NO20062954L - Pyrazolylderivater i form av legemidler for behandling av av akutt eller kronisk neuronal regresjon - Google Patents

Pyrazolylderivater i form av legemidler for behandling av av akutt eller kronisk neuronal regresjon

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Publication number
NO20062954L
NO20062954L NO20062954A NO20062954A NO20062954L NO 20062954 L NO20062954 L NO 20062954L NO 20062954 A NO20062954 A NO 20062954A NO 20062954 A NO20062954 A NO 20062954A NO 20062954 L NO20062954 L NO 20062954L
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Norway
Prior art keywords
radical
drugs
acute
treatment
nhc
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NO20062954A
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English (en)
Inventor
Jean-Luc Malleron
Serge Mignani
Arielle Genevois-Borella
Andrees Bohme
Corinne Terrier
Michel Evers
Jean Bouquerel
Youssef El-Ahmad
Gaetan Touyer
Jean-Francois Sabuco
Giles Doerflinger
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Aventis Pharma Sa
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Publication of NO20062954L publication Critical patent/NO20062954L/no

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  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse angår nye derivater med generell formel (I), hvori A, hvis tilstede, er et alkylradikal (C1-C6), et alkenylradikal (C3-C6), et alkynylradikal (C3-C6), et cykloalkylradikal (C3-C7), et cykloalkenylradikal (C5-C7), R1 er en NR6R7, azacykloalkyl (C4-C7), azacykloalkenyl (C5-C7), azabicykloalkyl (C5-C9) og azabicykloalkenyl (C6-C9)gruppe; A-R1 er slik at nitrogenet til R1 og nitrogenet 1 til pyrazolet er nødvendigvis separert med minst to karbonatomer, R3 er et H, halogen, OH, SH, NH2, ORc, SRc, SORa, SO2Ra, NHCHO, NRaRb, NHC(O)Ra, NHC(S)Ra og NHSO2Ra-radikal; R4 er et aryl eller heteroarylradikal; R5 er et H, halogen, CF3, CHF2, CH2F, lineært eller forgrenet alkyl (C1-C6) og cykloalkyl (C3-C7)-radikal, racerniske blandinger, enantiomerer og diastereoisomerer derav, og blandinger derav, tautomerer derav og farmasøytisk akseptable salter derav. formel (I)
NO20062954A 2003-11-25 2006-06-23 Pyrazolylderivater i form av legemidler for behandling av av akutt eller kronisk neuronal regresjon NO20062954L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0313775A FR2862647B1 (fr) 2003-11-25 2003-11-25 Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant
PCT/FR2004/002968 WO2005051917A1 (fr) 2003-11-25 2004-11-22 Derives de pyrazole a titre de medicaments pour le traitement des degenerescences neuronales aigues ou chroniques

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NO20062954L true NO20062954L (no) 2006-08-25

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NO20062954A NO20062954L (no) 2003-11-25 2006-06-23 Pyrazolylderivater i form av legemidler for behandling av av akutt eller kronisk neuronal regresjon

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US (2) US7524838B2 (no)
EP (1) EP1689720B1 (no)
JP (1) JP4833078B2 (no)
KR (1) KR20060123193A (no)
CN (2) CN102174017A (no)
AR (1) AR046632A1 (no)
AT (1) ATE428699T1 (no)
AU (1) AU2004293214B2 (no)
BR (1) BRPI0416926A (no)
CA (1) CA2544519A1 (no)
CY (1) CY1110333T1 (no)
DE (1) DE602004020660D1 (no)
DK (1) DK1689720T3 (no)
ES (1) ES2325446T3 (no)
FR (1) FR2862647B1 (no)
HR (1) HRP20090391T1 (no)
IL (1) IL175539A0 (no)
MA (1) MA28147A1 (no)
MY (1) MY141218A (no)
NO (1) NO20062954L (no)
NZ (1) NZ548071A (no)
PL (1) PL1689720T3 (no)
PT (1) PT1689720E (no)
RS (1) RS50836B (no)
RU (2) RU2376290C2 (no)
SG (1) SG131945A1 (no)
SI (1) SI1689720T1 (no)
TW (1) TWI343811B (no)
UY (1) UY28635A1 (no)
WO (1) WO2005051917A1 (no)
ZA (2) ZA200604051B (no)

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US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
EP2532240A3 (en) 2007-04-03 2013-03-13 E. I. du Pont de Nemours and Company Substituted benzene fungicides
JP5489997B2 (ja) * 2007-07-19 2014-05-14 シマベイ セラピューティクス， インコーポレーテッド 糖尿病および代謝疾患の治療のためのＲＵＰ３またはＧＰＲｌ１９受容体のアゴニストとしてのＮ−アザ環状置換ピロール、ピラゾール、イミダゾール、トリアゾールおよびテトラゾール誘導体
MX2010004177A (es) 2007-10-18 2010-05-03 Janssen Pharmaceutica Nv 1,2,4-triazoles trisustituidos.
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
KR101564303B1 (ko) 2008-03-19 2015-11-06 얀센 파마슈티카 엔.브이. 니코틴성 아세틸콜린 수용체 조절제로서의 삼치환된 1,2,4-트리아졸
CL2009001125A1 (es) 2008-05-09 2011-02-11 Janssen Pharmaceutica Nv Compuestos derivados de pirazol trisustituido, moduladores alostericos positivos de los receptores ach nicotinicos; composicion farmaceutica que los comprende; proceso de preparacion de la composicion; y su uso en el tratamiento de enfermedades de snc o inflamatorias.
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