BR0108965A - Derivados de 3-(diarilmetileno)-8-azabiciclo[3,2,1]octano - Google Patents
Derivados de 3-(diarilmetileno)-8-azabiciclo[3,2,1]octanoInfo
- Publication number
- BR0108965A BR0108965A BR0108965-0A BR0108965A BR0108965A BR 0108965 A BR0108965 A BR 0108965A BR 0108965 A BR0108965 A BR 0108965A BR 0108965 A BR0108965 A BR 0108965A
- Authority
- BR
- Brazil
- Prior art keywords
- agents
- diarylmethylene
- octane
- derivatives
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE 3-(DIARILMETILENO)-8-AZABICICLO[3,2,1]OCTANO". Esta invenção está direcionada à derivados de 3-(diarilmetileno)-8-azabiciclo[3:2:1]octano úteis como moduladores de receptores de <sym>opióide e <109>-opióide. Dependendo de seus efeitos antagonistas ou agonistas. Os compostos são analgésicos úteis, agentes antiinflamatórios e imunossupressores, agentes para o tratamento de condições psiquiatrícas e neurológicas, medicamentos para abuso de álcool e droga, agentes para tratamento de gastrite e diarréia, agentes cardiovascular e agentes para o tratamento de doenças respiratórias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18677800P | 2000-03-03 | 2000-03-03 | |
PCT/US2001/005735 WO2001066543A2 (en) | 2000-03-03 | 2001-02-22 | 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0108965A true BR0108965A (pt) | 2002-11-26 |
Family
ID=22686249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0108965-0A BR0108965A (pt) | 2000-03-03 | 2001-02-22 | Derivados de 3-(diarilmetileno)-8-azabiciclo[3,2,1]octano |
Country Status (12)
Country | Link |
---|---|
US (1) | US6552036B2 (pt) |
EP (1) | EP1263758A2 (pt) |
JP (1) | JP2003525938A (pt) |
KR (1) | KR20030009376A (pt) |
CN (1) | CN1426411A (pt) |
AR (1) | AR031556A1 (pt) |
AU (1) | AU2001241676A1 (pt) |
BR (1) | BR0108965A (pt) |
CA (1) | CA2402039A1 (pt) |
CO (1) | CO5280090A1 (pt) |
IL (1) | IL151550A0 (pt) |
WO (1) | WO2001066543A2 (pt) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0101765D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101770D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101771D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101769D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101766D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
SE0101773D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
BR0316747A (pt) * | 2002-12-18 | 2005-10-18 | Fmc Corp | Piperidinas n-(arilmetil substituìdas)-4-(metil dissubstituìdas) e piperazinas |
SE0300104D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
SE0300105D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
SE0300103D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
DE602004028228D1 (de) * | 2003-03-26 | 2010-09-02 | Merck Sharp & Dohme | Bicyclische piperidin-derivate als melanocortin-4 rezeptor-agonisten |
SE0300987D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
BRPI0409570A (pt) * | 2003-04-15 | 2006-04-18 | Pfizer Prod Inc | derivados de 3-benzidrilideno-8-aza-biciclo[3.2.1]octano com atividade receptora de opióides |
SE0301442D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations therof and uses thereof |
SE0301441D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
SE0301443D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
RU2005136524A (ru) * | 2003-05-16 | 2006-06-27 | Астразенека Аб (Se) | Производные диарилметилиденпиперидина, способы их получения и их применение |
SE0301445D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
EA015491B1 (ru) * | 2003-06-27 | 2011-08-30 | Янссен Фармацевтика Н.В. | ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ |
KR20060066070A (ko) * | 2003-07-28 | 2006-06-15 | 스미스클라인 비참 코포레이션 | 에스트로겐 수용체의 조절제로서의 시클로알킬리덴 화합물 |
TW200528448A (en) * | 2003-10-17 | 2005-09-01 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
SE0400026D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
US7435822B2 (en) * | 2004-02-03 | 2008-10-14 | Janssen Pharmaceutica N.V. | 3-(diheteroarylmethylene)-8-azabicyclo[3.2.1]octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo[3.2.1]octane derivatives |
KR20080027216A (ko) * | 2004-08-05 | 2008-03-26 | 얀센 파마슈티카 엔.브이. | 트리사이클릭 δ-오피오이드 조절자 |
US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
EP1809104A4 (en) * | 2004-09-23 | 2009-04-29 | Alexander Michalow | METHODS FOR REGULATING NEUROTRANSMITTER SYSTEMS BY INDUCING COUNTER-ADAPTATIONS |
CA2591963A1 (en) | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | Tricyclic o-opioid modulators |
KR20070087675A (ko) | 2004-12-22 | 2007-08-28 | 얀센 파마슈티카 엔.브이. | 트리사이클릭 δ-오피오이드 모듈레이터 |
AU2006203880A1 (en) | 2005-01-06 | 2006-07-13 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
WO2006138528A2 (en) | 2005-06-16 | 2006-12-28 | Janssen Pharmaceutica N.V | Tricyclic opioid modulators |
MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
FR2911874B1 (fr) * | 2007-01-25 | 2009-03-06 | Sanofi Aventis Sa | Derives d'urees de tropane, leur preparation et leur application en therapeutique |
GEP20125425B (en) | 2006-10-18 | 2012-03-26 | Pfizer Prod Inc | Biaryl ether urea compounds |
MY148880A (en) * | 2006-10-20 | 2013-06-14 | Astrazeneca Ab | N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression |
TWI409067B (zh) | 2007-02-28 | 2013-09-21 | Theravance Inc | 8-氮雜雙環〔3.2.1〕辛烷化合物之結晶型 |
CN109422740B (zh) * | 2017-08-27 | 2020-04-21 | 中南民族大学 | 一类莨菪烷型生物碱及其合成方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
JP3252485B2 (ja) * | 1992-10-21 | 2002-02-04 | 東レ株式会社 | 3環性トリアゾロ誘導体 |
SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
-
2001
- 2001-02-22 BR BR0108965-0A patent/BR0108965A/pt not_active IP Right Cessation
- 2001-02-22 CA CA002402039A patent/CA2402039A1/en not_active Abandoned
- 2001-02-22 CN CN01808773A patent/CN1426411A/zh active Pending
- 2001-02-22 KR KR1020027011575A patent/KR20030009376A/ko not_active Application Discontinuation
- 2001-02-22 US US09/791,246 patent/US6552036B2/en not_active Expired - Lifetime
- 2001-02-22 EP EP01912949A patent/EP1263758A2/en not_active Withdrawn
- 2001-02-22 JP JP2001565359A patent/JP2003525938A/ja active Pending
- 2001-02-22 AU AU2001241676A patent/AU2001241676A1/en not_active Abandoned
- 2001-02-22 IL IL15155001A patent/IL151550A0/xx unknown
- 2001-02-22 WO PCT/US2001/005735 patent/WO2001066543A2/en not_active Application Discontinuation
- 2001-03-02 AR ARP010101010A patent/AR031556A1/es unknown
- 2001-03-05 CO CO01017369A patent/CO5280090A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2003525938A (ja) | 2003-09-02 |
US20020115662A1 (en) | 2002-08-22 |
US6552036B2 (en) | 2003-04-22 |
WO2001066543A3 (en) | 2002-03-14 |
AU2001241676A1 (en) | 2001-09-17 |
CO5280090A1 (es) | 2003-05-30 |
KR20030009376A (ko) | 2003-01-29 |
IL151550A0 (en) | 2003-04-10 |
WO2001066543A2 (en) | 2001-09-13 |
CA2402039A1 (en) | 2001-09-13 |
AR031556A1 (es) | 2003-09-24 |
EP1263758A2 (en) | 2002-12-11 |
CN1426411A (zh) | 2003-06-25 |
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Legal Events
Date | Code | Title | Description |
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B25A | Requested transfer of rights approved |
Free format text: JOHNSON & JOHNSON (US) |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A,9A,10A E 11A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |