ZA200706029B - Tricyclic &-opioid domulators - Google Patents

Tricyclic &-opioid domulators

Info

Publication number
ZA200706029B
ZA200706029B ZA200706029A ZA200706029A ZA200706029B ZA 200706029 B ZA200706029 B ZA 200706029B ZA 200706029 A ZA200706029 A ZA 200706029A ZA 200706029 A ZA200706029 A ZA 200706029A ZA 200706029 B ZA200706029 B ZA 200706029B
Authority
ZA
South Africa
Prior art keywords
tricyclic
opioid
domulators
modulators
pharmaceutical
Prior art date
Application number
ZA200706029A
Other languages
English (en)
Inventor
Steven J Coats
Decorte Bart
Mcdonnell Mark
Scott L Dax
Liu Li
James J Mcnally
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA200706029B publication Critical patent/ZA200706029B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Credit Cards Or The Like (AREA)
  • Electroluminescent Light Sources (AREA)
  • Lock And Its Accessories (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Semiconductor Lasers (AREA)
ZA200706029A 2004-12-22 2007-07-20 Tricyclic &-opioid domulators ZA200706029B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63831504P 2004-12-22 2004-12-22

Publications (1)

Publication Number Publication Date
ZA200706029B true ZA200706029B (en) 2008-12-31

Family

ID=36481352

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200706029A ZA200706029B (en) 2004-12-22 2007-07-20 Tricyclic &-opioid domulators

Country Status (17)

Country Link
US (3) US7439239B2 (zh)
EP (1) EP1833826B1 (zh)
JP (1) JP2008525482A (zh)
KR (1) KR20070092293A (zh)
CN (1) CN101115751A (zh)
AT (1) ATE432279T1 (zh)
AU (1) AU2005319060A1 (zh)
BR (1) BRPI0518563A2 (zh)
CA (1) CA2591963A1 (zh)
DE (1) DE602005014671D1 (zh)
EA (1) EA011674B1 (zh)
IL (1) IL184064A0 (zh)
MX (1) MX2007007626A (zh)
NI (1) NI200700163A (zh)
NO (1) NO20073776L (zh)
WO (1) WO2006069276A2 (zh)
ZA (1) ZA200706029B (zh)

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Publication number Priority date Publication date Assignee Title
CN100513407C (zh) 2003-06-27 2009-07-15 詹森药业有限公司 三环δ阿片样物质调节剂
EP1910353A1 (en) * 2004-08-05 2008-04-16 Janssen Pharmaceutica N.V. Tricyclic delta- opioid modulators
WO2006069276A2 (en) 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. TRICYCLIC ō-OPIOID MODULATORS
CN101119992A (zh) * 2004-12-22 2008-02-06 詹森药业有限公司 三环δ阿片样物质调节剂
BRPI0519198A2 (pt) * 2004-12-22 2008-12-30 Janssen Pharmaceutica Nv moduladores de delta-opiàide tricÍclicos
EP1846400A2 (en) * 2005-01-06 2007-10-24 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
JP2008543866A (ja) * 2005-06-16 2008-12-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式オピオイドモジュレーター
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AU2013370966A1 (en) * 2012-12-24 2015-06-18 Neurogastrx, Inc. Methods for treating GI tract disorders
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US10836757B1 (en) 2020-04-02 2020-11-17 Neurogastrx, Inc. Polymorphic forms of metopimazine
CN114236024B (zh) * 2021-12-07 2023-12-29 江苏宝众宝达药业股份有限公司 一种同时测定4-氟-3-硝基苯腈及其异构体含量的方法
CN114334022B (zh) * 2021-12-31 2022-11-18 杭州剂泰医药科技有限责任公司 一种化合物分子的溶解度预测模型及应用

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Also Published As

Publication number Publication date
US20060135763A1 (en) 2006-06-22
EA200701355A1 (ru) 2008-02-28
KR20070092293A (ko) 2007-09-12
NO20073776L (no) 2007-09-21
EP1833826A2 (en) 2007-09-19
CN101115751A (zh) 2008-01-30
JP2008525482A (ja) 2008-07-17
DE602005014671D1 (de) 2009-07-09
BRPI0518563A2 (pt) 2008-11-25
CA2591963A1 (en) 2006-06-29
EP1833826B1 (en) 2009-05-27
US7439239B2 (en) 2008-10-21
WO2006069276A3 (en) 2006-08-10
WO2006069276A2 (en) 2006-06-29
NI200700163A (es) 2008-02-04
EA011674B1 (ru) 2009-04-28
AU2005319060A1 (en) 2006-06-29
IL184064A0 (en) 2007-10-31
US20090042871A1 (en) 2009-02-12
US7652005B2 (en) 2010-01-26
ATE432279T1 (de) 2009-06-15
MX2007007626A (es) 2008-01-28
US20100093709A1 (en) 2010-04-15

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