NO20064355L - Nye ketoamider med sykliske P4-er som inhibitorer for NS3-serinprotease fra hepatitt C-virus - Google Patents
Nye ketoamider med sykliske P4-er som inhibitorer for NS3-serinprotease fra hepatitt C-virusInfo
- Publication number
- NO20064355L NO20064355L NO20064355A NO20064355A NO20064355L NO 20064355 L NO20064355 L NO 20064355L NO 20064355 A NO20064355 A NO 20064355A NO 20064355 A NO20064355 A NO 20064355A NO 20064355 L NO20064355 L NO 20064355L
- Authority
- NO
- Norway
- Prior art keywords
- ketoamides
- hepatitis
- virus
- inhibitors
- cyclic
- Prior art date
Links
- 102000012479 Serine Proteases Human genes 0.000 title 1
- 108010022999 Serine Proteases Proteins 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
- 108700012707 hepatitis C virus NS3 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000004797 ketoamides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229940122604 HCV protease inhibitor Drugs 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
- C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54850604P | 2004-02-27 | 2004-02-27 | |
| PCT/US2005/005924 WO2005085242A1 (en) | 2004-02-27 | 2005-02-24 | Novel ketoamides with cyclic p4's as inhibitors of ns3 serine protease of hepatitis c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20064355L true NO20064355L (no) | 2006-11-24 |
Family
ID=34919371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20064355A NO20064355L (no) | 2004-02-27 | 2006-09-26 | Nye ketoamider med sykliske P4-er som inhibitorer for NS3-serinprotease fra hepatitt C-virus |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7173057B2 (enExample) |
| EP (1) | EP1730142B1 (enExample) |
| JP (1) | JP4874227B2 (enExample) |
| KR (1) | KR20070026394A (enExample) |
| CN (1) | CN1946718A (enExample) |
| AR (1) | AR048023A1 (enExample) |
| AT (1) | ATE514691T1 (enExample) |
| AU (1) | AU2005219824B2 (enExample) |
| BR (1) | BRPI0508217A (enExample) |
| CA (1) | CA2557304C (enExample) |
| EC (1) | ECSP066792A (enExample) |
| IL (1) | IL177628A0 (enExample) |
| NO (1) | NO20064355L (enExample) |
| PE (1) | PE20050999A1 (enExample) |
| RU (1) | RU2006134000A (enExample) |
| TW (1) | TW200529822A (enExample) |
| WO (1) | WO2005085242A1 (enExample) |
| ZA (1) | ZA200607048B (enExample) |
Families Citing this family (72)
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| IN183120B (enExample) | 1996-10-18 | 1999-09-11 | Vertex Pharma | |
| US7491794B2 (en) | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| US10086511B2 (en) | 2003-11-10 | 2018-10-02 | Brooks Automation, Inc. | Semiconductor manufacturing systems |
| US8696298B2 (en) * | 2003-11-10 | 2014-04-15 | Brooks Automation, Inc. | Semiconductor manufacturing process modules |
| US7635694B2 (en) * | 2004-02-27 | 2009-12-22 | Schering Corporation | Cyclobutenedione-containing compounds as inhibitors of hepatitis C virus NS3 serine protease |
| TW200602037A (en) * | 2004-02-27 | 2006-01-16 | Schering Corp | Novel compounds as inhibitors of hepatitis C virus NS3 serine protease |
| AU2006252623A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Controlled-release formulation useful for treating disorders associated with hepatitis C virus |
| EP1919478B1 (en) * | 2005-06-02 | 2016-03-23 | Merck Sharp & Dohme Corp. | Combination of hcv protease inhibitors with a surfactant |
| US20060276407A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis C virus |
| US20070021351A1 (en) * | 2005-06-02 | 2007-01-25 | Schering Corporation | Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor |
| US20070237818A1 (en) * | 2005-06-02 | 2007-10-11 | Malcolm Bruce A | Controlled-release formulation of HCV protease inhibitor and methods using the same |
| US20060276404A1 (en) * | 2005-06-02 | 2006-12-07 | Anima Ghosal | Medicaments and methods combining a HCV protease inhibitor and an AKR competitor |
| WO2006130626A2 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Method for modulating activity of hcv protease through use of a novel hcv protease inhibitor to reduce duration of treatment period |
| US20060276406A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis C virus |
| US20060275366A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Controlled-release formulation |
| NZ563361A (en) | 2005-06-02 | 2011-02-25 | Schering Corp | HCV protease inhibitors in combination with food |
| BRPI0613962A2 (pt) * | 2005-07-25 | 2009-03-24 | Intermune Inc | inibidores macrocìclicos inovadores de replicação de vìrus da hepatite c |
| AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| DK1999129T3 (da) | 2005-10-11 | 2011-02-07 | Intermune Inc | Forbindelser og fremgangsmåder til inhibering af replikationen af hepatitis C-virus |
| US7705138B2 (en) * | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
| JP5409008B2 (ja) | 2005-11-11 | 2014-02-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | C型肝炎ウイルス改変体 |
| US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US20080045530A1 (en) * | 2006-04-11 | 2008-02-21 | Trixi Brandl | Organic Compounds and Their Uses |
| JP2009536158A (ja) * | 2006-04-11 | 2009-10-08 | ノバルティス アクチエンゲゼルシャフト | Hcv阻害剤 |
| US7825152B2 (en) | 2006-04-11 | 2010-11-02 | Novartis Ag | Organic compounds and their uses |
| KR20090024834A (ko) * | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규 억제제 |
| MX2009000882A (es) | 2006-08-17 | 2009-02-04 | Boehringer Ingelheim Int | Inhibidores de la polimerasa virica. |
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| US20080219806A1 (en) * | 2007-03-05 | 2008-09-11 | Van Der Meulen Peter | Semiconductor manufacturing process modules |
| JP2010522174A (ja) * | 2007-03-23 | 2010-07-01 | シェーリング コーポレイション | Hcvns3−プロテアーゼ阻害剤としてのヒドラジド−ペプチド |
| JP2010522172A (ja) * | 2007-03-23 | 2010-07-01 | シェーリング コーポレイション | Hcvns3プロテアーゼのp1−非エピメリ化ケトアミド阻害剤 |
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| BRPI0811447A2 (pt) * | 2007-05-10 | 2014-10-29 | Intermune Inc | Compostos, composição farmacêutica e métodos de inibição da atividade da protease ns3/ns4, de tratamento da fibrose hepática e de intensificação da função hepática num indivíduo tendo infecção de vírus da hepatite c. |
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| BR112012022125A2 (pt) | 2010-03-09 | 2016-11-01 | Merck Sharp & Dhme Corp | composto, sal de dicloridrato, composição farmacêutica, uso do composto, e, método para tratar um paciente |
| JP2013541499A (ja) | 2010-07-26 | 2013-11-14 | メルク・シャープ・エンド・ドーム・コーポレイション | 置換されたビフェニレン化合物およびウイルス性疾患の治療のためのその使用方法 |
| AU2011314168A1 (en) | 2010-09-29 | 2013-04-04 | Merck Sharp & Dohme Corp. | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
| JP5565320B2 (ja) * | 2011-01-06 | 2014-08-06 | 富士通株式会社 | 情報処理装置及び情報処理プログラム |
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| EA201391519A1 (ru) | 2011-04-13 | 2014-03-31 | Мерк Шарп И Доум Корп. | 2'-замещенные нуклеозидные производные и способы их применения для лечения вирусных заболеваний |
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| EP2755981A4 (en) | 2011-09-14 | 2015-03-25 | Merck Sharp & Dohme | SILICULAR HETEROCYCLIC DERIVATIVES AND METHOD FOR THEIR USE FOR THE TREATMENT OF VIRUS DISEASES |
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| US10167298B2 (en) | 2013-10-30 | 2019-01-01 | Merck Sharp & Dohme Corp. | Pseudopolymorphs of an HCV NS5A inhibitor and uses thereof |
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| WO2015134561A1 (en) | 2014-03-05 | 2015-09-11 | Idenix Pharmaceuticals, Inc. | Pharmaceutical compositions comprising a 5,5-fused heteroarylene flaviviridae inhibitor and their use for treating or preventing flaviviridae infection |
| CN104292130B (zh) * | 2014-10-13 | 2016-04-27 | 苏州永健生物医药有限公司 | 一种波普瑞韦中间体2-羟基-3-氨基-4-环丁基丁酰胺盐酸盐的合成方法 |
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| WO2023011443A1 (zh) * | 2021-08-02 | 2023-02-09 | 北京华益健康药物研究中心 | 用于治疗或预防冠状病毒感染的3cl蛋白酶小分子抑制剂及其用途 |
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| EP1737821B1 (en) * | 2004-02-27 | 2009-08-05 | Schering Corporation | 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease |
-
2005
- 2005-02-24 AT AT05723688T patent/ATE514691T1/de not_active IP Right Cessation
- 2005-02-24 US US11/065,647 patent/US7173057B2/en not_active Expired - Fee Related
- 2005-02-24 WO PCT/US2005/005924 patent/WO2005085242A1/en not_active Ceased
- 2005-02-24 JP JP2007500975A patent/JP4874227B2/ja not_active Expired - Fee Related
- 2005-02-24 PE PE2005000218A patent/PE20050999A1/es not_active Application Discontinuation
- 2005-02-24 AU AU2005219824A patent/AU2005219824B2/en not_active Ceased
- 2005-02-24 KR KR1020067017349A patent/KR20070026394A/ko not_active Ceased
- 2005-02-24 CA CA2557304A patent/CA2557304C/en not_active Expired - Fee Related
- 2005-02-24 CN CNA2005800126969A patent/CN1946718A/zh active Pending
- 2005-02-24 EP EP05723688A patent/EP1730142B1/en not_active Expired - Lifetime
- 2005-02-24 BR BRPI0508217-0A patent/BRPI0508217A/pt not_active IP Right Cessation
- 2005-02-24 RU RU2006134000/04A patent/RU2006134000A/ru not_active Application Discontinuation
- 2005-02-24 TW TW094105517A patent/TW200529822A/zh unknown
- 2005-02-25 AR ARP050100717A patent/AR048023A1/es not_active Application Discontinuation
-
2006
- 2006-08-22 IL IL177628A patent/IL177628A0/en unknown
- 2006-08-23 ZA ZA200607048A patent/ZA200607048B/xx unknown
- 2006-08-25 EC EC2006006792A patent/ECSP066792A/es unknown
- 2006-09-26 NO NO20064355A patent/NO20064355L/no not_active Application Discontinuation
- 2006-11-20 US US11/602,174 patent/US7619094B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070026394A (ko) | 2007-03-08 |
| TW200529822A (en) | 2005-09-16 |
| US7619094B2 (en) | 2009-11-17 |
| IL177628A0 (en) | 2006-12-31 |
| WO2005085242A1 (en) | 2005-09-15 |
| US7173057B2 (en) | 2007-02-06 |
| RU2006134000A (ru) | 2008-04-10 |
| CA2557304C (en) | 2013-08-06 |
| CN1946718A (zh) | 2007-04-11 |
| AU2005219824A1 (en) | 2005-09-15 |
| BRPI0508217A (pt) | 2007-07-17 |
| ECSP066792A (es) | 2006-11-16 |
| ATE514691T1 (de) | 2011-07-15 |
| ZA200607048B (en) | 2008-06-25 |
| JP4874227B2 (ja) | 2012-02-15 |
| JP2007525518A (ja) | 2007-09-06 |
| CA2557304A1 (en) | 2005-09-15 |
| PE20050999A1 (es) | 2005-12-01 |
| US20070093430A1 (en) | 2007-04-26 |
| AU2005219824B2 (en) | 2007-11-29 |
| US20050222047A1 (en) | 2005-10-06 |
| EP1730142A1 (en) | 2006-12-13 |
| EP1730142B1 (en) | 2011-06-29 |
| AR048023A1 (es) | 2006-03-22 |
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