NO300197B1 - Preparater omfattende tramadol og et opioid - Google Patents
Preparater omfattende tramadol og et opioid Download PDFInfo
- Publication number
- NO300197B1 NO300197B1 NO923453A NO923453A NO300197B1 NO 300197 B1 NO300197 B1 NO 300197B1 NO 923453 A NO923453 A NO 923453A NO 923453 A NO923453 A NO 923453A NO 300197 B1 NO300197 B1 NO 300197B1
- Authority
- NO
- Norway
- Prior art keywords
- tramadol
- opioid
- oxycodone
- codeine
- preparations
- Prior art date
Links
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title claims description 50
- 229960004380 tramadol Drugs 0.000 title claims description 50
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 title claims description 50
- 238000002360 preparation method Methods 0.000 title description 36
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims description 42
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims description 38
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims description 24
- 229960002085 oxycodone Drugs 0.000 claims description 24
- 229960004126 codeine Drugs 0.000 claims description 21
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims description 18
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims description 17
- 229960000240 hydrocodone Drugs 0.000 claims description 17
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims description 17
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 13
- PPKXEPBICJTCRU-XMZRARIVSA-N (R,R)-tramadol hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-XMZRARIVSA-N 0.000 claims description 10
- 229960003107 tramadol hydrochloride Drugs 0.000 claims description 10
- 239000003937 drug carrier Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- 230000000202 analgesic effect Effects 0.000 description 17
- 239000003814 drug Substances 0.000 description 13
- 229940079593 drug Drugs 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 239000011550 stock solution Substances 0.000 description 12
- 241000699670 Mus sp. Species 0.000 description 8
- 239000000730 antalgic agent Substances 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 6
- 239000000890 drug combination Substances 0.000 description 6
- 239000000014 opioid analgesic Substances 0.000 description 6
- 229940005483 opioid analgesics Drugs 0.000 description 6
- DKSZLDSPXIWGFO-BLOJGBSASA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 description 5
- 229940035676 analgesics Drugs 0.000 description 5
- 229960004415 codeine phosphate Drugs 0.000 description 5
- 239000012458 free base Substances 0.000 description 5
- 206010022998 Irritability Diseases 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229940121367 non-opioid analgesics Drugs 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 2
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 2
- 206010038678 Respiratory depression Diseases 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229960005181 morphine Drugs 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- BQNSLJQRJAJITR-UHFFFAOYSA-N 1,1,2-trichloro-1,2-difluoroethane Chemical compound FC(Cl)C(F)(Cl)Cl BQNSLJQRJAJITR-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 description 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010060800 Hot flush Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- 229940127450 Opioid Agonists Drugs 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 241000011102 Thera Species 0.000 description 1
- LLRZWSLBLGNDFM-XFKAJCMBSA-N [(4R,4aS,7aR,12bS)-9-methoxy-3-methyl-7-oxo-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-4a-yl] hydrogen sulfate Chemical compound S(=O)(=O)(O)O[C@@]12CCC([C@H]3[C@]11C=4C(=C(C=CC=4C[C@H]2N(C)CC1)OC)O3)=O LLRZWSLBLGNDFM-XFKAJCMBSA-N 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 208000029618 autoimmune pulmonary alveolar proteinosis Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- IFKLAQQSCNILHL-QHAWAJNXSA-N butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 description 1
- 229960001113 butorphanol Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 229960000920 dihydrocodeine Drugs 0.000 description 1
- RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000003979 granulating agent Substances 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229960001797 methadone Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000003402 opiate agonist Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 229960003617 oxycodone hydrochloride Drugs 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000000294 tussive effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Dental Preparations (AREA)
- Fats And Perfumes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75592391A | 1991-09-06 | 1991-09-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO923453D0 NO923453D0 (no) | 1992-09-04 |
| NO923453L NO923453L (no) | 1993-03-08 |
| NO300197B1 true NO300197B1 (no) | 1997-04-28 |
Family
ID=25041253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO923453A NO300197B1 (no) | 1991-09-06 | 1992-09-04 | Preparater omfattende tramadol og et opioid |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5468744A (ko) |
| EP (1) | EP0534628B1 (ko) |
| JP (1) | JP3244540B2 (ko) |
| KR (1) | KR100236666B1 (ko) |
| CN (1) | CN1051705C (ko) |
| AT (1) | ATE145330T1 (ko) |
| AU (1) | AU657351B2 (ko) |
| CA (1) | CA2077637C (ko) |
| DE (1) | DE69215316T2 (ko) |
| DK (1) | DK0534628T3 (ko) |
| ES (1) | ES2096726T3 (ko) |
| GR (1) | GR3022515T3 (ko) |
| HU (1) | HU217584B (ko) |
| IL (1) | IL103070A (ko) |
| MX (1) | MX9205106A (ko) |
| MY (1) | MY110317A (ko) |
| NO (1) | NO300197B1 (ko) |
| NZ (1) | NZ244250A (ko) |
| PH (1) | PH31112A (ko) |
| TW (1) | TW271394B (ko) |
| ZA (1) | ZA926732B (ko) |
| ZW (1) | ZW14392A1 (ko) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100243956B1 (ko) | 1991-09-06 | 2000-03-02 | 랄프 알. 팔로 | 트라마돌 물질 및 아세트아미노펜을 포함하는 통증 치료용 약제학적 조성물 |
| US5968551A (en) | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
| US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| IL109460A (en) | 1993-05-10 | 1998-03-10 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
| IL110014A (en) | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
| US7740881B1 (en) | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release |
| US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
| KR100354702B1 (ko) | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | 약학조성물의제조방법및서방형조성물 |
| US5891471A (en) | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
| US5843480A (en) | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
| GB9422154D0 (en) | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
| US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
| US6017963A (en) * | 1995-11-14 | 2000-01-25 | Euro-Celtique, S.A. | Formulation for intranasal administration |
| GB9523566D0 (en) * | 1995-11-17 | 1996-01-17 | Euro Celtique Sa | Pharmaceutical formulation |
| DE19601744C2 (de) * | 1996-01-19 | 1998-04-16 | Gruenenthal Gmbh | Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol |
| DE19641576C1 (de) * | 1996-10-09 | 1998-05-07 | Gruenenthal Gmbh | Kombinationspräparat enthaltend Tramadol und einen Calcium-Kanal Antagonisten |
| DE19712398A1 (de) * | 1997-03-25 | 1998-10-01 | Gruenenthal Gmbh | Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel |
| WO1999003820A1 (en) | 1997-07-15 | 1999-01-28 | Russinsky Limited | Tramadol, salts thereof and process for their preparation |
| US6156342A (en) * | 1998-05-26 | 2000-12-05 | Andex Pharmaceuticals, Inc. | Controlled release oral dosage form |
| US6608073B1 (en) | 1998-10-14 | 2003-08-19 | New Millennium Pharmaceutical Research, Inc. | Intranasal codeine for the rapid suppression of cough and rapid relief of pain |
| US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
| DE19918325A1 (de) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion |
| US20030118641A1 (en) * | 2000-07-27 | 2003-06-26 | Roxane Laboratories, Inc. | Abuse-resistant sustained-release opioid formulation |
| EP1210118B1 (en) | 1999-08-20 | 2004-12-08 | Ortho-McNeil Pharmaceutical, Inc. | Composition comprising a tramadol material and an anticonvulsant drug |
| DE19940740A1 (de) * | 1999-08-31 | 2001-03-01 | Gruenenthal Gmbh | Pharmazeutische Salze |
| PE20010623A1 (es) | 1999-10-05 | 2001-07-07 | Gruenenthal Chemie | Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria |
| RU2230556C2 (ru) | 1999-10-29 | 2004-06-20 | Эро-Селтик, С.А. | Препаративные формы гидрокодона с контролируемым высвобождением |
| US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
| WO2001034125A2 (en) * | 1999-11-09 | 2001-05-17 | Darwin Discovery Limited | Therapeutic use and formulation of (-)-tramadol |
| AU2002227383B2 (en) | 2000-10-30 | 2004-07-08 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
| US6974839B2 (en) | 2001-03-16 | 2005-12-13 | Dmi Biosciences, Inc. | Method of delaying ejaculation |
| UA81224C2 (uk) | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
| US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
| AU2002364517A1 (en) | 2001-11-30 | 2003-06-17 | Sepracor Inc. | Tramadol analogs and uses thereof |
| EP1364649A1 (en) * | 2002-05-23 | 2003-11-26 | Cilag AG | Adduct of topiramate and tramadol hydrochioride and uses thereof |
| US20040058946A1 (en) * | 2002-07-05 | 2004-03-25 | Buchwald Stephen L. | Abuse-resistant prodrugs of oxycodone and other pharmaceuticals |
| TW200427448A (en) * | 2002-12-13 | 2004-12-16 | Cilag Ag | Controlled release preparations comprising tramadol and topiramate |
| WO2007104108A1 (en) * | 2006-03-15 | 2007-09-20 | Graydon,, Cameron | Non-codeine opioid analgesic process and formulations |
| LT2596784T (lt) * | 2007-11-23 | 2017-03-27 | Grünenthal GmbH | Tapentadolio kompozicijos |
| US20090264454A1 (en) * | 2008-04-16 | 2009-10-22 | Nickell Robert P | Combined hydrocodone and analgesic formulation and method |
| US20100003322A1 (en) * | 2008-07-03 | 2010-01-07 | Lai Felix S | Enteric coated hydrophobic matrix formulation |
| US20100190752A1 (en) | 2008-09-05 | 2010-07-29 | Gruenenthal Gmbh | Pharmaceutical Combination |
| US10702485B2 (en) | 2011-07-09 | 2020-07-07 | Syntrix Biosystems Inc. | Compositions and methods for overcoming resistance to tramadol |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| AU2402392A (en) * | 1991-08-06 | 1993-03-02 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New anti-diarrheic agents |
| AU2062892A (en) * | 1991-08-16 | 1993-02-18 | Mcneil-Ppc, Inc. | Potentiation of antitussive effect of dextromethorphan |
-
1992
- 1992-09-04 EP EP92308076A patent/EP0534628B1/en not_active Expired - Lifetime
- 1992-09-04 ZA ZA926732A patent/ZA926732B/xx unknown
- 1992-09-04 DE DE69215316T patent/DE69215316T2/de not_active Expired - Lifetime
- 1992-09-04 HU HU9202845A patent/HU217584B/hu unknown
- 1992-09-04 NO NO923453A patent/NO300197B1/no not_active IP Right Cessation
- 1992-09-04 MX MX9205106A patent/MX9205106A/es unknown
- 1992-09-04 AU AU22185/92A patent/AU657351B2/en not_active Expired
- 1992-09-04 DK DK92308076.6T patent/DK0534628T3/da active
- 1992-09-04 PH PH44893A patent/PH31112A/en unknown
- 1992-09-04 CA CA002077637A patent/CA2077637C/en not_active Expired - Lifetime
- 1992-09-04 ZW ZW14392A patent/ZW14392A1/xx unknown
- 1992-09-04 MY MYPI92001591A patent/MY110317A/en unknown
- 1992-09-04 AT AT92308076T patent/ATE145330T1/de active
- 1992-09-04 ES ES92308076T patent/ES2096726T3/es not_active Expired - Lifetime
- 1992-09-05 CN CN92111382A patent/CN1051705C/zh not_active Expired - Lifetime
- 1992-09-05 KR KR1019920016227A patent/KR100236666B1/ko not_active IP Right Cessation
- 1992-09-06 IL IL10307092A patent/IL103070A/en not_active IP Right Cessation
- 1992-09-07 NZ NZ244250A patent/NZ244250A/en not_active IP Right Cessation
- 1992-09-07 JP JP26269392A patent/JP3244540B2/ja not_active Expired - Lifetime
- 1992-11-10 TW TW081108967A patent/TW271394B/zh not_active IP Right Cessation
-
1994
- 1994-06-30 US US08/268,382 patent/US5468744A/en not_active Expired - Lifetime
-
1997
- 1997-02-12 GR GR960403334T patent/GR3022515T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100236666B1 (ko) | 2000-03-02 |
| MY110317A (en) | 1998-04-30 |
| TW271394B (ko) | 1996-03-01 |
| NO923453D0 (no) | 1992-09-04 |
| ES2096726T3 (es) | 1997-03-16 |
| AU657351B2 (en) | 1995-03-09 |
| JPH06107540A (ja) | 1994-04-19 |
| HUT63556A (en) | 1993-09-28 |
| CN1051705C (zh) | 2000-04-26 |
| EP0534628A1 (en) | 1993-03-31 |
| US5468744A (en) | 1995-11-21 |
| JP3244540B2 (ja) | 2002-01-07 |
| HU217584B (hu) | 2000-02-28 |
| PH31112A (en) | 1998-02-23 |
| ZA926732B (en) | 1994-03-04 |
| DE69215316D1 (de) | 1997-01-02 |
| IL103070A0 (en) | 1993-02-21 |
| HU9202845D0 (en) | 1992-11-30 |
| DE69215316T2 (de) | 1997-03-20 |
| DK0534628T3 (da) | 1996-12-09 |
| KR930005617A (ko) | 1993-04-20 |
| ATE145330T1 (de) | 1996-12-15 |
| EP0534628B1 (en) | 1996-11-20 |
| NO923453L (no) | 1993-03-08 |
| CN1071835A (zh) | 1993-05-12 |
| AU2218592A (en) | 1993-03-11 |
| CA2077637A1 (en) | 1993-03-07 |
| NZ244250A (en) | 1994-01-26 |
| GR3022515T3 (en) | 1997-05-31 |
| IL103070A (en) | 1996-10-16 |
| MX9205106A (es) | 1993-05-01 |
| ZW14392A1 (en) | 1994-05-11 |
| CA2077637C (en) | 2007-01-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO300197B1 (no) | Preparater omfattende tramadol og et opioid | |
| NO302736B1 (no) | Farmasöytisk preparat omfattende tramadol og ibuprofen | |
| HU219332B (hu) | Transz-(+)-2-[(dimetil-amino)-metil]-1-(3-metoxi-fenil)-ciklohexanolt és acetaminofent tartalmazó szinergetikus gyógyszerkészítmények | |
| EP0306060B1 (en) | Pharmaceutical products providing enhanced analgesia | |
| JP4925074B2 (ja) | ミルタザピンと１種以上の選択的セロトニン再取り込み阻害剤とを含む医薬組成物 | |
| US6043244A (en) | Method and composition for treating migraine | |
| NO332342B1 (no) | Farmasoytisk preparat omfattende en kombinasjon av tramadol materiale og et krampestillende medikament samt anvendelse derav | |
| HU178867B (en) | Process for preparing synergetic analgetic composition containing nalbuphine and acetaminophene | |
| US4322427A (en) | Analgetic compositions and methods of use | |
| US6326374B1 (en) | Compositions comprising GABA analogs and caffeine | |
| EP1643985B1 (en) | The combination of a serotonin reuptake inhibitors and agomelatine | |
| US5708036A (en) | Method of treating premature uterine contractions using the optically active R(-)-isomer of albuterol | |
| JPS61200912A (ja) | 鎮痛剤組成物 | |
| Curson et al. | Mianserin and agranulocytosis. | |
| WO2008035177A2 (en) | Combination of mt1 and mt2 melatonin receptor agonists and a norepinephrine/dopamine reuptake inhibitor | |
| US5739139A (en) | Acetaminophen and dimenhydrinate analgesics | |
| KR20020086945A (ko) | 비스테로이드성 항염증제를 포함하는 두통 치료용 약제조합물 | |
| WO2004026291A1 (fr) | Formulations orales d'ibuprofene et de tramadol, methodes de preparation de ces dernieres | |
| JPS646169B2 (ko) | ||
| Bleiberg et al. | Original Paper A Double-blind, Randomised Comparison of the Anti-emetic Efficacy of Two Intravenous Doses of Dolasetron Mesilate and Granisetron in Patients Receiving High Dose Cisplatin Chemotherapy | |
| WO1998058637A1 (en) | Acetaminophen and diphenhydramine analgesics | |
| WO1997048390A1 (en) | Analgesics combining acetaminophen with meclizine | |
| MXPA01002151A (en) | Use of epinastine as antitussivum | |
| MXPA97004579A (en) | Pharmaceutical composition comprising mirtazapine and one or more selective seroton reabsorption inhibitors | |
| MXPA00011648A (es) | Composiciones que comprenden analogos gaba y cafeina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |