NO20061060L - Antagonistiske analoger av GH-RH (2003) - Google Patents

Antagonistiske analoger av GH-RH (2003)

Info

Publication number
NO20061060L
NO20061060L NO20061060A NO20061060A NO20061060L NO 20061060 L NO20061060 L NO 20061060L NO 20061060 A NO20061060 A NO 20061060A NO 20061060 A NO20061060 A NO 20061060A NO 20061060 L NO20061060 L NO 20061060L
Authority
NO
Norway
Prior art keywords
analogs
inhibit
hgh
antagonistic analogs
antagonistic
Prior art date
Application number
NO20061060A
Other languages
English (en)
Inventor
Ren Zhi Cai
Andrew V Schally
Josef Varga
Marta Zerandi
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Publication of NO20061060L publication Critical patent/NO20061060L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Det blir tilveiebrakt en ny serie med syntetiske antagonistiske analoger av hGH-RH(1-29)NH2. Disse analoger hemmer aktiviteten av endogen hGH-RH på hypofyse-GHRH-reseptorer, og hindrer derfor frigjøringen av veksthormon. Analogene hemmer også prolifereringen av humane cancere gjennom en direkte effekt på cancercellen. De høyere hemmende potensene til de nye analogene sammenlignet med de som tidligere er beskrevet, er et resultat fra erstatning av forskjellige aminosyrer.
NO20061060A 2003-08-05 2006-03-03 Antagonistiske analoger av GH-RH (2003) NO20061060L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49270603P 2003-08-05 2003-08-05
PCT/US2004/024183 WO2005016953A2 (en) 2003-08-05 2004-07-26 Antagonistic analogs of gh-rh (2003)

Publications (1)

Publication Number Publication Date
NO20061060L true NO20061060L (no) 2006-05-03

Family

ID=34193144

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061060A NO20061060L (no) 2003-08-05 2006-03-03 Antagonistiske analoger av GH-RH (2003)

Country Status (19)

Country Link
US (1) US7452865B2 (no)
EP (1) EP1651662A4 (no)
JP (1) JP2007526900A (no)
KR (1) KR20060088875A (no)
CN (1) CN1871020A (no)
AR (1) AR049149A1 (no)
AU (1) AU2004265280A1 (no)
BR (1) BRPI0413257A (no)
CA (1) CA2534436A1 (no)
IL (1) IL173201A0 (no)
MX (1) MXPA06001369A (no)
NO (1) NO20061060L (no)
PL (1) PL380437A1 (no)
RS (1) RS20060086A (no)
RU (1) RU2335506C2 (no)
SG (1) SG136958A1 (no)
TW (1) TW200517400A (no)
WO (1) WO2005016953A2 (no)
ZA (1) ZA200600966B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009108364A2 (en) * 2008-02-27 2009-09-03 Ipsen Pharma S.A.S. Antagonistic analogues of ghrh
US8691942B2 (en) 2008-03-28 2014-04-08 University Of Miami N- and C- terminal substituted antagonistic analogs of GH-RH
AU2009228244A1 (en) * 2008-03-28 2009-10-01 The United States Of America Represented By The United States Department Of Veteran's Affairs Novel N-and C-terminal substituted -antagonistic analogs of human GH-RH
EP3590956A1 (en) * 2008-06-12 2020-01-08 Ipsen Bioinnovation Limited Suppression of neuroendocrine diseases
JP5799397B2 (ja) 2008-06-12 2015-10-28 イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ 癌の抑制
US8796216B2 (en) 2008-06-12 2014-08-05 Syntaxin Limited Suppression of neuroendocrine diseases
US8227421B2 (en) 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists
WO2011153491A2 (en) 2010-06-03 2011-12-08 University Of Miami Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets
MX2013012259A (es) 2011-04-21 2013-11-22 Theratechnologies Inc Analogos del factor de liberacion de la hormona de crecimiento (grf) y usos de estos.
US9079974B2 (en) 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
WO2014004934A2 (en) * 2012-06-27 2014-01-03 University Of Miami Compositions and methods of treating alzheimer's disease
WO2014100809A2 (en) 2012-12-21 2014-06-26 University Of Miami Ghrh agonists for the treatment of ischemic disorders
EP2935317B1 (en) 2012-12-21 2019-03-27 University of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
AU2020218272A1 (en) 2019-02-08 2021-09-02 United States Government As Represented By The Department Of Veterans Affairs Growth hormone-releasing hormone antagonists and uses thereof
CA3178840A1 (en) 2020-04-27 2021-11-04 The University Of Miami Method of treating an inflammatory disorder
CN114195881B (zh) * 2021-12-16 2022-09-16 浙江湃肽生物股份有限公司 一种制备醋酸舍莫瑞林的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942489A (en) * 1996-05-03 1999-08-24 The Administrators Of The Tulane Educational Fund HGH-RH(1-29)NH2 analogues having antagonistic activity
US6057422A (en) * 1998-11-25 2000-05-02 The Administrators Of The Tulane Educational Fund Antagonistic analogs of GH-RH inhibiting IGF-I and -II

Also Published As

Publication number Publication date
EP1651662A2 (en) 2006-05-03
RU2335506C2 (ru) 2008-10-10
SG136958A1 (en) 2007-11-29
WO2005016953A3 (en) 2006-02-09
CN1871020A (zh) 2006-11-29
AU2004265280A1 (en) 2005-02-24
ZA200600966B (en) 2007-05-30
CA2534436A1 (en) 2005-02-24
RS20060086A (en) 2008-08-07
BRPI0413257A (pt) 2006-10-03
TW200517400A (en) 2005-06-01
PL380437A1 (pl) 2007-01-22
WO2005016953A2 (en) 2005-02-24
JP2007526900A (ja) 2007-09-20
EP1651662A4 (en) 2009-07-01
US20070042950A1 (en) 2007-02-22
RU2006106701A (ru) 2007-09-20
KR20060088875A (ko) 2006-08-07
IL173201A0 (en) 2006-06-11
US7452865B2 (en) 2008-11-18
MXPA06001369A (es) 2007-02-19
AR049149A1 (es) 2006-07-05

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Legal Events

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