NO305318B1 - Heterocykliske forbindelser og anvendelser derav - Google Patents
Heterocykliske forbindelser og anvendelser deravInfo
- Publication number
- NO305318B1 NO305318B1 NO950009A NO950009A NO305318B1 NO 305318 B1 NO305318 B1 NO 305318B1 NO 950009 A NO950009 A NO 950009A NO 950009 A NO950009 A NO 950009A NO 305318 B1 NO305318 B1 NO 305318B1
- Authority
- NO
- Norway
- Prior art keywords
- group
- substituted
- compound
- alkyl
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929214185A GB9214185D0 (en) | 1992-07-03 | 1992-07-03 | Novel compounds |
GB929227030A GB9227030D0 (en) | 1992-12-29 | 1992-12-29 | Novel compounds |
GB939311027A GB9311027D0 (en) | 1993-05-28 | 1993-05-28 | Novel compounds |
PCT/GB1993/001363 WO1994001420A1 (en) | 1992-07-03 | 1993-06-29 | Heterocyclic compounds as pharmaceutical |
Publications (3)
Publication Number | Publication Date |
---|---|
NO950009D0 NO950009D0 (no) | 1995-01-02 |
NO950009L NO950009L (no) | 1995-03-02 |
NO305318B1 true NO305318B1 (no) | 1999-05-10 |
Family
ID=27266276
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO950009A NO305318B1 (no) | 1992-07-03 | 1995-01-02 | Heterocykliske forbindelser og anvendelser derav |
NO990227A NO990227D0 (no) | 1992-07-03 | 1999-01-19 | Heterocykliske forbindelser som farmas°ytika |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO990227A NO990227D0 (no) | 1992-07-03 | 1999-01-19 | Heterocykliske forbindelser som farmas°ytika |
Country Status (19)
Country | Link |
---|---|
US (2) | US6048883A (de) |
EP (2) | EP1000938A1 (de) |
JP (1) | JPH07508747A (de) |
KR (1) | KR950702545A (de) |
CN (2) | CN1042532C (de) |
AT (1) | ATE207470T1 (de) |
AU (1) | AU678974B2 (de) |
CA (1) | CA2139442A1 (de) |
CZ (1) | CZ1095A3 (de) |
DE (1) | DE69331010D1 (de) |
FI (1) | FI950016A (de) |
HU (1) | HUT71247A (de) |
MX (1) | MX9303981A (de) |
NO (2) | NO305318B1 (de) |
NZ (1) | NZ253742A (de) |
PL (2) | PL176885B1 (de) |
RU (1) | RU2134686C1 (de) |
SK (1) | SK695A3 (de) |
WO (1) | WO1994001420A1 (de) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9311661D0 (en) * | 1993-06-05 | 1993-07-21 | Smithkline Beecham Plc | Novel compounds |
GB9311644D0 (en) * | 1993-06-05 | 1993-07-21 | Smithkline Beecham Plc | Novel compounds |
GB9315148D0 (en) * | 1993-07-22 | 1993-09-08 | Smithkline Beecham Plc | Novel compounds |
GB9326171D0 (en) * | 1993-12-22 | 1994-02-23 | Smithkline Beecham Plc | Novel compounds |
WO1996004261A1 (en) * | 1994-07-29 | 1996-02-15 | Smithkline Beecham Plc | Benzoxazoles and pryridine derivatives useful in the treatment of the type ii diabetes |
CN1158123A (zh) * | 1994-07-29 | 1997-08-27 | 史密丝克莱恩比彻姆有限公司 | 用于治疗ii型糖尿病的苯并噁唑吡啶衍生物 |
GB9600464D0 (en) * | 1996-01-09 | 1996-03-13 | Smithkline Beecham Plc | Novel method |
US6090836A (en) * | 1996-02-02 | 2000-07-18 | Merck & Co., Inc. | Benzisoxazole-derived antidiabetic compounds |
US6020382A (en) * | 1996-02-02 | 2000-02-01 | Merck & Co., Inc. | Method of treating diabetes and related disease states |
US5847008A (en) * | 1996-02-02 | 1998-12-08 | Merck & Co., Inc. | Method of treating diabetes and related disease states |
US5859051A (en) * | 1996-02-02 | 1999-01-12 | Merck & Co., Inc. | Antidiabetic agents |
GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
US6090839A (en) * | 1996-12-23 | 2000-07-18 | Merck & Co., Inc. | Antidiabetic agents |
US6160000A (en) * | 1996-12-23 | 2000-12-12 | Merck & Co., Inc. | Antidiabetic agents based on aryl and heteroarylacetic acids |
BR9810142A (pt) | 1997-06-18 | 2000-08-08 | Smithkline Beecham Plc | Tratamento de diabete com tiazolidinadiona e sulfonil-uréia |
CN1280574A (zh) | 1997-10-27 | 2001-01-17 | 雷迪研究基金会 | 新的杂环化合物及其在医药中的应用、它们的制备方法和含有它们的药物组合物 |
BR9812770A (pt) | 1997-10-27 | 2000-12-12 | Reddy Research Foundation | Compostos bicìclicos, processo para seu preparo e composições farmacêuticas contendo os mesmos |
US6265401B1 (en) | 1997-10-27 | 2001-07-24 | Reddy-Cheminor, Inc. | Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them |
US6440961B1 (en) | 1997-10-27 | 2002-08-27 | Dr. Reddy's Research Foundation | Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
PL193086B1 (pl) * | 1997-10-27 | 2007-01-31 | Reddys Lab Ltd Dr | Nowe związki tricykliczne i związki pośrednie, sposób ich wytwarzania, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie |
GB2380997B (en) * | 1997-10-27 | 2003-07-02 | Reddys Lab Ltd Dr | Novel aryl-oxysubstituted alkyl carboxylic acids; process for their preparation and pharmaceutical compositions containing them |
US6444816B1 (en) | 1997-10-27 | 2002-09-03 | Dr. Reddy's Research Foundation | Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof |
US6369067B1 (en) | 1997-10-27 | 2002-04-09 | Dr. Reddy's Research Foundation | Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
WO1999019313A1 (en) * | 1997-10-27 | 1999-04-22 | Dr. Reddy's Research Foundation | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them |
EP1073643B1 (de) * | 1998-04-23 | 2004-12-29 | Dr. Reddy's Laboratories Ltd. | Heterozyklische verbindungen,und deren verwendung in arzneimittel,verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen |
SE9801992D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
EP1131070B1 (de) | 1998-11-12 | 2008-09-03 | SmithKline Beecham plc | Arzneimittel zur gesteuerten freisetzung eines insulin sensibilisators und metformin |
DZ2937A1 (fr) | 1998-11-12 | 2004-03-15 | Smithkline Beecham Plc | Compositions nouvelles de sensibilidants à l'insuline. |
US7000106B2 (en) * | 1999-03-26 | 2006-02-14 | Siemens Communications, Inc. | Methods and apparatus for kernel mode encryption of computer telephony |
US6972294B1 (en) | 1999-04-20 | 2005-12-06 | Novo Nordisk, A/S | Compounds, their preparation and use |
JP2003508389A (ja) | 1999-08-27 | 2003-03-04 | エリ リリー アンド カンパニー | ビアリール−オキサ(チア)ゾール誘導体およびそのpparモジュレーターとしての使用 |
SE9904415D0 (sv) * | 1999-12-03 | 1999-12-03 | Astra Ab | New process |
NZ520402A (en) * | 2000-01-19 | 2006-04-28 | Cadila Healthcare Ltd | Novel compounds having hypolipedemic, hypocholesteremic activites, process for their preparation and pharmaceutical compositions containing them |
MXPA02007295A (es) * | 2000-01-28 | 2002-11-29 | Novo Nordisk As | Derivados de acido propionico alquinilsubstituidos y su uso contra diabetes y obesidad. |
US6569901B2 (en) | 2000-01-28 | 2003-05-27 | Novo Nordisk A/S | Alkynyl-substituted propionic acid derivatives, their preparation and use |
US6555577B1 (en) | 2000-01-28 | 2003-04-29 | Novo Nordisk A/S | Compounds, their preparation and use |
US6509374B2 (en) | 2000-04-17 | 2003-01-21 | Novo Nordisk A/S | Compounds, their preparation and use |
GB0014969D0 (en) | 2000-06-19 | 2000-08-09 | Smithkline Beecham Plc | Novel method of treatment |
US6559335B2 (en) | 2000-09-22 | 2003-05-06 | Dr. Reddy's Laboratories Limited | Process for the preparation of 3-aryl-2-hydroxy propanoic acid |
TWI311133B (en) | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
KR100654516B1 (ko) | 2001-05-15 | 2006-12-05 | 에프. 호프만-라 로슈 아게 | 당뇨병 치료에서 ppar-알파 및 -감마 활성제로서사용하기 위한 카복실산 치환된 옥사졸 유도체 |
US6987123B2 (en) * | 2001-07-26 | 2006-01-17 | Cadila Healthcare Limited | Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine |
US6869967B2 (en) | 2001-07-30 | 2005-03-22 | Novo Nordisk A/S | Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives |
US7067530B2 (en) | 2001-07-30 | 2006-06-27 | Novo Nordisk A/S | Compounds, their preparation and use |
US7371777B2 (en) | 2001-08-17 | 2008-05-13 | Eisai Co., Ltd. | Cyclic compound and PPAR agonist |
US7220877B2 (en) | 2001-10-17 | 2007-05-22 | Novo Nordisk A/S | Compounds, their preparation and use |
AU2002351752A1 (en) | 2001-12-29 | 2003-07-30 | Novo Nordisk A/S | Combined use of a glp-1 compound and another drug for treating dyslipidemia |
US8216609B2 (en) * | 2002-08-05 | 2012-07-10 | Torrent Pharmaceuticals Limited | Modified release composition of highly soluble drugs |
US8268352B2 (en) * | 2002-08-05 | 2012-09-18 | Torrent Pharmaceuticals Limited | Modified release composition for highly soluble drugs |
US7232828B2 (en) | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
JP4533141B2 (ja) * | 2002-08-30 | 2010-09-01 | エフ.ホフマン−ラ ロシュ アーゲー | PPARα及びPPARγアゴニストとしての新規2−アリールチアゾール化合物 |
BR0314261A (pt) | 2002-09-12 | 2005-07-26 | Hoffmann La Roche | Compostos, processo de preparação de um composto, composição farmacêutica que compreende o mesmo, utilização de um composto, método para tratamento e/ou profilaxia de enfermidades e utilização e/ou método de tratamento |
CN100343250C (zh) | 2002-11-25 | 2007-10-17 | 霍夫曼-拉罗奇有限公司 | 吲哚衍生物 |
US7816385B2 (en) | 2002-12-20 | 2010-10-19 | High Point Pharmaceuticals, Llc | Dimeric dicarboxylic acid derivatives, their preparation and use |
US6653334B1 (en) | 2002-12-27 | 2003-11-25 | Kowa Co., Ltd. | Benzoxazole compound and pharmaceutical composition containing the same |
JP2007500219A (ja) * | 2003-05-16 | 2007-01-11 | アンビット バイオサイエンシス コーポレーション | 複素環化合物およびその使用法 |
US20050182125A1 (en) * | 2003-05-16 | 2005-08-18 | Ambit Biosciences Corporation | Pyrrole compounds and uses thereof |
US20040248972A1 (en) * | 2003-05-16 | 2004-12-09 | Ambit Biosciences Corporation | Compounds and uses thereof |
CA2598934A1 (en) * | 2005-02-25 | 2006-08-31 | Takeda Pharmaceutical Company Limited | Pyridyl acetic acid compounds |
WO2008117982A1 (en) * | 2007-03-28 | 2008-10-02 | Crystal Genomics, Inc. | Heterocyclic carboxylic acid derivatives and pharmaceutical composition for inhibiting lipid accumulation containing same |
EP2154131A4 (de) * | 2007-04-26 | 2011-09-21 | Pharmafrontier Co Ltd | Inhibitor des g-protein-gekoppelten rezeptors und pharmazeutisches produkt |
CN107056671A (zh) | 2011-01-31 | 2017-08-18 | 卡迪拉保健有限公司 | 脂肪代谢障碍的治疗 |
EA201592020A1 (ru) | 2013-04-22 | 2016-05-31 | Кадила Хелзкэр Лимитед | Новая композиция для неалкогольной жировой болезни печени (нажбп) |
EP3004053B1 (de) | 2013-05-30 | 2021-03-24 | Cadila Healthcare Limited | Verfahren zur herstellung von pyrrolen mit hypolipidämischer hypocholesterämischer aktivität |
TW201636015A (zh) | 2013-07-05 | 2016-10-16 | 卡地拉保健有限公司 | 協同性組成物 |
IN2013MU02470A (de) | 2013-07-25 | 2015-06-26 | Cadila Healthcare Ltd | |
CN103467406B (zh) * | 2013-09-03 | 2014-12-17 | 浙江医药高等专科学校 | 卤素取代的四氮唑羧酸类化合物、其制备方法和用途 |
CN103467409B (zh) * | 2013-09-03 | 2015-01-07 | 浙江医药高等专科学校 | 取代的四氮唑羧酸类化合物及其用途 |
CN103467407B (zh) * | 2013-09-03 | 2015-04-22 | 浙江医药高等专科学校 | 四氮唑羧酸类化合物及其用途 |
CN103467408B (zh) * | 2013-09-03 | 2015-01-21 | 浙江医药高等专科学校 | 一类四氮唑羧酸类化合物及其用途 |
CN103467405B (zh) * | 2013-09-03 | 2015-01-07 | 浙江医药高等专科学校 | 一类四氮唑羧酸类化合物、其制备方法和用途 |
IN2013MU02905A (de) | 2013-09-06 | 2015-07-03 | Cadila Healthcare Ltd | |
WO2017064635A2 (en) | 2015-10-14 | 2017-04-20 | Cadila Healthcare Limited | Pyrrole compound, compositions and process for preparation thereof |
US20180243263A1 (en) | 2016-12-09 | 2018-08-30 | Cadila Healthcare Ltd. | Treatment for primary biliary cholangitis |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE186724T1 (de) * | 1987-09-04 | 1999-12-15 | Beecham Group Plc | Substituierte thiazolidindionderivate |
US5194443A (en) * | 1987-09-04 | 1993-03-16 | Beecham Group P.L.C. | Compounds |
US5232925A (en) * | 1987-09-04 | 1993-08-03 | Beecham Group P.L.C. | Compounds |
US5089514A (en) * | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
GB9017218D0 (en) * | 1990-08-06 | 1990-09-19 | Beecham Group Plc | Novel compounds |
-
1993
- 1993-06-29 US US08/360,755 patent/US6048883A/en not_active Expired - Fee Related
- 1993-06-29 JP JP6503071A patent/JPH07508747A/ja active Pending
- 1993-06-29 SK SK6-95A patent/SK695A3/sk unknown
- 1993-06-29 NZ NZ253742A patent/NZ253742A/en unknown
- 1993-06-29 PL PL93316129A patent/PL176885B1/pl unknown
- 1993-06-29 EP EP99204395A patent/EP1000938A1/de not_active Withdrawn
- 1993-06-29 RU RU94046169A patent/RU2134686C1/ru active
- 1993-06-29 AU AU45068/93A patent/AU678974B2/en not_active Ceased
- 1993-06-29 DE DE69331010T patent/DE69331010D1/de not_active Expired - Lifetime
- 1993-06-29 CA CA002139442A patent/CA2139442A1/en not_active Abandoned
- 1993-06-29 CZ CZ9510A patent/CZ1095A3/cs unknown
- 1993-06-29 PL PL93307087A patent/PL174610B1/pl unknown
- 1993-06-29 HU HU9500006A patent/HUT71247A/hu unknown
- 1993-06-29 EP EP93914841A patent/EP0648212B1/de not_active Expired - Lifetime
- 1993-06-29 WO PCT/GB1993/001363 patent/WO1994001420A1/en not_active Application Discontinuation
- 1993-06-29 AT AT93914841T patent/ATE207470T1/de not_active IP Right Cessation
- 1993-06-29 KR KR1019940704886A patent/KR950702545A/ko not_active Application Discontinuation
- 1993-07-01 MX MX9303981A patent/MX9303981A/es not_active IP Right Cessation
- 1993-07-02 CN CN93109874A patent/CN1042532C/zh not_active Expired - Fee Related
-
1995
- 1995-01-02 NO NO950009A patent/NO305318B1/no not_active IP Right Cessation
- 1995-01-02 FI FI950016A patent/FI950016A/fi unknown
- 1995-06-02 US US08/458,335 patent/US5869495A/en not_active Expired - Fee Related
-
1998
- 1998-05-14 CN CN98108909A patent/CN1215724A/zh active Pending
-
1999
- 1999-01-19 NO NO990227A patent/NO990227D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
RU94046169A (ru) | 1996-10-27 |
SK695A3 (en) | 1995-07-11 |
CA2139442A1 (en) | 1994-01-20 |
CN1095716A (zh) | 1994-11-30 |
EP0648212A1 (de) | 1995-04-19 |
WO1994001420A1 (en) | 1994-01-20 |
ATE207470T1 (de) | 2001-11-15 |
CN1042532C (zh) | 1999-03-17 |
KR950702545A (ko) | 1995-07-29 |
JPH07508747A (ja) | 1995-09-28 |
NZ253742A (en) | 1997-06-24 |
NO990227L (no) | 1995-03-02 |
AU4506893A (en) | 1994-01-31 |
CZ1095A3 (en) | 1995-10-18 |
EP1000938A1 (de) | 2000-05-17 |
HU9500006D0 (en) | 1995-03-28 |
US5869495A (en) | 1999-02-09 |
NO950009D0 (no) | 1995-01-02 |
EP0648212B1 (de) | 2001-10-24 |
DE69331010D1 (de) | 2001-11-29 |
PL176885B1 (pl) | 1999-08-31 |
CN1215724A (zh) | 1999-05-05 |
HUT71247A (en) | 1995-11-28 |
MX9303981A (es) | 1994-04-29 |
PL174610B1 (pl) | 1998-08-31 |
RU2134686C1 (ru) | 1999-08-20 |
FI950016A0 (fi) | 1995-01-02 |
US6048883A (en) | 2000-04-11 |
NO950009L (no) | 1995-03-02 |
PL307087A1 (en) | 1995-05-02 |
AU678974B2 (en) | 1997-06-19 |
FI950016A (fi) | 1995-03-02 |
NO990227D0 (no) | 1999-01-19 |
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