SI2246362T1 - Polimerni konjugati mutiranega neoblastina - Google Patents

Polimerni konjugati mutiranega neoblastina

Info

Publication number
SI2246362T1
SI2246362T1 SI200432136T SI200432136T SI2246362T1 SI 2246362 T1 SI2246362 T1 SI 2246362T1 SI 200432136 T SI200432136 T SI 200432136T SI 200432136 T SI200432136 T SI 200432136T SI 2246362 T1 SI2246362 T1 SI 2246362T1
Authority
SI
Slovenia
Prior art keywords
polymer conjugates
mutated neublastin
neublastin
mutated
polymer
Prior art date
Application number
SI200432136T
Other languages
English (en)
Inventor
Dinah Wen-Yee Sah
R. Blake Pepinsky
Paula Ann Boriack-Sjodin
Stephan S. Miller
Anthony Rossomando
Laura Silvian
Original Assignee
Biogen Idec Ma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/356,264 external-priority patent/US7442370B2/en
Application filed by Biogen Idec Ma Inc. filed Critical Biogen Idec Ma Inc.
Publication of SI2246362T1 publication Critical patent/SI2246362T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
SI200432136T 2003-01-31 2004-02-02 Polimerni konjugati mutiranega neoblastina SI2246362T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/356,264 US7442370B2 (en) 2001-02-01 2003-01-31 Polymer conjugates of mutated neublastin
EP10173737.7A EP2246362B1 (en) 2003-01-31 2004-02-02 Polymer conjugates of mutated neublastin

Publications (1)

Publication Number Publication Date
SI2246362T1 true SI2246362T1 (sl) 2014-04-30

Family

ID=35006489

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200432136T SI2246362T1 (sl) 2003-01-31 2004-02-02 Polimerni konjugati mutiranega neoblastina
SI200431548T SI1594436T1 (sl) 2003-01-31 2004-02-02 Mutirani neoblastin

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200431548T SI1594436T1 (sl) 2003-01-31 2004-02-02 Mutirani neoblastin

Country Status (27)

Country Link
EP (3) EP2301960A3 (sl)
JP (3) JP4742025B2 (sl)
KR (2) KR101216331B1 (sl)
CN (2) CN102367277B (sl)
AT (1) ATE478891T1 (sl)
AU (1) AU2004209966B9 (sl)
BR (1) BRPI0407170A (sl)
CA (1) CA2514510C (sl)
CY (2) CY1111196T1 (sl)
DE (1) DE602004028801D1 (sl)
DK (2) DK1594436T3 (sl)
EA (1) EA008743B1 (sl)
ES (2) ES2450115T3 (sl)
GE (3) GEP20084464B (sl)
HK (1) HK1085663A1 (sl)
IL (2) IL169945A (sl)
IS (1) IS7938A (sl)
ME (1) MEP43808A (sl)
MX (1) MXPA05008168A (sl)
NO (1) NO20054025L (sl)
NZ (2) NZ581460A (sl)
PL (1) PL383683A1 (sl)
PT (2) PT1594436E (sl)
RS (1) RS52910B (sl)
SI (2) SI2246362T1 (sl)
UA (2) UA105892C2 (sl)
ZA (1) ZA200505707B (sl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE478891T1 (de) * 2003-01-31 2010-09-15 Biogen Idec Inc Neublastin-mutanten
NZ553420A (en) * 2004-08-19 2010-02-26 Biogen Idec Inc Refolding transforming growth factor beta family proteins
US20140092376A1 (en) * 2012-10-01 2014-04-03 Momentive Performance Materials, Inc. Container and method for in-line analysis of protein compositions
JP2020505069A (ja) * 2017-01-25 2020-02-20 テッサ・セラピューティクス・リミテッド ＴＧＦ−βデコイ受容体
US20230074641A1 (en) * 2020-01-27 2023-03-09 Silcotek Corp. Biopharmaceutical manufacturing process and product

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WO1990006952A1 (en) 1988-12-22 1990-06-28 Kirin-Amgen, Inc. Chemically modified granulocyte colony stimulating factor
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
AU661854B2 (en) 1991-06-27 1995-08-10 Bristol-Myers Squibb Company CTL4A receptor, fusion proteins containing it and uses thereof
CA2092271C (en) 1993-03-09 2009-10-13 Eddie Reed Use of g-csf for treating taxol side-effects
US5834029A (en) 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
US5770577A (en) * 1994-11-14 1998-06-23 Amgen Inc. BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
EE9800377A (et) 1996-05-08 1999-04-15 Biogen, Incorporated Ret-i ligand (RetL) närvi- ja neerukasvu stimuleerimiseks
KR100195886B1 (ko) 1996-11-01 1999-06-15 김상조 당뇨병 치료용 의약조성물
IL133974A0 (en) * 1997-07-14 2001-04-30 Bolder Biotechnology Inc Derivatives of growth hormone and related proteins
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US20020055467A1 (en) * 1998-07-06 2002-05-09 Johansen Teit E. Novel neurotrophic factors
US20020002269A1 (en) * 1998-09-29 2002-01-03 Jeffrey D. Milbrandt Artemin, a neurotrophic factor
JP2002531128A (ja) * 1998-12-09 2002-09-24 アムジエン・インコーポレーテツド 神経栄養因子ｇｒｎｆ４
EP1423139A2 (en) * 2000-12-22 2004-06-02 Genentech, Inc. New use of artemin, a member of the gdnf ligand family
EA009771B1 (ru) * 2001-02-01 2008-04-28 Байоджен Айдек Ма, Инк. Полипептид нейбластина, способы его получения и применения
JP4499362B2 (ja) * 2001-03-28 2010-07-07 バイオジェン・アイデック・エムエイ・インコーポレイテッド ニューロパシーの疼痛を処置するためのニューブラスチンポリペプチドの使用
ATE478891T1 (de) * 2003-01-31 2010-09-15 Biogen Idec Inc Neublastin-mutanten
CA2864810A1 (en) * 2003-04-18 2004-11-04 Biogen Idec Ma, Inc. Polymer-conjugated glycosylated neublastin

Also Published As

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MXPA05008168A (es) 2005-10-05
NZ581460A (en) 2010-02-26
IS7938A (is) 2005-07-12
CA2514510A1 (en) 2004-08-19
RS20050585A (en) 2007-11-15
ZA200505707B (en) 2007-01-31
EP2301960A2 (en) 2011-03-30
RS52910B (en) 2014-02-28
AU2004209966A1 (en) 2004-08-19
JP2011078434A (ja) 2011-04-21
DK1594436T3 (da) 2010-12-13
NO20054025L (no) 2005-10-31
PT2246362E (pt) 2014-03-10
UA91178C2 (ru) 2010-07-12
EP2246362A3 (en) 2011-02-23
KR20120099161A (ko) 2012-09-06
PT1594436E (pt) 2010-11-29
NZ541921A (en) 2010-01-29
EA200501212A2 (ru) 2006-08-25
HK1085663A1 (en) 2006-09-01
EP2246362A2 (en) 2010-11-03
KR20050099514A (ko) 2005-10-13
GEP20115137B (en) 2011-01-10
GEP20135982B (en) 2013-12-10
NO20054025D0 (no) 2005-08-30
AU2004209966B2 (en) 2008-04-17
UA105892C2 (uk) 2014-07-10
IL169945A (en) 2015-03-31
CY1111196T1 (el) 2015-06-11
EP1594436A2 (en) 2005-11-16
CA2514510C (en) 2013-10-01
CN101166753A (zh) 2008-04-23
AU2004209966A2 (en) 2004-08-19
ATE478891T1 (de) 2010-09-15
DE602004028801D1 (de) 2010-10-07
EP2301960A3 (en) 2011-08-03
GEP20084464B (en) 2008-08-25
IL227752A0 (en) 2013-09-30
SI1594436T1 (sl) 2011-01-31
KR101293805B1 (ko) 2013-08-06
EA008743B1 (ru) 2007-08-31
EP1594436B1 (en) 2010-08-25
EP2246362B1 (en) 2013-12-18
ES2351215T3 (es) 2011-02-01
JP2010184924A (ja) 2010-08-26
MEP43808A (en) 2011-02-10
ES2450115T3 (es) 2014-03-24
CN102367277A (zh) 2012-03-07
AU2004209966B9 (en) 2008-06-26
EP1594436A4 (en) 2008-05-28
JP2007525152A (ja) 2007-09-06
KR101216331B1 (ko) 2012-12-28
JP4742025B2 (ja) 2011-08-10
CN102367277B (zh) 2014-04-09
BRPI0407170A (pt) 2006-02-21
PL383683A1 (pl) 2008-04-14
CY1115085T1 (el) 2016-12-14
DK2246362T3 (en) 2014-03-10
EA200501212A3 (ru) 2006-10-27

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