NO20073776L - Trisykliske delta-opioidmodulatorer - Google Patents

Trisykliske delta-opioidmodulatorer

Info

Publication number
NO20073776L
NO20073776L NO20073776A NO20073776A NO20073776L NO 20073776 L NO20073776 L NO 20073776L NO 20073776 A NO20073776 A NO 20073776A NO 20073776 A NO20073776 A NO 20073776A NO 20073776 L NO20073776 L NO 20073776L
Authority
NO
Norway
Prior art keywords
delta opioid
tricyclic
modulators
opioid modulators
tricyclic delta
Prior art date
Application number
NO20073776A
Other languages
English (en)
Norwegian (no)
Inventor
Li Liu
Scott L Dax
Bart Decorte
Mark Mcdonnell
James J Mcnally
Steven J Coats
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20073776L publication Critical patent/NO20073776L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Electroluminescent Light Sources (AREA)
  • Lock And Its Accessories (AREA)
  • Credit Cards Or The Like (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20073776A 2004-12-22 2007-07-19 Trisykliske delta-opioidmodulatorer NO20073776L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63831504P 2004-12-22 2004-12-22
PCT/US2005/046691 WO2006069276A2 (en) 2004-12-22 2005-12-21 TRICYCLIC ō-OPIOID MODULATORS

Publications (1)

Publication Number Publication Date
NO20073776L true NO20073776L (no) 2007-09-21

Family

ID=36481352

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073776A NO20073776L (no) 2004-12-22 2007-07-19 Trisykliske delta-opioidmodulatorer

Country Status (17)

Country Link
US (3) US7439239B2 (zh)
EP (1) EP1833826B1 (zh)
JP (1) JP2008525482A (zh)
KR (1) KR20070092293A (zh)
CN (1) CN101115751A (zh)
AT (1) ATE432279T1 (zh)
AU (1) AU2005319060A1 (zh)
BR (1) BRPI0518563A2 (zh)
CA (1) CA2591963A1 (zh)
DE (1) DE602005014671D1 (zh)
EA (1) EA011674B1 (zh)
IL (1) IL184064A0 (zh)
MX (1) MX2007007626A (zh)
NI (1) NI200700163A (zh)
NO (1) NO20073776L (zh)
WO (1) WO2006069276A2 (zh)
ZA (1) ZA200706029B (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA015491B1 (ru) * 2003-06-27 2011-08-30 Янссен Фармацевтика Н.В. ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ
KR20080027216A (ko) * 2004-08-05 2008-03-26 얀센 파마슈티카 엔.브이. 트리사이클릭 δ-오피오이드 조절자
EP1836196A1 (en) * 2004-12-22 2007-09-26 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
KR20070087675A (ko) * 2004-12-22 2007-08-28 얀센 파마슈티카 엔.브이. 트리사이클릭 δ-오피오이드 모듈레이터
CA2591963A1 (en) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. Tricyclic o-opioid modulators
AU2006203880A1 (en) * 2005-01-06 2006-07-13 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
WO2006138528A2 (en) * 2005-06-16 2006-12-28 Janssen Pharmaceutica N.V Tricyclic opioid modulators
US7557119B2 (en) 2005-07-21 2009-07-07 Rensselaer Polytechnic Institute Large substituent, non-phenolic opioids
PL2291368T3 (pl) * 2008-04-24 2013-05-31 Allergan Inc Podstawione gama laktamy jako środki terapeutyczne
CN102741226B (zh) * 2009-10-30 2016-01-06 詹森药业有限公司 4-取代的-2-苯氧基-苯胺δ阿片类受体调节剂
IT1396951B1 (it) * 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
JP5872585B2 (ja) * 2010-12-22 2016-03-01 パーデュー、ファーマ、リミテッド、パートナーシップ リン置換キノキサリンタイプピペリジン化合物とその使用
LT2725908T (lt) 2011-06-29 2017-09-11 Alkermes, Inc. Periferinio poveikio opioidų junginiai
CN104884064A (zh) 2012-12-24 2015-09-02 纽洛佳斯特拉斯公司 用于治疗胃肠道病症的方法
US9844554B2 (en) 2014-06-24 2017-12-19 Neurogastrx, Inc. Prodrugs of metopimazine
US10836757B1 (en) 2020-04-02 2020-11-17 Neurogastrx, Inc. Polymorphic forms of metopimazine
CN114236024B (zh) * 2021-12-07 2023-12-29 江苏宝众宝达药业股份有限公司 一种同时测定4-氟-3-硝基苯腈及其异构体含量的方法
CN114334022B (zh) * 2021-12-31 2022-11-18 杭州剂泰医药科技有限责任公司 一种化合物分子的溶解度预测模型及应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2368006A (en) * 1943-10-07 1945-01-23 Searle & Co Heterocyclic tertiary amines
FR1159125A (fr) * 1953-03-27 1958-06-23 Promonta Chem Fab Procédé pour préparer des dérivés de la phényl-thiazine présentant comme substituant basique un noyau hétérocyclique contenant un atome d'azote
US2901478A (en) * 1957-02-11 1959-08-25 Promonta Chem Fab Phenothiazine compounds
US3179665A (en) * 1959-12-16 1965-04-20 Wander Ag Dr A 9-(n-ethyl and n-propyl piperidyl-3'-methyl)-thioxanthenes
DE1159954B (de) * 1961-11-25 1963-12-27 Boehringer & Soehne Gmbh Verfahren zur Herstellung neuer 10-(Alkoxypiperidinopropyl)-phenthiazine und ihrer Salze
DE1670118A1 (de) 1966-07-22 1970-11-05 Boehringer Mannheim Gmbh Verfahren zur Herstellung neuer Derivate des 6,11-Dihydro-dibenz[b,e]oxepins und ihrer Salze
US3470188A (en) * 1967-01-05 1969-09-30 Smithkline Corp 9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes
NL6818027A (zh) * 1968-01-09 1969-07-11
GB1250534A (zh) 1969-03-03 1971-10-20
US3987042A (en) * 1969-03-03 1976-10-19 Claude Gueremy Phenothiazine derivative
US3931232A (en) * 1974-06-24 1976-01-06 Smithkline Corporation 3-Alkyl xanthene compounds
US4086350A (en) * 1974-11-06 1978-04-25 Smithkline Corporation Pharmaceutical compositions and method of producing anti-psychotic activity without extrapyramidal symptoms
ZA756550B (en) 1974-11-06 1976-09-29 Smithkline Corp Pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms
US4285956A (en) * 1978-05-12 1981-08-25 Kefalas A/S Xanthene and thioxanthene derivatives, compositions thereof and treatment therewith
US4356184A (en) * 1980-06-04 1982-10-26 G. D. Searle & Co. Anti-allergic or antihypertensive 1-piperidinylmethyl benzenamines
US4666907A (en) * 1983-10-05 1987-05-19 Merck Frosst Canada, Inc. Phenothiazine and derivatives and analogs and use as leukotriene biosynthesis inhibitors
US4777177A (en) * 1984-10-19 1988-10-11 Ciba-Geigy Corporation Pesticidal thioxanthen-9-ylidenepiperidines
FR2689013B1 (fr) * 1992-03-30 1995-05-05 Rhone Poulenc Rorer Sa Nouvelle application thérapeutique des dérivés de la phénothiazine.
ZA978792B (en) * 1996-10-04 1998-04-06 Novo Nordisk As N-substituted azaheterocyclic compounds.
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
US6040318A (en) * 1997-06-25 2000-03-21 Novo Nordisk A/S Tricycle substituted with azaheterocyclic carboxylic acids
WO1999000376A1 (en) 1997-06-25 1999-01-07 Novo Nordisk A/S Novel heterocyclic compounds
CA2316341A1 (en) 1997-12-24 1999-07-08 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
US6306876B1 (en) * 1999-12-22 2001-10-23 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives
BR0108965A (pt) 2000-03-03 2002-11-26 Ortho Mcneil Pharm Inc Derivados de 3-(diarilmetileno)-8-azabiciclo[3,2,1]octano
WO2001072303A1 (en) * 2000-03-29 2001-10-04 Research Triangle Institute Selective ligands for the delta opioid receptor
EP1353909B1 (en) 2000-10-31 2005-04-06 Rensselaer Polytechnic Institute 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioidreceptor binding agents
US6887876B2 (en) 2000-12-14 2005-05-03 Ortho-Mcneil Pharmaceutical, Inc. Benzamidine derivatives
JP4566459B2 (ja) * 2001-06-07 2010-10-20 株式会社日立製作所 表示装置
US6601009B2 (en) * 2001-07-12 2003-07-29 Yahoo Inc Method and system of automatic bandwidth detection
US7060711B2 (en) * 2001-10-25 2006-06-13 Biofrontera Bioscience Gmbh Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
EP1306376A1 (en) 2001-10-25 2003-05-02 Biofrontera Pharmaceuticals AG Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
EP1321169A1 (en) 2001-12-18 2003-06-25 Biofrontera Pharmaceuticals AG Combination of a serotonin receptor antagonist with a histidine decarboxylase inhibitor as a medicament
MXPA05002884A (es) 2002-09-18 2005-06-22 Fmc Corp Derivados triciclicos insecticidas.
WO2004035541A1 (en) 2002-10-15 2004-04-29 Janssen Pharmaceutica, N.V. Benzyl substituted (piperidin-4-yl) aminobenzamido derivatives as delta-opiod receptor modulators
BRPI0409570A (pt) 2003-04-15 2006-04-18 Pfizer Prod Inc derivados de 3-benzidrilideno-8-aza-biciclo[3.2.1]octano com atividade receptora de opióides
EA015491B1 (ru) 2003-06-27 2011-08-30 Янссен Фармацевтика Н.В. ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ
US7372923B2 (en) * 2003-12-19 2008-05-13 Infineon Technologies Ag Method for equalization of a payload signal, taking into account an interference source
KR20080027216A (ko) * 2004-08-05 2008-03-26 얀센 파마슈티카 엔.브이. 트리사이클릭 δ-오피오이드 조절자
DE102004055057A1 (de) * 2004-11-15 2006-05-24 Infineon Technologies Ag Ausgangsschaltung
KR20070087675A (ko) 2004-12-22 2007-08-28 얀센 파마슈티카 엔.브이. 트리사이클릭 δ-오피오이드 모듈레이터
EP1836196A1 (en) 2004-12-22 2007-09-26 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
CA2591963A1 (en) 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. Tricyclic o-opioid modulators
AU2006203880A1 (en) * 2005-01-06 2006-07-13 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
WO2006138528A2 (en) * 2005-06-16 2006-12-28 Janssen Pharmaceutica N.V Tricyclic opioid modulators

Also Published As

Publication number Publication date
KR20070092293A (ko) 2007-09-12
CN101115751A (zh) 2008-01-30
EA011674B1 (ru) 2009-04-28
AU2005319060A1 (en) 2006-06-29
EA200701355A1 (ru) 2008-02-28
ZA200706029B (en) 2008-12-31
US7652005B2 (en) 2010-01-26
US20090042871A1 (en) 2009-02-12
US7439239B2 (en) 2008-10-21
WO2006069276A2 (en) 2006-06-29
MX2007007626A (es) 2008-01-28
DE602005014671D1 (de) 2009-07-09
WO2006069276A3 (en) 2006-08-10
NI200700163A (es) 2008-02-04
CA2591963A1 (en) 2006-06-29
JP2008525482A (ja) 2008-07-17
EP1833826B1 (en) 2009-05-27
ATE432279T1 (de) 2009-06-15
US20060135763A1 (en) 2006-06-22
US20100093709A1 (en) 2010-04-15
EP1833826A2 (en) 2007-09-19
IL184064A0 (en) 2007-10-31
BRPI0518563A2 (pt) 2008-11-25

Similar Documents

Publication Publication Date Title
ATE432279T1 (de) Tricyclische delta-opioid-modulatoren
TW200716134A (en) Tricyclic opioid modulators
TW200621767A (en) Tricyclic δ-opioid modulators
UA86024C2 (ru) Трициклические дельта-опиоидные модуляторы
TW200716546A (en) Oxindole compounds and their uses as therapeutic agents
EA200700118A1 (ru) Амидосоединения и их применение в качестве лекарственных средств
BRPI0510177B8 (pt) composto, composição farmacêutica e uso do mesmo
TW200608960A (en) 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
MY142589A (en) Benzimidazole derivatives : preparation and pharmaceutical applications
TW200608966A (en) 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
EA200900828A1 (ru) Соединения и композиции в качестве ингибиторов активности каннабиноидного рецептора 1
PA8493701A1 (es) Compuestos para tratar la obesidad
TW200724543A (en) Heterocyclic compounds and their uses as therapeutic agents
EA200601212A1 (ru) Ингибиторы фосфодиэстеразы, получение и их терапевтическое применение
WO2006074388A3 (en) TRICYCLIC δ-OPIOID MODULATORS
TW200621244A (en) Modulators of muscarinic receptors
ATE457027T1 (de) Substituierte 1,4,8-triazaspiroä4.5 decan-2-on- verbindungen zur behandlung von fettsucht
EA200602115A1 (ru) Опиоидные соединения, замещенные карбоксамидогруппой
MXPA06003363A (es) Derivados de fenil-piperazina como moduladores de receptores muscarinicos.
MX2007007627A (es) Moduladores delta-opioides triciclicos.
MX2007006382A (es) Moduladores de receptores muscarinicos.
MA31630B1 (fr) Dérivés de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamides et de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]-diazépine-7-carboxamides, leur préparation et leur application en thérapeutique
EA200702136A1 (ru) Композиции станнсопорфина и их применение
TW200603791A (en) Compounds and compositions as cathepsin S inhibitors
UA83142C2 (en) 3-aminocyclopentane carboxyamidine as modulators of chemokine receptors

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application