NO301718B1 - Fremgangsmåte for fremstilling av et polypeptid med cytokinsynteseinhiberingsfaktoraktivitet - Google Patents

Fremgangsmåte for fremstilling av et polypeptid med cytokinsynteseinhiberingsfaktoraktivitet Download PDF

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Publication number
NO301718B1
NO301718B1 NO915115A NO915115A NO301718B1 NO 301718 B1 NO301718 B1 NO 301718B1 NO 915115 A NO915115 A NO 915115A NO 915115 A NO915115 A NO 915115A NO 301718 B1 NO301718 B1 NO 301718B1
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Norway
Prior art keywords
vol
amino acid
acid sequence
csif
cells
Prior art date
Application number
NO915115A
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English (en)
Norwegian (no)
Other versions
NO915115L (no
NO915115D0 (no
Inventor
Timothy R Mosmann
Kevin W Moore
Martha W Bond
Paulo J M Vieira
Original Assignee
Schering Corp
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Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO915115D0 publication Critical patent/NO915115D0/no
Publication of NO915115L publication Critical patent/NO915115L/no
Publication of NO301718B1 publication Critical patent/NO301718B1/no

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5428IL-10
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO915115A 1989-06-28 1991-12-27 Fremgangsmåte for fremstilling av et polypeptid med cytokinsynteseinhiberingsfaktoraktivitet NO301718B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37266789A 1989-06-28 1989-06-28
US45395189A 1989-12-20 1989-12-20
PCT/US1990/003554 WO1991000349A1 (en) 1989-06-28 1990-06-28 Cytokine synthesis inhibitory factor, antagonists thereof, and methods of using same

Publications (3)

Publication Number Publication Date
NO915115D0 NO915115D0 (no) 1991-12-27
NO915115L NO915115L (no) 1992-02-26
NO301718B1 true NO301718B1 (no) 1997-12-01

Family

ID=27005854

Family Applications (1)

Application Number Title Priority Date Filing Date
NO915115A NO301718B1 (no) 1989-06-28 1991-12-27 Fremgangsmåte for fremstilling av et polypeptid med cytokinsynteseinhiberingsfaktoraktivitet

Country Status (22)

Country Link
EP (2) EP0567450B1 (cs)
JP (1) JP2813063B2 (cs)
KR (1) KR0183035B1 (cs)
CN (3) CN1051393A (cs)
AT (1) ATE180833T1 (cs)
AU (1) AU635058B2 (cs)
CA (1) CA2062763C (cs)
CS (1) CS414591A3 (cs)
DE (1) DE69033143T2 (cs)
DK (1) DK0567450T3 (cs)
ES (1) ES2132068T3 (cs)
FI (1) FI107926B (cs)
GR (1) GR3030404T3 (cs)
HK (2) HK1040493B (cs)
HU (1) HU216310B (cs)
IL (1) IL94878A (cs)
NO (1) NO301718B1 (cs)
NZ (1) NZ234291A (cs)
PT (1) PT94514B (cs)
SG (1) SG52282A1 (cs)
TW (1) TW218383B (cs)
WO (1) WO1991000349A1 (cs)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827513A (en) * 1990-06-29 1998-10-27 Schering Corporation Methods of treating insulin-dependent diabetes mellitus by administration of IL-10
SK279556B6 (sk) * 1991-01-16 1998-12-02 Schering Corporation Liečivo na liečenie nádorov pacienta
US6106823A (en) * 1991-01-16 2000-08-22 Schering Corporation Treatment of neoplastic disease with interleukin-10
MX9200161A (es) * 1991-01-16 1992-07-01 Schering Corp Uso de interleucina-10 en inmunoterapia adoptiva de cancer
DE4122402A1 (de) * 1991-07-04 1993-01-07 Schering Ag Verwendung von interleukin 10 zur herstellung von arzneimitteln mit tumorhemmender wirksamkeit
DK0600970T3 (da) * 1991-08-06 2000-05-29 Schering Corp Anvendelse af interleukin-10-analoger eller -antagonister til behandling af endotoksin- eller superantigeninduceret tokscit
US5833976A (en) * 1991-08-06 1998-11-10 Schering Corporation Use of interleukin-10 (IL-10) to treat endotoxin- or superantigen-induced toxicity
WO1993017698A1 (en) * 1992-03-04 1993-09-16 Schering Corporation Use of interleukin-10 to suppress graft-vs.-host disease
US6277635B1 (en) 1992-03-04 2001-08-21 Schering Corporation Use of interleukin-10 to produce a population of suppressor cells
US6884410B1 (en) 1992-03-04 2005-04-26 Schering Corporation Methods for modulating antigen-specific immune responses
AU3801193A (en) * 1992-03-20 1993-10-21 Schering Corporation Use of interleukin-10 to induce the production of interleukin-1 receptor antagonist
EP0801951A3 (en) * 1992-08-20 1998-05-20 Schering Corporation Novel uses of Il-4 and/or Il-10, and antibodies against the same
US5601815A (en) * 1992-08-21 1997-02-11 Schering Corp IL-4 and IL-10 to downregulate delayed-type hypersensitivity and cytokine expresion by T-cells
JPH08501549A (ja) * 1992-09-18 1996-02-20 スケアリング コーポレイション Hiv感染された患者におけるtヘルパー細胞の免疫担当能力の回復
DK0662837T3 (da) * 1992-10-01 1999-11-08 Schering Corp Anvendelse af IL-10 til forhindring af insulinafhængig diabetes mellitus
TW381026B (en) * 1993-01-13 2000-02-01 Schering Corp Method of extracorporally activating cytolytic activity of peripheral blood mononuclear cells and pharmaceutical composition comprising the activated peripheral blood mononuclear cells
JPH08510719A (ja) * 1993-02-01 1996-11-12 ユニヴェルシテ リブル ドゥ ブリュッセル アンスティテュション ダンセニュマン ユニヴェルシテル 有効量のインターロイキン−10、その類似体および/または作動薬を含有する医薬組成物の使用
US5328989A (en) * 1993-03-05 1994-07-12 Schering-Plough Purification of human interleukin-10 from a cell culture medium
US5449688A (en) * 1993-03-30 1995-09-12 The United States Of America As Represented By The Department Of Health And Human Services Method of treating chronic inflammatory diseases
IL110413A0 (en) * 1993-07-26 1994-10-21 Schering Corp Agonists and antagonists of human interleukin-10
US5650060A (en) * 1994-01-28 1997-07-22 Minnesota Mining And Manufacturing Company Ionically conductive agent, system for cathodic protection of galvanically active metals, and method and apparatus for using same
CA2194444C (en) * 1994-07-05 2003-01-14 Christian Gronhoj Larsen Immunomodulators
US5770190A (en) * 1995-07-14 1998-06-23 Schering Corporation Method of treatment of acute leukemia with inteleukin-10
CN101307106B (zh) * 1995-12-13 2013-06-12 儿童医学中心公司 内皮细胞增殖抑制剂及其应用方法
AU4385696A (en) * 1996-01-18 1997-08-11 Christian Gronhoj Larsen Synthetic il-10 analogues
WO1997038695A1 (en) * 1996-04-17 1997-10-23 Prendergast Patrick T Dhea combination therapy
WO1998009644A2 (en) * 1996-09-06 1998-03-12 Schering Corporation Method for lowering cholesterol levels
WO1998047516A1 (en) * 1997-04-17 1998-10-29 Prendergast Patrick T Combination therapy utilising 17-ketosteroids and interleukin inhibitors, or interleukin-10 potionally with interleukin inhibitors
US6465176B1 (en) * 1998-10-02 2002-10-15 Message Pharmaceuticals, Inc. Method for identifying compounds RNA/RNA binding protein interactions
AU5047600A (en) * 1999-05-27 2000-12-18 Schering Corporation Mammalian interleukin-10 homologs: il-d110 and il-d210
AU8729101A (en) 2000-03-31 2001-10-15 Idec Pharma Corp Combined use of anti-cytokine antibodies or antagonists and anti-CD20 for the treatment of B cell lymphoma
US8491912B2 (en) 2010-06-16 2013-07-23 Allergan, Inc. Methods of treating ocular and other diseases with Syn-134R polypeptide
WO2017160599A1 (en) 2016-03-14 2017-09-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of cd300b antagonists to treat sepsis and septic shock
JP2020508436A (ja) 2016-12-07 2020-03-19 プロジェニティ, インコーポレイテッド 胃腸管の検出方法、装置およびシステム
CA3054156A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Treatment of a disease of the gastrointestinal tract with il-10 or an il-10 agonist
US20220249814A1 (en) 2018-11-19 2022-08-11 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
EP4309722A3 (en) 2019-12-13 2024-08-07 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
GB202003428D0 (en) * 2020-03-10 2020-04-22 Univ Dundee IL-10 mutiens

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78197A (en) * 1985-03-22 1991-07-18 Genentech Inc Nucleic acid encoding tgf-beta and its uses
IE62650B1 (en) * 1989-08-04 1995-02-22 David & Sons Ltd Dispensing apparatus
KR960015199B1 (ko) * 1989-12-20 1996-11-01 쉐링 코포레이션 인터페론-γ의 억제제로서의 BCRF1 단백질

Also Published As

Publication number Publication date
CA2062763C (en) 2010-01-05
CS414591A3 (en) 1992-12-16
DE69033143D1 (de) 1999-07-08
IL94878A0 (en) 1991-04-15
JPH04502560A (ja) 1992-05-14
ATE180833T1 (de) 1999-06-15
IL94878A (en) 2003-01-12
HU216310B (hu) 1999-06-28
DK0567450T3 (da) 1999-12-13
AU635058B2 (en) 1993-03-11
EP0567450B1 (en) 1999-06-02
EP0405980A1 (en) 1991-01-02
HUT61048A (en) 1992-11-30
NZ234291A (en) 1992-11-25
CN1318589C (zh) 2007-05-30
HU906705D0 (en) 1992-03-30
GR3030404T3 (en) 1999-09-30
KR920701437A (ko) 1992-08-11
HK1008834A1 (en) 1999-05-21
KR0183035B1 (ko) 1999-04-01
NO915115L (no) 1992-02-26
CN1317343A (zh) 2001-10-17
SG52282A1 (en) 1998-09-28
HK1040531A1 (en) 2002-06-14
FI107926B (fi) 2001-10-31
FI916126A0 (fi) 1991-12-27
NO915115D0 (no) 1991-12-27
HK1040493B (zh) 2005-12-16
CN1198642C (zh) 2005-04-27
PT94514B (pt) 1998-02-27
ES2132068T3 (es) 1999-08-16
EP0567450A1 (en) 1993-11-03
JP2813063B2 (ja) 1998-10-22
HK1040493A1 (en) 2002-06-14
CN1051393A (zh) 1991-05-15
DE69033143T2 (de) 1999-10-21
WO1991000349A1 (en) 1991-01-10
HK1040531B (zh) 2008-01-11
CN1317569A (zh) 2001-10-17
PT94514A (pt) 1991-04-18
AU6077090A (en) 1991-01-17
TW218383B (cs) 1994-01-01
CA2062763A1 (en) 1990-12-29

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