A1 (de) * | 2002-05-21 | 2003-12-11 | Nutrinova Gmbh | ß-Glucanhaltiges Sorbinsäurepräparat als Futtermittelzusatz in der Nutztieraufzucht |
US7018986B2 (en) * | 2002-09-20 | 2006-03-28 | Immudyne | Use of beta glucans for the treatment of osteoporosis and other diseases of bone resorption |
GB0225502D0 (en) * | 2002-11-01 | 2002-12-11 | Zoolife Internat Ltd | Therapeutic and prophylactic preparations |
GB0225503D0 (en) * | 2002-11-01 | 2002-12-11 | Zoolife Internat Ltd | Gel feed |
JP2004210895A (ja) * | 2002-12-27 | 2004-07-29 | Immudyne Japan:Kk | 免疫機能を有する可能性β−グルカンの製造方法及び用途 |
CA2514544A1 (fr) * | 2003-01-29 | 2004-08-12 | Immudyne, Inc. | Immunostimulant pour animaux |
GB2399752A (en) * | 2003-03-26 | 2004-09-29 | Micap Plc | Pharmaceutical composition comprising a fungal cell or cell fragment as adjuvant |
EP1711058B1 (fr) | 2004-01-23 | 2021-09-15 | Eden Research Plc | Methode d'extermination de nematodes comprenant l'application d'un terpene |
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US7306818B2 (en) * | 2005-01-03 | 2007-12-11 | Promd Biotech Co., Ltd. | Method for preventing and/or treating viral infection in aquatic animals |
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JP5489462B2 (ja) * | 2005-10-24 | 2014-05-14 | ユニバーシティ オブ マサチューセッツ | 骨病状の遺伝子治療のための組成物およびそれらの使用法 |
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US8389485B2 (en) * | 2007-10-29 | 2013-03-05 | University Of Massachusetts | Encapsulated nanoparticles for nucleic acid delivery |
US20110008476A1 (en) * | 2007-11-13 | 2011-01-13 | Biotec Pharmacon Asa | Methods of Treating or Preventing Inflammatory Diseases of the Intestinal Tract |
EP2211900A1 (fr) * | 2007-11-19 | 2010-08-04 | Calanus AS | Compositions de copépode bioactives, procédés pour leur production, et utilisation de ces compositions pour prévenir ou traiter des hôtes infestés par des ectoparasites similaires au plan phylogénétique |
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WO2010078536A1 (fr) | 2009-01-05 | 2010-07-08 | Rxi Pharmaceuticals Corporation | Inhibition de pcsk9 par arni |
US20100267661A1 (en) * | 2009-03-17 | 2010-10-21 | Immudyne, Inc. | Beta glucans and methods of use thereof |
CN106074591B (zh) | 2010-03-24 | 2020-01-14 | 菲奥医药公司 | 眼部症候中的rna干扰 |
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US9242857B2 (en) | 2010-08-14 | 2016-01-26 | University Of Massachusetts | Yeast cell wall particles for receptor-targeted nanoparticle delivery |
WO2012120290A2 (fr) | 2011-03-04 | 2012-09-13 | Sana Pharma As | Formulations cosmétiques |
GB201220940D0 (en) | 2012-11-21 | 2013-01-02 | Eden Research Plc | Method P |
US20160278367A1 (en) | 2013-11-21 | 2016-09-29 | Eden Research Plc | Pesticidal Composition |
CA2932753A1 (fr) | 2013-12-04 | 2015-06-11 | Rxi Pharmaceuticals Corporation | Methodes de traitement de cicatrisation a l'aide d'oligonucleotides chimiquement modifies |
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US20170051290A1 (en) | 2014-05-01 | 2017-02-23 | Rxi Pharmaceuticals Corporation | Methods for treatment of disorders in the front of the eye utilizing nucleic acid molecules |
EP3188799B1 (fr) | 2014-09-05 | 2022-07-06 | Phio Pharmaceuticals Corp. | Méthodes de traitement de troubles cutanés et du vieillissement à l'aide d'acides nucléiques ciblant tyr ou mmp1 |
AU2015364508A1 (en) | 2014-12-18 | 2017-07-06 | Alnylam Pharmaceuticals, Inc. | ReversirTM compounds |
GB201501793D0 (en) | 2015-02-03 | 2015-03-18 | Eden Research Plc | Encapsulation of high potency active agents |
WO2017007825A1 (fr) | 2015-07-06 | 2017-01-12 | Rxi Pharmaceuticals Corporation | Procédés pour le traitement de troubles neurologiques à l'aide d'une petite molécule synergique et approche thérapeutique utilisant des acides nucléiques |
JP6983752B2 (ja) | 2015-07-06 | 2021-12-17 | フィオ ファーマシューティカルズ コーポレーションPhio Pharmaceuticals Corp. | スーパーオキシドディスムターゼ1(sod1)を標的とする核酸分子 |
EP3138573A1 (fr) | 2015-07-09 | 2017-03-08 | Danstar Ferment AG | Compositions et procédés de stimulation de réponses immunitaires chez l'homme et/ou un animal |
JP2018531037A (ja) | 2015-10-19 | 2018-10-25 | アールエックスアイ ファーマシューティカルズ コーポレーション | 長い非コードrnaを標的とする減少したサイズの自己送達型核酸化合物 |
CN106719136A (zh) * | 2016-11-30 | 2017-05-31 | 蚌埠市渔歌农业科技有限公司 | 一种防治鲶鱼病害的养殖方法 |
JP6530846B1 (ja) * | 2018-10-09 | 2019-06-12 | アサヒグループホールディングス株式会社 | 免疫賦活剤及び感染予防方法 |
US20230002766A1 (en) | 2019-11-08 | 2023-01-05 | Phio Pharmaceuticals Corp. | Chemically modified oligonucleotides targeting bromodomain containing protein 4 (brd4) for immunotherapy |
WO2022244580A1 (fr) * | 2021-05-21 | 2022-11-24 | アサヒグループホールディングス株式会社 | Immunostimulateur et procédé de production d'une composition de glucane |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3301848A (en) * | 1962-10-30 | 1967-01-31 | Pillsbury Co | Polysaccharides and methods for production thereof |
GB2076418A (en) * | 1980-05-22 | 1981-12-02 | Sankyo Co | Hydrolyzed polysaccharide |
SE456911B (sv) * | 1983-12-19 | 1988-11-14 | Olle Larm | Vattenloeslig, aminerad beta-1,3-bunden d-glukan och makrofagstimulerande komposition innehaallande densamma |
JPS6120561A (ja) * | 1984-07-09 | 1986-01-29 | 住友ベークライト株式会社 | 医療用吸着剤 |
US4810646A (en) * | 1984-11-28 | 1989-03-07 | Massachusetts Institute Of Technology | Glucan compositions and process for preparation thereof |
US4739046A (en) * | 1985-08-19 | 1988-04-19 | Luzio Nicholas R Di | Soluble phosphorylated glucan |
JPS6337801A (ja) * | 1986-07-31 | 1988-02-18 | Matsushita Electric Ind Co Ltd | タ−ンテ−ブル |
CA1330303C (fr) * | 1989-02-20 | 1994-06-21 | Libor Henry Nikl | Composition et methode permettant d'accroitre l'efficacite d'un vaccin pour les poissons |
-
1991
- 1991-04-12 CA CA002040374A patent/CA2040374C/fr not_active Expired - Lifetime
- 1991-06-26 AU AU79338/91A patent/AU628752B2/en not_active Expired
- 1991-07-04 JP JP3164603A patent/JP2828799B2/ja not_active Expired - Lifetime
- 1991-07-04 DE DE69128308T patent/DE69128308T2/de not_active Expired - Lifetime
- 1991-07-04 DK DK91111143T patent/DK0466037T3/da active
- 1991-07-04 ES ES91111143T patent/ES2109929T3/es not_active Expired - Lifetime
- 1991-07-04 EP EP91111143A patent/EP0466037B1/fr not_active Expired - Lifetime
- 1991-07-04 AT AT91111143T patent/ATE160787T1/de not_active IP Right Cessation
- 1991-07-05 NO NO19912645A patent/NO305705B1/no not_active IP Right Cessation
- 1991-07-05 FI FI913275A patent/FI104537B/fi not_active IP Right Cessation
-
1994
- 1994-02-02 US US08/190,435 patent/US5401727A/en not_active Expired - Lifetime
-
1998
- 1998-02-12 GR GR980400302T patent/GR3026130T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2040374C (fr) | 1998-06-16 |
NO912645L (no) | 1992-01-07 |
FI104537B (fi) | 2000-02-29 |
JP2828799B2 (ja) | 1998-11-25 |
FI913275A (fi) | 1992-01-07 |
AU628752B2 (en) | 1992-09-17 |
FI913275A0 (fi) | 1991-07-05 |
GR3026130T3 (en) | 1998-05-29 |
US5401727A (en) | 1995-03-28 |
JPH04253703A (ja) | 1992-09-09 |
DE69128308D1 (de) | 1998-01-15 |
CA2040374A1 (fr) | 1992-01-07 |
DE69128308T2 (de) | 1998-03-26 |
DK0466037T3 (da) | 1998-08-10 |
EP0466037A3 (en) | 1992-10-28 |
EP0466037A2 (fr) | 1992-01-15 |
AU7933891A (en) | 1992-01-23 |
EP0466037B1 (fr) | 1997-12-03 |
NO912645D0 (no) | 1991-07-05 |
ES2109929T3 (es) | 1998-02-01 |
ATE160787T1 (de) | 1997-12-15 |
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