NO20083382L - Reduksjon av 5-(aryl-diazenyl)-4,6-dihalogen-pyrimidin - Google Patents
Reduksjon av 5-(aryl-diazenyl)-4,6-dihalogen-pyrimidinInfo
- Publication number
- NO20083382L NO20083382L NO20083382A NO20083382A NO20083382L NO 20083382 L NO20083382 L NO 20083382L NO 20083382 A NO20083382 A NO 20083382A NO 20083382 A NO20083382 A NO 20083382A NO 20083382 L NO20083382 L NO 20083382L
- Authority
- NO
- Norway
- Prior art keywords
- compound
- formula
- diazenyl
- dihalo
- pyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
Abstract
Fremgangsmåte for syntese av forbindelse med formel (I), hvor R1 og R2 er uavhengig klor eller fluor, og hvor R3 er H, alkyl, aralkyl eller en alkyleter eller alkyl-tioeter. Fremgangsmåten omfatter reduksjon av en diazenyl forbindelse med formel (II) med en ikke-katalytisk eller med en katalytisk mengde av en homogen organisk, ikke-metall katalysator til den tilsvarende hydrazo forbindelsen med formel (III). I det andre trinnet benyttes katalytisk hydrogenering av hydrazo forbindelsen med en heterogen Ni-katalysator hvorved forbindelsen med formel (I) dannes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06002822 | 2006-02-13 | ||
EP06009627 | 2006-05-10 | ||
PCT/EP2007/001216 WO2007093368A1 (en) | 2006-02-13 | 2007-02-13 | Reduction of 5-(aryl-diazenyl)-4,6-dihalo-pyrimidine |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20083382L true NO20083382L (no) | 2008-08-27 |
Family
ID=37909713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20083382A NO20083382L (no) | 2006-02-13 | 2008-08-05 | Reduksjon av 5-(aryl-diazenyl)-4,6-dihalogen-pyrimidin |
Country Status (17)
Country | Link |
---|---|
US (2) | US8114996B2 (no) |
EP (1) | EP1987012B1 (no) |
JP (1) | JP5275046B2 (no) |
CN (1) | CN101384561B (no) |
AT (1) | ATE466845T1 (no) |
AU (1) | AU2007214713B2 (no) |
BR (1) | BRPI0707725A2 (no) |
CA (1) | CA2636619A1 (no) |
DE (1) | DE602007006281D1 (no) |
ES (1) | ES2345287T3 (no) |
HK (1) | HK1128465A1 (no) |
NO (1) | NO20083382L (no) |
PL (1) | PL1987012T3 (no) |
PT (1) | PT1987012E (no) |
SI (1) | SI1987012T1 (no) |
TW (1) | TWI385156B (no) |
WO (1) | WO2007093368A1 (no) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103130726A (zh) * | 2013-02-07 | 2013-06-05 | 许学农 | 替卡格雷中间体4,6-二氯-2-(丙巯基)-5-氨基嘧啶的制备方法 |
WO2014206187A1 (zh) | 2013-06-24 | 2014-12-31 | 苏州明锐医药科技有限公司 | 替卡格雷及其中间体的制备方法 |
CN104610237B (zh) * | 2013-11-05 | 2018-03-30 | 正大天晴药业集团股份有限公司 | 一种替格瑞洛的制备方法及其中间体 |
CN103923020A (zh) * | 2014-04-02 | 2014-07-16 | 黄河三角洲京博化工研究院有限公司 | 一种2-丙硫基-4,6-二氯-5-氨基嘧啶的制备方法 |
CN105294573B (zh) * | 2015-06-16 | 2018-07-10 | 厦门医学院 | 一种合成4,6-二氯-2-(丙硫基)-5-氨基嘧啶的方法 |
CN111763175A (zh) * | 2020-07-23 | 2020-10-13 | 广州康瑞泰药业有限公司 | 4,6-二氯-2-(硫丙基)-5-氨基嘧啶的纯化方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6393760A (ja) * | 1986-10-08 | 1988-04-25 | Kemipuro Kasei Kk | 芳香族ヒドラゾ化合物の製造法 |
SE0401001D0 (sv) * | 2004-03-31 | 2004-03-31 | Astrazeneca Ab | Chemical process |
-
2007
- 2007-02-13 DE DE602007006281T patent/DE602007006281D1/de active Active
- 2007-02-13 PL PL07711520T patent/PL1987012T3/pl unknown
- 2007-02-13 CN CN2007800052127A patent/CN101384561B/zh not_active Expired - Fee Related
- 2007-02-13 PT PT07711520T patent/PT1987012E/pt unknown
- 2007-02-13 AU AU2007214713A patent/AU2007214713B2/en not_active Ceased
- 2007-02-13 BR BRPI0707725-4A patent/BRPI0707725A2/pt not_active IP Right Cessation
- 2007-02-13 CA CA002636619A patent/CA2636619A1/en not_active Abandoned
- 2007-02-13 ES ES07711520T patent/ES2345287T3/es active Active
- 2007-02-13 AT AT07711520T patent/ATE466845T1/de active
- 2007-02-13 TW TW096105204A patent/TWI385156B/zh not_active IP Right Cessation
- 2007-02-13 WO PCT/EP2007/001216 patent/WO2007093368A1/en active Application Filing
- 2007-02-13 JP JP2008554657A patent/JP5275046B2/ja not_active Expired - Fee Related
- 2007-02-13 EP EP07711520A patent/EP1987012B1/en not_active Not-in-force
- 2007-02-13 SI SI200730309T patent/SI1987012T1/sl unknown
- 2007-02-13 US US12/160,343 patent/US8114996B2/en not_active Expired - Fee Related
-
2008
- 2008-08-05 NO NO20083382A patent/NO20083382L/no not_active Application Discontinuation
-
2009
- 2009-07-10 HK HK09106202.2A patent/HK1128465A1/xx not_active IP Right Cessation
-
2012
- 2012-01-05 US US13/343,860 patent/US20120130058A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PT1987012E (pt) | 2010-07-16 |
ATE466845T1 (de) | 2010-05-15 |
AU2007214713A1 (en) | 2007-08-23 |
EP1987012B1 (en) | 2010-05-05 |
TWI385156B (zh) | 2013-02-11 |
BRPI0707725A2 (pt) | 2011-05-10 |
US20120130058A1 (en) | 2012-05-24 |
DE602007006281D1 (de) | 2010-06-17 |
HK1128465A1 (no) | 2009-10-30 |
TW200740772A (en) | 2007-11-01 |
CN101384561B (zh) | 2012-01-04 |
SI1987012T1 (sl) | 2010-09-30 |
EP1987012A1 (en) | 2008-11-05 |
JP2009526796A (ja) | 2009-07-23 |
AU2007214713B2 (en) | 2011-09-01 |
CN101384561A (zh) | 2009-03-11 |
WO2007093368A1 (en) | 2007-08-23 |
AU2007214713A8 (en) | 2008-08-28 |
US8114996B2 (en) | 2012-02-14 |
JP5275046B2 (ja) | 2013-08-28 |
CA2636619A1 (en) | 2007-08-23 |
ES2345287T3 (es) | 2010-09-20 |
PL1987012T3 (pl) | 2010-11-30 |
US20110178298A1 (en) | 2011-07-21 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |