NO20064357L - Nye forbindelser som inhibitorer for hepatitt C-virus-NS3-serinprotease - Google Patents

Nye forbindelser som inhibitorer for hepatitt C-virus-NS3-serinprotease

Info

Publication number
NO20064357L
NO20064357L NO20064357A NO20064357A NO20064357L NO 20064357 L NO20064357 L NO 20064357L NO 20064357 A NO20064357 A NO 20064357A NO 20064357 A NO20064357 A NO 20064357A NO 20064357 L NO20064357 L NO 20064357L
Authority
NO
Norway
Prior art keywords
hepatitis
virus
inhibitors
serine protease
new compounds
Prior art date
Application number
NO20064357A
Other languages
English (en)
Norwegian (no)
Inventor
Viyyoor Moopil Girijavallabhan
Anil K Saksena
F George Njoroge
Stephane L Bogen
Kevin X Chen
Srikanth Venkatraman
Mousumi Sannigrahi
Ashok Arasappan
Frank Bennett
Angela I Padilla-Acevedo
Edwin Jao
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO20064357L publication Critical patent/NO20064357L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0827Tripeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20064357A 2004-02-27 2006-09-26 Nye forbindelser som inhibitorer for hepatitt C-virus-NS3-serinprotease NO20064357L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54853504P 2004-02-27 2004-02-27
PCT/US2005/005773 WO2005087725A2 (en) 2004-02-27 2005-02-24 Novel compounds as inhibitors of hepatitis c virus ns3 serine protease

Publications (1)

Publication Number Publication Date
NO20064357L true NO20064357L (no) 2006-11-24

Family

ID=34962125

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20064357A NO20064357L (no) 2004-02-27 2006-09-26 Nye forbindelser som inhibitorer for hepatitt C-virus-NS3-serinprotease

Country Status (20)

Country Link
US (2) US7186747B2 (xx)
EP (2) EP1939213B1 (xx)
JP (1) JP2007525511A (xx)
KR (1) KR20060124729A (xx)
CN (1) CN1972956A (xx)
AR (1) AR047903A1 (xx)
AT (2) ATE478889T1 (xx)
AU (1) AU2005222056A1 (xx)
BR (1) BRPI0508186A (xx)
CA (1) CA2557249A1 (xx)
DE (2) DE602005023224D1 (xx)
EC (1) ECSP066794A (xx)
ES (2) ES2349328T3 (xx)
HK (2) HK1095837A1 (xx)
IL (1) IL177627A0 (xx)
NO (1) NO20064357L (xx)
RU (1) RU2006134002A (xx)
TW (1) TW200529823A (xx)
WO (1) WO2005087725A2 (xx)
ZA (1) ZA200607053B (xx)

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Also Published As

Publication number Publication date
CA2557249A1 (en) 2005-09-22
US7186747B2 (en) 2007-03-06
WO2005087725A2 (en) 2005-09-22
IL177627A0 (en) 2006-12-31
RU2006134002A (ru) 2008-04-10
WO2005087725A3 (en) 2005-10-27
EP1939213A1 (en) 2008-07-02
US20050245458A1 (en) 2005-11-03
KR20060124729A (ko) 2006-12-05
ATE434621T1 (de) 2009-07-15
DE602005015093D1 (de) 2009-08-06
TW200529823A (en) 2005-09-16
DE602005023224D1 (de) 2010-10-07
ATE478889T1 (de) 2010-09-15
AR047903A1 (es) 2006-03-01
US20070142300A1 (en) 2007-06-21
AU2005222056A1 (en) 2005-09-22
ZA200607053B (en) 2009-02-25
ES2327544T3 (es) 2009-10-30
US7425576B2 (en) 2008-09-16
EP1737881A2 (en) 2007-01-03
EP1737881B1 (en) 2009-06-24
CN1972956A (zh) 2007-05-30
HK1118066A1 (en) 2009-01-30
HK1095837A1 (en) 2007-05-18
ECSP066794A (es) 2006-11-16
BRPI0508186A (pt) 2007-08-14
ES2349328T3 (es) 2010-12-30
EP1939213B1 (en) 2010-08-25
JP2007525511A (ja) 2007-09-06

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