NO20054025L - Polymerkonjugater av mutert neublastin. - Google Patents

Polymerkonjugater av mutert neublastin.

Info

Publication number
NO20054025L
NO20054025L NO20054025A NO20054025A NO20054025L NO 20054025 L NO20054025 L NO 20054025L NO 20054025 A NO20054025 A NO 20054025A NO 20054025 A NO20054025 A NO 20054025A NO 20054025 L NO20054025 L NO 20054025L
Authority
NO
Norway
Prior art keywords
polymer conjugates
neublastin
mutant neublastin
polymer
mutant
Prior art date
Application number
NO20054025A
Other languages
English (en)
Other versions
NO20054025D0 (no
Inventor
R Blake Pepinsky
Dinah W Y Sah
Paula Ann Boriack-Sjodin
Stephan S Miller
Anthony Rossomando
Laura Silvian
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/356,264 external-priority patent/US7442370B2/en
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of NO20054025D0 publication Critical patent/NO20054025D0/no
Publication of NO20054025L publication Critical patent/NO20054025L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
NO20054025A 2003-01-31 2005-08-30 Polymerkonjugater av mutert neublastin. NO20054025L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/356,264 US7442370B2 (en) 2001-02-01 2003-01-31 Polymer conjugates of mutated neublastin
PCT/US2004/002763 WO2004069176A2 (en) 2001-02-01 2004-02-02 Polymer conjugates of mutated neublastin

Publications (2)

Publication Number Publication Date
NO20054025D0 NO20054025D0 (no) 2005-08-30
NO20054025L true NO20054025L (no) 2005-10-31

Family

ID=35006489

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20054025A NO20054025L (no) 2003-01-31 2005-08-30 Polymerkonjugater av mutert neublastin.

Country Status (27)

Country Link
EP (3) EP2246362B1 (no)
JP (3) JP4742025B2 (no)
KR (2) KR101293805B1 (no)
CN (2) CN101166753A (no)
AT (1) ATE478891T1 (no)
AU (1) AU2004209966B9 (no)
BR (1) BRPI0407170A (no)
CA (1) CA2514510C (no)
CY (2) CY1111196T1 (no)
DE (1) DE602004028801D1 (no)
DK (2) DK2246362T3 (no)
EA (1) EA008743B1 (no)
ES (2) ES2450115T3 (no)
GE (3) GEP20084464B (no)
HK (1) HK1085663A1 (no)
IL (2) IL169945A (no)
IS (1) IS7938A (no)
ME (1) MEP43808A (no)
MX (1) MXPA05008168A (no)
NO (1) NO20054025L (no)
NZ (2) NZ541921A (no)
PL (1) PL383683A1 (no)
PT (2) PT1594436E (no)
RS (1) RS52910B (no)
SI (2) SI1594436T1 (no)
UA (2) UA91178C2 (no)
ZA (1) ZA200505707B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20084464B (en) * 2003-01-31 2008-08-25 Biogen Idec Inc Mutated neublastin
KR101241551B1 (ko) * 2004-08-19 2013-03-11 바이오겐 아이덱 엠에이 인코포레이티드 전환 성장 인자 베타 패밀리 단백질의 리폴딩
US20140092376A1 (en) * 2012-10-01 2014-04-03 Momentive Performance Materials, Inc. Container and method for in-line analysis of protein compositions
JP2020505069A (ja) * 2017-01-25 2020-02-20 テッサ・セラピューティクス・リミテッド ＴＧＦ−βデコイ受容体
WO2021154599A1 (en) * 2020-01-27 2021-08-05 Silcotek Corp. Biopharmaceutical manufacturing process and product

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU187037B (en) 1983-04-19 1985-10-28 Tibor Sinko Rope-stretching device
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
CA2006596C (en) 1988-12-22 2000-09-05 Rika Ishikawa Chemically-modified g-csf
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
JP3722375B2 (ja) 1991-06-27 2005-11-30 ブリストル−マイヤーズ スクイブ カンパニー Ｃｔｌａ４レセプター、それを含有する融合タンパク質およびそれらの使用
CA2092271C (en) 1993-03-09 2009-10-13 Eddie Reed Use of g-csf for treating taxol side-effects
US5834029A (en) 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
US5770577A (en) * 1994-11-14 1998-06-23 Amgen Inc. BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
DE69736428T2 (de) 1996-05-08 2007-08-30 Biogen Idec Ma Inc., Cambridge RET-LIGAND 3 (RetL3), UM NEURALES UND RENALES WACHSTUM ZU STIMULIEREN
KR100195886B1 (ko) 1996-11-01 1999-06-15 김상조 당뇨병 치료용 의약조성물
WO1999003887A1 (en) * 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
US6593133B1 (en) * 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
US20020055467A1 (en) * 1998-07-06 2002-05-09 Johansen Teit E. Novel neurotrophic factors
US6284540B1 (en) * 1998-09-29 2001-09-04 Washington University Artemin, a novel neurotrophic factor
WO2000034475A2 (en) * 1998-12-09 2000-06-15 Amgen Inc. Grnf4, a gdnf-related neurotrophic factor
IL156559A0 (en) * 2000-12-22 2004-01-04 Genentech Inc New use of artemin, a member of the gdnf ligand family
ES2289091T3 (es) * 2001-02-01 2008-02-01 Biogen Idec Ma Inc. Conjugados polimeros de neublastina y metodos para usar los mismos.
CN1525866B (zh) * 2001-03-28 2013-05-29 比奥根艾迪克Ma公司 神经胚活素多肽的治疗作用
GEP20084464B (en) * 2003-01-31 2008-08-25 Biogen Idec Inc Mutated neublastin
EP1897552B1 (en) * 2003-04-18 2009-06-17 Biogen Idec MA Inc. Polymer-conjugated glycosylated neublastin

Also Published As

Publication number Publication date
KR101216331B1 (ko) 2012-12-28
AU2004209966A2 (en) 2004-08-19
ATE478891T1 (de) 2010-09-15
PL383683A1 (pl) 2008-04-14
MXPA05008168A (es) 2005-10-05
NZ581460A (en) 2010-02-26
AU2004209966B2 (en) 2008-04-17
AU2004209966B9 (en) 2008-06-26
CY1111196T1 (el) 2015-06-11
CN101166753A (zh) 2008-04-23
KR101293805B1 (ko) 2013-08-06
GEP20084464B (en) 2008-08-25
AU2004209966A1 (en) 2004-08-19
DE602004028801D1 (de) 2010-10-07
ZA200505707B (en) 2007-01-31
CN102367277A (zh) 2012-03-07
BRPI0407170A (pt) 2006-02-21
EA200501212A2 (ru) 2006-08-25
JP2011078434A (ja) 2011-04-21
JP2007525152A (ja) 2007-09-06
SI2246362T1 (sl) 2014-04-30
ES2450115T3 (es) 2014-03-24
DK1594436T3 (da) 2010-12-13
RS52910B (en) 2014-02-28
EP2246362A2 (en) 2010-11-03
JP4742025B2 (ja) 2011-08-10
EP1594436A2 (en) 2005-11-16
KR20050099514A (ko) 2005-10-13
EP1594436A4 (en) 2008-05-28
DK2246362T3 (en) 2014-03-10
PT1594436E (pt) 2010-11-29
SI1594436T1 (sl) 2011-01-31
JP2010184924A (ja) 2010-08-26
HK1085663A1 (en) 2006-09-01
IL169945A (en) 2015-03-31
EP2301960A2 (en) 2011-03-30
CY1115085T1 (el) 2016-12-14
EP2301960A3 (en) 2011-08-03
CN102367277B (zh) 2014-04-09
CA2514510C (en) 2013-10-01
GEP20115137B (en) 2011-01-10
EP2246362A3 (en) 2011-02-23
EA200501212A3 (ru) 2006-10-27
MEP43808A (en) 2011-02-10
NO20054025D0 (no) 2005-08-30
IS7938A (is) 2005-07-12
RS20050585A (en) 2007-11-15
PT2246362E (pt) 2014-03-10
UA91178C2 (ru) 2010-07-12
CA2514510A1 (en) 2004-08-19
EP2246362B1 (en) 2013-12-18
NZ541921A (en) 2010-01-29
KR20120099161A (ko) 2012-09-06
IL227752A0 (en) 2013-09-30
EP1594436B1 (en) 2010-08-25
UA105892C2 (uk) 2014-07-10
GEP20135982B (en) 2013-12-10
EA008743B1 (ru) 2007-08-31
ES2351215T3 (es) 2011-02-01

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