NO20063205L - Inhibitorer for hepatitt C-virus NS3/NS4A-serinprotease - Google Patents
Inhibitorer for hepatitt C-virus NS3/NS4A-serinproteaseInfo
- Publication number
- NO20063205L NO20063205L NO20063205A NO20063205A NO20063205L NO 20063205 L NO20063205 L NO 20063205L NO 20063205 A NO20063205 A NO 20063205A NO 20063205 A NO20063205 A NO 20063205A NO 20063205 L NO20063205 L NO 20063205L
- Authority
- NO
- Norway
- Prior art keywords
- hepatitis
- virus
- inhibitors
- serine protease
- ns4a serine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Den foreliggende oppfinnelse beskriver nye forbindelser som har HCV-proteaseinhibitoraktivitet, samt fremgangsmåter for fremstilling av slike forbindelser. Ved en annen utførelsesform beskriver oppfinnelsen farmasøytiske preparater som omfatter slike forbindelser, samt fremgangsmåter for anvendelse av dem til å behandle forstyrrelser forbundet med HCV-proteasen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52884503P | 2003-12-11 | 2003-12-11 | |
PCT/US2004/041579 WO2005058821A1 (en) | 2003-12-11 | 2004-12-09 | Inhibitors of hepatitis c virus ns3/ns4a serine protease |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20063205L true NO20063205L (no) | 2006-09-08 |
Family
ID=34699904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20063205A NO20063205L (no) | 2003-12-11 | 2006-07-10 | Inhibitorer for hepatitt C-virus NS3/NS4A-serinprotease |
Country Status (18)
Country | Link |
---|---|
US (1) | US7485625B2 (no) |
EP (1) | EP1742913A1 (no) |
JP (1) | JP2007513971A (no) |
KR (1) | KR20060118532A (no) |
CN (1) | CN100509784C (no) |
AR (1) | AR046758A1 (no) |
AU (1) | AU2004298498B2 (no) |
BR (1) | BRPI0416902A (no) |
CA (1) | CA2549167A1 (no) |
CO (1) | CO5700736A2 (no) |
EC (1) | ECSP066626A (no) |
IL (1) | IL176237A0 (no) |
NO (1) | NO20063205L (no) |
PE (1) | PE20050940A1 (no) |
RU (1) | RU2006124594A (no) |
TW (1) | TW200518746A (no) |
WO (1) | WO2005058821A1 (no) |
ZA (1) | ZA200604638B (no) |
Families Citing this family (79)
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UA66767C2 (uk) | 1996-10-18 | 2004-06-15 | Вертекс Фармасьютикалс Інкорпорейтед | Інгібітори серин-протеаз, фармацевтична композиція, спосіб інгібування активності та спосіб лікування або профілактики вірусної інфекції гепатиту с |
US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
WO2006130666A2 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Medicaments and methods combining a hcv protease inhibitor and an akr competitor |
US20070237818A1 (en) * | 2005-06-02 | 2007-10-11 | Malcolm Bruce A | Controlled-release formulation of HCV protease inhibitor and methods using the same |
PE20070011A1 (es) * | 2005-06-02 | 2007-03-08 | Schering Corp | Formulaciones farmaceuticas de compuestos inhibidores de proteasa del vhc o catepsina |
EP1891089B1 (en) | 2005-06-02 | 2014-11-05 | Merck Sharp & Dohme Corp. | HCV protease inhibitors in combination with food |
CA2615626A1 (en) * | 2005-07-18 | 2007-01-25 | Novartis Ag | Small animal model for hcv replication |
EP2305697A3 (en) * | 2005-07-25 | 2011-07-27 | Intermune, Inc. | Macrocyclic inhibitors of Hepatitis C virus replication |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
DE602006019323D1 (de) * | 2005-10-11 | 2011-02-10 | Intermune Inc | Verbindungen und verfahren zur inhibierung der replikation des hepatitis-c-virus |
US7772183B2 (en) * | 2005-10-12 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7705138B2 (en) * | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
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WO2007083620A1 (ja) * | 2006-01-20 | 2007-07-26 | Kaneka Corporation | β-アミノ-α-ヒドロキシ酸アミド誘導体の製造法 |
US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
JP5167244B2 (ja) | 2006-04-11 | 2013-03-21 | ノバルティス アーゲー | Hcv/hiv阻害剤およびそれらの使用 |
WO2007120595A2 (en) * | 2006-04-11 | 2007-10-25 | Novartis Ag | Amines for the treatment of hcv |
WO2007137080A2 (en) | 2006-05-23 | 2007-11-29 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
JP5301270B2 (ja) * | 2006-05-26 | 2013-09-25 | 株式会社カネカ | 光学活性3−アミノ−2−ヒドロキシプロピオン酸シクロプロピルアミド誘導体およびその塩の製造方法 |
US9526769B2 (en) * | 2006-06-06 | 2016-12-27 | Enanta Pharmaceuticals, Inc. | Macrocylic oximyl hepatitis C protease inhibitors |
UY30437A1 (es) * | 2006-06-26 | 2008-01-31 | Enanta Pharm Inc | Quinoxalinil macroceclicos inhibidores de serina proteasa del virus de la hepatitis c |
DE102006059317A1 (de) | 2006-07-04 | 2008-01-10 | Evonik Degussa Gmbh | Verfahren zur Herstellung von β-Amino-α-hydroxy-carbonsäureamiden |
KR20090024834A (ko) * | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규 억제제 |
US7662779B2 (en) * | 2006-08-11 | 2010-02-16 | Enanta Pharmaceuticals, Inc. | Triazolyl macrocyclic hepatitis C serine protease inhibitors |
RU2009109355A (ru) | 2006-08-17 | 2010-09-27 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Ингибиторы вырусной полимеразы |
EP2057278A2 (en) * | 2006-08-28 | 2009-05-13 | Vertex Pharmceuticals Incorporated | Method for identifying protease inhibitors |
US20100216161A1 (en) | 2009-02-26 | 2010-08-26 | Vertex Pharmaceuticals Incorporated | Method for identifying protease inhibitors |
DE102006042147A1 (de) * | 2006-09-06 | 2008-03-27 | Dynamit Nobel Gmbh Explosivstoff- Und Systemtechnik | Hydrochloride von 3-Amino-2-hydroxycarbonsäureamiden |
US8003604B2 (en) * | 2006-11-16 | 2011-08-23 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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CA2677487A1 (en) | 2007-02-09 | 2008-08-14 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
US20090155209A1 (en) * | 2007-05-03 | 2009-06-18 | Blatt Lawrence M | Novel macrocyclic inhibitors of hepatitis c virus replication |
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US8419332B2 (en) * | 2007-10-19 | 2013-04-16 | Atlas Bolt & Screw Company Llc | Non-dimpling fastener |
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AR075584A1 (es) | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
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EP2435424B1 (en) | 2009-05-29 | 2015-01-21 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
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CA2774145C (en) * | 2009-09-15 | 2015-10-27 | Taigen Biotechnology Co., Ltd. | Hcv protease inhibitors |
US20120276047A1 (en) | 2009-11-25 | 2012-11-01 | Rosenblum Stuart B | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
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WO2011103933A1 (en) * | 2010-02-25 | 2011-09-01 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg | PROCESS FOR THE PREPARATION OF α-ACYLOXY β-FORMAMIDO AMIDES |
BR112012022125A2 (pt) | 2010-03-09 | 2016-11-01 | Merck Sharp & Dhme Corp | composto, sal de dicloridrato, composição farmacêutica, uso do composto, e, método para tratar um paciente |
AU2011286276A1 (en) | 2010-07-26 | 2013-01-24 | Merck Sharp & Dohme Corp. | Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases |
WO2012050848A1 (en) | 2010-09-29 | 2012-04-19 | Schering Corporation | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
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KR20140003521A (ko) | 2010-12-30 | 2014-01-09 | 이난타 파마슈티칼스, 인코포레이티드 | 페난트리딘 매크로사이클릭 c형 간염 세린 프로테아제 억제제 |
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Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3216325A (en) * | 1962-04-16 | 1965-11-09 | Dole Valve Co | Pneumatic control system |
DE60111509T2 (de) | 2000-04-03 | 2006-05-11 | Vertex Pharmaceuticals Inc., Cambridge | Inhibitoren von Serin-Proteasen, insbesondere der Hepatitis-C-Virus NS23-Protease |
SI1385870T1 (sl) * | 2000-07-21 | 2010-08-31 | Schering Corp | Peptidi kot NS3-serin proteazni inhibitorji virusa hepatitisa C |
US7244721B2 (en) * | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
EP1343807B1 (en) | 2000-12-12 | 2009-04-29 | Schering Corporation | Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus |
WO2003062228A1 (en) | 2002-01-23 | 2003-07-31 | Schering Corporation | Proline compounds as ns3-serine protease inhibitors for use in treatment of hepatites c virus infection |
-
2004
- 2004-12-09 TW TW093138050A patent/TW200518746A/zh unknown
- 2004-12-09 KR KR1020067011224A patent/KR20060118532A/ko not_active Application Discontinuation
- 2004-12-09 WO PCT/US2004/041579 patent/WO2005058821A1/en active Application Filing
- 2004-12-09 JP JP2006544061A patent/JP2007513971A/ja not_active Ceased
- 2004-12-09 US US11/007,910 patent/US7485625B2/en not_active Expired - Fee Related
- 2004-12-09 PE PE2004001217A patent/PE20050940A1/es not_active Application Discontinuation
- 2004-12-09 AU AU2004298498A patent/AU2004298498B2/en not_active Expired - Fee Related
- 2004-12-09 CA CA002549167A patent/CA2549167A1/en not_active Abandoned
- 2004-12-09 EP EP04813838A patent/EP1742913A1/en not_active Withdrawn
- 2004-12-09 BR BRPI0416902-6A patent/BRPI0416902A/pt not_active IP Right Cessation
- 2004-12-09 AR ARP040104589A patent/AR046758A1/es unknown
- 2004-12-09 RU RU2006124594/04A patent/RU2006124594A/ru not_active Application Discontinuation
- 2004-12-09 CN CNB2004800367937A patent/CN100509784C/zh not_active Expired - Fee Related
-
2006
- 2006-06-06 ZA ZA200604638A patent/ZA200604638B/en unknown
- 2006-06-08 EC EC2006006626A patent/ECSP066626A/es unknown
- 2006-06-09 CO CO06056306A patent/CO5700736A2/es not_active Application Discontinuation
- 2006-06-11 IL IL176237A patent/IL176237A0/en unknown
- 2006-07-10 NO NO20063205A patent/NO20063205L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BRPI0416902A (pt) | 2007-01-16 |
JP2007513971A (ja) | 2007-05-31 |
AR046758A1 (es) | 2005-12-21 |
TW200518746A (en) | 2005-06-16 |
CA2549167A1 (en) | 2005-06-30 |
ECSP066626A (es) | 2006-10-25 |
AU2004298498A1 (en) | 2005-06-30 |
KR20060118532A (ko) | 2006-11-23 |
CN1890215A (zh) | 2007-01-03 |
RU2006124594A (ru) | 2008-01-27 |
EP1742913A1 (en) | 2007-01-17 |
ZA200604638B (en) | 2007-04-25 |
IL176237A0 (en) | 2006-10-05 |
PE20050940A1 (es) | 2005-11-08 |
US7485625B2 (en) | 2009-02-03 |
WO2005058821A1 (en) | 2005-06-30 |
CO5700736A2 (es) | 2006-11-30 |
CN100509784C (zh) | 2009-07-08 |
AU2004298498B2 (en) | 2008-09-11 |
US20050153900A1 (en) | 2005-07-14 |
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