NO20074771L - Polyoksyalkylen kjedeinneholdende lipidderivat og lipidhinnestruktur inneholdende slikt derivat - Google Patents

Polyoksyalkylen kjedeinneholdende lipidderivat og lipidhinnestruktur inneholdende slikt derivat

Info

Publication number
NO20074771L
NO20074771L NO20074771A NO20074771A NO20074771L NO 20074771 L NO20074771 L NO 20074771L NO 20074771 A NO20074771 A NO 20074771A NO 20074771 A NO20074771 A NO 20074771A NO 20074771 L NO20074771 L NO 20074771L
Authority
NO
Norway
Prior art keywords
derivative
lipid
polyoxyalkylene chain
membrane structure
structure containing
Prior art date
Application number
NO20074771A
Other languages
English (en)
Other versions
NO344209B1 (no
Inventor
Kenji Sakanoue
Hiroshi Kiwada
Tatsuhiro Ishida
Chika Ito
Kazuhiro Kubo
Hiroshi Kikuchi
Original Assignee
Univ Tokushima
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tokushima filed Critical Univ Tokushima
Publication of NO20074771L publication Critical patent/NO20074771L/no
Publication of NO344209B1 publication Critical patent/NO344209B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Et polyoksyalkylenkjedeinneholdende lipidderivat, som er representert ved den følgende formelen (1):. hvor L, Y, W, X, X, X, OA, Z, ml, m2, m3, ni, n2 og n3 er som definert i redegjørelsen.
NO20074771A 2005-02-18 2007-09-18 Lipidmembranstruktur inneholdende et polyoksyalkylenkjedeinneholdende lipidderivat og et polyoksyalkylenkjedeinneholdende lipidderivat NO344209B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005043196 2005-02-18
PCT/JP2006/303356 WO2006088245A1 (ja) 2005-02-18 2006-02-17 ポリオキシアルキレン鎖含有脂質誘導体及び該誘導体を含有する脂質膜構造体

Publications (2)

Publication Number Publication Date
NO20074771L true NO20074771L (no) 2007-11-19
NO344209B1 NO344209B1 (no) 2019-10-14

Family

ID=36916630

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074771A NO344209B1 (no) 2005-02-18 2007-09-18 Lipidmembranstruktur inneholdende et polyoksyalkylenkjedeinneholdende lipidderivat og et polyoksyalkylenkjedeinneholdende lipidderivat

Country Status (7)

Country Link
US (1) US20090202619A1 (no)
EP (2) EP2382996B1 (no)
JP (2) JPWO2006088245A1 (no)
CN (2) CN101238142B (no)
CA (1) CA2598316C (no)
NO (1) NO344209B1 (no)
WO (1) WO2006088245A1 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010026621A1 (ja) * 2008-09-02 2010-03-11 エーザイ・アール・アンド・ディー・マネジメント株式会社 ポリカチオン化リン脂質誘導体
US8143413B2 (en) 2008-09-02 2012-03-27 Eisai R&D Management Co., Ltd. Polycationized phospholipid derivatives
PL226015B1 (pl) * 2011-03-03 2017-06-30 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Liposomowy preparat zawierajacy przeciwnowotworowa substancje aktywna, sposob jego wytwarzania i zawierajaca go kompozycja farmaceutyczna
JP7205827B2 (ja) * 2018-03-29 2023-01-17 日油株式会社 分解性ポリエチレングリコール誘導体
CN109627261A (zh) * 2018-12-22 2019-04-16 常州金远药业制造有限公司 一类正电荷磷脂的合成方法
EP4342929A1 (en) * 2021-06-30 2024-03-27 Jenkem Technology Co. Ltd. (Tianjin) Polyethylene glycol lipid and use thereof

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
JP3220180B2 (ja) 1991-05-23 2001-10-22 三菱化学株式会社 薬剤含有タンパク質結合リポソーム
US5643575A (en) * 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
TW527183B (en) * 1996-06-06 2003-04-11 Daiichi Seiyaku Co Drug complex
TW520297B (en) * 1996-10-11 2003-02-11 Sequus Pharm Inc Fusogenic liposome composition and method
ATE244572T1 (de) * 1996-10-15 2003-07-15 Liposome Co Inc Peptid-lipid konjugate, liposomen und liposomale arzneimittelverabreichung
US6339069B1 (en) * 1996-10-15 2002-01-15 Elan Pharmaceuticalstechnologies, Inc. Peptide-lipid conjugates, liposomes and lipsomal drug delivery
JPH1192405A (ja) 1997-09-19 1999-04-06 Dai Ichi Seiyaku Co Ltd 薬物複合体
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US7238368B2 (en) * 1999-04-23 2007-07-03 Alza Corporation Releasable linkage and compositions containing same
AU2001253456A1 (en) * 2000-04-13 2001-10-30 Emory University Antithrombogenic membrane mimetic compositions and methods
JP4710109B2 (ja) * 2000-07-24 2011-06-29 日油株式会社 ポリアルキレンオキシド修飾リン脂質、その製造方法および用途
JP4123856B2 (ja) * 2001-07-31 2008-07-23 日油株式会社 生体関連物質の修飾剤およびポリオキシアルキレン誘導体の製造方法
JPWO2004063216A1 (ja) * 2003-01-10 2006-06-15 アステラス製薬株式会社 血中滞留および癌組織特異的薬物送達のためのコンジュゲート
US20040228831A1 (en) * 2003-05-15 2004-11-18 Belinka Benjamin A. Polymeric conjugates for tissue activated drug delivery
JP4361764B2 (ja) 2003-07-28 2009-11-11 九州電力株式会社 配電用絶縁機材の絶縁抵抗測定装置
JP4595319B2 (ja) * 2003-12-03 2010-12-08 コニカミノルタエムジー株式会社 リポソーム用脂質、リポソームおよびそれらの製造方法

Also Published As

Publication number Publication date
NO344209B1 (no) 2019-10-14
WO2006088245A1 (ja) 2006-08-24
US20090202619A1 (en) 2009-08-13
EP1854807A1 (en) 2007-11-14
CA2598316A1 (en) 2006-08-24
EP1854807A4 (en) 2009-04-01
CN103027893B (zh) 2014-11-12
JP2012107015A (ja) 2012-06-07
CN101238142A (zh) 2008-08-06
JP5490085B2 (ja) 2014-05-14
EP2382996B1 (en) 2015-01-14
CN101238142B (zh) 2012-11-14
CA2598316C (en) 2013-10-15
EP2382996A3 (en) 2012-03-28
JPWO2006088245A1 (ja) 2008-07-10
EP2382996A2 (en) 2011-11-02
CN103027893A (zh) 2013-04-10

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